Detailed information for compound 567409

Basic information

Technical information
  • TDR Targets ID: 567409
  • Name: 4-amino-5-hydroxy-1-[4-hydroxy-5-(hydroxymeth yl)tetrahydrofuran-2-yl]pyrimidin-2-one
  • MW: 243.217 | Formula: C9H13N3O5
  • H donors: 4 H acceptors: 4 LogP: -1.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)n1cc(O)c(nc1=O)N
  • InChi: 1S/C9H13N3O5/c10-8-5(15)2-12(9(16)11-8)7-1-4(14)6(3-13)17-7/h2,4,6-7,13-15H,1,3H2,(H2,10,11,16)
  • InChiKey: CKZJTNZSBMVFSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-amino-5-hydroxy-1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-pyrimidinone
  • 4-azanyl-5-hydroxy-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 4-amino-5-hydroxy-1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidin-2-one
  • 4-amino-5-hydroxy-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 5-hydroxy-2'-deoxycytidine
  • 2'-Deoxy-5-hydroxycytidine
  • Cytidine, 2'-deoxy-5-hydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi chromobox protein homolog 3 0.004 0.0972 0.1007
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis transfer RNA-Gly 0.0219 0.86 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0087 0.5
Echinococcus multilocularis non capsid protein NS 1 0.0105 0.3771 0.4385
Mycobacterium tuberculosis Conserved protein 0.0037 0.0828 0.0809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.7284 1
Onchocerca volvulus 0.0037 0.0828 0.0239
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0828 0.0933
Onchocerca volvulus 0.0043 0.1116 0.0546
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.7284 0.8193
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0972 0.0892
Plasmodium falciparum pyruvate kinase 0.0034 0.0697 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0828 0.0962
Echinococcus multilocularis non capsid protein NS 1 0.0105 0.3771 0.4385
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0697 0.823
Echinococcus multilocularis non capsid protein NS 1 0.0105 0.3771 0.4385
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0828 0.0809
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0697 0.0694
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0828 0.0747
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0697 0.0615
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0828 0.0747
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0828 0.0809
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.2429 0.2825
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0828 0.0809
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0697 0.01
Schistosoma mansoni pyruvate kinase 0.0034 0.0697 0.0785
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0697 0.01
Brugia malayi Ets-domain containing protein 0.0074 0.2429 0.2667
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0828 0.0747
Onchocerca volvulus 0.0037 0.0828 0.0239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0618 0.0719
Echinococcus multilocularis pyruvate kinase 0.0034 0.0697 0.081
Trichomonas vaginalis set domain proteins, putative 0.0251 1 1
Echinococcus multilocularis non capsid protein NS 1 0.0105 0.3771 0.4385
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.1052
Echinococcus granulosus pyruvate kinase 0.0034 0.0697 0.0956
Leishmania major hypothetical protein, conserved 0.0037 0.0828 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0828 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0087 0.125
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0828 1
Schistosoma mansoni hypothetical protein 0.018 0.6944 0.7828
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0828 0.0747
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.8697 0.9802
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0828 1
Schistosoma mansoni ets-related 0.0225 0.8871 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.7284 0.8211
Schistosoma mansoni chromobox protein 0.0071 0.2309 0.2603
Brugia malayi beta-lactamase family protein 0.0037 0.0828 0.0843
Mycobacterium tuberculosis Conserved protein 0.0037 0.0828 0.0809
Mycobacterium tuberculosis Conserved protein 0.0037 0.0828 0.0809
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0697 0.8417
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0618 0.0719
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0828 0.0933
Loa Loa (eye worm) hypothetical protein 0.0023 0.0264 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Loa Loa (eye worm) beta-lactamase 0.0037 0.0828 0.0843
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0474 0.039
Schistosoma mansoni pyruvate kinase 0.0034 0.0697 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0828 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Giardia lamblia Pyruvate kinase 0.0034 0.0697 1
Echinococcus multilocularis chromobox protein 1 0.0071 0.2309 0.2685
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Loa Loa (eye worm) hypothetical protein 0.0031 0.0603 0.0587
Echinococcus multilocularis geminin 0.018 0.6944 0.8075
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0828 0.0809
Schistosoma mansoni gabp alpha 0.0074 0.2429 0.2739
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0474 0.039
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0828 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Onchocerca volvulus 0.0037 0.0828 0.0239
Echinococcus granulosus pyruvate kinase 0.0034 0.0697 0.0956
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0087 0.012
Mycobacterium ulcerans hypothetical protein 0.0037 0.0828 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.7284 0.8211
Echinococcus granulosus chromobox protein 1 0.0071 0.2309 0.317
Chlamydia trachomatis pyruvate kinase 0.0034 0.0697 0.5
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.2429 0.2667
Echinococcus multilocularis transfer RNA-Gly 0.0219 0.86 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0264 0.0201
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0264 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0828 0.0809
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0618 0.747
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Leishmania major pyruvate kinase 0.0034 0.0697 0.823
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0697 0.823
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.7284 0.847
Echinococcus granulosus chromobox protein 1 0.0071 0.2309 0.317
Schistosoma mansoni ap endonuclease 0.0019 0.0087 0.0098
Trichomonas vaginalis esterase, putative 0.0037 0.0828 0.0747
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0697 0.823
Echinococcus multilocularis chromobox protein 1 0.0071 0.2309 0.2685
Loa Loa (eye worm) fli-1 protein 0.0225 0.8871 1
Echinococcus multilocularis transfer RNA-Gly 0.0219 0.86 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0828 1
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.2309 0.253
Brugia malayi Ets-domain containing protein 0.0074 0.2429 0.2667
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0087 0.0101
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1101 0.1023
Schistosoma mansoni chromobox protein 0.0071 0.2309 0.2603
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.1116 0.1259
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni hypothetical protein 0.018 0.6944 0.7828
Mycobacterium ulcerans beta-lactamase 0.0037 0.0828 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0828 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1101 0.1023
Echinococcus multilocularis transfer RNA-Trp 0.0219 0.86 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0828 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2309 0.2242
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0087 0.5
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus granulosus geminin 0.018 0.6944 0.9534
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0828 0.0809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.7284 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.197 0.2144
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Loa Loa (eye worm) hypothetical protein 0.0037 0.0828 0.0843
Loa Loa (eye worm) hypothetical protein 0.0032 0.0618 0.0605
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0697 0.0694
Brugia malayi beta-lactamase family protein 0.0037 0.0828 0.0843
Loa Loa (eye worm) hypothetical protein 0.0034 0.0697 0.0694
Brugia malayi Pre-SET motif family protein 0.0221 0.8697 0.9802
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0618 0.0697
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0568 0.078
Schistosoma mansoni hypothetical protein 0.0105 0.3771 0.4251
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1101 0.053
Brugia malayi Pre-SET motif family protein 0.0032 0.0618 0.0605
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2309 0.2242
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0618 0.0849
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0697 0.0694
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0828 0.0843
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0697 0.823
Echinococcus granulosus 5'partial|3'partial|non capsid protein NS 1 0.0105 0.3771 0.5177
Brugia malayi Fli-1 protein 0.0225 0.8871 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0618 0.0697
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0618 0.0697
Brugia malayi beta-lactamase 0.0037 0.0828 0.0843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.7284 0.8211
Plasmodium vivax SET domain protein, putative 0.0032 0.0618 0.747
Mycobacterium ulcerans lipase LipD 0.0037 0.0828 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.7284 0.8193
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0697 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0828 0.0747
Leishmania major pyruvate kinase 0.0034 0.0697 0.823
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0697 0.823
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0828 0.0843
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0828 0.1136
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0972 0.0392
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0087 0.125
Brugia malayi Heterochromatin protein 1 0.0071 0.2309 0.253
Loa Loa (eye worm) hypothetical protein 0.004 0.0972 0.1007
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.2429 0.3335
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0697 0.0615
Toxoplasma gondii exonuclease III APE 0.0019 0.0087 0.1052
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0697 0.0694
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0697 0.081
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0697 0.0694
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0828 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.7284 0.847
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.9246 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0395 0.0459
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0697 0.8417
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0972 0.0892
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0697 0.0665
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0828 0.0809
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1
Echinococcus multilocularis non capsid protein NS 1 0.0219 0.86 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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