Detailed information for compound 555912

Basic information

Technical information
  • TDR Targets ID: 555912
  • Name: 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)tet rahydrofuran-2-yl]imidazole-4-carboxamide
  • MW: 258.231 | Formula: C9H14N4O5
  • H donors: 5 H acceptors: 5 LogP: -2.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc(c1N)C(=O)N
  • InChi: 1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)
  • InChiKey: RTRQQBHATOEIAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-4-imidazolecarboxamide
  • 5-azanyl-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
  • 5-amino-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)imidazole-4-carboxamide
  • 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
  • acadesine
  • 37642-57-2
  • 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl-
  • 5-Amino-1-.beta.-ribofuranosyl-imidazole-4-carboxamide
  • 5-Amino-1.beta.-D-ribofuranosylimidazole-4-carboxyamide
  • 5-Aminoimidazole-4-carboxamide riboside
  • Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl-
  • NSC105823
  • NSC117661
  • NCIOpen2_007316
  • NCGC00096051-01
  • NCGC00096051-02

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0289 0.0914 0.0914
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.044 0.1433 0.1688
Loa Loa (eye worm) hypothetical protein 0.044 0.1433 0.1433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0066 0.0149 0.0149
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2496 0.849 0.849
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.1433 0.1818
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.044 0.1433 0.1433
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.044 0.1433 0.1433
Trypanosoma brucei cAMP-specific phosphodiesterase 0.044 0.1433 0.1818
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0123 0.0123
Echinococcus multilocularis protein jagged 2 0.0046 0.0082 0.0082
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0137 0.0161
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0064 0.0073
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.044 0.1433 0.1433
Brugia malayi EGF-like domain containing protein 0.0046 0.0082 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0099 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Leishmania major hypothetical protein, conserved 0.044 0.1433 0.1818
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.2235 0.7594 1
Loa Loa (eye worm) glutaminase 0.0268 0.0845 0.0845
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Brugia malayi Cytochrome P450 family protein 0.0025 0.001 0.0012
Echinococcus granulosus integrin alpha 3 0.0401 0.13 0.13
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.044 0.1433 0.1688
Echinococcus granulosus geminin 0.0507 0.1664 0.1664
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0099 0.0561
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.044 0.1433 0.1433
Schistosoma mansoni integrin alpha 0.0523 0.1719 0.1719
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0054 0.0379
Leishmania major hypothetical protein, conserved 0.2235 0.7594 1
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0123 0.0123
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.044 0.1433 0.1433
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.2235 0.7594 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.0672 0.0672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0091 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0099 0.1563
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.044 0.1433 0.1433
Schistosoma mansoni glutaminase 0.0268 0.0845 0.0845
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0064 0.0073
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 1
Trichomonas vaginalis hypothetical protein 0.0046 0.0082 0.0108
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0123 0.1752
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 0.2197
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0137 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0099 0.0561
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.048 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Treponema pallidum fructose-bisphosphate aldolase 0.0332 0.1062 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0091 0.0108
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0149 0.0149
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0091 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Loa Loa (eye worm) hypothetical protein 0.044 0.1433 0.1433
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.044 0.1433 0.1433
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0228 0.0228
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0028 0.0197
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.044 0.1433 0.1433
Loa Loa (eye worm) hypothetical protein 0.0149 0.0433 0.0433
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Plasmodium falciparum cGMP-specific phosphodiesterase 0.044 0.1433 1
Echinococcus granulosus fibrillin 2 0.0046 0.0082 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0228 0.02
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.044 0.1433 0.1688
Plasmodium vivax phosphodiesterase gamma, putative 0.044 0.1433 1
Loa Loa (eye worm) hypothetical protein 0.0396 0.1281 0.1281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.0558 0.0657
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0099 0.0561
Echinococcus multilocularis geminin 0.0507 0.1664 0.1664
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.044 0.1433 0.1433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0149 0.0149
Giardia lamblia High cysteine protein 0.0046 0.0082 0.0025
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.1433 0.1818
Echinococcus granulosus integrin alpha ps 0.0112 0.0309 0.0309
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.044 0.1433 0.1818
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Brugia malayi EGF-like domain containing protein 0.0046 0.0082 0.0096
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) acetyltransferase 0.0144 0.0419 0.0419
Onchocerca volvulus 0.0149 0.0433 0.2527
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.048 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0218 0.0672 0.0672
Echinococcus multilocularis integrin alpha ps 0.0235 0.0728 0.0728
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0063 0.0063
Giardia lamblia Hypothetical protein 0.044 0.1433 0.1384
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Toxoplasma gondii hypothetical protein 0.0046 0.0082 0.0054
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0122 0.0342 0.0342
Schistosoma mansoni integrin beta subunit 0.0845 0.2824 0.2824
Giardia lamblia Tenascin precursor 0.0046 0.0082 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2936 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0228 0.0228
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0099 0.0561
Echinococcus granulosus integrin beta 2 0.1063 0.3572 0.3572
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0149 0.0149
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0034 0.0038 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.044 0.1433 0.1818
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.1818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Brugia malayi RNA binding protein 0.0062 0.0137 0.0161
Schistosoma mansoni hypothetical protein 0.0062 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.044 0.1433 0.1433
Schistosoma mansoni hypothetical protein 0.0034 0.0038 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0099 0.0116
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis muscleblind protein 1 0.0153 0.045 0.045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Plasmodium falciparum phosphodiesterase gamma, putative 0.044 0.1433 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0254 0.0254
Onchocerca volvulus 0.0107 0.029 0.1694
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.044 0.1433 0.1433
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.044 0.1433 0.1818
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0069 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.0558 0.0558
Brugia malayi hypothetical protein 0.0126 0.0355 0.0418
Trypanosoma brucei cAMP-specific phosphodiesterase 0.044 0.1433 0.1818
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Schistosoma mansoni integrin alpha-ps 0.0122 0.0342 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0123 0.2099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0099 0.1563
Echinococcus multilocularis integrin alpha ps 0.0235 0.0728 0.0728
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.044 0.1433 0.1433
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0123 0.1752
Loa Loa (eye worm) hypothetical protein 0.0046 0.0082 0.0082
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0064 0.0064
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Brugia malayi hypothetical protein 0.0041 0.0063 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Brugia malayi glutaminase DH11.1 0.0268 0.0845 0.0995
Schistosoma mansoni alpha glucosidase 0.0041 0.0064 0.0064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0396 0.1281 0.1509
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0228 0.4425
Giardia lamblia Tenascin-37 0.0046 0.0082 0.0025
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Loa Loa (eye worm) hypothetical protein 0.0051 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0153 0.045 0.045
Echinococcus multilocularis tumor protein p63 0.0408 0.1324 0.1324
Onchocerca volvulus 0.006 0.0128 0.0748
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0069 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.044 0.1433 0.1433
Brugia malayi TAR-binding protein 0.0062 0.0137 0.0161
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0137 0.0137
Brugia malayi EGF-like domain containing protein 0.0046 0.0082 0.0096
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0064 0.0064
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0419 0.0419
Schistosoma mansoni lipoxygenase 0.0063 0.0138 0.0138
Trichomonas vaginalis glutaminase, putative 0.0268 0.0845 0.473
Echinococcus granulosus adam 0.0046 0.0082 0.0082
Brugia malayi Integrin alpha pat-2 precursor 0.0523 0.1719 0.2025
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis conserved hypothetical protein 0.044 0.1433 0.8295
Brugia malayi hypothetical protein 0.0149 0.0433 0.051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Echinococcus multilocularis fibrillin 2 0.0046 0.0082 0.0082
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0138 0.0138
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Brugia malayi hypothetical protein 0.0218 0.0672 0.0791
Loa Loa (eye worm) hypothetical protein 0.0153 0.045 0.045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.1062 1
Echinococcus multilocularis fibrillin 1 0.0046 0.0082 0.0082
Brugia malayi Integrin beta pat-3 precursor 0.1435 0.4849 0.5711
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0149 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0099 0.1192
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0254 0.0254
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.2496 0.849 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.0558 0.0558
Loa Loa (eye worm) PDE1B protein 0.044 0.1433 0.1433
Schistosoma mansoni microtubule-associated protein tau 0.1493 0.5047 0.5047
Brugia malayi Kelch motif family protein 0.0218 0.0672 0.0791
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0069 0.0481
Giardia lamblia Tenascin-X 0.0046 0.0082 0.0025
Plasmodium falciparum cGMP-specific phosphodiesterase 0.044 0.1433 1
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Giardia lamblia Neurogenic locus notch-like protein 0.0046 0.0082 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0099 0.0561
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0054 0.0379
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trichomonas vaginalis set domain proteins, putative 0.0522 0.1715 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.044 0.1433 0.1433
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus granulosus muscleblind protein 0.0153 0.045 0.045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) hypothetical protein 0.0046 0.0082 0.0082
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni hypothetical protein 0.0112 0.0309 0.0309
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0064 0.0075
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) hypothetical protein 0.0046 0.0082 0.0082
Echinococcus multilocularis adam 0.0046 0.0082 0.0082
Schistosoma mansoni alpha-glucosidase 0.0159 0.047 0.047
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.044 0.1433 0.1818
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0038 0.0045
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0228 0.02
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0099 0.0417
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0063 0.0063
Giardia lamblia Neurogenic locus Notch protein precursor 0.0046 0.0082 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.048 0.5381
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0099 0.0417
Giardia lamblia Fructose-bisphosphate aldolase 0.0332 0.1062 0.1011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0149 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0254 0.0254
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0099 0.0116
Giardia lamblia hypothetical protein 0.044 0.1433 0.1384
Entamoeba histolytica hypothetical protein 0.0041 0.0063 0.0066
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0054 0.0166
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Giardia lamblia Tenascin-like 0.0046 0.0082 0.0025
Leishmania major cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.1818
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 1
Loa Loa (eye worm) glutaminase 2 0.0268 0.0845 0.0845
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.8295
Entamoeba histolytica hypothetical protein 0.0041 0.0063 0.0066
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 0.1591
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0069 0.0069
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0028 0.0197
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Onchocerca volvulus 0.0051 0.0099 0.0576
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1718 0.5821 0.5821
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.044 0.1433 0.1433
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0064 0.0064
Loa Loa (eye worm) RNA binding protein 0.0062 0.0137 0.0137
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0069 0.0029
Echinococcus granulosus integrin alpha ps 0.0235 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.2936 1 1
Entamoeba histolytica hypothetical protein 0.0041 0.0063 0.0066
Echinococcus multilocularis muscleblind protein 0.0153 0.045 0.045
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0558 0.0558
Echinococcus granulosus microtubule associated protein 2 0.1493 0.5047 0.5047
Loa Loa (eye worm) hypothetical protein 0.0126 0.0355 0.0355
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.1062 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.0355 0.2072
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.001 0.001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.044 0.1433 0.1688
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Brugia malayi Pre-SET motif family protein 0.0066 0.0149 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0254 0.0254
Brugia malayi Pre-SET motif family protein 0.0459 0.1497 0.1763
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0254 0.0254
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0099 0.0561
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.044 0.1433 0.1433
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Giardia lamblia High cysteine protein 0.0046 0.0082 0.0025
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0137 0.0137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0063 0.0063
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0046 0.0082 0.0108
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Trichomonas vaginalis conserved hypothetical protein 0.044 0.1433 0.8295
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.1433 0.1818
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0099 0.0561
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) integrin beta-2 0.1435 0.4849 0.4849
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0419 0.0493
Echinococcus multilocularis integrin alpha 3 0.0401 0.13 0.13
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0149 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0137 0.0137
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis integrin beta 2 0.1063 0.3572 0.3572
Brugia malayi Muscleblind-like protein 0.0153 0.045 0.053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0099 0.0099
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.044 0.1433 0.1433
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2936 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0254 0.0299
Echinococcus granulosus tar DNA binding protein 0.0062 0.0137 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0091 0.0108
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.044 0.1433 0.1688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0254 0.0254
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.1818
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Loa Loa (eye worm) hypothetical protein 0.0126 0.0355 0.0355
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 0.1932
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.044 0.1433 0.1818
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 0.2197
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0057 0.0396
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.1497 0.1497
Onchocerca volvulus Huntingtin homolog 0.0126 0.0355 0.2072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0099 0.0417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Schistosoma mansoni hypothetical protein 0.0507 0.1664 0.1664
Mycobacterium ulcerans glutaminase 0.0268 0.0845 1
Onchocerca volvulus 0.0046 0.0082 0.0478
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.044 0.1433 0.8295
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2936 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Loa Loa (eye worm) hypothetical protein 0.0112 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0054
Giardia lamblia hypothetical protein 0.0046 0.0082 0.0025
Schistosoma mansoni hypothetical protein 0.0507 0.1664 0.1664
Entamoeba histolytica hypothetical protein 0.0041 0.0063 0.0066
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.044 0.1433 0.1688
Echinococcus granulosus fibrillin 1 0.0046 0.0082 0.0082
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Loa Loa (eye worm) integrin alpha pat-2 0.0806 0.2691 0.2691
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.044 0.1433 0.1433
Schistosoma mansoni hypothetical protein 0.0041 0.0063 0.0063
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2936 1 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2936 1 1
Plasmodium vivax SET domain protein, putative 0.0066 0.0149 0.1039
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2936 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.2496 0.849 0.849
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0099 0.1192
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0138 0.0138
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0064 0.0036
Schistosoma mansoni alpha-glucosidase 0.0159 0.047 0.047
Brugia malayi Probable ClpP-like protease 0.0089 0.0228 0.0269
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.044 0.1433 0.1818
Loa Loa (eye worm) hypothetical protein 0.0046 0.0082 0.0082
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2496 0.849 0.849
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0228 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.044 0.1433 0.1818
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0128 0.0128
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0099 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.1493 0.5047 0.5047
Loa Loa (eye worm) hypothetical protein 0.0411 0.1333 0.1333
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0099 0.0116
Echinococcus multilocularis integrin alpha ps 0.0112 0.0309 0.0309
Brugia malayi EGF-like domain containing protein 0.0046 0.0082 0.0096
Schistosoma mansoni integrin alpha-ps 0.0235 0.0728 0.0728
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0089 0.0228 0.0228
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0228 0.1591
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0141 0.0141
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0137 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0149 0.0149
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0419 0.0419
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0099 0.0046
Loa Loa (eye worm) hypothetical protein 0.0051 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.006 0.0128 0.0128
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.044 0.1433 0.1818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.1062 0.6049
Plasmodium falciparum phosphodiesterase delta, putative 0.044 0.1433 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.044 0.1433 0.1409
Trichomonas vaginalis conserved hypothetical protein 0.044 0.1433 0.8295
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.044 0.1433 0.8295
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0228 0.0228
Onchocerca volvulus 0.0522 0.1715 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0069 0.0041
Onchocerca volvulus 0.0066 0.0149 0.0868
Mycobacterium ulcerans hypothetical protein 0.0051 0.0099 0.0561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0254 0.0254
Echinococcus granulosus tumor protein p63 0.0408 0.1324 0.1324

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 3.6125 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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