Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.254 | 0.7376 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.254 | 0.7376 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0044 | 0.2396 | 0.6897 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0027 | 0.1154 | 0.2786 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.254 | 0.7376 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0027 | 0.1154 | 0.2786 |
Mycobacterium ulcerans | proteasome PrcB | 0.0056 | 0.3333 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.254 | 0.6362 |
Brugia malayi | proteasome subunit beta type 1 | 0.0044 | 0.2396 | 0.7189 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0027 | 0.1154 | 0.2786 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0313 | 0.5 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0056 | 0.3333 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0027 | 0.1154 | 0.2786 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0044 | 0.2396 | 0.6897 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0056 | 0.3333 | 1 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0313 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.254 | 0.7622 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0044 | 0.2396 | 0.215 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0044 | 0.2396 | 0.6897 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.6906 | 0.8837 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0027 | 0.1154 | 0.2786 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7773 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0056 | 0.3333 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0044 | 0.2396 | 0.6897 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0027 | 0.1154 | 0.0868 |
Brugia malayi | glutathione reductase | 0.0046 | 0.254 | 0.7622 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0027 | 0.1154 | 0.2786 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.6906 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.254 | 0.7376 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0313 | 0.0941 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0056 | 0.3333 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0056 | 0.3333 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0027 | 0.1154 | 0.2786 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0056 | 0.3333 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0044 | 0.2396 | 0.5699 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0027 | 0.1154 | 0.2786 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.254 | 0.2985 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0044 | 0.2396 | 0.5699 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0056 | 0.3333 | 0.3117 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0044 | 0.2396 | 0.6897 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0027 | 0.1154 | 0.2786 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0044 | 0.2396 | 0.6897 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.6906 | 0.8837 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0056 | 0.3333 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0056 | 0.3333 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7773 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0056 | 0.3333 | 0.4047 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0027 | 0.1154 | 0.2786 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0027 | 0.1154 | 0.0868 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.6906 | 0.8837 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0056 | 0.3333 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0027 | 0.1154 | 0.2786 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.254 | 0.7376 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0104 | 0.6906 | 0.8047 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0044 | 0.2396 | 0.6897 |
Leishmania major | trypanothione reductase | 0.0046 | 0.254 | 0.7376 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0056 | 0.3333 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.254 | 0.7376 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.254 | 0.6362 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7773 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0056 | 0.3333 | 1 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0027 | 0.1154 | 0.2786 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0044 | 0.2396 | 0.6897 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0044 | 0.2396 | 0.6897 |
Echinococcus granulosus | proteasome prosome macropain | 0.0056 | 0.3333 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0044 | 0.2396 | 0.6897 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.254 | 0.7376 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0044 | 0.2396 | 0.6897 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.254 | 0.7376 |
Brugia malayi | proteasome subunit beta type 2 | 0.0027 | 0.1154 | 0.3464 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.254 | 0.7376 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7773 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0056 | 0.3333 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0056 | 0.3333 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.