Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0873 | 0.0873 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1992 | 0.5613 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0262 | 0.0262 |
Echinococcus multilocularis | adam | 0.0057 | 0.1522 | 0.1294 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0094 | 0.3345 | 0.3166 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0479 | 0.0704 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1061 | 0.2592 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.3484 | 0.3484 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1992 | 0.1992 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3345 | 1 |
Onchocerca volvulus | 0.0047 | 0.1061 | 0.5 | |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0094 | 0.3345 | 1 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0094 | 0.3345 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0262 | 0.0262 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0479 | 0.0223 |
Brugia malayi | Reprolysin | 0.0076 | 0.2473 | 0.2473 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.444 | 0.444 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.444 | 0.444 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.3484 | 0.3484 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0479 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0262 | 0.0262 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0057 | 0.1522 | 0.1522 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0057 | 0.1522 | 0.4088 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1061 | 0.2592 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0479 | 0.0223 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1061 | 0.1061 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.444 | 0.444 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1992 | 0.1992 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0479 | 0.0704 |
Echinococcus granulosus | adam | 0.0057 | 0.1522 | 0.1294 |
Loa Loa (eye worm) | reprolysin | 0.0094 | 0.3345 | 0.3345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.