TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 649.84 | Formula: C36H47N3O6S
H donors: 5 H acceptors: 5 LogP: 6.59 Rotable bonds: 20
Rule of 5 violations (Lipinski): 2
SMILES: Oc1ccc(cc1)CC(C(=O)N[C@H]([C@H](CSc1ccccc1)O)CC(C)C)NC(=O)C(NC(=O)OC(C)(C)C)Cc1ccccc1
InChi: 1S/C36H47N3O6S/c1-24(2)20-29(32(41)23-46-28-14-10-7-11-15-28)37-33(42)30(22-26-16-18-27(40)19-17-26)38-34(43)31(21-25-12-8-6-9-13-25)39-35(44)45-36(3,4)5/h6-19,24,29-32,40-41H,20-23H2,1-5H3,(H,37,42)(H,38,43)(H,39,44)/t29-,30?,31?,32-/m1/s1
InChiKey: IXKWUGLXGDNKPE-OYTHYRDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0243	0.0601	1
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0224	0.0538	0.0538
Brugia malayi	SH2 domain containing protein	0.0242	0.0595	0.0595
Echinococcus granulosus	activated cdc42 kinase 1	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Echinococcus multilocularis	FL cytokine receptor	0.0242	0.0595	0.0595
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0224	0.0538	0.0538
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	sodium bile acid cotransporter	0.3098	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.045	0.1282	0.4837
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Tyrosine-protein kinase abl-1	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Brugia malayi	hypothetical protein	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0243	0.0601	0.0601
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0673	0.2014	0.2014
Echinococcus granulosus	protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Tyrosine-protein kinase PR2	0.0242	0.0595	0.0595
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0242	0.0595	0.0595
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0243	0.0601	0.0601
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.0538	0.0538
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0242	0.0595	0.0595
Brugia malayi	hypothetical protein	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/ALK protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	kinase suppressor of Ras 1	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.0538	0.0538
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	protein kinase	0.0242	0.0595	0.0595
Brugia malayi	ephrin receptor 1 precursor	0.0242	0.0595	0.0595
Giardia lamblia	Kinase, NEK	0.0242	0.0595	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	SH2 domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	haspin protein kinase	0.0063	0.0006	0.0006
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	hypothetical protein	0.0223	0.0532	0.0532
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/ROR protein kinase	0.0245	0.0607	0.0607
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0242	0.0595	0.0595
Giardia lamblia	Kinase	0.0242	0.0595	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/INSR protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	protein tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0242	0.0595	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0245	0.0607	0.0607
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Guanylyl cyclase protein 23	0.0242	0.0595	0.0595
Echinococcus granulosus	protein tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Plasmodium vivax	protein kinase, putative	0.0242	0.0595	0.5
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	C-terminal src kinase protein 1	0.0242	0.0595	0.0595
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Raf kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/RYK protein kinase	0.0242	0.0595	0.0595
Brugia malayi	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	sodium bile acid cotransporter	0.3098	1	1
Echinococcus multilocularis	sodium bile acid cotransporter	0.3098	1	1
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	sodium bile acid cotransporter	0.3098	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Brugia malayi	Receptor family ligand binding region containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	sodium bile acid cotransporter	0.3098	1	1
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0223	0.0532	0.0532
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	epidermal growth factor receptor	0.0242	0.0595	0.0595
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0242	0.0595	0.0595
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0242	0.0595	0.0595
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.0673	0.2014	0.2014
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Giardia lamblia	Kinase, NEK	0.0242	0.0595	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0243	0.0601	0.0601
Schistosoma mansoni	sodium-bile acid cotransporter related	0.3098	1	1
Plasmodium falciparum	protein kinase, putative	0.0243	0.0601	1
Brugia malayi	SRC-1	0.0242	0.0595	0.0595
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0224	0.0538	0.0538
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0243	0.0601	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0243	0.0601	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0242	0.0595	0.0595
Echinococcus granulosus	sodium bile acid cotransporter	0.3098	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0243	0.0601	1
Schistosoma mansoni	tyrosine kinase	0.0245	0.0607	0.0607
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	activin receptor type	0.0243	0.0601	0.0601
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.0538	0.0538
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0242	0.0595	0.0595
Schistosoma mansoni	ephrin receptor	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase shark	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/CSK protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0243	0.0601	0.0601
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.3098	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0242	0.0595	0.0595
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase shark	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0242	0.0595	0.0595
Echinococcus multilocularis	epidermal growth factor receptor	0.0242	0.0595	0.0595
Echinococcus granulosus	maternal embryonic leucine zipper kinase	0.045	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0269	0.0686	0.0686
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Leishmania major	protein kinase, putative	0.0243	0.0601	1
Schistosoma mansoni	protein kinase	0.0243	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	c src tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	hypothetical protein	0.0223	0.0532	0.0532
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.0538	0.0538
Echinococcus granulosus	tyrosine protein kinase pr2	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.0538	0.0538
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine RGC	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0224	0.0538	0.0538
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/Met protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0245	0.0607	0.0607
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0242	0.0595	0.0595
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0242	0.0595	0.0595
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	protein tyrosine kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Blk	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/ACK protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	heat shock protein 70	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0242	0.0595	0.0595
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0243	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	ephrin receptor	0.0242	0.0595	0.0595
Trichomonas vaginalis	CAMK family protein kinase	0.0673	0.2014	1
Echinococcus granulosus	integrin linked protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0245	0.0607	0.0607
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0734	0.2216	0.2216
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	insulin receptor	0.0242	0.0595	0.0595
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/DDR protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Kinase associated domain 1 family protein	0.0223	0.0532	0.0532
Schistosoma mansoni	serine/threonine kinase	0.0683	0.2049	0.2049
Echinococcus multilocularis	epidermal growth factor receptor	0.0242	0.0595	0.0595
Echinococcus granulosus	raf serine:threonine protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	transfer RNA-Thr	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0242	0.0595	0.0595
Trypanosoma brucei	protein kinase, putative	0.0243	0.0601	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0242	0.0595	0.0595
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0242	0.0595	0.0595
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	sodium-bile acid cotransporter related	0.1256	0.3936	0.3936
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	integrin linked protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FAK protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	activin receptor type	0.0243	0.0601	0.0601
Echinococcus multilocularis	insulin receptor	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Srms	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine kinase	0.0242	0.0595	0.0595
Trichomonas vaginalis	CAMK family protein kinase	0.045	0.1282	0.4837
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	sodium-bile acid cotransporter	0.1841	0.5864	0.5864
Brugia malayi	Furin-like cysteine rich region family protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	maternal embryonic leucine zipper kinase	0.045	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Onchocerca volvulus	Tyrosine kinase homolog	0.0245	0.0607	0.0012
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	calcium activated potassium channel	0.0224	0.0538	0.0538
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0242	0.0595	0.0595
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase csk	0.0242	0.0595	0.0595
Echinococcus granulosus	activated cdc42 kinase 1	0.0242	0.0595	0.0595
Loa Loa (eye worm)	serine/threonine protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Echinococcus multilocularis	activated cdc42 kinase 1	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase HCK	0.0242	0.0595	0.0595
Echinococcus granulosus	epidermal growth factor receptor	0.0242	0.0595	0.0595
Schistosoma mansoni	hypothetical protein	0.0223	0.0532	0.0532
Loa Loa (eye worm)	TK protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0242	0.0595	0.0595
Loa Loa (eye worm)	SRC-1	0.0242	0.0595	0.0595
Giardia lamblia	Protein 21.1	0.0242	0.0595	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	calcium activated potassium channel	0.0224	0.0538	0.0538
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	protein-tyrosine kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Echinococcus granulosus	receptor type guanylyl cyclase	0.0242	0.0595	0.0595
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0243	0.0601	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0242	0.0595	0.0595
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0242	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Brugia malayi	integrin-linked kinase	0.0242	0.0595	0.0595
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0242	0.0595	0.0595
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0242	0.0595	0.0595
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0242	0.0595	0.0595
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0242	0.0595	0.0595
Echinococcus granulosus	natriuretic peptide receptor 1	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0242	0.0595	0.0595
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0242	0.0595	0.0595
Brugia malayi	Protein kinase domain containing protein	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0242	0.0595	0.0595
Schistosoma mansoni	protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/EPH protein kinase	0.0242	0.0595	0.0595
Loa Loa (eye worm)	TK/FER protein kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0245	0.0607	0.0607
Echinococcus multilocularis	c src tyrosine kinase	0.0242	0.0595	0.0595
Onchocerca volvulus		0.3098	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0242	0.0595	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0269	0.0686	0.0686
Schistosoma mansoni	hypothetical protein	0.0242	0.0595	0.0595
Schistosoma mansoni	tyrosine kinase	0.0242	0.0595	0.0595
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0242	0.0595	0.0595

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	0 uM	The compound was tested for inhibition of human renal renin at the pH optimum 6.0 ;ND means no data	ChEMBL.	3305946
Inhibition (binding)	= 11 %	Inhibition of porcine pepsin	ChEMBL.	3305946
Inhibition (binding)	= 21 %	Inhibition of human renal renin at the concentration of 10e-5 M.	ChEMBL.	3305946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 161560

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 57943