Detailed information for compound 586476

Basic information

Technical information
  • TDR Targets ID: 586476
  • Name: 3-[(3R)-1-propyl-3-piperidyl]phenol hydrochlo ride
  • MW: 255.784 | Formula: C14H22ClNO
  • H donors: 1 H acceptors: 1 LogP: 3.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCC[C@@H](C1)c1cccc(c1)O.Cl
  • InChi: 1S/C14H21NO.ClH/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12;/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3;1H/t13-;/m0./s1
  • InChiKey: NRHUDETYKUBQJT-ZOWNYOTGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3R)-1-propyl-3-piperidinyl]phenol hydrochloride
  • 3-[(3R)-1-propylpiperidin-3-yl]phenol hydrochloride
  • n-N-propyl-3-(3-hydroxyphenyl)piperidine
  • 85976-54-1
  • R-3-PPP hydrochloride
  • EU-0100986
  • P102_SIGMA
  • R()-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride
  • R()-3-PPP hydrochloride
  • R-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus 5-hydroxytryptamine (serotonin) receptor 2A Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens dopamine receptor D3 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TYRA-2 protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) neuropeptide F receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis g protein coupled receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0118922 0.0444935 0.252389
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0047868 0.00324195 0.00324195
Echinococcus granulosus neuropeptide receptor 0.0118922 0.0444935 0.0734209
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0329392 0.166686 0.290904
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0329392 0.166686 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Echinococcus granulosus g protein coupled receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni amine GPCR 0.0118922 0.0444935 0.252389
Brugia malayi RE15519p 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni opsin-like receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0118922 0.0444935 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0118922 0.0444935 0.252389
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0118922 0.0444935 0.252389
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.00655881 0.0135297 0.0103212
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptide Y receptor 0.0118922 0.0444935 0.252389
Brugia malayi Dopamine receptor protein 2 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0118922 0.0444935 0.252389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi neuropeptide F receptor 0.0118922 0.0444935 0.252389
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0107872 0.0380785 1
Schistosoma mansoni opsin-like receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0107872 0.0380785 0.21314
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni growth hormone secretagogue receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptides capa receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptide Y receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi Serotonin receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Brugia malayi AKH receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) melatonin receptor type 1A 0.0118922 0.0444935 0.252389
Echinococcus granulosus 7TM GPCR rhodopsin 0.0118922 0.0444935 0.0734209
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0118922 0.0444935 0.252389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptides capa receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni neuropeptide receptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Echinococcus granulosus sex peptide receptor 0.0118922 0.0444935 0.0734209
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni neuropeptide F-like receptor 0.0118922 0.0444935 0.252389
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0107872 0.0380785 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0118922 0.0444935 0.0734209
Brugia malayi sulfakinin receptor protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis fmrfamide receptor 0.0118922 0.0444935 0.252389
Entamoeba histolytica hypothetical protein 0.0047868 0.00324195 0.5
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Echinococcus multilocularis sex peptide receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni myosin xvIII 0.0118922 0.0444935 0.252389
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Echinococcus granulosus hypothetical protein 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptide receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptide FF receptor 2 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis neuropeptide receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 0.21314
Brugia malayi glucose-6-phosphate dehydrogenase 0.0107872 0.0380785 0.21314
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0118922 0.0444935 0.252389
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus peptide allatostatin:somatostatin 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis allatostatin A receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0118922 0.0444935 0.252389
Echinococcus granulosus g-protein coupled receptor 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0118922 0.0444935 0.252389
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Schistosoma mansoni histamine h1 receptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Schistosoma mansoni neuropeptide receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni neuropeptide F-like receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0118922 0.0444935 0.252389
Entamoeba histolytica hypothetical protein 0.0047868 0.00324195 0.5
Brugia malayi putative neuropeptide receptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni alpha-1 adrenergic receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus biogenic amine 5HT receptor 0.0118922 0.0444935 0.0734209
Echinococcus granulosus allatostatin A receptor 0.0118922 0.0444935 0.0734209
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0047868 0.00324195 0.5
Brugia malayi larval opioid receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus neuropeptides capa receptor 0.0118922 0.0444935 0.0734209
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni amine GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine (5HT) receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Brugia malayi G-protein coupled receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus 7tm_1 domain containing protein 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0118922 0.0444935 0.252389
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0107872 0.0380785 0.5
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis orexin receptor type 2 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0329392 0.166686 1
Brugia malayi Melatonin receptor type 1A 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Schistosoma mansoni hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis g protein coupled receptor 0.0118922 0.0444935 0.252389
Mycobacterium leprae Probable hydrolase 0.0047868 0.00324195 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0118922 0.0444935 0.252389
Schistosoma mansoni hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni neuropeptide receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 0.0349498
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0118922 0.0444935 0.252389
Schistosoma mansoni amine GPCR 0.0118922 0.0444935 0.252389
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis G protein coupled receptor 139 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine (5HT) receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus neuropeptides capa receptor 0.0118922 0.0444935 0.0734209
Echinococcus granulosus biogenic amine 5HT receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Brugia malayi GnHR receptor homolog 0.0118922 0.0444935 0.252389
Echinococcus granulosus tachykinin peptides receptor 99D 0.0118922 0.0444935 0.0734209
Schistosoma mansoni neuropeptide f receptor 76f 0.0118922 0.0444935 0.252389
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.176473 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis dro:myosuppressin receptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0118922 0.0444935 0.252389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Echinococcus multilocularis neuropeptide receptor A26 0.0118922 0.0444935 0.252389
Echinococcus granulosus alpha 1A adrenergic receptor 0.0118922 0.0444935 0.0734209
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0118922 0.0444935 0.0734209
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0329392 0.166686 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0107872 0.0380785 0.21314
Loa Loa (eye worm) G-protein coupled receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0118922 0.0444935 0.252389
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0047868 0.00324195 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus serotonin receptor 0.0118922 0.0444935 0.0734209
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0118922 0.0444935 0.252389
Echinococcus granulosus orexin receptor type 2 0.0118922 0.0444935 0.0734209
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0107872 0.0380785 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0118922 0.0444935 0.252389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0047868 0.00324195 0.5
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni amine GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni amine GPCR 0.0118922 0.0444935 0.252389
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0118922 0.0444935 0.0734209
Onchocerca volvulus 0.0118922 0.0444935 1
Schistosoma mansoni opsin-like receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus fmrfamide receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni adenoreceptor 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0118922 0.0444935 0.252389
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus neuropeptide s receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni neuropeptide receptor 0.0118922 0.0444935 0.252389
Brugia malayi Serotonin receptor 0.0118922 0.0444935 0.252389
Brugia malayi follicle stimulating hormone receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis fmrfamide receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus neuropeptide Y receptor 0.0118922 0.0444935 0.0734209
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0118922 0.0444935 0.252389
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Mycobacterium tuberculosis Possible phosphatase 0.0047868 0.00324195 0.00324195
Brugia malayi neuropeptide F receptor 0.0118922 0.0444935 0.252389
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0118922 0.0444935 0.0734209
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus neuropeptide FF receptor 2 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Echinococcus multilocularis serotonin receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi G protein-coupled receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Brugia malayi putative neuropeptide receptor NPR1 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis g-protein coupled receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus granulosus neuropeptide receptor 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0329392 0.166686 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus somatostatin receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni biogenic amine receptor 0.0118922 0.0444935 0.252389
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047868 0.00324195 0.00324195
Echinococcus granulosus rhodopsin orphan GPCR 0.0118922 0.0444935 0.0734209
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0107872 0.0380785 1
Schistosoma mansoni hypothetical protein 0.0118922 0.0444935 0.252389
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0047868 0.00324195 0.5
Mycobacterium ulcerans epoxide hydrolase EphA 0.176473 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0118922 0.0444935 0.0734209
Brugia malayi Dopamine receptor protein 1 0.0118922 0.0444935 0.252389
Brugia malayi G-protein coupled receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus Neuropeptide F receptor homolog 0.0118922 0.0444935 1
Onchocerca volvulus 0.0118922 0.0444935 1
Loa Loa (eye worm) neuropeptide F receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Schistosoma mansoni biogenic amine receptor 0.0118922 0.0444935 0.252389
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0047868 0.00324195 0.5
Brugia malayi ORL1-like opioid receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus g protein coupled receptor 0.0118922 0.0444935 0.0734209
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis somatostatin receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) G-protein coupled receptor 0.0118922 0.0444935 0.252389
Echinococcus multilocularis serotonin receptor 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Schistosoma mansoni hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus G protein coupled receptor 139 0.0118922 0.0444935 0.0734209
Echinococcus multilocularis g protein coupled receptor 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus tm gpcr rhodopsin 0.0118922 0.0444935 0.0734209
Echinococcus granulosus neuropeptide Y receptor 0.0118922 0.0444935 0.0734209
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0107872 0.0380785 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0107872 0.0380785 0.0620032
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 1
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0107872 0.0380785 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Brugia malayi hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus Solute carrier family 22 5 0.101562 0.565093 1
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0107872 0.0380785 1
Onchocerca volvulus 0.0118922 0.0444935 1
Mycobacterium tuberculosis Probable hydrolase 0.0047868 0.00324195 0.00324195
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0118922 0.0444935 0.0734209
Brugia malayi Dopamine receptor 0.0118922 0.0444935 0.252389
Echinococcus granulosus g protein coupled receptor 0.0118922 0.0444935 0.0734209
Brugia malayi Tachykinin-like peptides receptor 99D 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0118922 0.0444935 0.252389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0118922 0.0444935 0.252389
Onchocerca volvulus 0.0118922 0.0444935 1
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389
Echinococcus granulosus tm gpcr rhodopsin 0.0118922 0.0444935 0.0734209
Loa Loa (eye worm) hypothetical protein 0.0118922 0.0444935 0.252389

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.71135 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A). (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 92.419 uM PubChem BioAssay. Counterscreen for agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A): Luminescence-based cell-based high throughput dose response assay to identify agonists of the mu 1 opioid receptor (OPRM1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = -5 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
Potency (functional) = 0.0002 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 0.0002 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 0.1585 uM PubChem BioAssay. qHTS of D3 Dopamine Receptor Agonist: D3 Dopamine Receptor B-arrestin Agonist Confirmatory Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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