Detailed information for compound 579976

Basic information

Technical information
  • TDR Targets ID: 579976
  • Name: 1-methyl-N5-[3-[3-(1-piperidylmethyl)phenoxy] propyl]-1,2,4-triazole-3,5-diamine
  • MW: 344.455 | Formula: C18H28N6O
  • H donors: 2 H acceptors: 2 LogP: 2.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nn(c(n1)NCCCOc1cccc(c1)CN1CCCCC1)C
  • InChi: 1S/C18H28N6O/c1-23-18(21-17(19)22-23)20-9-6-12-25-16-8-5-7-15(13-16)14-24-10-3-2-4-11-24/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H3,19,20,21,22)
  • InChiKey: NRIGRKAXOLMTSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-N5-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,2,4-triazole-3,5-diamine
  • (5-amino-2-methyl-1,2,4-triazol-3-yl)-[3-[3-(piperidinomethyl)phenoxy]propyl]amine
  • 1-methyl-5-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,2,4-triazole-3,5-diamine
  • lamtidine
  • 1-methyl-N'-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,2,4-triazole-3,5-diamine
  • 1-methyl-N'-[3-[3-(1-piperidylmethyl)phenoxy]propyl]-1,2,4-triazole-3,5-diamine
  • 73278-54-3
  • C11804
  • AH 22216
  • Lamtidina [Spanish]
  • Lamtidine [BAN:INN]
  • Lamtidinum [Latin]
  • 1-(m-(3-((3-Amino-1-methyl-1H-1,2,4-triazol-5-yl)amino)propoxy)benzyl)piperidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.004 0.0063
Plasmodium vivax SET domain protein, putative 0.0029 0.0061 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0139 0.0218
Onchocerca volvulus 0.0048 0.0139 0.1568
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0099 0.5
Brugia malayi RNA, U transporter 1 0.0084 0.0285 0.0447
Entamoeba histolytica Ran family GTPase 0.0022 0.0031 0.0048
Echinococcus multilocularis protein patched 0.0086 0.0293 0.0293
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0031 0.0048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0139 0.6654
Schistosoma mansoni inositol monophosphatase 0.0073 0.0241 0.0377
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0139 0.6654
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.004 0.0063
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0139 0.0218
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0293 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0061 0.0096
Loa Loa (eye worm) hypothetical protein 0.02 0.0761 0.1192
Echinococcus granulosus snurportin 1 0.0315 0.123 0.1926
Schistosoma mansoni aryl hydrocarbon receptor 0.018 0.068 0.1065
Loa Loa (eye worm) hypothetical protein 0.0086 0.0293 0.046
Trichomonas vaginalis importin beta-1, putative 0.0024 0.004 0.0063
Echinococcus multilocularis survival motor neuron protein 1 0.0481 0.1909 0.1909
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0008 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0102 0.016
Trypanosoma brucei N-myristoyl transferase, putative 0.1575 0.6383 1
Brugia malayi hypothetical protein 0.0016 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.014
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0139 0.0218
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0139 0.1335
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0061 0.0096
Echinococcus multilocularis protein dispatched 1 0.0098 0.0343 0.0343
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0008 0.0013
Entamoeba histolytica hypothetical protein 0.0073 0.0241 0.0378
Echinococcus multilocularis snurportin 1 0.0315 0.123 0.123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0081 0.3889
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0098
Schistosoma mansoni hypothetical protein 0.0173 0.0651 0.102
Toxoplasma gondii exonuclease III APE 0.0038 0.0099 0.4095
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0099 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.014
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0063 0.2607
Brugia malayi Importin beta-1 subunit 0.0029 0.0063 0.0098
Schistosoma mansoni hypothetical protein 0.0173 0.0651 0.102
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0139 0.1335
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0008 0.0013
Brugia malayi hypothetical protein 0.0481 0.1909 0.299
Echinococcus granulosus tumor protein p63 0.0687 0.2752 0.4312
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.1575 0.6383 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0218
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0063 0.0098
Entamoeba histolytica hypothetical protein 0.0073 0.0241 0.0378
Schistosoma mansoni survival motor neuron protein 0.0098 0.0343 0.0538
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0089 0.4273
Mycobacterium leprae Possible regulatory protein 0.0016 0.0008 0.0392
Entamoeba histolytica hypothetical protein 0.0073 0.0241 0.0378
Schistosoma mansoni ap endonuclease 0.0038 0.0099 0.0154
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0241 0.0378
Loa Loa (eye worm) hypothetical protein 0.0105 0.0373 0.0584
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0102 0.016
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0139 0.0218
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0099 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0061 0.0096
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0139 0.1335
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0241 0.0377
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0241 0.0377
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.1575 0.6383 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.123 0.1926
Loa Loa (eye worm) glutaminase 0.0269 0.1044 0.1635
Brugia malayi PAS domain containing protein 0.0062 0.0196 0.0308
Leishmania major protein kinase, putative 0.0016 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0101 0.0353 0.0554
Giardia lamblia CDC72 0.1575 0.6383 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0099 0.0154
Onchocerca volvulus 0.0029 0.0061 0.0691
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0081 0.3889
Schistosoma mansoni single-minded 0.0062 0.0196 0.0308
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0118 0.0423 0.0663
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0091 0.0143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0061 0.0061
Leishmania major protein kinase, putative 0.0021 0.0029 0.0046
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0048
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0102 0.016
Mycobacterium ulcerans hypothetical protein 0.0048 0.0139 0.1335
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.1575 0.6383 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0139 0.6654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0125 0.0196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0099 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0139 0.1335
Brugia malayi Pre-SET motif family protein 0.0203 0.0773 0.1212
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0209 1
Echinococcus granulosus single minded 2 0.005 0.0145 0.0227
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0761 0.1192
Schistosoma mansoni ap endonuclease 0.0038 0.0099 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0139 0.1335
Trypanosoma cruzi N-myristoyl transferase, putative 0.1575 0.6383 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0091 0.0143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0125 0.0196
Loa Loa (eye worm) inositol-1 0.0073 0.0241 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0008 0.0013
Leishmania major importin beta-1 subunit, putative 0.0024 0.004 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0241 0.0378
Plasmodium falciparum importin beta, putative 0.0029 0.0063 0.0098
Echinococcus multilocularis geminin 0.0173 0.0651 0.0651
Plasmodium vivax importin-beta 2, putative 0.0029 0.0063 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0125 0.0196
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0057 0.0089
Schistosoma mansoni inositol monophosphatase 0.0073 0.0241 0.0377
Brugia malayi hypothetical protein 0.0025 0.0044 0.0068
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.013 0.013
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0099 0.0099
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0008 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0099 0.4707
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0099 0.0106
Brugia malayi CHE-14 protein 0.0086 0.0293 0.046
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.001 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0241 0.2305
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0068
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0139 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0293 0.046
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0099 0.0154
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.001 0.0016
Echinococcus granulosus aryl hydrocarbon receptor 0.0134 0.0491 0.077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0061 0.0096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0099 0.0154
Trichomonas vaginalis glutaminase, putative 0.0269 0.1044 0.1635
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0209 1
Echinococcus granulosus geminin 0.0173 0.0651 0.102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0139 0.6654
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.001 0.0016
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0044 0.0068
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0008 0.0013
Schistosoma mansoni glutaminase 0.0269 0.1044 0.1635
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0241 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0099 0.0154
Loa Loa (eye worm) glutaminase 2 0.0269 0.1044 0.1635
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0044 0.0068
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0089 0.014
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0241 0.0377
Echinococcus multilocularis expressed conserved protein 0.0188 0.0711 0.0711
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0008 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0099 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0117 0.0183
Loa Loa (eye worm) hypothetical protein 0.0481 0.1909 0.299
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0044 0.1816
Onchocerca volvulus 0.0098 0.0343 0.3864
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0125 0.0196
Echinococcus granulosus survival motor neuron protein 1 0.0481 0.1909 0.299
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0761 0.0761
Echinococcus granulosus importin subunit beta 1 0.0029 0.0063 0.0098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0773 0.1212
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0343 0.0538
Loa Loa (eye worm) hypothetical protein 0.0118 0.0423 0.0663
Mycobacterium ulcerans putative regulatory protein 0.0046 0.013 0.1249
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Trichomonas vaginalis ran, putative 0.0022 0.0031 0.0048
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.1575 0.6383 0.6383
Loa Loa (eye worm) hypothetical protein 0.0118 0.0425 0.0666
Onchocerca volvulus 0.0101 0.0353 0.3978
Schistosoma mansoni hypothetical protein 0.0098 0.0343 0.0538
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0139 0.0218
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0061 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0081 0.3889
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0008 0.0013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0048
Schistosoma mansoni ran 0.0022 0.0031 0.0048
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0139 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0099 0.0154
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0218
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0008 0.0013
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0008 0.0013
Schistosoma mansoni hypothetical protein 0.0083 0.0281 0.044
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0008 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0099 0.0154
Entamoeba histolytica hypothetical protein 0.0073 0.0241 0.0378
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0048
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0099 0.0154
Echinococcus granulosus Niemann Pick C1 protein 0.0286 0.1112 0.1743
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0008 0.0013
Entamoeba histolytica hypothetical protein 0.0024 0.004 0.0063
Brugia malayi hypothetical protein 0.0073 0.0241 0.0378
Onchocerca volvulus 0.0231 0.0888 1
Trypanosoma cruzi N-myristoyl transferase, putative 0.1575 0.6383 1
Echinococcus granulosus expressed conserved protein 0.0188 0.0711 0.1114
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0761 0.1192
Schistosoma mansoni N-myristoyltransferase 0.1575 0.6383 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0888 0.1392
Schistosoma mansoni hypothetical protein 0.0315 0.123 0.1926
Brugia malayi glutaminase DH11.1 0.0269 0.1044 0.1635
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0099 0.0154
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0008 0.0013
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0063 0.0063
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0008 0.0013
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0353 0.0554
Trypanosoma brucei N-myristoyltransferase 0.1575 0.6383 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0013
Loa Loa (eye worm) N-myristoyltransferase 2 0.1575 0.6383 1
Leishmania major N-myristoyl transferase, putative 0.1575 0.6383 1
Trichomonas vaginalis N-myristoyl transferase, putative 0.1035 0.4174 0.6539
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0099 0.0944
Leishmania major GTP-binding protein, putative 0.0022 0.0031 0.0048
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0048
Brugia malayi Inositol-1 0.0073 0.0241 0.0377
Trichomonas vaginalis N-myristoyl transferase, putative 0.1575 0.6383 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0139 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0139 0.0218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0061 0.255
Schistosoma mansoni ran 0.0022 0.0031 0.0048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0241 0.0377
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0241 0.0377
Schistosoma mansoni hypothetical protein 0.0083 0.0281 0.044
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0008 0.0013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0031 0.0048
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0089 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0061 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0125 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0125 0.0196
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0293 0.046
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0139 0.0218
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0241 0.0377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0061 0.0096
Schistosoma mansoni hypothetical protein 0.0083 0.0281 0.044
Echinococcus multilocularis Niemann Pick C1 protein 0.0286 0.1112 0.1112
Echinococcus multilocularis aryl hydrocarbon receptor 0.0134 0.0491 0.0491
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0063 0.0098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0241 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0125 0.0125
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0117 0.0183
Schistosoma mansoni hypothetical protein 0.0073 0.0241 0.0378
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0241 0.0377
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.004 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0089 0.0857
Loa Loa (eye worm) hypothetical protein 0.0134 0.0489 0.0767
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0068
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.0068
Schistosoma mansoni importin beta-1 0.0029 0.0063 0.0098
Brugia malayi N-myristoyltransferase 2 0.1575 0.6383 1
Echinococcus multilocularis tumor protein p63 0.0687 0.2752 0.2752
Brugia malayi Pre-SET motif family protein 0.0029 0.0061 0.0096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.0048
Onchocerca volvulus 0.0134 0.0489 0.5508
Schistosoma mansoni patched 1 0.0086 0.0293 0.046
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0008 0.0013
Onchocerca volvulus 0.0047 0.0133 0.1492
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0241 0.0241
Mycobacterium ulcerans glutaminase 0.0269 0.1044 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0031 0.1283
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0761 0.1192
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0008 0.0013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0241 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0125 0.0196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0083 0.0281 0.044
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.0774 0.1212
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0241 0.0377
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0089 0.014
Brugia malayi bHLH-PAS transcription factor 0.0046 0.013 0.0204
Brugia malayi hypothetical protein 0.0016 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0218
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0293 0.046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0125 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0081 0.3889
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.1575 0.6383 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0139 0.1335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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