Detailed information for compound 589073

Basic information

Technical information
  • TDR Targets ID: 589073
  • Name: 7-chloro-6-hydroxy-5H-phenazin-1-one
  • MW: 246.649 | Formula: C12H7ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 2.1 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1O)[nH]c1c(n2)c(=O)ccc1
  • InChi: 1S/C12H7ClN2O2/c13-6-4-5-8-11(12(6)17)15-7-2-1-3-9(16)10(7)14-8/h1-5,15,17H
  • InChiKey: VPWUZRMAUXMUOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,6-dihydroxy-2-chlorophenazine
  • 93768-40-2
  • 1,6-Phenazinediol, 2-chloro-
  • 2-Chloro-1,6-phenazinediol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0164 0.0201
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0045 0.0132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0102
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0016 0.0164 0.147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0657 0.0808
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Brugia malayi cathepsin L-like precursor 0.0011 0.0083 0.0242
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0083 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0049 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0821 0.0821
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0164 0.147
Brugia malayi CXXC zinc finger family protein 0.0028 0.0344 0.1007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Schistosoma mansoni cpg binding protein 0.003 0.0369 0.0369
Echinococcus granulosus cathepsin l1 0.0016 0.0164 0.0139
Loa Loa (eye worm) hypothetical protein 0.0545 0.8135 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0851 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Onchocerca volvulus 0.0028 0.0344 0.475
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0083 0.0083
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0164 1
Schistosoma mansoni cpg binding protein 0.003 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0851 1
Echinococcus granulosus GPCR family 2 0.0015 0.0153 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0164 0.1924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0083 0.4547
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0344 0.0423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0025 0.0025
Echinococcus multilocularis GPCR, family 2 0.0015 0.0153 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0153 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0083 0.0242
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0164 0.0479
Loa Loa (eye worm) cysteine protease 0.0016 0.0164 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0657 0.1922
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0045 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0083 0.4547
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0102
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0164 0.0139
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.342 0.3403
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0201
Onchocerca volvulus 0.0016 0.0164 0.147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Plasmodium vivax vivapain-2 0.0016 0.0164 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0188
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0164 0.147
Loa Loa (eye worm) ctsf protein 0.0016 0.0164 0.0201
Loa Loa (eye worm) hypothetical protein 0.0232 0.342 0.4203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Brugia malayi hypothetical protein 0.0232 0.342 1
Schistosoma mansoni hypothetical protein 0.0015 0.0153 0.0153
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0164 0.0139
Schistosoma mansoni survival motor neuron protein 0.0047 0.0633 0.0633
Echinococcus multilocularis cathepsin L 0.0008 0.0045 0.002
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0164 0.147
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0153 0.0446
Loa Loa (eye worm) hypothetical protein 0.0049 0.0657 0.0808
Loa Loa (eye worm) hypothetical protein 0.0011 0.0083 0.0102
Plasmodium vivax vivapain-2 0.0016 0.0164 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0062
Echinococcus granulosus cysteine protease 0.0008 0.0045 0.002
Onchocerca volvulus 0.0016 0.0164 0.147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Brugia malayi Cathepsin L-like precursor 0.0011 0.0083 0.0242
Schistosoma mansoni cpg binding protein 0.0028 0.0344 0.0344
Onchocerca volvulus 0.0016 0.0164 0.147
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0164 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0164 0.0139
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0045 0.053
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.342 0.3403
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0153 0.0128
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0402 0.5974 0.5974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Schistosoma mansoni hypothetical protein 0.0015 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Plasmodium vivax vivapain-1 0.0008 0.0045 0.2757
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0045 0.053
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0164 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Echinococcus granulosus cpg binding protein 0.003 0.0369 0.0345
Onchocerca volvulus 0.0016 0.0164 0.147
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0153 0.0128
Plasmodium vivax unspecified product 0.0008 0.0045 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0153 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Echinococcus multilocularis cpg binding protein 0.003 0.0369 0.0345
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0045 0.002
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0045 0.0045
Loa Loa (eye worm) fibroinase 0.0016 0.0164 0.0201
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5974 0.5964
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0153 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0164 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0851 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0045 0.0045
Plasmodium vivax vivapain-3 0.0008 0.0045 0.2757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.8135 1
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5974 0.5964
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0164 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0045 0.2002
Echinococcus multilocularis cysteine protease 0.0016 0.0164 0.0139
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0045 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Schistosoma mansoni hypothetical protein 0.0047 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0545 0.8135 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0725 0.0704
Leishmania major cathepsin L-like protease 0.0062 0.0851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Echinococcus multilocularis cysteine protease 0.0016 0.0164 0.0139
Schistosoma mansoni hypothetical protein 0.0033 0.0424 0.0424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0657 0.1922
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0545 0.8135 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0633 0.1851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0164 0.0139
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0164 1
Onchocerca volvulus 0.0016 0.0164 0.147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0164 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0164 0.0479
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.077 0.905
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0164 0.0139
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0045 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0164 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0164 0.0139
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0153 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Onchocerca volvulus 0.0016 0.0164 0.147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Toxoplasma gondii hypothetical protein 0.0545 0.8135 1
Schistosoma mansoni hypothetical protein 0.0015 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0015 0.0153 0.0153
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0083 0.0242
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0045 0.053
Echinococcus granulosus cathepsin L 0.0008 0.0045 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Onchocerca volvulus 0.0047 0.0633 1
Echinococcus granulosus cathepsin l1 0.0011 0.0083 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0851 1
Leishmania major cathepsin L-like protease 0.0062 0.0851 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0652 0.7656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0164 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0424 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0045 0.2002
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0851 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0424 0.1239
Leishmania major cathepsin L-like protease 0.0062 0.0851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0164 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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