Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Brugia malayi | nicalin | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0197 | 0.0908 | 0.0908 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.1238 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.1238 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0197 | 0.0908 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.1238 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0093 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0197 | 0.0908 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0197 | 0.0908 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1238 | 1 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Leishmania major | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.1238 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.0908 | 1 |
Brugia malayi | FXNA | 0.0197 | 0.0908 | 0.0908 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0197 | 0.0908 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0197 | 0.0908 | 0.0908 |
Brugia malayi | leucyl aminopeptidase | 0.0197 | 0.0908 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0908 | 0.0908 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0197 | 0.0908 | 0.0908 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0197 | 0.0908 | 0.0908 |
Leishmania major | hypothetical protein, conserved | 0.0197 | 0.0908 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0197 | 0.0908 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0197 | 0.0908 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0197 | 0.0908 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0197 | 0.0908 | 0.0908 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0197 | 0.0908 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.009 uM | Cytotoxic activity of the compound against human epidermoid carcinoma cells (KB) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.01 uM | Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.08 uM | Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.6 uM | Cytotoxic activity against african green monkey (C. aethiops) kidney epithelial cells (VERO) | ChEMBL. | 10780917 |
Inhibition (functional) | = 54 % | Cell Cycle inhibition against mouse lymphocytic leukemia cells (L1210) at 10 microM | ChEMBL. | 10780917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.