Detailed information for compound 567824

Basic information

Technical information
  • TDR Targets ID: 567824
  • Name: S-benzyl N,N-dipropylcarbamothioate
  • MW: 251.388 | Formula: C14H21NOS
  • H donors: 0 H acceptors: 1 LogP: 3.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)SCc1ccccc1)CCC
  • InChi: 1S/C14H21NOS/c1-3-10-15(11-4-2)14(16)17-12-13-8-6-5-7-9-13/h5-9H,3-4,10-12H2,1-2H3
  • InChiKey: NQLVQOSNDJXLKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-dipropylcarbamothioic acid S-benzyl ester
  • S-(phenylmethyl) N,N-dipropylcarbamothioate
  • N,N-dipropylthiocarbamic acid S-benzyl ester
  • prosulfocarb
  • S-(phenylmethyl) (dipropylamino)methanethioate
  • (dipropylamino)methanethioic acid S-(phenylmethyl) ester
  • (dipropylamino)methanethioic acid S-(benzyl) ester
  • 52888-80-9
  • 36520_RIEDEL
  • Arkade
  • BRN 4804364
  • Benzyl dipropylthiolcarbamate
  • Boxer (ICI Agrochemicals)
  • Carbamic acid, dipropylthio-, S-benzyl ester (7CI)
  • Carbamothioic acid, dipropyl-, S-(phenylmethyl) ester
  • Defi
  • N,N-Dipropylthiocarbamate de S-benzyle [French]
  • Prosulfurocarb herbicide
  • R 15574
  • RCRA waste no. U387
  • S-(Phenylmethyl) dipropylcarbamothioate
  • S-Benzyl N,N-dipropylthiocarbamate
  • S-Benzyl dipropyl thiolcarbamate
  • S-Benzyl dipropylthiocarbamate
  • S-Benzyl dipropylthiocarbamate (IUPAC)
  • S-Benzyl dipropylthiolcarbamate
  • S-Benzyl-N,N-dipropylthiocarbamat [German]
  • SC 0574
  • EE4017306
  • N,N-Dipropiltiocarbamato de S-bencilo [Spanish]
  • N,N-Dipropiltiocarbamato de S-benzilo [Portuguese]
  • N,N-Dipropiltiocarbammato di S-benzile [Italian]
  • S-Benzyl-N,N-dipropylthiocarbamaat [Dutch]
  • S-Benzyl-N,N-dipropylthiocarbamat [Danish]
  • S-Benzyl-N,N-dipropylthiocarbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0949 0.0949
Echinococcus multilocularis sodium and chloride dependent glycine 0.0076 0.1845 0.1845
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1526 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0076 0.1845 0.1845
Echinococcus granulosus GPCR family 2 0.0047 0.0949 0.0949
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.096 0.1185
Loa Loa (eye worm) hypothetical protein 0.0051 0.1083 0.2733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Loa Loa (eye worm) cysteine protease 0.0017 0.0072 0.0181
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0949 0.2395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0902 0.0902
Onchocerca volvulus 0.0017 0.0072 0.0267
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1155 0.1155
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0627 0.0774
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0627 0.0627
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.096 0.2423
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0045 0.0906 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.1845 0.4657
Giardia lamblia Glycogen phosphorylase 0.0104 0.2682 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1155 0.1155
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0072 0.0267
Schistosoma mansoni hypothetical protein 0.01 0.2568 0.317
Onchocerca volvulus 0.0017 0.0072 0.0267
Onchocerca volvulus 0.0017 0.0072 0.0267
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0902 0.2277
Echinococcus granulosus sodium and chloride dependent glycine 0.0076 0.1845 0.1845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1083 0.1337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0902 0.1114
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1155 0.1155
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.2568 0.648
Brugia malayi carbohydrate phosphorylase 0.0104 0.2682 0.6768
Schistosoma mansoni hypothetical protein 0.0047 0.0949 0.1171
Echinococcus granulosus sodium and chloride dependent glycine 0.0076 0.1845 0.1845
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1526 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0072 0.0072
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.096 0.096
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0072 0.0072
Echinococcus multilocularis glycogen phosphorylase 0.0104 0.2682 0.2682
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1526 1
Entamoeba histolytica hypothetical protein 0.0036 0.0627 0.2127
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0 0.5
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0902 0.0902
Echinococcus granulosus glycogen phosphorylase 0.0104 0.2682 0.2682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0627 0.0627
Onchocerca volvulus 0.0017 0.0072 0.0267
Schistosoma mansoni sodium/chloride dependent transporter 0.0076 0.1845 0.2278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Schistosoma mansoni glycogen phosphorylase 0.0104 0.2682 0.3311
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.096 0.1185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.3963 1
Plasmodium vivax vivapain-2 0.0017 0.0072 1
Onchocerca volvulus 0.0017 0.0072 0.0267
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.5095 0.5095
Schistosoma mansoni hypothetical protein 0.0285 0.8101 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.2682 1
Echinococcus multilocularis tumor protein p63 0.0348 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0072 0.0181
Schistosoma mansoni hypothetical protein 0.0047 0.0949 0.1171
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.096 0.096
Entamoeba histolytica hypothetical protein 0.0036 0.0627 0.2127
Chlamydia trachomatis glycogen phosphorylase 0.0104 0.2682 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0072 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0076 0.1845 0.2278
Trichomonas vaginalis glycogen phosphorylase, putative 0.0104 0.2682 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0072 0.0181
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.096 0.1185
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1526 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0045 0.0906 0.3198
Brugia malayi mbt repeat family protein 0.0047 0.096 0.2423
Echinococcus multilocularis Glycosyl transferase, family 35 0.0104 0.2682 0.2682
Entamoeba histolytica hypothetical protein 0.0036 0.0627 0.2127
Loa Loa (eye worm) ctsf protein 0.0017 0.0072 0.0181
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Schistosoma mansoni hypothetical protein 0.0047 0.0949 0.1171
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0072 0.0267
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1155 0.1155
Leishmania major cathepsin L-like protease 0.0066 0.1526 1
Onchocerca volvulus 0.0047 0.096 0.358
Echinococcus multilocularis cysteine protease 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0047 0.096 0.2423
Brugia malayi hypothetical protein 0.0036 0.0627 0.1582
Echinococcus multilocularis GPCR, family 2 0.0047 0.0949 0.0949
Onchocerca volvulus Glycogen phosphorylase homolog 0.0104 0.2682 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0072 0.0267
Entamoeba histolytica glycogen phosphorylase, putative 0.0045 0.0906 0.3198
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0072 0.0089
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0045 0.0906 0.5
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1104 0.7098
Echinococcus granulosus Glycosyl transferase family 35 0.0104 0.2682 0.2682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0949 0.2395
Echinococcus multilocularis glycogen phosphorylase 0.0104 0.2682 0.2682
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0949 0.0949
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0072 1
Schistosoma mansoni hypothetical protein 0.0036 0.0627 0.0774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0072 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0902 0.2277
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1155 0.2914
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.1355 0.8824
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0949 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0949 0.2395
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.096 0.358
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0072 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3115 0.7859
Plasmodium vivax vivapain-2 0.0017 0.0072 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0076 0.1845 0.4657
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0076 0.1845 0.4657
Echinococcus granulosus cathepsin l1 0.0017 0.0072 0.0072
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0072 0.0072
Loa Loa (eye worm) MBCTL1 0.0053 0.1155 0.2914
Schistosoma mansoni glycogen phosphorylase 0.0104 0.2682 0.3311
Echinococcus granulosus glycogen phosphorylase 0.0104 0.2682 0.2682
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0902 0.1114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Entamoeba histolytica glycogen phosphorylase, putative 0.0104 0.2682 1
Schistosoma mansoni glycogen phosphorylase 0.0045 0.0906 0.1119
Onchocerca volvulus 0.0017 0.0072 0.0267
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.096 0.096
Brugia malayi MH2 domain containing protein 0.0119 0.3115 0.7859
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0902 0.0902
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3115 0.7859
Leishmania major cathepsin L-like protease 0.0066 0.1526 1
Loa Loa (eye worm) fibroinase 0.0017 0.0072 0.0181
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0072 0.0181
Onchocerca volvulus 0.0017 0.0072 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.3963 1
Brugia malayi mbt repeat family protein 0.0047 0.096 0.2423
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.5095 0.5095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.3963 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0072 1
Leishmania major cathepsin L-like protease 0.0066 0.1526 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0076 0.1845 0.4657
Loa Loa (eye worm) glycogen phosphorylase 0.0104 0.2682 0.6768
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1155 0.1425
Entamoeba histolytica hypothetical protein 0.0036 0.0627 0.2127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0949 0.0949
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0902 0.1114
Loa Loa (eye worm) hypothetical protein 0.0147 0.3963 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0949 0.2395
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0181
Loa Loa (eye worm) hypothetical protein 0.01 0.2568 0.648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.096 0.096
Schistosoma mansoni hypothetical protein 0.0047 0.0949 0.1171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1526 0.5
Echinococcus multilocularis cysteine protease 0.0017 0.0072 0.0072
Trichomonas vaginalis glycogen phosphorylase, putative 0.0104 0.2682 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1155 0.2914
Entamoeba histolytica glycogen phosphorylase, putative 0.0045 0.0906 0.3198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0902 0.0902
Onchocerca volvulus 0.0051 0.1083 0.4038
Toxoplasma gondii cathepsin CPL 0.0017 0.0072 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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