Detailed information for compound 567877

Basic information

Technical information
  • TDR Targets ID: 567877
  • Name: sirodesmin
  • MW: 486.559 | Formula: C20H26N2O8S2
  • H donors: 2 H acceptors: 6 LogP: -0.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@]12SS[C@@]3(N(C1=O)[C@@H]1C[C@]4([C@H]([C@@]1(C3)O)OC(=O)C)O[C@@H](C(C4=O)(C)C)C)C(=O)N2C
  • InChi: 1S/C20H26N2O8S2/c1-9-16(3,4)12(25)18(30-9)6-11-17(28,13(18)29-10(2)24)7-19-14(26)21(5)20(8-23,32-31-19)15(27)22(11)19/h9,11,13,23,28H,6-8H2,1-5H3/t9-,11-,13+,17+,18+,19-,20-/m1/s1
  • InChiKey: KTAIGLOGMSQPCG-AUVCUMBHSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • NSC 294408

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.109 0.5145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0489 0.0489
Brugia malayi CXXC zinc finger family protein 0.0028 0.0377 0.0415
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0377 0.0415
Echinococcus multilocularis muscleblind protein 1 0.0147 0.343 0.343
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1193 0.1322
Echinococcus granulosus hexokinase 0.0096 0.2116 0.2116
Brugia malayi Hexokinase family protein 0.0096 0.2116 0.2347
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0168 0.0276
Echinococcus multilocularis muscleblind protein 0.0147 0.343 0.343
Brugia malayi hypothetical protein 0.0043 0.0764 0.0845
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0044 0.0046
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0015 0.0024 0.0024
Echinococcus multilocularis hexokinase 0.0096 0.2116 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Entamoeba histolytica hypothetical protein 0.0043 0.0764 0.3601
Schistosoma mansoni cd36 antigen 0.0051 0.0958 0.0958
Brugia malayi Hexokinase family protein 0.006 0.1197 0.1326
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1611 0.1611
Brugia malayi chromobox protein homolog 3 0.0047 0.0859 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2075 0.2075
Schistosoma mansoni cpg binding protein 0.003 0.0418 0.0418
Echinococcus multilocularis Chromo domain 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.043 0.0475
Echinococcus multilocularis hexokinase 0.0096 0.2116 0.2116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0138 0.015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0434 0.0479
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0066 0.1332 0.1476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Loa Loa (eye worm) hypothetical protein 0.0051 0.0958 0.1061
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.5201 0.5774
Loa Loa (eye worm) hypothetical protein 0.0135 0.3114 0.3456
Echinococcus granulosus hexokinase 0.0096 0.2116 0.2116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2075 0.2075
Toxoplasma gondii hexokinase 0.0096 0.2116 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2075 0.2075
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.2075 0.2302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2075 0.2075
Loa Loa (eye worm) hypothetical protein 0.0135 0.3114 0.3456
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0951 0.1591
Brugia malayi SET domain containing protein 0.0017 0.0082 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0168 0.0276
Schistosoma mansoni hypothetical protein 0.0019 0.0138 0.0138
Treponema pallidum hexokinase (hxk) 0.0096 0.2116 0.5
Echinococcus granulosus CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0859 0.1437
Brugia malayi Heterochromatin protein 1 0.0084 0.1807 0.2004
Schistosoma mansoni hypothetical protein 0.0404 1 1
Loa Loa (eye worm) hexokinase 0.0096 0.2116 0.2347
Echinococcus granulosus chromobox protein 1 0.0084 0.1807 0.1807
Schistosoma mansoni hypothetical protein 0.0335 0.824 0.824
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1807 0.3027
Brugia malayi CHD4 protein 0.0015 0.0044 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0951 0.1591
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0044 0.0044
Echinococcus granulosus tar DNA binding protein 0.0076 0.1611 0.1611
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0139 0.0644
Brugia malayi hypothetical protein 0.0051 0.0958 0.1061
Loa Loa (eye worm) hexokinase 0.0096 0.2116 0.2347
Schistosoma mansoni chromobox protein 0.0084 0.1807 0.1807
Onchocerca volvulus 0.0037 0.0598 0.0661
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0138 0.0138
Loa Loa (eye worm) hexokinase 0.003 0.0413 0.0455
Echinococcus multilocularis cpg binding protein 0.003 0.0418 0.0418
Schistosoma mansoni chromobox protein 0.0014 0.0003 0.0003
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.003 0.043 0.1473
Loa Loa (eye worm) hypothetical protein 0.0147 0.343 0.3807
Echinococcus multilocularis chromobox protein 1 0.0084 0.1807 0.1807
Plasmodium vivax SET domain protein, putative 0.0033 0.0489 0.23
Echinococcus multilocularis chromobox protein 1 0.0084 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.006 0.1193 0.1322
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.043 0.2023
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0859 0.1437
Leishmania major hexokinase, putative 0.0096 0.2116 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0138 0.0138
Plasmodium falciparum hexokinase 0.0096 0.2116 1
Brugia malayi RNA binding protein 0.0076 0.1611 0.1786
Trichomonas vaginalis set domain proteins, putative 0.0246 0.5961 1
Brugia malayi CD36 family protein 0.0135 0.3114 0.3456
Echinococcus multilocularis hexokinase type 2 0.0096 0.2116 0.2116
Loa Loa (eye worm) hexokinase type II 0.0096 0.2116 0.2347
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0041 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0047 0.0859 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0506 0.0844
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1611 0.1786
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0139 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0139 0.0139
Echinococcus granulosus lysosome membrane protein 2 0.0135 0.3114 0.3114
Onchocerca volvulus 0.0096 0.2116 0.2347
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.043 0.2023
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.043 0.2023
Brugia malayi Pre-SET motif family protein 0.0033 0.0489 0.054
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0434 0.0479
Brugia malayi hexokinase type II 0.0031 0.0434 0.0479
Echinococcus granulosus CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Loa Loa (eye worm) hypothetical protein 0.0365 0.9005 1
Schistosoma mansoni hypothetical protein 0.0019 0.0138 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.2075 0.2075
Brugia malayi hypothetical protein 0.003 0.043 0.0475
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0139 0.0151
Loa Loa (eye worm) hypothetical protein 0.0051 0.0958 0.1061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0139 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1807 0.2004
Echinococcus granulosus CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Entamoeba histolytica hexokinase 2 0.0096 0.2116 1
Schistosoma mansoni chromobox protein 0.0014 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0079 0.0128
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0138 0.015
Onchocerca volvulus 0.0365 0.9005 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0135 0.3114 0.3456
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0041 0.0709 0.0709
Brugia malayi hexokinase 0.0096 0.2116 0.2347
Brugia malayi Pre-SET motif family protein 0.0217 0.5201 0.5774
Brugia malayi TAR-binding protein 0.0076 0.1611 0.1786
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0147 0.343 0.3807
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0003 0.0003
Trypanosoma cruzi hexokinase, putative 0.0096 0.2116 1
Onchocerca volvulus 0.0046 0.0842 0.0932
Brugia malayi isocitrate dehydrogenase 0.0019 0.0139 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1254 0.1254
Echinococcus multilocularis CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0764 0.0764
Echinococcus granulosus cpg binding protein 0.003 0.0418 0.0418
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Leishmania major hexokinase, putative 0.0096 0.2116 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0138 0.015
Loa Loa (eye worm) hexokinase 0.006 0.1197 0.1326
Brugia malayi MH2 domain containing protein 0.0144 0.3346 0.3713
Onchocerca volvulus Hexokinase homolog 0.006 0.1197 0.1326
Echinococcus multilocularis chromobox protein 2 0.0014 0.0003 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0139 0.0644
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.043 0.1473
Schistosoma mansoni CD36-like class B scavenger receptor 0.0135 0.3114 0.3114
Schistosoma mansoni hypothetical protein 0.0335 0.824 0.824
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0489 0.0489
Schistosoma mansoni chromobox protein 0.0084 0.1807 0.1807
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0138 0.0138
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0135 0.3114 0.3114
Echinococcus multilocularis CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Entamoeba histolytica hypothetical protein 0.0043 0.0764 0.3601
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0859 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.2075 0.2075
Entamoeba histolytica hypothetical protein 0.0043 0.0764 0.3601
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.0051 0.0958 0.1061
Brugia malayi hypothetical protein 0.002 0.0154 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Onchocerca volvulus 0.0246 0.5961 0.6618
Entamoeba histolytica hexokinase 1 0.0096 0.2116 1
Echinococcus multilocularis dnaJ subfamily B 0.0404 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0139 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0489 0.0489
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0139 0.0139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0138 0.0138
Brugia malayi hypothetical protein 0.0365 0.9005 1
Echinococcus granulosus hexokinase 0.0096 0.2116 0.2116
Echinococcus multilocularis geminin 0.0335 0.824 0.824
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0091 0.0148
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1611 0.1786
Entamoeba histolytica hypothetical protein 0.0043 0.0764 0.3601
Echinococcus multilocularis CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Echinococcus granulosus CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1193 0.1322
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0489 0.0489
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0139 0.0644
Echinococcus multilocularis hexokinase 0.0096 0.2116 0.2116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0705 0.078
Onchocerca volvulus 0.0014 0.0003 0.000000036712
Schistosoma mansoni SET domain protein 0.0016 0.0065 0.0065
Brugia malayi hypothetical protein 0.0051 0.0958 0.1061
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0764 0.0764
Schistosoma mansoni hexokinase 0.0096 0.2116 0.2116
Loa Loa (eye worm) RNA binding protein 0.0076 0.1611 0.1786
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0489 0.0489
Echinococcus granulosus hexokinase type 2 0.0096 0.2116 0.2116
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1807 0.3027
Echinococcus granulosus geminin 0.0335 0.824 0.824
Echinococcus granulosus muscleblind protein 0.0147 0.343 0.343
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1611 0.1611
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.043 0.1473
Trypanosoma brucei hexokinase, putative 0.0096 0.2116 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0041 0.0705 0.0705
Echinococcus multilocularis lysosome membrane protein 2 0.0135 0.3114 0.3114
Schistosoma mansoni cpg binding protein 0.003 0.0418 0.0418
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.2075 0.2075
Schistosoma mansoni SET domain protein 0.0041 0.0709 0.0709
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0091 0.0148
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0003 0.0003
Echinococcus multilocularis CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0139 0.0139
Schistosoma mansoni cpg binding protein 0.0028 0.0377 0.0377
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0951 0.1053
Onchocerca volvulus 0.0096 0.2116 0.2347
Echinococcus multilocularis GPCR, family 2 0.0019 0.0138 0.0138
Onchocerca volvulus 0.0028 0.0377 0.0415
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0489 0.054
Schistosoma mansoni hypothetical protein 0.0019 0.0138 0.0138
Echinococcus granulosus CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Onchocerca volvulus 0.006 0.1197 0.1326
Loa Loa (eye worm) hypothetical protein 0.0037 0.0598 0.0661
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3346 0.3713
Echinococcus granulosus chromobox protein 1 0.0084 0.1807 0.1807
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0764 0.0764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.2075 0.2302
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.043 0.1473
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.043 0.2023
Schistosoma mansoni hypothetical protein 0.0014 0.0003 0.0003
Brugia malayi Muscleblind-like protein 0.0147 0.343 0.3807
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0506 0.0844
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0015 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1193 0.1322
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0003 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0139 0.0644
Brugia malayi Hexokinase family protein 0.003 0.0413 0.0455
Echinococcus multilocularis CD36 class B scavenger receptor 0.0135 0.3114 0.3114
Onchocerca volvulus 0.0096 0.2116 0.2347
Echinococcus granulosus Chromo domain 0.0014 0.0003 0.0003
Plasmodium vivax hexokinase, putative 0.0096 0.2116 1
Trypanosoma cruzi hexokinase, putative 0.0096 0.2116 1
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0135 0.3114 0.3456
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0705 0.078
Schistosoma mansoni CD36-like class B scavenger receptor 0.0135 0.3114 0.3114
Echinococcus granulosus Chromobox protein 3 0.0014 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0043 0.0764 0.0764
Trypanosoma brucei hexokinase 0.0096 0.2116 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3346 0.3713
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.041 0.041
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0489 0.23
Echinococcus granulosus GPCR family 2 0.0019 0.0138 0.0138
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0168 0.0276
Trypanosoma brucei hexokinase 0.0096 0.2116 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0003 0.0003
Echinococcus granulosus chromobox protein 2 0.0014 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0019 0.0138 0.0138
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0489 0.0489
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1611 0.1786

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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