Detailed information for compound 574683

Basic information

Technical information
  • TDR Targets ID: 574683
  • Name: (E)-2-[[2-(2-aminopropanoylamino)-4-hydroxy-4 -oxo-butanoyl]amino]-5-phosphono-pent-3-enoic acid
  • MW: 381.276 | Formula: C12H20N3O9P
  • H donors: 7 H acceptors: 9 LogP: -6.09 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CC(C(=O)NC(C(=O)O)C=CCP(=O)(O)O)NC(=O)C(N)C
  • InChi: 1S/C12H20N3O9P/c1-6(13)10(18)15-8(5-9(16)17)11(19)14-7(12(20)21)3-2-4-25(22,23)24/h2-3,6-8H,4-5,13H2,1H3,(H,14,19)(H,15,18)(H,16,17)(H,20,21)(H2,22,23,24)/b3-2+
  • InChiKey: BMFVTRZNBFRUMH-NSCUHMNNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-2-[[2-[(2-amino-1-oxopropyl)amino]-4-hydroxy-1,4-dioxobutyl]amino]-5-phosphono-3-pentenoic acid
  • (E)-2-[[2-(2-azanylpropanoylamino)-4-hydroxy-4-oxo-butanoyl]amino]-5-phosphono-pent-3-enoic acid
  • (E)-2-[[2-(alanylamino)-4-hydroxy-4-keto-butanoyl]amino]-5-phosphono-pent-3-enoic acid
  • (E)-2-[[2-(2-aminopropanoylamino)-4-hydroxy-4-oxobutanoyl]amino]-5-phosphonopent-3-enoic acid
  • plumbemycin A
  • (E)-2-[[2-[(2-amino-1-oxopropyl)amino]-4-hydroxy-1,4-dioxobutyl]amino]-5-phosphonopent-3-enoic acid
  • 62896-18-8
  • Antibiotic N-1409 A
  • BRN 2490358
  • D-Norvaline, N-(N-L-alanyl-L-alpha-aspartyl)-3,4-didehydro-5-phosphono-, (Z)-
  • N-1409 A
  • cis-N-(N-L-Alanyl-L-alpha-aspartyl)-3,4-didehydro-5-phosphono-D-norvaline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0031 0.0031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2635 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0358 0.3977 1
Onchocerca volvulus 0.0038 0.0344 0.2096
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Echinococcus granulosus geminin 0.0167 0.1812 0.4557
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0475 0.1185
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0344 0.0856
Loa Loa (eye worm) glutamate receptor 0.0018 0.0125 0.0306
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0036 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0673 0.1693
Schistosoma mansoni metabotropic glutamate receptor 0.0039 0.0359 0.0902
Brugia malayi Ets-domain containing protein 0.001 0.0036 0.0081
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0893 0.3219
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0036 0.009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0344 0.0856
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0344 0.1079
Onchocerca volvulus 0.001 0.0031 0.017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0893 0.3219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0321 0.0806
Treponema pallidum NADH oxidase 0.0013 0.0067 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0475 0.1193
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1002 0.3642
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0344 0.9924
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1
Brugia malayi Receptor family ligand binding region containing protein 0.0012 0.0053 0.0124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.011 0.0268
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0036 0.009
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0036 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0031 0.017
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Brugia malayi hypothetical protein 0.0151 0.1626 0.4082
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0352 0.0884
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0042 0.0395 0.0984
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.0247 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0893 0.3219
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0036 0.009
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0036 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0893 0.8348
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.0061 0.061 0.1527
Echinococcus multilocularis cpg binding protein 0.0031 0.0265 0.0265
Brugia malayi Ets-domain containing protein 0.0071 0.0728 0.1822
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0525 0.1311
Brugia malayi metabotropic glutamate receptor type 2 0.0023 0.0175 0.043
Schistosoma mansoni hypothetical protein 0.001 0.0036 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Onchocerca volvulus 0.0029 0.0247 0.1497
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis GPCR, family 2 0.0017 0.011 0.011
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0031 0.017
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0039 0.0359 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.007
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0036 0.0036
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0036 0.0081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0031 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0031 0.0079
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0667
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0352 0.0352
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0893 0.3219
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Plasmodium falciparum thioredoxin reductase 0.0038 0.0346 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0031 0.0031
Brugia malayi beta-lactamase family protein 0.0038 0.0344 0.0856
Loa Loa (eye worm) glutathione reductase 0.0038 0.0346 0.0861
Trypanosoma brucei trypanothione reductase 0.0038 0.0346 1
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0036 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0344 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.007
Echinococcus multilocularis geminin 0.0167 0.1812 0.1812
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0525 0.1311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0673 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0247 0.0611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0344 0.0864
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0031 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0067 0.0158
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0036 0.009
Mycobacterium ulcerans beta-lactamase 0.0038 0.0344 0.4567
Loa Loa (eye worm) hypothetical protein 0.0054 0.0525 0.1311
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0344 0.9924
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0036 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0673 0.1693
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0344 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0344 1
Schistosoma mansoni hypothetical protein 0.0008 0.0004 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0031 0.0079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0031 0.0079
Schistosoma mansoni ets 0.001 0.0036 0.009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.011 0.0268
Echinococcus multilocularis ets variant gene 4 0.001 0.0036 0.0036
Brugia malayi steroid hormone receptor 0.001 0.0031 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0031 0.007
Schistosoma mansoni coup transcription factor 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Schistosoma mansoni ets-related 0.001 0.0036 0.009
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0031 0.007
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0167
Trichomonas vaginalis esterase, putative 0.0038 0.0344 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0079
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0031 0.0079
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0346 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0344 0.4567
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0036 0.0036
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0358 0.3977 0.3977
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0012 0.0053 0.0124
Toxoplasma gondii ABC1 family protein 0.0038 0.0344 0.4567
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0031 0.0079
Brugia malayi Ets-domain containing protein 0.0071 0.0728 0.1822
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0031 0.0079
Echinococcus granulosus GPCR family 2 0.0017 0.011 0.0277
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Brugia malayi hypothetical protein 0.0036 0.0321 0.0797
Schistosoma mansoni hypothetical protein 0.0167 0.1812 0.4557
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0031 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0031 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0475 0.1185
Schistosoma mansoni cpg binding protein 0.0031 0.0265 0.0667
Leishmania major hypothetical protein, conserved 0.0038 0.0344 0.4567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0475 0.1193
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.011 0.0277
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.011 0.0277
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0067 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.011 0.011
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0037
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0728 0.183
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0031 0.0031
Brugia malayi beta-lactamase 0.0038 0.0344 0.0856
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0566 0.1414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0057 0.0566 0.0566
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0358 0.3977 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.011 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0333 0.0828
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0344 0.9924
Brugia malayi transcription factor E74 isoform 0.001 0.0036 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0031 0.007
Echinococcus granulosus cpg binding protein 0.0031 0.0265 0.0667
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0031 0.0079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0031 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0031 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0321 0.0806
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0031 0.007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0031 0.0079
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.007
Mycobacterium ulcerans lipase LipD 0.0038 0.0344 0.4567
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0346 0.1087
Schistosoma mansoni hypothetical protein 0.0037 0.0333 0.0837
Mycobacterium tuberculosis Probable reductase 0.0086 0.0893 0.3219
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.007
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0036 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0344 0.1079
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0036 0.0081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0031
Toxoplasma gondii thioredoxin reductase 0.0038 0.0346 0.4602
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0031 0.007
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0728 0.0728
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0673 1
Schistosoma mansoni ets-related 0.0217 0.2376 0.5974
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0344 0.0864
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor 0.001 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0344 0.4567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0124
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0079
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0277
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0167
Brugia malayi nuclear receptor NHR-88 0.001 0.0031 0.007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Schistosoma mansoni metabotropic glutamate receptor 0.0023 0.0175 0.0439
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0344 0.1079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0475 0.0475
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0067 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0893 0.3219
Brugia malayi nuclear hormone receptor 0.001 0.0031 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Schistosoma mansoni hypothetical protein 0.0036 0.0321 0.0806
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0673 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0039 0.0359 0.0902
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0344 0.0864
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0036 0.009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0067 0.0067
Leishmania major trypanothione reductase 0.0038 0.0346 0.4602
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0067 0.5
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0027 0.0059
Onchocerca volvulus 0.0038 0.0344 0.2096
Loa Loa (eye worm) beta-lactamase 0.0038 0.0344 0.0856
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1002 0.3642
Loa Loa (eye worm) fli-1 protein 0.0217 0.2376 0.597
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0673 0.0673
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1002 1
Entamoeba histolytica hypothetical protein 0.0036 0.0321 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0344 0.1079
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0031 0.007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0027 0.0059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0673 0.2362
Echinococcus multilocularis protein C ets 2 0.001 0.0036 0.0036
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0525 0.1311
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0358 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0031 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0031 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0081
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0346 0.0861
Echinococcus granulosus protein C ets 2 0.001 0.0036 0.009
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0004 0.001
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0012 0.0053 0.0124
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0031 0.0031
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0067 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0031 0.0079
Onchocerca volvulus 0.0151 0.1626 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0031 0.0079
Onchocerca volvulus 0.0038 0.0344 0.2096
Brugia malayi Fli-1 protein 0.0217 0.2376 0.597
Echinococcus granulosus metabotropic glutamate receptor 5 0.0057 0.0566 0.1422
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0036 0.009
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0344 0.1079
Loa Loa (eye worm) hypothetical protein 0.0151 0.1626 0.4082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0053 0.0516 0.1298
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0036 0.0036
Plasmodium vivax glutathione reductase, putative 0.0038 0.0346 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1002 0.3642
Brugia malayi beta-lactamase family protein 0.0038 0.0344 0.0856
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0475 0.0475
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0344 0.1079
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0333 0.0828
Brugia malayi Thioredoxin reductase 0.0038 0.0346 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0031 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0346 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0344 0.1079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0475 0.1193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.007
Schistosoma mansoni hypothetical protein 0.001 0.0036 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.007
Brugia malayi ecdysteroid receptor 0.001 0.0031 0.007
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0358 0.3977 1
Schistosoma mansoni gabp alpha 0.0071 0.0728 0.183
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0031 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0031 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0673 0.1693
Schistosoma mansoni elf1 0.001 0.0036 0.009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.054 0.7801
Schistosoma mansoni hypothetical protein 0.0167 0.1812 0.4557
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0728 0.1822
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0614 0.1545
Brugia malayi Metabotropic glutamate receptor precursor. 0.0046 0.0444 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0031 0.007
Brugia malayi glutathione reductase 0.0038 0.0346 0.0861
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0247 0.0611
Plasmodium falciparum glutathione reductase 0.0038 0.0346 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0344 0.4567
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0344 0.9924
Loa Loa (eye worm) glutamate receptor 0.0046 0.0444 0.1108
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0344 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0031 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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