Detailed information for compound 574177

Basic information

Technical information
  • TDR Targets ID: 574177
  • Name: 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxy-chro men-4-one
  • MW: 330.289 | Formula: C17H14O7
  • H donors: 3 H acceptors: 4 LogP: 2.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)c1oc2cc(O)cc(c2c(=O)c1O)O
  • InChi: 1S/C17H14O7/c1-22-10-3-8(4-11(7-10)23-2)17-16(21)15(20)14-12(19)5-9(18)6-13(14)24-17/h3-7,18-19,21H,1-2H3
  • InChiKey: HEJAFZFLVQINJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one
  • 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxy-chromone
  • 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxychromen-4-one
  • morelosin
  • 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxy-4-chromenone
  • 62008-19-9
  • 3,5,7-Trihydroxy-3',5'-dimethoxyflavone
  • 4H-1-Benzopyran-4-one, 2-(3,5-dimethoxyphenyl)-3,5,7-trihydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.0101 0.203 0.264
Leishmania major glucose transporter, lmgt3 0.0031 0.0438 0.8107
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0414 1
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0059 0.002
Echinococcus multilocularis geminin 0.0344 0.756 0.7557
Plasmodium vivax importin-beta 2, putative 0.0028 0.0363 0.0334
Echinococcus granulosus jumonji domain containing protein 0.0032 0.045 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0118
Plasmodium falciparum protein kinase 6 0.043 0.9519 1
Plasmodium vivax hexose transporter 0.0101 0.203 0.2094
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0172 0.0203
Schistosoma mansoni lamin 0.0026 0.0321 0.0366
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3452 0.3595
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0237 0.395
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0429 0.0617
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0046 0.0035
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0237 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.009
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0438 0.8107
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Entamoeba histolytica hypothetical protein 0.0023 0.0241 0.3939
Trypanosoma brucei glucose transporter 2A 0.0031 0.0438 0.8107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.009
Brugia malayi jmjC domain containing protein 0.002 0.0172 0.0153
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0385 0.0374
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0521 0.0511
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0046 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0059 0.0273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Leishmania major basic transcription factor 3a, putative 0.0034 0.0499 0.9375
Echinococcus granulosus neuropeptide receptor A26 0.0451 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Echinococcus granulosus lamin dm0 0.0026 0.0321 0.031
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0429 0.0617
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0193 0.0237
Brugia malayi jmjC domain containing protein 0.002 0.0172 0.0153
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0172 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Schistosoma mansoni hypothetical protein 0.0035 0.0521 0.0632
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0237 0.0254
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0046 0.0035
Echinococcus granulosus phd:f box containing protein 0.002 0.0172 0.0162
Plasmodium falciparum protein kinase 7 0.0286 0.6244 0.6542
Brugia malayi hypothetical protein 0.0014 0.0046 0.0004
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0429 0.0404
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 0.9519 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0046 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.1412 0.1817
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0499 0.2281
Entamoeba histolytica hypothetical protein 0.0023 0.0237 0.3842
Schistosoma mansoni ran 0.0021 0.0193 0.0196
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0429 0.0617
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0414 1
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0046 0.0035
Brugia malayi beta-NAC-like protein 0.0034 0.0499 0.0539
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.203 0.2021
Schistosoma mansoni jumonji domain containing protein 0.002 0.0172 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0172 0.0203
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0237 0.395
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0414 0.1855
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0414 0.0439
Brugia malayi Sugar transporter family protein 0.0101 0.203 0.2348
Loa Loa (eye worm) hypothetical protein 0.0036 0.0541 0.0635
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0429 0.0418
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0159 1
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0438 0.1973
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Leishmania major GTP-binding protein, putative 0.0021 0.0193 0.3048
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0172 0.2612
Leishmania major importin beta-1 subunit, putative 0.0023 0.0241 0.4042
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0193 0.0227
Brugia malayi Sugar transporter family protein 0.0014 0.0046 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0203
Schistosoma mansoni hypothetical protein 0.0344 0.756 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0046 0.0035
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0237 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0901 0.1059
Schistosoma mansoni jumonji domain containing protein 0.0106 0.214 0.2787
Schistosoma mansoni importin beta-1 0.0028 0.0363 0.0421
Echinococcus multilocularis neuropeptide s receptor 0.0451 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0241 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.203 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0241 0.0984
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0237 0.0308
Echinococcus granulosus geminin 0.0344 0.756 0.7557
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0237 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0172 0.2612
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0237 0.0226
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.6564 0.7715
Schistosoma mansoni ap endonuclease 0.0015 0.0059 0.0018
Echinococcus granulosus importin subunit beta 1 0.0028 0.0363 0.0352
Schistosoma mansoni ap endonuclease 0.0015 0.0059 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0803 0.0944
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0193 0.3048
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0172 0.0162
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0499 0.9375
Echinococcus granulosus transcription factor btf3 0.0034 0.0499 0.0488
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0046 0.0004
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0113 0.1383
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0101 0.009
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0414 0.0404
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0429 0.0456
Echinococcus multilocularis peregrin 0.0023 0.0245 0.0235
Brugia malayi hypothetical protein 0.0386 0.8508 1
Brugia malayi hypothetical protein 0.0014 0.0046 0.0004
Schistosoma mansoni hypothetical protein 0.0023 0.0245 0.0265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0059 0.0273
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0414 0.7681
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0438 0.8107
Brugia malayi major facilitator superfamily protein 0.0014 0.0046 0.0004
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0237 0.5182
Echinococcus granulosus solute carrier family 22 0.0014 0.0046 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0245 0.0321
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Echinococcus multilocularis solute carrier family 22 0.0014 0.0046 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.031 0.0365
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0499 0.9512
Giardia lamblia PHD finger protein 15 0.0023 0.0245 0.5408
Schistosoma mansoni hypothetical protein 0.0101 0.203 0.264
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0172 0.0203
Plasmodium vivax JmjC domain containing protein 0.002 0.0172 0.0133
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0193 0.0183
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0414 0.049
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0499 0.9375
Echinococcus granulosus lamin 0.0026 0.0321 0.031
Brugia malayi Importin beta-1 subunit 0.0028 0.0363 0.0378
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0499 0.2281
Entamoeba histolytica hypothetical protein 0.0034 0.0499 0.9512
Schistosoma mansoni protein kinase 0.0031 0.0429 0.0509
Echinococcus multilocularis transcription factor btf3 0.0034 0.0499 0.0488
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0237 0.0961
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0237 0.0226
Schistosoma mansoni lamin 0.0026 0.0321 0.0366
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0385 0.0374
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0529 1
Trypanosoma brucei glucose transporter 1E 0.0031 0.0438 0.8107
Schistosoma mansoni transcription factor btf3 0.0034 0.0499 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0438 0.1973
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0101 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0429 0.1927
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0321 0.0329
Brugia malayi Sugar transporter family protein 0.0014 0.0046 0.0004
Echinococcus multilocularis PHD finger protein rhinoceros 0.0023 0.0245 0.0235
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0059 0.1166
Schistosoma mansoni intermediate filament proteins 0.0026 0.0321 0.0366
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0172 0.0168
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0541 0.0588
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0438 0.8107
Echinococcus multilocularis musashi 0.0026 0.0321 0.031
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.1412 0.1402
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0414 0.049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.1412 0.1817
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0072
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0172 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Echinococcus granulosus solute carrier family 22 0.0014 0.0046 0.0035
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0059 0.007
Echinococcus granulosus intermediate filament protein 0.0026 0.0321 0.031
Schistosoma mansoni glucose transport protein 0.0101 0.203 0.264
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0172 0.0162
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0529 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0101 0.0118
Schistosoma mansoni glucose transport protein 0.0101 0.203 0.264
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3452 0.3595
Schistosoma mansoni hypothetical protein 0.0344 0.756 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0046 0.0054
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0237 0.0229
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0023 0.0245 0.0265
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.092 0.1036
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0046 0.0004
Brugia malayi RNA, U transporter 1 0.008 0.1544 0.1774
Echinococcus multilocularis neuropeptide receptor A26 0.0451 1 1
Onchocerca volvulus 0.0386 0.8508 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.1412 0.1402
Trichomonas vaginalis ran, putative 0.0021 0.0193 0.0742
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0429 0.0504
Echinococcus multilocularis snurportin 1 0.03 0.6564 0.656
Loa Loa (eye worm) sugar transporter 0.0014 0.0046 0.0054
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0529 1
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0172 0.0162
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0059 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0321 0.0377
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0245 0.0288
Brugia malayi jmjC domain containing protein 0.002 0.0172 0.0153
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0429 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Echinococcus multilocularis solute carrier family 22 0.0014 0.0046 0.0035
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0429 0.0404
Schistosoma mansoni hypothetical protein 0.03 0.6564 0.8674
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0529 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0321 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0237 0.0254
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0529 1
Trypanosoma cruzi hexose transporter 0.0031 0.0438 0.8107
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0193 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0521 0.0632
Echinococcus granulosus snurportin 1 0.03 0.6564 0.656
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0529 0.051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0059 0.0049
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0429 0.0404
Onchocerca volvulus Alhambra homolog 0.0023 0.0245 0.0235
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0529 0.051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0173 0.0641
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Leishmania major glucose transporter, lmgt2 0.0031 0.0438 0.8107
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0245 0.0321
Echinococcus granulosus peregrin 0.0023 0.0245 0.0235
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0193 0.3048
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0363 0.6553
Brugia malayi jmjC domain containing protein 0.002 0.0172 0.0153
Brugia malayi major facilitator superfamily protein 0.0014 0.0046 0.0004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Brugia malayi hypothetical protein 0.0014 0.0046 0.0004
Loa Loa (eye worm) hypothetical protein 0.0386 0.8508 1
Echinococcus multilocularis General substrate transporter 0.0087 0.1705 0.1696
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0172 0.0133
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0059 0.0691
Schistosoma mansoni phd/f-box containing protein 0.002 0.0172 0.0168
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0122 0.2493 0.2484
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0059 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3452 0.5495
Leishmania major glucose transporter, lmgt1 0.0031 0.0438 0.8107
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.1412 0.1659
Entamoeba histolytica protein kinase, putative 0.0031 0.0429 0.799
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0059 0.0014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0429 0.0418
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0237 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0172 0.0168
Echinococcus multilocularis solute carrier family 22 0.0014 0.0046 0.0035
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0363 0.051
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0203
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0241 0.0984
Echinococcus granulosus solute carrier family 22 0.0014 0.0046 0.0035
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0237 0.0201
Plasmodium falciparum importin beta, putative 0.0028 0.0363 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0429 0.0404
Brugia malayi hypothetical protein 0.0035 0.0521 0.0565
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0059 0.0066
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0122 0.2493 0.2484
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0046 0.0004
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0499 0.9375
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0499 0.0478
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0429 0.0504
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0521 0.0511
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.203 0.3201
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0438 0.1973
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0429 0.0509
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0499 0.073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0059 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0438 0.1973
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0013
Toxoplasma gondii exonuclease III APE 0.0015 0.0059 0.0021
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0046 0.0035
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0159 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0438 0.8107
Leishmania major hypothetical protein, conserved 0.002 0.0172 0.2612
Echinococcus granulosus PHD finger protein rhinoceros 0.0023 0.0245 0.0235
Plasmodium falciparum hexose transporter 0.0101 0.203 0.2094
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0172 0.0203
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.203 0.2021
Entamoeba histolytica protein kinase, putative 0.0031 0.0429 0.799
Loa Loa (eye worm) hypothetical protein 0.0025 0.0284 0.0334
Loa Loa (eye worm) hypothetical protein 0.0026 0.0321 0.0377
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0059 0.0358
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0193 0.0183
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0172 0.0162
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0237 0.3046
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0429 0.0404
Onchocerca volvulus 0.0026 0.0321 0.0325
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Schistosoma mansoni hypothetical protein 0.0036 0.0541 0.0658
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0288
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0429 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0438 0.8107
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0237 0.0201
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0499 0.0586
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0414 0.0439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0414 0.0404
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0172 0.0203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0054
Brugia malayi jmjC domain containing protein 0.0122 0.2493 0.2894
Loa Loa (eye worm) sugar transporter 0.0101 0.203 0.2386
Echinococcus multilocularis GPCR, family 2 0.0017 0.0101 0.009
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0438 0.8107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.092 0.1081
Echinococcus multilocularis lamin 0.0026 0.0321 0.031
Brugia malayi jmjC domain containing protein 0.0074 0.1412 0.1617
Plasmodium falciparum phd finger protein, putative 0.0023 0.0245 0.021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0363 0.0426
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.092 0.1036
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0241 0.4042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0101 0.0068
Echinococcus multilocularis phd:f box containing protein 0.002 0.0172 0.0162
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0172 0.0162
Schistosoma mansoni protein phosphatase 2C 0.002 0.0172 0.0168
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0363 0.0352
Schistosoma mansoni ran 0.0021 0.0193 0.0196
Trypanosoma brucei glucose transporter, putative 0.0031 0.0438 0.8107
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0193 0.3048
Loa Loa (eye worm) hypothetical protein 0.0053 0.092 0.1081
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0193 0.3998
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0059 0.0049
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0438 0.1973
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0429 0.7919
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0043 0.005
Echinococcus granulosus GPCR family 2 0.0017 0.0101 0.009
Leishmania major protein kinase, putative 0.0031 0.0429 0.7919
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0059 1
Schistosoma mansoni protein kinase 0.0031 0.0429 0.0509
Brugia malayi Bromodomain containing protein 0.0023 0.0245 0.0239
Entamoeba histolytica Ran family GTPase 0.0021 0.0193 0.29
Brugia malayi Cam kinase protein 1 0.0031 0.0429 0.0456
Schistosoma mansoni protein kinase 0.0031 0.0429 0.0509
Echinococcus multilocularis jumonji domain containing protein 0.0032 0.045 0.044
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0363 0.6553
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0172 0.2612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0504
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0438 0.1973
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0072
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0438 0.8107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0237 0.395
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0429 0.0404
Echinococcus multilocularis lamin dm0 0.0026 0.0321 0.031
Brugia malayi intermediate filament protein 0.0026 0.0321 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0499 0.2281
Toxoplasma gondii protein kinase, putative 0.0286 0.6244 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0499 0.0478
Brugia malayi PHD-finger family protein 0.0023 0.0245 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0414 0.0487
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0101 0.009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0059 0.0273
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0059 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0429 0.0404
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0193 0.0155
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0529 0.0779
Loa Loa (eye worm) hypothetical protein 0.003 0.0414 0.0487
Echinococcus granulosus General substrate transporter 0.0087 0.1705 0.1696
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0193 0.0155
Onchocerca volvulus 0.0026 0.0321 0.0325
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0245 0.021
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0172 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0438 0.1973

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.