Detailed information for compound 585962

Basic information

Technical information
  • TDR Targets ID: 585962
  • Name: FCE 22250
  • MW: 834.951 | Formula: C44H58N4O12
  • H donors: 6 H acceptors: 8 LogP: 5.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: CO[C@H]1C=CO[C@@]2(C)Oc3c(C2=O)c2C(=O)C(=CN/N=C/N4CCCCC4)C(=C(c2c(c3C)O)O)NC(=O)C(=CC=C[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]1C)OC(=O)C)C)O)C)O)C)C
  • InChi: 1S/C44H58N4O12/c1-22-14-13-15-23(2)43(56)47-34-29(20-45-46-21-48-17-11-10-12-18-48)38(53)31-32(39(34)54)37(52)27(6)41-33(31)42(55)44(8,60-41)58-19-16-30(57-9)24(3)40(59-28(7)49)26(5)36(51)25(4)35(22)50/h13-16,19-22,24-26,30,35-36,40,45,50-52,54H,10-12,17-18H2,1-9H3,(H,47,56)/b14-13+,19-16+,23-15+,29-20+,46-21+/t22-,24+,25+,26+,30-,35-,36+,40+,44-/m0/s1
  • InChiKey: SRGITGUCGGVOQM-YNQXYWRISA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0015 0.0099 0.0326
Loa Loa (eye worm) hypothetical protein 0.0263 0.539 1
Brugia malayi DNA topoisomerase III 0.0034 0.0509 0.115
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0329 0.0232
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0034 0.0509 0.0848
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1807 0.3353
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0744 0.1265
Toxoplasma gondii heat shock protein HSP90 0.0015 0.0099 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0329 0.0719
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0034 0.0509 0.0848
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1117 0.2072
Brugia malayi Probable DNA topoisomerase II 0.0112 0.2167 0.4898
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0744 0.3346
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.1308 0.2427
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1117 0.2072
Echinococcus multilocularis rho GTPase activating protein 20 0.0034 0.0509 0.0944
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Giardia lamblia Kinase, CMGC GSK 0.0099 0.1896 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0099 0.0326
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0112 0.2167 0.4898
Brugia malayi Endoplasmin precursor 0.0015 0.0099 0.0223
Entamoeba histolytica DNA topoisomerase III, putative 0.0034 0.0509 0.2244
Toxoplasma gondii heat shock protein 90, putative 0.0015 0.0099 0.0012
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0744 0.3346
Trypanosoma cruzi DNA topoisomerase II, putative 0.0078 0.1436 0.2487
Trypanosoma brucei protein kinase, putative 0.0099 0.1896 0.33
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Schistosoma mansoni ets-related 0.0217 0.4424 0.8208
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0352
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0191 0.0093
Chlamydia trachomatis DNA gyrase subunit B 0.0314 0.6481 0.6446
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0099 0.0183
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0329 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.1896 0.8731
Trypanosoma brucei Heat shock protein 83, putative 0.0015 0.0099 0.0123
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Brugia malayi RNA binding protein 0.0063 0.1117 0.2524
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1117 0.2072
Treponema pallidum DNA topoisomerase I (topA) 0.0034 0.0509 0.0414
Trypanosoma brucei DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0167 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1117 0.2072
Plasmodium falciparum glycogen synthase kinase 3 0.0099 0.1896 0.1815
Schistosoma mansoni gabp alpha 0.0072 0.1308 0.2427
Loa Loa (eye worm) TOPoisomerase family member 0.0112 0.2167 0.402
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0248 0.056
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0744 0.3593
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0744 0.1265
Leishmania major DNA topoisomerase ii 0.0078 0.1436 0.2487
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0034 0.0509 0.0414
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.019 0.0095
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Schistosoma mansoni endoplasmin 0.0015 0.0099 0.0183
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0329 0.0232
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.1308 0.2427
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0015 0.0099 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1117 0.2072
Echinococcus granulosus tar DNA binding protein 0.0063 0.1117 0.2072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.019 0.0092
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0744 0.1265
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0034 0.0509 0.0944
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0015 0.0099 0.0183
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0276 0.5686 1
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0744 0.1381
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0099 0.0326
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0263 0.539 1
Mycobacterium ulcerans DNA topoisomerase I 0.0034 0.0509 0.0414
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0276 0.5686 1
Plasmodium vivax heat shock protein 86, putative 0.0015 0.0099 0.0003
Mycobacterium ulcerans DNA gyrase subunit B 0.0478 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0478 1 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0099 0.0326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1807 0.4085
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0352
Loa Loa (eye worm) heat shock protein 90 0.0015 0.0099 0.0183
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0034 0.0509 0.0944
Schistosoma mansoni DNA topoisomerase II 0.0112 0.2167 0.402
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0478 1 1
Plasmodium vivax DNA topoisomerase II, putative 0.0112 0.2167 0.2091
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0112 0.2167 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0099 0.1896 0.33
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0112 0.2167 0.402
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0478 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.1896 0.8731
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1117 0.2524
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Brugia malayi kinase, mitochondrial precursor 0.0015 0.0099 0.0223
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0112 0.2167 1
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0034 0.0509 0.1282
Brugia malayi heat shock protein 90 0.0015 0.0099 0.0223
Loa Loa (eye worm) RNA binding protein 0.0063 0.1117 0.2072
Plasmodium falciparum DNA topoisomerase 3, putative 0.0034 0.0509 0.0414
Schistosoma mansoni heat shock protein 0.0015 0.0099 0.0183
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.1308 0.2427
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0099 0.0123
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0329 0.0232
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0744 0.1381
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0744 0.1265
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0099 0.0326
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Echinococcus granulosus heat shock protein 0.0015 0.0099 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0329 0.1402
Echinococcus granulosus bloom syndrome protein 0.0022 0.0248 0.046
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0099 0.0012
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Brugia malayi cell division control protein 2 homolog 0.0045 0.0744 0.1683
Giardia lamblia DNA topoisomerase II 0.0097 0.1846 0.9725
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1807 0.3353
Echinococcus multilocularis protein kinase shaggy 0.0099 0.1896 0.3517
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0099 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0099 0.0003
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0478 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0099 0.0123
Brugia malayi DNA topoisomerase III beta-1 0.0034 0.0509 0.115
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0099 0.1896 0.3517
Entamoeba histolytica protein kinase domain containing protein 0.0099 0.1896 0.8731
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1807 0.3353
Loa Loa (eye worm) hypothetical protein 0.0126 0.2465 0.4573
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0283
Giardia lamblia Kinase, CMGC GSK 0.0099 0.1896 1
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0034 0.0509 0.0944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1807 0.3353
Trichomonas vaginalis endoplasmin, putative 0.0015 0.0099 0.0326
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0099 0.1896 0.3517
Leishmania major DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Brugia malayi GRF zinc finger family protein 0.0034 0.0509 0.115
Loa Loa (eye worm) fli-1 protein 0.0217 0.4424 0.8208
Loa Loa (eye worm) hypothetical protein 0.0061 0.1086 0.2016
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0329 0.0743
Echinococcus multilocularis heat shock protein 0.0015 0.0099 0.0183
Trichomonas vaginalis DNA topoisomerase II, putative 0.0112 0.2167 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0329 0.0232
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0744 0.3593
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0099 0.0123
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0112 0.2167 0.4898
Schistosoma mansoni endoplasmin 0.0015 0.0099 0.0183
Plasmodium vivax endoplasmin, putative 0.0015 0.0099 0.0003
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0744 0.1381
Brugia malayi intracellular kinase 0.0099 0.1896 0.4285
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0744 0.3346
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0329 0.0232
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.019 0.0092
Entamoeba histolytica DNA topoisomerase II, putative 0.0112 0.2167 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0099 0.1896 0.3517
Loa Loa (eye worm) hypothetical protein 0.0026 0.0329 0.061
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.2664
Giardia lamblia DNA topoisomerase III 0.0034 0.0509 0.2282
Trypanosoma brucei developmentally regulated phosphoprotein 0.0015 0.0099 0.0123
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0078 0.1436 0.2487
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0744 0.1381
Plasmodium vivax DNA topoisomerase 3, putative 0.0034 0.0509 0.0417
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0329 0.053
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0099 0.0123
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0034 0.0509 0.0944
Trypanosoma cruzi DNA topoisomerase II, putative 0.0078 0.1436 0.2487
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0329 0.0743
Trypanosoma brucei DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0149 0.0276
Brugia malayi Ets-domain containing protein 0.0072 0.1308 0.2957
Loa Loa (eye worm) RecQ helicase 0.0022 0.0248 0.046
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0099 0.1896 0.3224
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0352
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0099 0.0123
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0744 0.1381
Plasmodium vivax protein kinase Crk2 0.0045 0.0744 0.0655
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.0099 0.0326
Entamoeba histolytica DNA topoisomerase III, putative 0.0034 0.0509 0.2244
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0329 0.0232
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0744 0.1166
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0263 0.539 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0329 0.0232
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0034 0.0509 0.2244
Plasmodium vivax glycogen synthase kinase 3, putative 0.0099 0.1896 0.1817
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0744 0.1381
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0744 0.1265
Plasmodium falciparum DNA topoisomerase 2 0.0112 0.2167 0.2089
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0744 0.3346
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.0099 0.0123
Chlamydia trachomatis DNA topoisomerase I 0.0034 0.0509 0.0414
Giardia lamblia DNA topoisomerase III 0.0034 0.0509 0.2282
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0744 0.1381
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0329 0.1402
Trypanosoma brucei DNA topoisomerase ii 0.0276 0.5686 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0714 0.1325
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Echinococcus granulosus heat shock protein 90 0.0015 0.0099 0.0183
Toxoplasma gondii DNA topoisomerase family protein 0.0034 0.0509 0.0745
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.0099 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0329 0.0232
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0329 0.1402
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0099 0.0326
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0099 0.1896 0.3517
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0744 0.1381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0329 0.0232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0329 0.061
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0248 0.1024
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0276 0.5686 1
Onchocerca volvulus 0.0099 0.1896 0.8524
Schistosoma mansoni pyruvate dehydrogenase 0.0015 0.0099 0.0183
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0112 0.2167 0.402
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0744 0.1381
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1117 0.2072
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0263 0.539 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0112 0.2167 0.3709
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0744 0.1381
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0744 0.3346
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0099 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0099 0.0183
Leishmania major hypothetical protein, conserved 0.0015 0.0099 0.0123
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.0099 0.0326
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0034 0.0509 0.2244
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.019 0.0092
Onchocerca volvulus 0.0034 0.0509 0.098
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0744 0.1381
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0099 0.1896 0.33
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0329 0.053
Brugia malayi TAR-binding protein 0.0063 0.1117 0.2524
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1117 0.2072
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0099 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0329 0.0743
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0744 0.1381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1807 0.3353
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0034 0.0509 0.0944
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.019 0.0092
Leishmania major mitochondrial DNA topoisomerase II 0.0276 0.5686 1
Echinococcus multilocularis heat shock protein 90 0.0015 0.0099 0.0183
Brugia malayi Fli-1 protein 0.0217 0.4424 1
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0165 0.3297 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0099 0.1896 0.3517
Trypanosoma brucei DNA topoisomerase IA, putative 0.0034 0.0509 0.0848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0167 0.0069
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0248 0.1024
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0329 0.053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0167 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.1896 0.8731
Leishmania major DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Leishmania major DNA topoisomerase 1A 0.0034 0.0509 0.0848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0329 0.0719
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0112 0.2167 1
Loa Loa (eye worm) endoplasmin 0.0015 0.0099 0.0183
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1117 0.2072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1807 0.3353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0167 0.0069
Trypanosoma cruzi DNA topoisomerase III, putative 0.0034 0.0509 0.0848
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0744 0.1265
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0034 0.0509 0.0944
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0099 0.0123
Trypanosoma cruzi Heat shock protein 83, putative 0.0015 0.0099 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0329 0.061
Schistosoma mansoni heat shock protein 0.0015 0.0099 0.0183
Loa Loa (eye worm) DNA topoisomerase III 0.0034 0.0509 0.0944
Plasmodium falciparum DNA gyrase subunit B 0.0478 1 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0015 0.0099 0.0123
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.0099 0.0326
Loa Loa (eye worm) hypothetical protein 0.0126 0.2465 0.4573
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.0099 0.0123
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Echinococcus granulosus protein kinase shaggy 0.0099 0.1896 0.3517
Brugia malayi hypothetical protein 0.0126 0.2465 0.5571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1807 0.3353
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Entamoeba histolytica protein kinase, putative 0.0099 0.1896 0.8731
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.2664
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0248 0.046
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0744 0.1265
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0099 0.0123
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0744 0.1381
Brugia malayi Ets-domain containing protein 0.0072 0.1308 0.2957
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0099 0.0326
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0744 0.1265
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0078 0.1436 0.2487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1807 0.3353
Trypanosoma brucei heat shock protein, putative 0.0015 0.0099 0.0123
Brugia malayi Protein kinase domain containing protein 0.0045 0.0744 0.1683
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0034 0.0509 0.0745
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0352
Leishmania major heat shock protein 83-1 0.0015 0.0099 0.0123
Plasmodium falciparum protein kinase 5 0.0045 0.0744 0.0652

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.