Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0292 | 0.2884 | 0.2884 |
Onchocerca volvulus | 0.006 | 0.0538 | 0.0332 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0134 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | ACC-1 protein | 0.0292 | 0.2884 | 0.2871 |
Schistosoma mansoni | o-methyltransferase | 0.006 | 0.0538 | 0.0798 |
Brugia malayi | hypothetical protein | 0.023 | 0.2261 | 0.2249 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1292 | 0.1278 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0134 | 0.1292 | 0.1919 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | O-methyltransferase | 0.006 | 0.0538 | 0.0522 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0157 | 0.1521 | 0.1507 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0292 | 0.2884 | 0.2884 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0438 | 0.4372 | 0.6493 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1292 | 0.1278 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0229 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Onchocerca volvulus | Putative nachr subunit | 0.0994 | 1 | 1 |
Onchocerca volvulus | 0.0438 | 0.4372 | 0.425 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0292 | 0.2884 | 0.4283 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0292 | 0.2884 | 0.2884 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.006 | 0.0538 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0134 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2261 | 0.2248 |
Loa Loa (eye worm) | ACC-1 protein | 0.0292 | 0.2884 | 0.2871 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0134 | 0.1292 | 0.1919 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0213 | 0.0196 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0292 | 0.2884 | 0.2871 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0405 | 0.039 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0134 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0134 | 0.1292 | 0.1277 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0292 | 0.2884 | 0.2872 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.2261 | 0.2261 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.006 | 0.0538 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0213 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0134 | 0.1292 | 0.1919 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0157 | 0.1521 | 0.2259 |
Onchocerca volvulus | 0.0134 | 0.1292 | 0.1103 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.0672 | 0.6733 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.2261 | 0.2261 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0157 | 0.1521 | 0.2259 |
Echinococcus multilocularis | nAChR subunit | 0.0157 | 0.1521 | 0.1521 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0292 | 0.2884 | 0.2884 |
Onchocerca volvulus | 0.0134 | 0.1292 | 0.1103 | |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0292 | 0.2884 | 0.2872 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0292 | 0.2884 | 0.2872 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Mycobacterium ulcerans | O-methyltransferase | 0.0578 | 0.5787 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0157 | 0.1521 | 0.1521 |
Schistosoma mansoni | o-methyltransferase | 0.006 | 0.0538 | 0.0798 |
Onchocerca volvulus | 0.0047 | 0.0405 | 0.0197 | |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0292 | 0.2884 | 0.4283 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0134 | 0.1292 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0157 | 0.1521 | 0.1507 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0518 | 0.5179 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.3009 | 0.2997 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0672 | 0.6733 | 0.6733 |
Loa Loa (eye worm) | O-methyltransferase | 0.006 | 0.0538 | 0.0521 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0229 | 0.034 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0292 | 0.2884 | 0.2872 |
Onchocerca volvulus | 0.0292 | 0.2884 | 0.2729 | |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0405 | 0.0602 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0134 | 0.1292 | 0.1278 |
Brugia malayi | O-methyltransferase family protein | 0.006 | 0.0538 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0292 | 0.2884 | 0.2884 |
Schistosoma mansoni | o-methyltransferase | 0.006 | 0.0538 | 0.0798 |
Schistosoma mansoni | o-methyltransferase | 0.006 | 0.0538 | 0.0798 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0134 | 0.1292 | 0.1919 |
Brugia malayi | Cation transporter family protein | 0.0292 | 0.2884 | 0.2872 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0292 | 0.2884 | 0.4283 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0994 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0292 | 0.2884 | 0.4283 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0292 | 0.2884 | 0.2871 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.0466 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | LGC-31 protein | 0.0292 | 0.2884 | 0.2871 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Onchocerca volvulus | 0.0292 | 0.2884 | 0.2729 | |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0292 | 0.2884 | 0.2884 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0994 | 1 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0292 | 0.2884 | 0.2872 |
Echinococcus granulosus | dnaJ subfamily B | 0.0398 | 0.3962 | 0.3962 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0134 | 0.1292 | 0.1278 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0994 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0994 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0994 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0292 | 0.2884 | 0.2872 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0994 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1292 | 0.1278 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0157 | 0.1521 | 0.2259 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.4372 | 0.4362 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0405 | 0.0602 |
Schistosoma mansoni | hypothetical protein | 0.0398 | 0.3962 | 0.5885 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1292 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0017 | 0.0017 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0229 | 0.0229 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0292 | 0.2884 | 0.2872 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0213 | 0.0197 |
Onchocerca volvulus | 0.006 | 0.0538 | 0.0332 | |
Brugia malayi | O-methyltransferase family protein | 0.006 | 0.0538 | 0.0522 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0157 | 0.1521 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Schistosoma mansoni | nAChR subunit | 0.0134 | 0.1292 | 0.1919 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0292 | 0.2884 | 0.2872 |
Onchocerca volvulus | 0.0438 | 0.4372 | 0.425 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1292 | 0.1278 |
Brugia malayi | Cation transporter family protein | 0.0292 | 0.2884 | 0.2872 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0672 | 0.6733 | 0.6733 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0134 | 0.1292 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Brugia malayi | Cation transporter family protein | 0.0438 | 0.4372 | 0.4363 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.4372 | 0.4362 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0398 | 0.3962 | 0.3962 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0134 | 0.1292 | 0.1292 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0994 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0134 | 0.1292 | 0.1278 |
Onchocerca volvulus | 0.0438 | 0.4372 | 0.425 | |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0438 | 0.4372 | 0.6493 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0292 | 0.2884 | 0.2884 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0994 | 1 | 1 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0134 | 0.1292 | 0.1278 |
Onchocerca volvulus | 0.0157 | 0.1521 | 0.1337 | |
Brugia malayi | O-methyltransferase family protein | 0.006 | 0.0538 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1292 | 0.1277 |
Schistosoma mansoni | nAChR subunit | 0.0134 | 0.1292 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Entamoeba histolytica | hypothetical protein | 0.0157 | 0.1521 | 0.5 |
Echinococcus multilocularis | nAChR subunit | 0.0292 | 0.2884 | 0.2884 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Onchocerca volvulus | 0.0157 | 0.1521 | 0.1337 | |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0134 | 0.1292 | 0.1292 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0017 | 0.0017 |
Onchocerca volvulus | 0.0134 | 0.1292 | 0.1103 | |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1521 | 0.1506 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0292 | 0.2884 | 0.2884 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0157 | 0.1521 | 0.1507 |
Schistosoma mansoni | nAChR subunit | 0.0292 | 0.2884 | 0.4283 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.2884 | 0.2871 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0157 | 0.1521 | 0.1507 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0538 | 0.0521 |
Echinococcus granulosus | nAChR subunit | 0.0292 | 0.2884 | 0.2884 |
Onchocerca volvulus | 0.0292 | 0.2884 | 0.2729 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.053 | 0.0788 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0229 | 0.0229 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0292 | 0.2884 | 0.2872 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 52.8705 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 55.1293 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 55.1293 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 68.7989 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 68.7989 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 74.0722 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 76.9588 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.