Detailed information for compound 583182

Basic information

Technical information
  • TDR Targets ID: 583182
  • Name: (2S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihyd roxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ox y-propanoic acid
  • MW: 267.233 | Formula: C9H17NO8
  • H donors: 6 H acceptors: 6 LogP: -5.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H](OC[C@@H](C(=O)O)N)[C@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C9H17NO8/c10-3(8(15)16)2-17-9-7(14)6(13)5(12)4(1-11)18-9/h3-7,9,11-14H,1-2,10H2,(H,15,16)/t3-,4+,5+,6-,7-,9-/m0/s1
  • InChiKey: HGTOXWOVJAONKK-DHGOSONXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-3-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]propanoic acid
  • (2S)-2-azanyl-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-propanoic acid
  • (2S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-propionic acid
  • (2S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropanoic acid
  • O-mannopyranosylserine
  • (2S)-2-amino-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-propanoic acid
  • 78609-14-0
  • O-Man-ser
  • O-Mannopyranosyl-L-serine
  • (2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid
  • 3-O-(alpha-D-mannopyranosyl)-L-serine
  • CHEBI:37556
  • O-(alpha-D-mannopyranosyl)-L-serine
  • O-(alpha-D-mannosyl)-L-serine
  • L-Serine, O-alpha-D-mannopyranosyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0099 0.2196
Mycobacterium ulcerans hypothetical protein 0.0025 0.0109 0.2486
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0236 0.023
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0048 0.0042
Brugia malayi PAS domain containing protein 0.0062 0.0566 0.1886
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0024 0.0593
Schistosoma mansoni hypothetical protein 0.0042 0.0313 0.0338
Brugia malayi metabotropic glutamate receptor type 2 0.0104 0.1082 0.3606
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0028 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0099 0.2196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0917 0.1075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0266 0.0956
Loa Loa (eye worm) hypothetical protein 0.0118 0.1248 0.4158
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0266 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0048 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2419 0.806
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0109 0.0364
Loa Loa (eye worm) hypothetical protein 0.0043 0.0333 0.1108
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0048 0.0161
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0333 0.0326
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0217 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0176
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0048 0.0049
Echinococcus multilocularis tyrosine kinase 0.002 0.0048 0.0042
Brugia malayi Receptor family ligand binding region containing protein 0.0055 0.0475 0.1582
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0331
Brugia malayi MH2 domain containing protein 0.0122 0.1303 0.4341
Echinococcus multilocularis glutamate receptor 2 0.002 0.0048 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0917 0.1052
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0331
Echinococcus granulosus GPCR family 3 C terminal 0.0035 0.0228 0.0261
Mycobacterium tuberculosis Conserved protein 0.0025 0.0109 0.475
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0266 0.0956
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.0706
Trypanosoma cruzi fatty acid desaturase, putative 0.0261 0.3001 1
Onchocerca volvulus Poor gastrulation protein homolog 0.0035 0.0228 0.0608
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0028 0.0021
Echinococcus granulosus tyrosine kinase 0.002 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0589
Schistosoma mansoni inositol monophosphatase 0.0038 0.0266 0.0281
Echinococcus multilocularis aryl hydrocarbon receptor 0.0135 0.1453 0.1447
Brugia malayi Inositol-1 0.0038 0.0266 0.0886
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0109 0.2486
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0177 0.017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0266 0.0956
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0331
Brugia malayi hypothetical protein 0.0035 0.0236 0.0787
Loa Loa (eye worm) acyl-CoA desaturase 0.0261 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0331
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0109 0.0121
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.4472
Echinococcus granulosus geminin 0.0174 0.1932 0.2273
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0266 0.2351
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0333 0.0385
Leishmania major fatty-acid desaturase, putative 0.0261 0.3001 1
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.2477 0.8236
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0333 0.1196
Onchocerca volvulus 0.0024 0.0099 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0331
Trypanosoma cruzi fatty acid desaturase, putative 0.0261 0.3001 1
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.1039 0.1219
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0028 0.5
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0266 0.7043
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0099 0.2196
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.2196
Echinococcus granulosus glutamate receptor 2 0.002 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0104 0.1082 0.3606
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0331
Echinococcus multilocularis protein patched 0.0043 0.0333 0.0326
Echinococcus granulosus expressed conserved protein 0.0095 0.0964 0.113
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.1039 0.3464
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0109 0.0364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0428 0.1427
Echinococcus multilocularis protein dispatched 1 0.0049 0.0408 0.0401
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0028 0.0101
Leishmania major extracellular receptor, putative 0.002 0.0048 0.0161
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0109 0.0364
Schistosoma mansoni inositol monophosphatase 0.0038 0.0266 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0176
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0266 0.0886
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0048 0.0024
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0118 0.1248 0.4158
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0048 0.0161
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0109 0.2486
Mycobacterium ulcerans hypothetical protein 0.0025 0.0109 0.2486
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0099 0.0706
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.2477 0.8253
Brugia malayi bHLH-PAS transcription factor 0.0046 0.0367 0.1224
Brugia malayi hypothetical protein 0.002 0.0048 0.0161
Schistosoma mansoni tyrosine kinase 0.002 0.0048 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0099 0.458
Onchocerca volvulus 0.0243 0.278 0.9252
Loa Loa (eye worm) hypothetical protein 0.0119 0.1254 0.418
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.023 0.0766
Entamoeba histolytica hypothetical protein 0.0035 0.0236 0.2057
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.002 0.0048 0.0042
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0048 0.0049
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0261 0.3001 1
Onchocerca volvulus 0.0261 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0917 0.1052
Brugia malayi follicle stimulating hormone receptor 0.0235 0.2683 0.8939
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1303 0.4341
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0028 0.0116
Plasmodium vivax SET domain protein, putative 0.0031 0.0177 0.0513
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.848 0.8479
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.2683 0.8939
Loa Loa (eye worm) hypothetical protein 0.0035 0.0228 0.0759
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0035 0.0228 0.0608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0099 0.2196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0917 0.1052
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0048 0.0161
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.0048 0.0049
Schistosoma mansoni single-minded 0.0062 0.0566 0.0637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0917 0.0911
Echinococcus granulosus glutamate receptor 2 0.002 0.0048 0.0049
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0266 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0177 0.0176
Schistosoma mansoni glutamate receptor NMDA 0.002 0.0048 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Loa Loa (eye worm) hypothetical protein 0.0035 0.023 0.0766
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0266 0.0886
Loa Loa (eye worm) inositol-1 0.0038 0.0266 0.0886
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0266 0.0306
Brugia malayi Metabotropic glutamate receptor precursor. 0.0055 0.0475 0.1582
Loa Loa (eye worm) hypothetical protein 0.0126 0.1342 0.4472
Loa Loa (eye worm) glutamate receptor 0.0084 0.0835 0.2782
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0331
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.0367 0.0361
Echinococcus granulosus aryl hydrocarbon receptor 0.0135 0.1453 0.1707
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0917 0.3056
Entamoeba histolytica hypothetical protein 0.0035 0.0236 0.2057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.0706
Schistosoma mansoni hypothetical protein 0.0035 0.0236 0.0246
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0217 1
Schistosoma mansoni hypothetical protein 0.0035 0.023 0.0239
Leishmania major stearic acid desaturase, putative 0.0261 0.3001 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0331
Trypanosoma brucei fatty acid desaturase, putative 0.0261 0.3001 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0048 0.0042
Trypanosoma cruzi extracellular receptor, putative 0.002 0.0048 0.0161
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.5637 0.5634
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.0048 0.0161
Mycobacterium ulcerans hypothetical protein 0.0024 0.0099 0.2196
Schistosoma mansoni metabotropic glutamate receptor 0.0104 0.1082 0.1247
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Schistosoma mansoni hypothetical protein 0.0174 0.1932 0.2253
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.0048 0.0042
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0035 0.0228 0.0759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Schistosoma mansoni hypothetical protein 0.0042 0.0313 0.0338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0917 0.1075
Echinococcus granulosus metabotropic glutamate receptor 5 0.0104 0.1082 0.1269
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.0048 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1447 0.482
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0055 0.0475 0.1582
Schistosoma mansoni hypothetical protein 0.0042 0.0313 0.0338
Mycobacterium ulcerans putative regulatory protein 0.0046 0.0367 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0177 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0099 0.4266
Schistosoma mansoni hypothetical protein 0.0042 0.0313 0.0338
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0266 0.0886
Onchocerca volvulus 0.0031 0.0177 0.0435
Schistosoma mansoni hypothetical protein 0.0035 0.0228 0.0236
Brugia malayi Guanylyl cyclase protein 23 0.002 0.0048 0.0161
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0104 0.1082 0.1076
Loa Loa (eye worm) hypothetical protein 0.0051 0.0428 0.1427
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.2477 0.8253
Loa Loa (eye worm) hypothetical protein 0.0055 0.0475 0.1582
Loa Loa (eye worm) hypothetical protein 0.0053 0.0452 0.1507
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Brugia malayi CHE-14 protein 0.0043 0.0333 0.1108
Echinococcus multilocularis metabotropic glutamate receptor 2 0.002 0.0048 0.0042
Entamoeba histolytica hypothetical protein 0.0035 0.0236 0.2057
Loa Loa (eye worm) glutamate receptor 0.0055 0.0475 0.1582
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0028 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0428 0.1427
Echinococcus granulosus single minded 2 0.0046 0.0367 0.0426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0236 0.0271
Echinococcus multilocularis glutamate receptor 2 0.002 0.0048 0.0042
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0028 0.0093
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0048 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.2196
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0084 0.0835 0.0955
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0177 0.6253
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.4381
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1571 0.1565
Echinococcus granulosus neuropeptide s receptor 0.0476 0.5637 0.6644
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0428 0.1427
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0048 0.0161
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0163 0.0184
Echinococcus multilocularis geminin 0.0174 0.1932 0.1927
Echinococcus granulosus microtubule associated protein 2 0.0708 0.848 1
Leishmania major hypothetical protein, conserved 0.0218 0.2477 0.8253
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1571 0.1846
Brugia malayi hypothetical protein 0.0126 0.1342 0.4472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Brugia malayi acyl-CoA desaturase 0.0261 0.3001 1
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.848 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.1039 1
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.5637 0.6644
Schistosoma mansoni protein kinase 0.002 0.0048 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0236 0.2057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0028 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0028 0.0093
Trypanosoma cruzi fatty acid desaturase, putative 0.0261 0.3001 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0333 0.0385
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0109 0.475
Plasmodium falciparum stearoyl-CoA desaturase 0.0261 0.3001 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0028 0.0025
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0028 0.0013
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0099 0.4266
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.002 0.0048 0.0049
Entamoeba histolytica hypothetical protein 0.002 0.0048 0.0201
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0017 0.0007 0.0022
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0109 0.0393
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0266 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0035 0.0228 0.0759
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.0048 0.0042
Brugia malayi Pre-SET motif family protein 0.0031 0.0177 0.0589
Onchocerca volvulus 0.0047 0.0374 0.1102
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0028 0.0013
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0055 0.0475 0.1582
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Brugia malayi Pre-SET motif family protein 0.0213 0.2419 0.806
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0048 0.0049
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0109 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0917 0.3056
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0109 0.2486
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1303 0.4341
Schistosoma mansoni tyrosine kinase 0.002 0.0048 0.0024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0177 0.017
Onchocerca volvulus 0.0261 0.3001 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1039 0.3464
Onchocerca volvulus 0.0134 0.1447 0.4735
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0917 0.0911
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0236 0.0246
Trichomonas vaginalis set domain proteins, putative 0.0243 0.278 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.1342 0.4381
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0048 0.0042
Echinococcus granulosus metabotropic glutamate receptor 2 0.002 0.0048 0.0049
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.5637 0.5634
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0028 0.0093
Echinococcus multilocularis GPCR, family 3, C terminal 0.0035 0.0228 0.0221
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0266 0.08
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.1039 0.1034
Echinococcus multilocularis expressed conserved protein 0.0095 0.0964 0.0958
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1059 0.1219
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0048 0.0161
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0028 0.0787
Schistosoma mansoni patched 1 0.0043 0.0333 0.036
Schistosoma mansoni hypothetical protein 0.0174 0.1932 0.2253
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0028 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0161
Schistosoma mansoni aryl hydrocarbon receptor 0.0181 0.2019 0.2356
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.2196
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0333 0.1108
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0099 0.458

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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