TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 197.665 | Formula: C9H12ClN3
H donors: 2 H acceptors: 0 LogP: 1.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN/C(=N\C)/Nc1cccc(c1)Cl
InChi: 1S/C9H12ClN3/c1-11-9(12-2)13-8-5-3-4-7(10)6-8/h3-6H,1-2H3,(H2,11,12,13)
InChiKey: QXMDECHLFJHTCT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cation transporter family protein	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	404 aa	445 aa	22.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.08	0.4543	1
Leishmania major	cysteine peptidase A (CPA)	0.08	0.4543	1
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1249	0.1249
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0048	0.0047	0.0047
Onchocerca volvulus		0.08	0.4543	1
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Onchocerca volvulus		0.08	0.4543	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0186	0.0874	0.0874
Trypanosoma cruzi	cysteine peptidase, putative	0.08	0.4543	0.4021
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Entamoeba histolytica	cysteine proteinase, putative	0.0435	0.2362	0.4054
Echinococcus multilocularis	cathepsin b	0.1713	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0435	0.2362	0.4054
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0435	0.2362	0.163
Echinococcus granulosus	cathepsin L	0.0435	0.2362	0.2355
Brugia malayi	Papain family cysteine protease containing protein	0.08	0.4543	0.4543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Echinococcus granulosus	nmda type glutamate receptor	0.0093	0.0318	0.031
Schistosoma mansoni	glutamate receptor NMDA	0.013	0.0536	0.0536
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0551	0.3056	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0551	0.3056	0.3056
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Loa Loa (eye worm)	cysteine protease	0.08	0.4543	0.4543
Echinococcus multilocularis	cathepsin L cysteine protease	0.08	0.4543	0.4543
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Loa Loa (eye worm)	cathepsin B	0.0658	0.3697	0.3697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.08	0.4543	0.4539
Echinococcus multilocularis	cathepsin L	0.0435	0.2362	0.2362
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0435	0.2362	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0658	0.3697	0.3697
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0095	0.0328	0.0328
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0051	0.0068	0.006
Entamoeba histolytica	cysteine proteinase, putative	0.0435	0.2362	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.08	0.4543	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Entamoeba histolytica	cysteine proteinase, putative	0.0551	0.3056	0.5946
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0658	0.3697	0.6119
Trypanosoma cruzi	cysteine peptidase, putative	0.0249	0.1249	0.0411
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0051	0.0068	0.006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Loa Loa (eye worm)	glutamate receptor	0.0048	0.0047	0.0047
Brugia malayi	fibroinase precursor	0.0186	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Echinococcus multilocularis	cysteine protease	0.08	0.4543	0.4543
Trypanosoma cruzi	cruzipain precursor, putative	0.0249	0.1249	0.0411
Schistosoma mansoni	cathepsin S (C01 family)	0.0186	0.0874	0.0874
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0186	0.0874	0.0874
Schistosoma mansoni	glutamate receptor NMDA	0.0095	0.0328	0.0328
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Schistosoma mansoni	cathepsin s	0.0249	0.1249	0.1249
Echinococcus granulosus	cathepsin L cysteine protease	0.0435	0.2362	0.2355
Brugia malayi	cathepsin F-like cysteine proteinase	0.0249	0.1249	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0551	0.3056	0.3056
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0186	0.0874	0.0874
Echinococcus granulosus	cathepsin L cysteine proteinase	0.08	0.4543	0.4539
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Giardia lamblia	Cathepsin B precursor	0.0658	0.3697	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1713	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.0874	0.0874
Plasmodium vivax	vivapain-2	0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0095	0.0328	0.032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Schistosoma mansoni	cathepsin F (C01 family)	0.08	0.4543	0.4543
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0658	0.3697	0.7692
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0186	0.0874	0.0874
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.08	0.4543	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0435	0.2362	0.2362
Toxoplasma gondii	cathepsin B	0.0658	0.3697	0.7692
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0046	0.0035	0.0035
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0186	0.0874	0.0874
Plasmodium vivax	vivapain-1	0.0435	0.2362	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Echinococcus granulosus	glutamate receptor 2	0.0051	0.0068	0.006
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.0874	0.0874
Loa Loa (eye worm)	fibroinase	0.08	0.4543	0.4543
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0008	0.0008
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Entamoeba histolytica	cysteine proteinase 2	0.0435	0.2362	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0249	0.1249	0.1249
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0186	0.0874	0.0874
Trypanosoma cruzi	cysteine peptidase, putative	0.08	0.4543	0.4021
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0051	0.0068	0.006
Echinococcus granulosus	cathepsin b	0.1713	1	1
Brugia malayi	cathepsin L precursor	0.0186	0.0874	0.0874
Trypanosoma cruzi	cysteine peptidase, putative	0.08	0.4543	0.4021
Echinococcus multilocularis	cathepsin b	0.1713	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0435	0.2362	0.2362
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1713	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0435	0.2362	0.163
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0435	0.2362	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0435	0.2362	0.2362
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Brugia malayi	Cathepsin L-like precursor	0.0249	0.1249	0.1249
Loa Loa (eye worm)	hypothetical protein	0.1713	1	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0051	0.0068	0.0068
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0551	0.3056	0.5946
Echinococcus multilocularis	glutamate receptor 2	0.0051	0.0068	0.0068
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.08	0.4543	0.4543
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Plasmodium vivax	vivapain-3	0.0435	0.2362	0.4054
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0551	0.3056	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.08	0.4543	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0051	0.0068	0.0068
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0249	0.1249	0.1249
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.0874	0.0874
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0551	0.3056	0.3056
Brugia malayi	Papain family cysteine protease containing protein	0.0435	0.2362	0.2362
Echinococcus multilocularis	nmda type glutamate receptor	0.009	0.0298	0.0298
Brugia malayi	cathepsin F-like cysteine proteinase	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.08	0.4543	0.4543
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.08	0.4543	0.4543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Onchocerca volvulus	Cathepsin L homolog	0.08	0.4543	1
Giardia lamblia	Cathepsin B precursor	0.0658	0.3697	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1249	0.1249
Brugia malayi	Papain family cysteine protease containing protein	0.0186	0.0874	0.0874
Entamoeba histolytica	cysteine proteinase, putative	0.0435	0.2362	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.08	0.4543	0.4543
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0051	0.0068	0.006
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0057	0.0103	0.0103
Schistosoma mansoni	cathepsin F (C01 family)	0.08	0.4543	0.4543
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.08	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0551	0.3056	0.3056
Echinococcus multilocularis	glutamate receptor NMDA	0.0078	0.023	0.023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Entamoeba histolytica	cysteine proteinase, putative	0.08	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Entamoeba histolytica	cysteine protease, putative	0.08	0.4543	1
Echinococcus multilocularis	cysteine protease	0.08	0.4543	0.4543
Echinococcus granulosus	cathepsin L	0.0186	0.0874	0.0867
Echinococcus granulosus	cysteine protease	0.0435	0.2362	0.2355
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Onchocerca volvulus		0.08	0.4543	1
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0186	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Onchocerca volvulus	Cathepsin F homolog	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Trypanosoma cruzi	cysteine peptidase, putative	0.08	0.4543	0.4021
Trypanosoma cruzi	cruzipain precursor, putative	0.08	0.4543	0.4021
Entamoeba histolytica	cysteine proteinase 1, putative	0.0435	0.2362	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0051	0.0068	0.0068
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Onchocerca volvulus		0.08	0.4543	1
Echinococcus granulosus	glutamate receptor NMDA	0.0078	0.023	0.0222
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0008	0.0008
Schistosoma mansoni	cathepsin F (C01 family)	0.0551	0.3056	0.3056
Brugia malayi	Cathepsin L-like precursor	0.0551	0.3056	0.3056
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0186	0.0874	0.0874
Loa Loa (eye worm)	ctsf protein	0.08	0.4543	0.4543
Brugia malayi	Papain family cysteine protease containing protein	0.0186	0.0874	0.0874
Echinococcus granulosus	nmda type glutamate receptor	0.009	0.0298	0.029
Brugia malayi	cathepsin L-like precursor	0.0551	0.3056	0.3056
Onchocerca volvulus		0.08	0.4543	1
Plasmodium vivax	vivapain-2	0.08	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1249	0.1249
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Echinococcus granulosus	cathepsin l1	0.08	0.4543	0.4539
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0186	0.0874	0.0874
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0658	0.3697	0.3093
Plasmodium falciparum	cysteine proteinase falcipain 3	0.08	0.4543	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0103	0.0103
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Schistosoma mansoni	cathepsin C	0.0186	0.0874	0.0874
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Onchocerca volvulus		0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0435	0.2362	0.163
Brugia malayi	Cathepsin L-like precursor	0.0551	0.3056	0.3056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.08	0.4543	0.4543
Trypanosoma cruzi	cysteine protease, putative	0.0435	0.2362	0.163
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Leishmania major	cathepsin L-like protease	0.08	0.4543	1
Brugia malayi	Papain family cysteine protease containing protein	0.0186	0.0874	0.0874
Onchocerca volvulus		0.0551	0.3056	0.5946
Brugia malayi	cathepsin L-like cysteine proteinase	0.0186	0.0874	0.0874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.08	0.4543	1
Toxoplasma gondii	cathepsin CPL	0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Onchocerca volvulus		0.08	0.4543	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Plasmodium vivax	unspecified product	0.0435	0.2362	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0435	0.2362	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.08	0.4543	1
Giardia lamblia	Cathepsin B precursor	0.0658	0.3697	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0435	0.2362	0.163
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1713	1	1
Echinococcus granulosus	cathepsin b	0.1713	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0435	0.2362	0.2362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.08	0.4543	1
Onchocerca volvulus	Cathepsin L homolog	0.08	0.4543	1
Entamoeba histolytica	cysteine protease, putative	0.0435	0.2362	0.4054
Echinococcus multilocularis	cathepsin L	0.0186	0.0874	0.0874
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1713	1	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0051	0.0068	0.0068
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0057	0.0103	0.0095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1713	1	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.08	0.4543	0.4543
Brugia malayi	Cathepsin L-like precursor	0.08	0.4543	0.4543
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0874	0.0874
Echinococcus granulosus	cathepsin l1	0.0551	0.3056	0.305
Plasmodium vivax	unspecified product	0.0249	0.1249	0.1022
Echinococcus multilocularis	nmda type glutamate receptor	0.0093	0.0318	0.0318

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10000 nM	Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.	ChEMBL.	11412989
Ki (binding)	> 10000 nM	Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.	ChEMBL.	11412989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 58262