Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0249 | 0.2178 | 0.6137 |
Onchocerca volvulus | 0.0109 | 0.0818 | 0.6512 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0748 | 0.2107 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.0787 | 0.2218 |
Onchocerca volvulus | 0.0074 | 0.0474 | 0.3773 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0113 | 0.0853 | 0.2221 |
Brugia malayi | RNA binding protein | 0.039 | 0.355 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0109 | 0.0818 | 0.0741 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0462 | 0.1091 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.025 | 0.0705 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0471 | 0.4335 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.039 | 0.355 | 0.3495 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.0474 | 0.1094 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0853 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0109 | 0.0818 | 0.2306 |
Brugia malayi | RNA recognition motif domain containing protein | 0.039 | 0.355 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0102 | 0.0748 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0109 | 0.0818 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.025 | 0.0705 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0474 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0474 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0109 | 0.0818 | 0.2306 |
Schistosoma mansoni | lamin | 0.0109 | 0.0818 | 0.212 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.0474 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0058 | 0.0326 | 0.0918 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0202 | 0.0341 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0058 | 0.0326 | 0.0918 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0474 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0109 | 0.0818 | 0.0741 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0102 | 0.0748 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.0474 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0853 | 0.2221 |
Schistosoma mansoni | tar DNA-binding protein | 0.039 | 0.355 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0474 | 0.1336 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0474 | 0.1094 |
Onchocerca volvulus | 0.0074 | 0.0474 | 0.3773 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.0474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0462 | 0.13 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.0474 | 0.1094 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0853 | 0.2404 |
Brugia malayi | MH2 domain containing protein | 0.0249 | 0.2178 | 0.6137 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.0474 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.039 | 0.355 | 0.3495 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0474 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0462 | 0.13 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0748 | 0.2107 |
Schistosoma mansoni | intermediate filament proteins | 0.0109 | 0.0818 | 0.212 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0154 | 0.1257 | 0.3385 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.0474 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0853 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0474 | 0.1336 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0748 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0818 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0474 | 0.1336 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0474 | 0.1336 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.0474 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1257 | 0.3541 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0397 | 0.1118 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0474 | 0.1127 |
Schistosoma mansoni | tar DNA-binding protein | 0.039 | 0.355 | 1 |
Onchocerca volvulus | 0.0109 | 0.0818 | 0.6512 | |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0474 | 0.1094 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0084 | 0.0235 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.039 | 0.355 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0748 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0474 | 0.0394 |
Onchocerca volvulus | 0.0154 | 0.1257 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.039 | 0.355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0084 | 0.0235 |
Schistosoma mansoni | tar DNA-binding protein | 0.039 | 0.355 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0113 | 0.0853 | 0.0776 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0853 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.0787 | 0.2218 |
Onchocerca volvulus | 0.0074 | 0.0474 | 0.3773 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0787 | 0.2218 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0474 | 0.5 |
Echinococcus granulosus | lamin | 0.0109 | 0.0818 | 0.0741 |
Brugia malayi | TAR-binding protein | 0.039 | 0.355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0799 | 0.2251 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0249 | 0.2178 | 0.6137 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0202 | 0.0119 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0202 | 0.0119 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0474 | 0.0394 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0109 | 0.0818 | 0.2306 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0474 | 0.6341 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0053 | 0.027 | 0.0188 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0853 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.039 | 0.355 | 1 |
Echinococcus multilocularis | lamin | 0.0109 | 0.0818 | 0.0741 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.0474 | 0.1094 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0102 | 0.0748 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0474 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0053 | 0.027 | 0.0188 |
Echinococcus granulosus | intermediate filament protein | 0.0109 | 0.0818 | 0.0741 |
Echinococcus multilocularis | musashi | 0.0109 | 0.0818 | 0.0741 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0084 | 0.0235 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.0474 | 0.1094 |
Schistosoma mansoni | tar DNA-binding protein | 0.039 | 0.355 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0102 | 0.0748 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0474 | 0.1127 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0084 | 0.0235 |
Echinococcus multilocularis | tumor protein p63 | 0.1053 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0113 | 0.0853 | 0.0776 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0748 | 1 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0474 | 0.1336 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.0474 | 0.1094 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0474 | 1 |
Schistosoma mansoni | lamin | 0.0109 | 0.0818 | 0.212 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Loa Loa (eye worm) | RNA binding protein | 0.039 | 0.355 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.0474 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.0787 | 0.2218 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0474 | 0.1336 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.027 | 0.076 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0474 | 0.1094 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.0474 | 0.1094 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.0474 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.