TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.526 | Formula: C26H29N3O4
H donors: 1 H acceptors: 2 LogP: 4.74 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1OC)C=CC(=Nc1ccc2c(c1)c(C)cc(n2)N1CCOCC1)O
InChi: 1S/C26H29N3O4/c1-4-33-23-9-5-19(16-24(23)31-3)6-10-26(30)27-20-7-8-22-21(17-20)18(2)15-25(28-22)29-11-13-32-14-12-29/h5-10,15-17H,4,11-14H2,1-3H3,(H,27,30)
InChiKey: RBSRLSNLDOCVBG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	neuropeptide s receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	vesicular acetylcholine transporter	0.2145	0.6013	0.6706
Schistosoma mansoni	amine GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0111	0.0277	0.0456
Echinococcus multilocularis	sex peptide receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Brugia malayi	Pre-SET motif family protein	0.0031	0.0051	0.0048
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.3192	0.8966	1
Brugia malayi	Dopamine receptor protein 1	0.0111	0.0277	0.0274
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0008	0.0005
Echinococcus multilocularis	neuropeptide receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.002	0.5
Onchocerca volvulus		0.0111	0.0277	0.0456
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0222	0.0365
Loa Loa (eye worm)	neuropeptide F receptor	0.0111	0.0277	0.031
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Schistosoma mansoni	microtubule-associated protein tau	0.0668	0.1849	0.3071
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	TYRA-2 protein	0.0111	0.0277	0.031
Schistosoma mansoni	histamine h1 receptor	0.0111	0.0277	0.0456
Echinococcus granulosus	7tm_1 domain containing protein	0.0111	0.0277	0.0309
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0008	0.0008
Schistosoma mansoni	ran	0.0021	0.0022	0.0033
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.0465	0.7042
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Echinococcus multilocularis	neuropeptides capa receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	importin beta-1	0.0028	0.0043	0.0067
Brugia malayi	Melatonin receptor type 1A	0.0111	0.0277	0.0274
Loa Loa (eye worm)	hypothetical protein	0.1624	0.4544	0.5092
Schistosoma mansoni	neuropeptide receptor	0.0111	0.0277	0.0456
Onchocerca volvulus		0.0111	0.0277	0.0456
Brugia malayi	vesicular acetylcholine transporter unc-17	0.2145	0.6013	0.6012
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0111	0.0277	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Brugia malayi	Serotonin receptor	0.0111	0.0277	0.0274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Schistosoma mansoni	neuropeptide F-like receptor	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0111	0.0277	0.0274
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.002	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Schistosoma mansoni	hypothetical protein	0.0111	0.0277	0.0456
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.2145	0.6013	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0111	0.0277	0.0309
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0022	0.002
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Onchocerca volvulus		0.0026	0.0038	0.0059
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0043	0.0045
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0022	0.0025
Trichomonas vaginalis	set domain proteins, putative	0.0244	0.0652	1
Schistosoma mansoni	hypothetical protein	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0111	0.0277	0.031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0111	0.0277	0.0456
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0111	0.0277	0.0274
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0008	0.0008
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0111	0.0277	0.0309
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	dna polymerase eta	0.002	0.002	0.0023
Echinococcus granulosus	neuropeptide Y receptor	0.0111	0.0277	0.0309
Plasmodium vivax	SET domain protein, putative	0.0031	0.0051	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0028	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.002	0.002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0015	0.0008	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Echinococcus multilocularis	dna polymerase kappa	0.002	0.002	0.0023
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0058	0.0064
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0051	0.0057
Onchocerca volvulus		0.0111	0.0277	0.0456
Echinococcus granulosus	serotonin receptor	0.0111	0.0277	0.0309
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0008	0.0005
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.002	0.0018
Onchocerca volvulus		0.0111	0.0277	0.0456
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	amine GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0111	0.0277	0.0456
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0051	0.0057
Echinococcus multilocularis	g protein coupled receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	hypothetical protein	0.0015	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0181	0.0202
Leishmania major	DNA polymerase kappa, putative	0.002	0.002	0.002
Echinococcus granulosus	tm gpcr rhodopsin	0.0111	0.0277	0.0309
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Onchocerca volvulus		0.0111	0.0277	0.0456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Brugia malayi	larval opioid receptor	0.0111	0.0277	0.0274
Echinococcus multilocularis	allatostatin A receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0111	0.0277	0.0309
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0043	0.8354
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0183	0.0479	0.0477
Schistosoma mansoni	hypothetical protein	0.0111	0.0277	0.0456
Brugia malayi	Dopamine receptor	0.0111	0.0277	0.0274
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0111	0.0277	0.0274
Brugia malayi	RE15519p	0.0111	0.0277	0.0274
Entamoeba histolytica	hypothetical protein	0.0023	0.0028	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0022	0.4846
Echinococcus granulosus	dna polymerase kappa	0.002	0.002	0.0023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0111	0.0277	0.0456
Brugia malayi	G protein-coupled receptor F59B2.13	0.0111	0.0277	0.0274
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0043	0.8354
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Schistosoma mansoni	opsin-like receptor	0.0111	0.0277	0.0456
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0111	0.0277	0.0456
Echinococcus granulosus	neuropeptide FF receptor 2	0.0111	0.0277	0.0309
Echinococcus granulosus	g protein coupled receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0111	0.0277	0.031
Onchocerca volvulus		0.0111	0.0277	0.0456
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0048	0.0053
Echinococcus multilocularis	serotonin receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0222	0.0248
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0111	0.0277	0.0309
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0022	1
Echinococcus granulosus	tissue type plasminogen activator	0.0014	0.0003	0.0003
Echinococcus granulosus	biogenic amine 5HT receptor	0.1511	0.4227	0.4714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Echinococcus granulosus	g protein coupled receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.0277	0.0456
Echinococcus multilocularis	neuropeptide Y receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	neuropeptide receptor	0.0111	0.0277	0.0456
Echinococcus multilocularis	serotonin receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0111	0.0277	0.0456
Echinococcus granulosus	tm gpcr rhodopsin	0.3192	0.8966	1
Echinococcus granulosus	neuropeptides capa receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0037	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0051	0.0057
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.002	0.0023
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0004	0.0001
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0028	0.0124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Brugia malayi	AKH receptor	0.0111	0.0277	0.0274
Onchocerca volvulus		0.0111	0.0277	0.0456
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.002	0.0019
Echinococcus granulosus	g-protein coupled receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	neuropeptide receptor	0.0111	0.0277	0.0456
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.002	0.002
Echinococcus granulosus	sex peptide receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	fmrfamide receptor	0.0111	0.0277	0.0309
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.002	0.0023
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.0569	0.0637
Echinococcus granulosus	intermediate filament protein	0.0026	0.0038	0.0042
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.0277	0.0456
Echinococcus granulosus	neuropeptides capa receptor	0.0111	0.0277	0.0309
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0058	0.0055
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0022	0.0022
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0111	0.0277	0.0309
Schistosoma mansoni	vesicular acetylcholine transporter	0.2145	0.6013	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.002	0.0018
Brugia malayi	GnHR receptor homolog	0.0111	0.0277	0.0274
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0111	0.0277	0.0456
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0028	0.0124
Loa Loa (eye worm)	hypothetical protein	0.3177	0.8924	1
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus granulosus	fmrfamide receptor	0.0111	0.0277	0.0309
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0222	0.0219
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0038	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	G-protein coupled receptor	0.0111	0.0277	0.031
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.2145	0.6013	0.6738
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0028	0.0029
Brugia malayi	Dopamine receptor protein 2	0.0111	0.0277	0.0274
Onchocerca volvulus		0.0077	0.0181	0.0296
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0222	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0222	0.0248
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0111	0.0277	0.0274
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.002	0.0019
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0111	0.0277	0.0309
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Schistosoma mansoni	amine GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	DNA polymerase eta	0.002	0.002	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	microtubule associated protein 2	0.0668	0.1849	0.2062
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0181	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0008
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0077	0.0181	0.0296
Schistosoma mansoni	amine GPCR	0.0111	0.0277	0.0456
Echinococcus granulosus	lamin	0.0026	0.0038	0.0042
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0051	0.008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.3177	0.8924	0.8924
Echinococcus granulosus	snurportin 1	0.0298	0.0805	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0111	0.0277	0.0456
Onchocerca volvulus		0.0068	0.0156	0.0256
Echinococcus multilocularis	microtubule associated protein 2	0.0668	0.1849	0.2062
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0101	0.0113
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0051	0.008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Schistosoma mansoni	hypothetical protein	0.0033	0.0058	0.0091
Echinococcus multilocularis	neuropeptides capa receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	neuropeptide F-like receptor	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0111	0.0277	0.0309
Echinococcus granulosus	GPCR family 2	0.0015	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0015	0.0008	0.0008
Trypanosoma brucei	C-8 sterol isomerase, putative	0.3177	0.8924	1
Schistosoma mansoni	opsin-like receptor	0.0111	0.0277	0.0456
Schistosoma mansoni	biogenic amine receptor	0.0111	0.0277	0.0456
Brugia malayi	neuropeptide F receptor	0.0111	0.0277	0.0274
Schistosoma mansoni	amine GPCR	0.0111	0.0277	0.0456
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0003	0.0003
Trypanosoma brucei	unspecified product	0.002	0.002	0.0019
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	snurportin 1	0.0298	0.0805	0.0898
Echinococcus multilocularis	tissue type plasminogen activator	0.0014	0.0003	0.0003
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0111	0.0277	0.0309
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0038	0.0043
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	hypothetical protein	0.0298	0.0805	0.1334
Echinococcus multilocularis	lamin	0.0026	0.0038	0.0042
Trichomonas vaginalis	ran, putative	0.0021	0.0022	0.003
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	somatostatin receptor	0.0111	0.0277	0.0309
Loa Loa (eye worm)	TK/ROR protein kinase	0.0014	0.0003	0.0003
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0077	0.0181	0.0296
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0101	0.0098
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Echinococcus granulosus	biogenic amine 5HT receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0222	0.0365
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0111	0.0277	0.0309
Echinococcus multilocularis	neuropeptide receptor A26	0.0111	0.0277	0.0309
Brugia malayi	G protein-coupled receptor	0.0111	0.0277	0.0274
Echinococcus multilocularis	musashi	0.0026	0.0038	0.0042
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0008	0.0008
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.002	0.002
Leishmania major	GTP-binding protein, putative	0.0021	0.0022	0.0022
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0101	0.0098
Onchocerca volvulus		0.0111	0.0277	0.0456
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0111	0.0277	0.0456
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0051	0.008
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0022	0.0022
Brugia malayi	putative neuropeptide receptor NPR1	0.0111	0.0277	0.0274
Brugia malayi	G-protein coupled receptor	0.0111	0.0277	0.0274
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0043	0.0048
Leishmania major	C-8 sterol isomerase-like protein	0.3177	0.8924	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.002	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.002	0.0019
Brugia malayi	Pre-SET motif family protein	0.0214	0.0569	0.0566
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0111	0.0277	0.031
Echinococcus granulosus	dna polymerase eta	0.002	0.002	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	g protein coupled receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	orexin receptor type 2	0.0111	0.0277	0.0309
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0222	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus multilocularis	neuropeptide Y receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	ran	0.0021	0.0022	0.0033
Echinococcus multilocularis	somatostatin receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	allatostatin A receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	dro:myosuppressin receptor	0.0111	0.0277	0.0309
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0051	0.008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0101	0.0113
Echinococcus multilocularis	neuropeptide s receptor	0.0111	0.0277	0.0309
Brugia malayi	ORL1-like opioid receptor	0.0111	0.0277	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Onchocerca volvulus		0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0043
Echinococcus multilocularis	conserved hypothetical protein	0.1289	0.3599	0.4013
Echinococcus granulosus	neuropeptide receptor A26	0.0111	0.0277	0.0309
Echinococcus multilocularis	g-protein coupled receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	g protein coupled receptor	0.0111	0.0277	0.0309
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0111	0.0277	0.0274
Onchocerca volvulus		0.0111	0.0277	0.0456
Brugia malayi	Importin beta-1 subunit	0.0028	0.0043	0.004
Echinococcus granulosus	neuropeptide Y receptor	0.0111	0.0277	0.0309
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Echinococcus granulosus	tm gpcr rhodopsin	0.0111	0.0277	0.0309
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0051	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0004	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0111	0.0277	0.0456
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0111	0.0277	0.0309
Schistosoma mansoni	adenoreceptor	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0111	0.0277	0.0456
Brugia malayi	intermediate filament protein	0.0026	0.0038	0.0035
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Echinococcus multilocularis	G protein coupled receptor 139	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0111	0.0277	0.0309
Brugia malayi	sulfakinin receptor protein	0.0111	0.0277	0.0274
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0111	0.0277	0.0456
Brugia malayi	putative neuropeptide receptor	0.0111	0.0277	0.0274
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.002	0.002
Schistosoma mansoni	neuropeptide receptor	0.0111	0.0277	0.0456
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0111	0.0277	0.0456
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1511	0.4227	0.4714
Schistosoma mansoni	hypothetical protein	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0048
Echinococcus multilocularis	g protein coupled receptor	0.0111	0.0277	0.0309
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.002	0.002
Echinococcus multilocularis	lamin dm0	0.0026	0.0038	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	biogenic amine receptor	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Onchocerca volvulus		0.0031	0.0051	0.008
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0298	0.0805	0.0902
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Echinococcus multilocularis	dro:myosuppressin receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	rhodopsin orphan GPCR	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.0023
Echinococcus multilocularis	vesicular acetylcholine transporter	0.2145	0.6013	0.6706
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Onchocerca volvulus		0.0111	0.0277	0.0456
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.3177	0.8924	1
Onchocerca volvulus		0.0244	0.0652	0.108
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0022	0.0025
Echinococcus granulosus	lamin dm0	0.0026	0.0038	0.0042
Echinococcus multilocularis	fmrfamide receptor	0.0111	0.0277	0.0309
Brugia malayi	G-protein coupled receptor	0.0111	0.0277	0.0274
Schistosoma mansoni	myosin xvIII	0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	opsin-like receptor	0.0111	0.0277	0.0456
Onchocerca volvulus		0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0479	0.0537
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.002	0.0029
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0111	0.0277	0.031
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0008	0.0008
Schistosoma mansoni	lamin	0.0026	0.0038	0.0059
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0111	0.0277	0.0309
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0022	0.4048
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.002	0.0023
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0038	0.0035
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0051	0.0057
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Plasmodium falciparum	importin beta, putative	0.0028	0.0043	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0222	0.0365
Echinococcus granulosus	neuropeptide receptor	0.0111	0.0277	0.0309
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0222	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0043	0.0048
Echinococcus granulosus	neuropeptide receptor	0.0111	0.0277	0.0309
Brugia malayi	RNA, U transporter 1	0.0079	0.0188	0.0186
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0043	0.0045
Onchocerca volvulus		0.0026	0.0038	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0111	0.0277	0.0456
Echinococcus granulosus	G protein coupled receptor 139	0.0111	0.0277	0.0309
Loa Loa (eye worm)	neuropeptide F receptor	0.0111	0.0277	0.031
Schistosoma mansoni	lamin	0.0026	0.0038	0.0059
Echinococcus granulosus	orexin receptor type 2	0.0111	0.0277	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Brugia malayi	follicle stimulating hormone receptor	0.0111	0.0277	0.0274
Onchocerca volvulus		0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0038	0.0043
Schistosoma mansoni	neuropeptide f receptor 76f	0.0111	0.0277	0.0456
Onchocerca volvulus		0.0111	0.0277	0.0456
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.002	0.0029
Onchocerca volvulus		0.0111	0.0277	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	hypothetical protein	0.0015	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Schistosoma mansoni	biogenic amine receptor	0.0111	0.0277	0.0456
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0028	0.0029
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0111	0.0277	0.0309
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.002	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0277	0.031
Onchocerca volvulus		0.0111	0.0277	0.0456
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0111	0.0277	0.031
Echinococcus granulosus	7TM GPCR rhodopsin	0.0111	0.0277	0.0309
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0111	0.0277	0.0456
Brugia malayi	neuropeptide F receptor	0.0111	0.0277	0.0274
Loa Loa (eye worm)	melatonin receptor type 1A	0.0111	0.0277	0.031
Loa Loa (eye worm)	G-protein coupled receptor	0.0111	0.0277	0.031
Entamoeba histolytica	Ran family GTPase	0.0021	0.0022	0.2447
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1511	0.4227	0.7028
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus granulosus	hypothetical protein	0.14	0.3911	0.4362
Brugia malayi	Trypsin family protein	0.0077	0.0181	0.0178
Onchocerca volvulus		0.0111	0.0277	0.0456
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0111	0.0277	0.0309
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0111	0.0277	0.0309
Brugia malayi	hypothetical protein	0.0111	0.0277	0.0274
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0008	0.0008
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.002	0.002
Leishmania major	DNA polymerase eta, putative	0.002	0.002	0.002
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0022	0.0025
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0022	0.4048

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 4.75 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 5 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 9.63 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 10.05 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 14 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 23 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 92 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 4.04	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= 5 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 14 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 23 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 92 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.05	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.90097 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL533342
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 592885