Detailed information for compound 568456

Basic information

Technical information
  • TDR Targets ID: 568456
  • Name: (2S)-2-amino-4-(4-aminocyclohexa-2,5-dien-1-y l)butanoic acid
  • MW: 196.246 | Formula: C10H16N2O2
  • H donors: 3 H acceptors: 2 LogP: -2.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](C(=O)O)CCC1C=CC(C=C1)N
  • InChi: 1S/C10H16N2O2/c11-8-4-1-7(2-5-8)3-6-9(12)10(13)14/h1-2,4-5,7-9H,3,6,11-12H2,(H,13,14)/t7?,8?,9-/m0/s1
  • InChiKey: LAJWZJCOWPUSOA-HACHORDNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-4-(4-amino-1-cyclohexa-2,5-dienyl)butanoic acid
  • (2S)-2-azanyl-4-(4-azanylcyclohexa-2,5-dien-1-yl)butanoic acid
  • (2S)-2-amino-4-(4-aminocyclohexa-2,5-dien-1-yl)butyric acid
  • amiclenomycin
  • (2S)-2-amino-4-(4-amino-1-cyclohexa-2,5-dienyl)butyric acid
  • AIDS-166730
  • AIDS166730
  • Amiclenomycin, BRN 5525177
  • Cyclohexadiene-1-butanoic acid, alpha,4-diamino-
  • L-2-Amino-4-(4'-amino-2',5'-cyclohexadienyl)butyric acid
  • NSC 246130
  • 2-AMINO-4-(4-AMINO-CYCLOHEXA-2,5-DIENYL)-BUTYRIC ACID
  • ACZ
  • CIS-AMICLENOMYCIN
  • TRANS-AMICLENOMYCIN

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Curated by TDR Targets References
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 436 aa 413 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0096 0.0316 0.027
Onchocerca volvulus Neuropeptide F receptor homolog 0.0096 0.0316 1
Brugia malayi hypothetical protein 0.0241 0.0913 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.0316 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0067 0.0243
Loa Loa (eye worm) hypothetical protein 0.0039 0.0079 0.0396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Schistosoma mansoni hypothetical protein 0.0096 0.0316 0.027
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.0316 0.122
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni adenoreceptor 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.0316 0.122
Schistosoma mansoni neuropeptide receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0194 0.0665
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0084 0.5
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Schistosoma mansoni biogenic amine receptor 0.0096 0.0316 0.027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.0316 0.122
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.0316 0.027
Echinococcus granulosus chromobox protein 1 0.0069 0.0204 0.071
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.0316 0.3102
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni P2X receptor subunit 0.0067 0.0194 0.0147
Schistosoma mansoni neuropeptide receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0218 0.082 0.8922
Echinococcus multilocularis chromobox protein 1 0.0069 0.0204 0.071
Brugia malayi Dopamine receptor protein 1 0.0096 0.0316 0.3102
Onchocerca volvulus 0.0096 0.0316 1
Trypanosoma brucei glucose transporter 2A 0.0036 0.0067 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.0316 0.027
Echinococcus multilocularis ornithine aminotransferase 0.0052 0.0135 0.0397
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.0316 0.122
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.0316 0.027
Schistosoma mansoni biogenic amine receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) fli-1 protein 0.0224 0.0844 0.9196
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0194 0.0665
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0477 0.1949
Echinococcus granulosus g protein coupled receptor 0.0096 0.0316 0.122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0218 0.082 0.0776
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0035
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0091 0.0418
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.0316 0.122
Schistosoma mansoni amine GPCR 0.0096 0.0316 0.027
Echinococcus granulosus chromobox protein 1 0.0069 0.0204 0.071
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.0316 0.3102
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0099 0.0232
Echinococcus multilocularis g protein coupled receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus multilocularis neuropeptide receptor 0.0096 0.0316 0.122
Schistosoma mansoni glucose transport protein 0.0115 0.0393 0.0347
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0196 0.1717
Brugia malayi sulfakinin receptor protein 0.0096 0.0316 0.3102
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0099 0.0472
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.0316 0.3102
Schistosoma mansoni hypothetical protein 0.0096 0.0316 0.027
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0194 0.0665
Brugia malayi neuropeptide F receptor 0.0096 0.0316 0.3102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0067 0.0088
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0091 0.1714
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.0316 0.027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0529 0.0483
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus granulosus serotonin receptor 0.0096 0.0316 0.122
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.0316 0.122
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.0316 0.122
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0218 0.082 0.8922
Brugia malayi Sugar transporter family protein 0.0115 0.0393 0.3993
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0067 0.0243
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.0316 0.122
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.0316 0.122
Plasmodium falciparum ornithine aminotransferase 0.0052 0.0135 0.1653
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0367 0.1434 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.0316 0.027
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.0316 0.122
Leishmania major glucose transporter, lmgt2 0.0036 0.0067 0.5
Brugia malayi Fli-1 protein 0.0224 0.0844 0.9194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0324 0.3196
Mycobacterium tuberculosis Probable aminotransferase 0.0367 0.1434 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.0316 0.122
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Onchocerca volvulus 0.0096 0.0316 1
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0052 0.0135 0.1009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0052 0.0135 0.0088
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0079 0.1268
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.0316 0.122
Echinococcus granulosus sex peptide receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0529 0.2185
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Brugia malayi Ets-domain containing protein 0.0074 0.0224 0.2036
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0512 0.2107
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0367 0.1434 1
Echinococcus multilocularis serotonin receptor 0.0218 0.082 0.3506
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0067 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.0316 0.122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.0316 0.122
Echinococcus multilocularis orexin receptor type 2 0.0096 0.0316 0.122
Plasmodium falciparum hexose transporter 0.0115 0.0393 1
Schistosoma mansoni amine GPCR 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0067 0.5
Echinococcus granulosus somatostatin receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.0316 0.3126
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0063 0.018 0.1556
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0367 0.1434 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.0316 0.3102
Brugia malayi Dopamine receptor protein 2 0.0096 0.0316 0.3102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni hypothetical protein 0.0096 0.0316 0.027
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0477 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0393 0.2574
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.0316 0.027
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.0316 0.122
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0067 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0067 0.5
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Echinococcus granulosus Aminotransferase class III 0.0052 0.0135 0.0397
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.0316 0.122
Brugia malayi G protein-coupled receptor 0.0096 0.0316 0.3102
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0529 0.5557
Echinococcus granulosus ornithine aminotransferase 0.0052 0.0135 0.0397
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.0316 0.122
Echinococcus granulosus neuropeptide receptor A26 0.0565 0.2249 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0099 0.0472
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0052 0.0135 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trypanosoma brucei glucose transporter 1E 0.0036 0.0067 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0204 0.1223
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0067 1
Echinococcus granulosus fmrfamide receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.0316 0.122
Onchocerca volvulus 0.0096 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0067 0.0196 0.1746
Loa Loa (eye worm) hypothetical protein 0.0241 0.0913 1
Schistosoma mansoni opsin-like receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Brugia malayi Melatonin receptor type 1A 0.0096 0.0316 0.3102
Brugia malayi AKH receptor 0.0096 0.0316 0.3102
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0367 0.1434 1
Echinococcus granulosus neuropeptide receptor 0.0096 0.0316 0.122
Schistosoma mansoni hypothetical protein 0.0036 0.0067 0.0019
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni chromobox protein 0.0069 0.0204 0.0157
Brugia malayi Ets-domain containing protein 0.0074 0.0224 0.2036
Schistosoma mansoni survival motor neuron protein 0.0049 0.0122 0.0075
Onchocerca volvulus 0.0049 0.0122 0.2861
Brugia malayi G-protein coupled receptor 0.0096 0.0316 0.3102
Schistosoma mansoni P2X receptor subunit 0.0067 0.0194 0.0147
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0194 0.0665
Schistosoma mansoni glucose transport protein 0.0115 0.0393 0.0347
Echinococcus multilocularis ornithine aminotransferase 0.0052 0.0135 0.0397
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.0316 0.027
Echinococcus granulosus g-protein coupled receptor 0.0096 0.0316 0.122
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.0316 0.3102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Trypanosoma cruzi hexose transporter 0.0036 0.0067 1
Mycobacterium ulcerans hypothetical protein 0.0367 0.1434 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0435 0.1761
Echinococcus multilocularis Aminotransferase class III 0.0052 0.0135 0.0397
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni opsin-like receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.0316 0.3126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0324 0.322
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0477 0.0431
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.0913 0.3932
Schistosoma mansoni chromobox protein 0.0069 0.0204 0.0157
Brugia malayi RE15519p 0.0096 0.0316 0.3102
Echinococcus multilocularis serotonin receptor 0.0218 0.082 0.3506
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.0316 0.122
Brugia malayi G-protein coupled receptor 0.0096 0.0316 0.3102
Brugia malayi ORL1-like opioid receptor 0.0096 0.0316 0.3102
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Onchocerca volvulus 0.0096 0.0316 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Onchocerca volvulus 0.0096 0.0316 1
Brugia malayi Serotonin receptor 0.0096 0.0316 0.3102
Echinococcus granulosus orexin receptor type 2 0.0096 0.0316 0.122
Schistosoma mansoni amine GPCR 0.0096 0.0316 0.027
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.0316 0.027
Onchocerca volvulus 0.0096 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis neuropeptide receptor 0.0096 0.0316 0.122
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Schistosoma mansoni hypothetical protein 0.0125 0.0435 0.039
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0194 0.0665
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Brugia malayi follicle stimulating hormone receptor 0.0096 0.0316 0.3102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0324 0.3196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.0316 0.122
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.0316 0.122
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.0316 0.122
Schistosoma mansoni P2X receptor subunit 0.0067 0.0194 0.0147
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0122 0.0862
Schistosoma mansoni histamine h1 receptor 0.0096 0.0316 0.027
Echinococcus multilocularis General substrate transporter 0.0099 0.0327 0.1267
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0048 0.0035
Loa Loa (eye worm) sugar transporter 0.0115 0.0393 0.4014
Schistosoma mansoni neuropeptide receptor 0.0096 0.0316 0.027
Brugia malayi putative neuropeptide receptor 0.0096 0.0316 0.3102
Schistosoma mansoni hypothetical protein 0.0115 0.0393 0.0347
Echinococcus granulosus allatostatin A receptor 0.0096 0.0316 0.122
Schistosoma mansoni ets-related 0.0224 0.0844 0.08
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0204 0.1835
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0435 0.1761
Brugia malayi Serotonin receptor 0.0096 0.0316 0.3102
Brugia malayi neuropeptide F receptor 0.0096 0.0316 0.3102
Schistosoma mansoni P2X receptor subunit 0.0067 0.0194 0.0147
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.0316 0.027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.0316 0.3126
Echinococcus multilocularis g protein coupled receptor 0.0096 0.0316 0.122
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.0316 0.027
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0096 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.0316 0.3126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Schistosoma mansoni hypothetical protein 0.0067 0.0196 0.0149
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0098 0.0324 0.322
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0067 1
Leishmania major glucose transporter, lmgt1 0.0036 0.0067 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.0316 0.3126
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.0316 0.027
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) acetyltransferase 0.0148 0.0529 0.5572
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0091 0.0418
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.0316 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0079 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.0316 0.122
Echinococcus granulosus biogenic amine 5HT receptor 0.0218 0.082 0.3506
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.0316 0.122
Echinococcus multilocularis g protein coupled receptor 0.0096 0.0316 0.122
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0204 0.1223
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0115 0.0393 0.157
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.0316 0.122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.0316 0.122
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0052 0.0135 0.5
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0067 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.0316 0.027
Trypanosoma brucei glucose transporter, putative 0.0036 0.0067 0.5
Plasmodium vivax hexose transporter 0.0115 0.0393 1
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Echinococcus multilocularis allatostatin A receptor 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis fmrfamide receptor 0.0096 0.0316 0.122
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.0316 0.122
Schistosoma mansoni hypothetical protein 0.0096 0.0316 0.027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.0316 0.027
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0067 0.0243
Brugia malayi Heterochromatin protein 1 0.0069 0.0204 0.1806
Onchocerca volvulus 0.0096 0.0316 1
Onchocerca volvulus 0.0096 0.0316 1
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0067 0.0243
Schistosoma mansoni amine GPCR 0.0096 0.0316 0.027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.0316 0.122
Echinococcus granulosus hypothetical protein 0.0096 0.0316 0.122
Echinococcus multilocularis fmrfamide receptor 0.0096 0.0316 0.122
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.0316 0.122
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.0913 0.3932
Echinococcus granulosus g protein coupled receptor 0.0096 0.0316 0.122
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0224 0.0801
Schistosoma mansoni hypothetical protein 0.0049 0.0122 0.0075
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis sex peptide receptor 0.0096 0.0316 0.122
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.0316 0.122
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.0316 0.122
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni biogenic amine receptor 0.0096 0.0316 0.027
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.0316 0.122
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.0316 0.3102
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0224 0.0801
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Brugia malayi hypothetical protein 0.0036 0.0067 0.0223
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.0316 0.122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Echinococcus multilocularis chromobox protein 1 0.0069 0.0204 0.071
Echinococcus multilocularis neuropeptide receptor A26 0.0565 0.2249 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Echinococcus multilocularis somatostatin receptor 0.0096 0.0316 0.122
Echinococcus granulosus neuropeptide receptor 0.0096 0.0316 0.122
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.0316 0.3102
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.0316 0.3126
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.0316 0.122
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0194 0.0665
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0067 0.0243
Brugia malayi larval opioid receptor 0.0096 0.0316 0.3102
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0224 0.2064
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0067 0.0243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0067 0.0088
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.0316 0.027
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.0316 0.3126
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.0316 0.122
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni glucose transport protein 0.0115 0.0393 0.0347
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.0316 0.3126
Onchocerca volvulus 0.0096 0.0316 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.0316 0.027
Schistosoma mansoni myosin xvIII 0.0096 0.0316 0.027
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.0316 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0079 0.0332
Leishmania major glucose transporter, lmgt3 0.0036 0.0067 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.0316 0.122
Onchocerca volvulus 0.0096 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.0316 0.027
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0052 0.0135 0.123
Brugia malayi Dopamine receptor 0.0096 0.0316 0.3102
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0067 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0079 0.0362
Echinococcus multilocularis neuropeptide s receptor 0.0565 0.2249 1
Echinococcus granulosus neuropeptide s receptor 0.0565 0.2249 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0067 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus granulosus General substrate transporter 0.0099 0.0327 0.1267
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Plasmodium vivax ornithine aminotransferase, putative 0.0052 0.0135 0.123
Toxoplasma gondii facilitative glucose transporter GT1 0.0115 0.0393 1
Brugia malayi GnHR receptor homolog 0.0096 0.0316 0.3102
Echinococcus granulosus g protein coupled receptor 0.0096 0.0316 0.122
Brugia malayi hypothetical protein 0.0096 0.0316 0.3102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.0393 0.157
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.0316 0.3102
Schistosoma mansoni opsin-like receptor 0.0096 0.0316 0.027
Schistosoma mansoni gabp alpha 0.0074 0.0224 0.0177
Onchocerca volvulus 0.0096 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.3126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.0316 0.027
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.0316 0.122
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.0316 0.027
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0084 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 257127  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 16984394
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 5713  
Annotator: crowther@u.washington.edu Comment: 2007-12-21 References: 16984394

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.