TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419 | Formula: C24H35ClN2O2
H donors: 2 H acceptors: 2 LogP: 5.5 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)Cc1c(O)ccc2c1ccc(c2CN1CCC(CC1)C)O.Cl
InChi: 1S/C24H34N2O2.ClH/c1-17-7-11-25(12-8-17)15-21-19-3-6-24(28)22(20(19)4-5-23(21)27)16-26-13-9-18(2)10-14-26;/h3-6,17-18,27-28H,7-16H2,1-2H3;1H
InChiKey: XNXZEMMFIJWTQB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0098	0.1896	0.1824
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0046	0.0722	0.1016
Loa Loa (eye worm)	hypothetical protein	0.007	0.127	0.127
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.1544	0.4664
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0098	0.1896	0.1896
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0704	0.1976
Brugia malayi	hypothetical protein	0.0156	0.3211	0.3151
Schistosoma mansoni	hypothetical protein	0.007	0.127	0.1672
Brugia malayi	photoreceptor-specific nuclear receptor	0.0098	0.1896	0.1824
Brugia malayi	bZIP transcription factor family protein	0.0164	0.3401	0.3343
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3186	0.3186
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0087	0.5
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0046	0.0722	0.0506
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0046	0.0722	0.0506
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.1896	0.1824
Echinococcus multilocularis	muscleblind protein	0.0155	0.3186	0.4195
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1007	0.1326
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0413	0.0581
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0704	0.0879
Onchocerca volvulus	Protein ultraspiracle homolog	0.0098	0.1896	0.1707
Brugia malayi	ecdysteroid receptor	0.0098	0.1896	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0455	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0098	0.1896	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Schistosoma mansoni	chromatin regulatory protein sir2	0.0082	0.1544	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1544	0.1544
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0098	0.1896	0.1824
Echinococcus granulosus	thyroid hormone receptor alpha	0.0046	0.0722	0.1016
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.1896	0.1824
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0227	0.0141
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.1896	0.1824
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0678	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0848	0.0848
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0413	0.0544
Brugia malayi	Nuclear hormone receptor E75	0.0046	0.0722	0.0641
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0413	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0154	0.3176	0.4182
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus multilocularis	hormone sensitive lipase	0.0215	0.4561	0.6005
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0087	0.0115
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0052	0.0848	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0227	0.0227
Brugia malayi	hypothetical protein	0.0072	0.1321	0.1244
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0413	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.1896	0.2666
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0227	0.0199
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0227	0.0199
Schistosoma mansoni	retinoic acid receptor RXR	0.0098	0.1896	0.2495
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0678	0.0954
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0052	0.0848	0.1116
Echinococcus multilocularis	thymidylate synthase	0.0327	0.7109	0.9359
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0722	0.1016
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0704	0.0879
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1007	0.131
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0098	0.1896	0.2666
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.3211	1
Mycobacterium tuberculosis	Hypothetical protein	0.0156	0.3211	0.4467
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1007	0.131
Schistosoma mansoni	jun-related protein	0.0133	0.2703	0.3559
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0046	0.0722	0.0951
Brugia malayi	orphan nuclear receptor NR2E1	0.0046	0.0722	0.0641
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1007	0.1326
Brugia malayi	hypothetical protein	0.0129	0.2601	0.2536
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0227	0.0199
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0227	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Onchocerca volvulus		0.0455	1	1
Echinococcus granulosus	thymidylate synthase	0.0327	0.7109	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0132	0.2662	0.3504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0098	0.1896	0.1896
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0098	0.1896	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0154	0.3176	0.4182
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0227	0.0227
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0227	0.0141
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.1544	0.4664
Brugia malayi	hypothetical protein	0.0052	0.0848	0.0767
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0164	0.3401	0.4478
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1007	0.1337
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0098	0.1896	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus granulosus	jun protein	0.0164	0.3401	0.4785
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0227	0.0141
Brugia malayi	nuclear hormone receptor	0.0046	0.0722	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0848	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0098	0.1896	0.2666
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Schistosoma mansoni	nuclear receptor	0.0046	0.0722	0.0951
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.1544	0.4664
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1007	0.131
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0678	0.0893
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1007	0.131
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	1
Echinococcus granulosus	muscleblind protein	0.0155	0.3186	0.4482
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.127	0.1193
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0132	0.2662	0.2662
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1007	0.1416
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0678	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0098	0.1896	0.2666
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0132	0.2662	0.2597
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0098	0.1896	0.1824
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0156	0.3211	0.4449
Echinococcus granulosus	ecdysone induced protein 78C	0.0098	0.1896	0.2666
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0087	0.0123
Loa Loa (eye worm)	thymidylate synthase	0.0327	0.7109	0.7109
Echinococcus granulosus	hormone sensitive lipase	0.0215	0.4561	0.6416
Brugia malayi	nuclear receptor NHR-88	0.0098	0.1896	0.1824
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0098	0.1896	0.1896
Echinococcus multilocularis	muscleblind protein 1	0.0155	0.3186	0.4195
Entamoeba histolytica	hypothetical protein	0.0072	0.1321	0.4791
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0678	0.0596
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0098	0.1896	0.1896
Brugia malayi	hypothetical protein	0.0052	0.0848	0.0767
Entamoeba histolytica	hypothetical protein	0.0072	0.1321	0.4791
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0227	0.0544
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.1327	0.1867
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0327	0.7109	1
Echinococcus granulosus	transcription factor Dp 1	0.0076	0.1404	0.1975
Loa Loa (eye worm)	runx1	0.0057	0.097	0.097
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0098	0.1896	0.1896
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0088	0.0032
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0052	0.0848	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1299	0.1299
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0227	0.023
Brugia malayi	ecdysone receptor	0.0046	0.0722	0.0641
Brugia malayi	Nuclear hormone receptor-like 1	0.0052	0.0848	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0848	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0132	0.2662	0.3504
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0088	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0046	0.0722	0.1016
Entamoeba histolytica	hypothetical protein	0.0072	0.1321	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0413	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0455	1	1
Echinococcus multilocularis	Protein lozenge	0.0057	0.097	0.1277
Loa Loa (eye worm)	nuclear hormone receptor	0.0046	0.0722	0.0722
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0098	0.1896	0.2495
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	0.9359
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1007	0.1326
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0227	0.0199
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0722	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0848	0.0848
Schistosoma mansoni	hypothetical protein	0.0251	0.5375	0.7076
Onchocerca volvulus		0.0046	0.0722	0.0506
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0082	0.1544	0.4664
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1007	0.131
Entamoeba histolytica	hypothetical protein	0.0072	0.1321	0.4791
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0046	0.0722	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Schistosoma mansoni	RAR-like nuclear receptor	0.0098	0.1896	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2009	0.2009
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0722	0.0951
Brugia malayi	nuclear receptor RXR	0.0052	0.0848	0.0767
Loa Loa (eye worm)	hypothetical protein	0.016	0.3299	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0227	0.0227
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0098	0.1896	0.1824
Brugia malayi	nuclear hormone receptor family member odr-7	0.0046	0.0722	0.0641
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0046	0.0722	0.0641
Onchocerca volvulus		0.0098	0.1896	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0215	0.4561	0.4561
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0349	0.7596	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0046	0.0722	0.0951
Brugia malayi	nuclear receptor NHR-67	0.0046	0.0722	0.0641
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0704	0.0879
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.1896	0.1824
Brugia malayi	hypothetical protein	0.0046	0.0722	0.0641
Echinococcus multilocularis	FTZ F1 alpha	0.0098	0.1896	0.2495
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0052	0.0848	0.1116
Echinococcus granulosus	GPCR family 2	0.0033	0.0413	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.1896	0.2495
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.1327	0.1747
Onchocerca volvulus		0.0327	0.7109	0.7041
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0227	0.0199
Brugia malayi	steroid hormone receptor	0.0098	0.1896	0.1824
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0227	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0848	0.0848
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0619	0.3647
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0164	0.3401	0.4785
Brugia malayi	Steroid receptor seven-up type 2	0.0098	0.1896	0.1824
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.1321	0.1739
Schistosoma mansoni	zinc finger protein	0.0046	0.0722	0.0951
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0413	0.0581
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0619	0.0757
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0087	0.0032
Brugia malayi	tailless protein	0.0046	0.0722	0.0641
Onchocerca volvulus		0.0129	0.2601	0.2429
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0215	0.4561	0.6005
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0098	0.1896	0.2495
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0227	0.0199
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0678	0.0893
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0046	0.0722	0.0951
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0619	0.2064
Schistosoma mansoni	nuclear hormone receptor	0.0098	0.1896	0.2495
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Echinococcus multilocularis	nuclear receptor nhr 48	0.0046	0.0722	0.0951
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0082	0.1544	0.147
Schistosoma mansoni	ap endonuclease	0.0018	0.0087	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0722	0.0722
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0132	0.2662	0.3667
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0327	0.7109	1
Schistosoma mansoni	thyroid hormone receptor	0.0349	0.7596	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0154	0.3176	0.3116
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0722	0.0951
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0132	0.2662	0.3667
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.2009	0.2009
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0046	0.0722	0.0951
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0132	0.2662	0.3667
Onchocerca volvulus		0.0046	0.0722	0.0506
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0722	0.0641
Schistosoma mansoni	ap endonuclease	0.0018	0.0087	0.0115
Loa Loa (eye worm)	acetyltransferase	0.0154	0.3176	0.3176
Schistosoma mansoni	lozenge	0.0057	0.097	0.1277
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0046	0.0722	0.1016
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0215	0.4561	0.6005
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0704	0.0991
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0098	0.1896	0.1707
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0132	0.2662	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0327	0.7109	1
Schistosoma mansoni	thyroid hormone receptor	0.0349	0.7596	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0413	0.0544
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0678	0.0893
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.2009	0.1938
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0098	0.1896	0.1824
Echinococcus granulosus	histone acetyltransferase KAT2B	0.015	0.3078	0.433
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0098	0.1896	0.1896
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Brugia malayi	Muscleblind-like protein	0.0155	0.3186	0.3126
Brugia malayi	hypothetical protein	0.0046	0.0722	0.0641
Echinococcus multilocularis	jun protein	0.0164	0.3401	0.4478
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0082	0.1544	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1896	0.1896
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0098	0.1896	0.1824
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0227	0.0544
Schistosoma mansoni	hypothetical protein	0.0133	0.2703	0.3559
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.2009	0.1938
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0098	0.1896	0.2495
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0052	0.0848	0.1193
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0098	0.1896	0.1896
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0098	0.1896	0.2666
Brugia malayi	conserved hypotetical protein	0.0046	0.0722	0.0641
Onchocerca volvulus	Bile acid receptor homolog	0.0098	0.1896	0.1707
Schistosoma mansoni	hypothetical protein	0.0033	0.0413	0.0544
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0251	0.5375	0.7076
Echinococcus granulosus	FTZ F1 alpha	0.0098	0.1896	0.2666
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0046	0.0722	0.0951
Loa Loa (eye worm)	steroid hormone receptor	0.0098	0.1896	0.1896
Schistosoma mansoni	hypothetical protein	0.0072	0.1321	0.1739
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0251	0.5375	0.7561
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0227	0.0199
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0098	0.1896	0.1824
Brugia malayi	thymidylate synthase	0.0327	0.7109	0.7083
Brugia malayi	Nuclear hormone receptor E75	0.0046	0.0722	0.0641
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0046	0.0722	0.0722
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0098	0.1896	0.2495
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0704	0.1976
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0413	0.0413
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0087	0.5
Echinococcus multilocularis	transcription factor Dp 1	0.0076	0.1404	0.1848
Schistosoma mansoni	nuclear receptor	0.0046	0.0722	0.0951
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0098	0.1896	0.2495
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0132	0.2662	0.3667
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0678	0.0954
Brugia malayi	nuclear hormone receptor	0.0098	0.1896	0.1824
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.1321	0.1858
Mycobacterium ulcerans	thymidylate synthase	0.0327	0.7109	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0327	0.7109	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0082	0.1544	0.2173
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0098	0.1896	0.1824
Echinococcus granulosus	nuclear receptor nhr 48	0.0046	0.0722	0.1016
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0227	0.0199
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0227	0.0544
Schistosoma mansoni	hypothetical protein	0.0033	0.0413	0.0544
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.1321	0.1739
Schistosoma mansoni	nuclear receptor nhr-48	0.0046	0.0722	0.0951
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0098	0.1896	0.2495
Brugia malayi	nuclear receptor RXR	0.0046	0.0722	0.0641
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0227	0.0199
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0227	0.023
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0098	0.1896	0.2495
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0046	0.0722	0.0722
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0098	0.1896	0.2495
Loa Loa (eye worm)	DR-78	0.0046	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3186	0.3186
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0098	0.1896	0.1824
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0098	0.1896	0.2495
Brugia malayi	Nuclear hormone receptor-like 1	0.0052	0.0848	0.0767
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0098	0.1896	0.2666
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0132	0.2662	0.3744
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0098	0.1896	0.2495
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0215	0.4561	0.6005
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0082	0.1544	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0046	0.0722	0.0641
Schistosoma mansoni	hypothetical protein	0.0033	0.0413	0.0544
Schistosoma mansoni	coup transcription factor	0.0098	0.1896	0.2495
Schistosoma mansoni	hypothetical protein	0.0033	0.0413	0.0544
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0098	0.1896	0.2495
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0413	0.0329
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0098	0.1896	0.2666

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 4.79 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 6.37 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 6.78 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 86 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 100 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 6.98	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -3 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 0 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 86 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 102 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.87	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.1334 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL580764
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 593096