Detailed information for compound 556809

Basic information

Technical information
  • TDR Targets ID: 556809
  • Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hyd roxymethyl)tetrahydrofuran-2-yl]-7-methyl-3H- purine-6,8-dione
  • MW: 313.267 | Formula: C11H15N5O6
  • H donors: 5 H acceptors: 5 LogP: -3.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(=O)n(c2c1[nH]c(N)nc2=O)C
  • InChi: 1S/C11H15N5O6/c1-15-4-7(13-10(12)14-8(4)20)16(11(15)21)9-6(19)5(18)3(2-17)22-9/h3,5-6,9,17-19H,2H2,1H3,(H3,12,13,14,20)/t3-,5-,6-,9-/m1/s1
  • InChiKey: HPKQEMIXSLRGJU-UUOKFMHZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-7-methyl-3H-purine-6,8-dione
  • 2-azanyl-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-3H-purine-6,8-dione
  • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-7-methyl-3H-purine-6,8-quinone
  • 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-3H-purine-6,8-dione
  • 7-methyl-8-oxoguanosine
  • 1H-Purine-6,8-dione, 2-amino-7,9-dihydro-7-methyl-9-b-D-ribofuranosyl-
  • AIDS-220726
  • AIDS220726
  • 2-Amino-7-methyl-9-(beta-ribofuranosyl)-1H,9H-purine-6,8-dione
  • 7-Methyl-8-oxo-7,8-dihydroguanosine
  • 7-me-8-OG
  • Guanosine, 7,8-dihydro-7-methyl-8-oxo-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0197 0.0028
Trypanosoma brucei unspecified product 0.0019 0.0197 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Loa Loa (eye worm) hypothetical protein 0.0147 0.3868 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0563 0.2736
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.275 1
Schistosoma mansoni glycogen phosphorylase 0.0108 0.275 0.6336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0197 0.1061
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0169 0.0616
Onchocerca volvulus 0.0018 0.0169 0.0616
Schistosoma mansoni hypothetical protein 0.0047 0.0989 0.2279
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0169 0.0438
Schistosoma mansoni thyroid hormone receptor 0.0132 0.3437 0.792
Onchocerca volvulus 0.0018 0.0169 0.0616
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0989 0.0834
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0197 0.0191
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.3868 1
Echinococcus multilocularis geminin 0.0164 0.434 0.4242
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0197 0.0716
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.1544 0.1544
Echinococcus multilocularis chromobox protein 1 0.0072 0.1712 0.1569
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.1171 0.2698
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.161 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0197 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0809 0.2941
Leishmania major cathepsin L-like protease 0.0068 0.161 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Schistosoma mansoni P2X receptor subunit 0.0066 0.1544 0.3557
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0563 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0197 0.1061
Echinococcus granulosus chromobox protein 1 0.0072 0.1712 0.1712
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0197 0.0716
Onchocerca volvulus 0.0018 0.0169 0.0616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2956 0.7644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0896 0.3259
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.144 0.8824
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.3868 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0169 0.0438
Schistosoma mansoni glycogen phosphorylase 0.0108 0.275 0.6336
Leishmania major DNA polymerase eta, putative 0.0019 0.0197 0.0191
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0994 0.3615
Loa Loa (eye worm) ctsf protein 0.0018 0.0169 0.0438
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0169 0.0616
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.3437 0.3324
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0989 0.0834
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0197 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0169 0.0616
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0169 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0989 0.2558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.275 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0169 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0197 0.0191
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0169 0.0169
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0585 0.1513
Schistosoma mansoni DNA polymerase eta 0.0019 0.0197 0.0454
Schistosoma mansoni hypothetical protein 0.0122 0.3156 0.7272
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0197 0.1061
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0197 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0809 0.2941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Schistosoma mansoni P2X receptor subunit 0.0066 0.1544 0.3557
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0197 0.0509
Loa Loa (eye worm) cysteine protease 0.0018 0.0169 0.0438
Onchocerca volvulus 0.0053 0.1171 0.4258
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0585 0.1513
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.2091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Loa Loa (eye worm) hypothetical protein 0.0018 0.0169 0.0438
Schistosoma mansoni P2X receptor subunit 0.0066 0.1544 0.3557
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0169 0.039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0197 0.0191
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.161 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Brugia malayi MH2 domain containing protein 0.0115 0.2956 0.7644
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Leishmania major DNA polymerase kappa, putative 0.0019 0.0197 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0472 0.1718
Echinococcus multilocularis Glycosyl transferase, family 35 0.0108 0.275 0.2625
Loa Loa (eye worm) hypothetical protein 0.0032 0.056 0.1447
Schistosoma mansoni thyroid hormone receptor 0.0132 0.3437 0.792
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0989 0.2558
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Leishmania major cathepsin L-like protease 0.0068 0.161 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0563 0.2736
Brugia malayi Heterochromatin protein 1 0.0072 0.1712 0.4425
Echinococcus multilocularis chromobox protein 1 0.0072 0.1712 0.1569
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.161 1
Echinococcus multilocularis GPCR, family 2 0.0047 0.0989 0.0834
Plasmodium vivax vivapain-2 0.0018 0.0169 0.5
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.0994 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0989 0.2558
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0896 0.3259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Loa Loa (eye worm) hypothetical protein 0.0101 0.2535 0.6555
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0197 0.1061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.3868 1
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.1544 0.1398
Entamoeba histolytica cysteine protease, putative 0.0018 0.0169 0.0616
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0989 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Echinococcus multilocularis tumor protein p63 0.0362 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Echinococcus granulosus geminin 0.0164 0.434 0.434
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Brugia malayi carbohydrate phosphorylase 0.0108 0.275 0.711
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.3156 0.3156
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0169 0.0616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Echinococcus multilocularis expressed protein 0.0032 0.0585 0.0423
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0169 0.0616
Onchocerca volvulus 0.0018 0.0169 0.0616
Trichomonas vaginalis rotamase, putative 0.0032 0.0563 0.2049
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1712 0.6224
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0994 0.2291
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Onchocerca volvulus Glycogen phosphorylase homolog 0.0108 0.275 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.2535 0.6555
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0197 0.0509
Giardia lamblia Glycogen phosphorylase 0.0108 0.275 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0809 0.2941
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0197 0.0191
Schistosoma mansoni hypothetical protein 0.0164 0.434 1
Schistosoma mansoni hypothetical protein 0.0164 0.434 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0197 0.0191
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0169 0.0438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0197 0.0509
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0197 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0989 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Loa Loa (eye worm) glycogen phosphorylase 0.0108 0.275 0.711
Schistosoma mansoni rotamase 0.0032 0.0585 0.1349
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.1712 0.4425
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0994 0.3615
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0472 0.1718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.161 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0169 0.0616
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0169 0.0169
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0197 0.0197
Echinococcus granulosus glycogen phosphorylase 0.0108 0.275 0.275
Echinococcus granulosus dna polymerase kappa 0.0019 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0101 0.2535 0.5842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0585 0.2128
Loa Loa (eye worm) hypothetical protein 0.0053 0.1171 0.3027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Schistosoma mansoni hypothetical protein 0.0047 0.0989 0.2279
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1192 0.7098
Chlamydia trachomatis glycogen phosphorylase 0.0108 0.275 0.5
Echinococcus granulosus GPCR family 2 0.0047 0.0989 0.0989
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Echinococcus granulosus expressed protein 0.0032 0.0585 0.0585
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0563 0.2736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0169 0.0616
Onchocerca volvulus 0.0018 0.0169 0.0616
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.275 0.2625
Loa Loa (eye worm) fibroinase 0.0018 0.0169 0.0438
Onchocerca volvulus 0.0032 0.056 0.2036
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.1544 0.1544
Echinococcus granulosus glycogen phosphorylase 0.0108 0.275 0.275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1712 0.6224
Onchocerca volvulus 0.0018 0.0169 0.0616
Schistosoma mansoni chromobox protein 0.0072 0.1712 0.3944
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0989 0.2558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0197 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0896 0.3259
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.1544 0.1398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Schistosoma mansoni hypothetical protein 0.0047 0.0989 0.2279
Schistosoma mansoni P2X receptor subunit 0.0066 0.1544 0.3557
Schistosoma mansoni chromobox protein 0.0072 0.1712 0.3944
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0994 0.3615
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0197 0.0454
Echinococcus granulosus dna polymerase eta 0.0019 0.0197 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Onchocerca volvulus 0.0018 0.0169 0.0616
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0169 0.039
Echinococcus multilocularis dna polymerase eta 0.0019 0.0197 0.0028
Schistosoma mansoni hypothetical protein 0.0047 0.0989 0.2279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0169 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2956 0.7644
Brugia malayi Cathepsin L-like precursor 0.0018 0.0169 0.0438
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0563 0.2049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.161 1
Echinococcus granulosus chromobox protein 1 0.0072 0.1712 0.1712
Trichomonas vaginalis rotamase, putative 0.0032 0.0585 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Plasmodium vivax vivapain-2 0.0018 0.0169 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0197 0.1061
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0563 0.3379
Echinococcus granulosus cathepsin l1 0.0018 0.0169 0.0169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0169 0.0616
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.275 0.2625
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0994 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.3156 0.3038
Leishmania major cathepsin L-like protease 0.0068 0.161 1
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.1544 0.1398
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.1544 0.1544
Echinococcus granulosus Glycosyl transferase family 35 0.0108 0.275 0.275
Brugia malayi chromobox protein homolog 3 0.004 0.0809 0.2091

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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