Detailed information for compound 625485

Basic information

Technical information
  • TDR Targets ID: 625485
  • Name: N-(3-chlorophenyl)-4-fluoro-3-(4-methylpiperi din-1-yl)sulfonylbenzamide
  • MW: 410.89 | Formula: C19H20ClFN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)S(=O)(=O)c1cc(ccc1F)C(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C19H20ClFN2O3S/c1-13-7-9-23(10-8-13)27(25,26)18-11-14(5-6-17(18)21)19(24)22-16-4-2-3-15(20)12-16/h2-6,11-13H,7-10H2,1H3,(H,22,24)
  • InChiKey: KHZBZVBUTILHHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-4-fluoro-3-[(4-methyl-1-piperidyl)sulfonyl]benzamide
  • N-(3-chlorophenyl)-4-fluoro-3-[(4-methyl-1-piperidinyl)sulfonyl]benzamide
  • N-(3-chlorophenyl)-4-fluoro-3-(4-methylpiperidin-1-yl)sulfonyl-benzamide
  • ZINC03022310
  • Oprea1_875794
  • EU-0029570

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0263 0.0696
Mycobacterium ulcerans sugar transporter 0.0029 0.0196 0.0379
Echinococcus granulosus solute carrier family 22 0.0029 0.0196 0.0515
Leishmania major glucose transporter, lmgt1 0.0064 0.0601 0.193
Loa Loa (eye worm) hypothetical protein 0.0062 0.0577 0.2513
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Brugia malayi RNA binding protein 0.0124 0.1294 0.5599
Toxoplasma gondii facilitative glucose transporter GT1 0.0207 0.2249 0.3201
Plasmodium vivax 6-phosphofructokinase, putative 0.0057 0.0518 0.0328
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0601 0.1705
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0211 0.2294 1
Onchocerca volvulus 0.0029 0.0196 0.0141
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0057 0.0518 0.0328
Leishmania major glucose transporter, lmgt2 0.0064 0.0601 0.193
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0577 0.1547
Brugia malayi hypothetical protein 0.0029 0.0196 0.0766
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0577 0.1547
Brugia malayi hypothetical protein 0.0035 0.0263 0.1061
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0393 0.0406
Loa Loa (eye worm) hypothetical protein 0.0046 0.0393 0.1713
Trypanosoma cruzi hexose transporter 0.0064 0.0601 0.193
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0162 0.0705
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0591 0.1215
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0592 0.0404
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0601 0.193
Echinococcus multilocularis solute carrier family 22 0.0029 0.0196 0.0515
Schistosoma mansoni glucose transporter 0.0029 0.0196 0.0096
Entamoeba histolytica protein kinase, putative 0.0063 0.0591 0.1618
Schistosoma mansoni protein kinase 0.0063 0.0591 0.1215
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0393 0.1284
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0196 0.0766
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0196 0.0096
Loa Loa (eye worm) hypothetical protein 0.0063 0.0591 0.2577
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0207 0.2249 0.6076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0196 0.0853
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0393 0.1284
Onchocerca volvulus 0.0029 0.0196 0.0141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0201 0.0531
Echinococcus granulosus lamin 0.0026 0.0162 0.0423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Loa Loa (eye worm) phosphofructokinase 0.0211 0.2294 1
Plasmodium vivax hexose transporter 0.0207 0.2249 0.2094
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0592 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.2249 0.8643
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0393 0.094
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0201 0.0531
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0592 0.0617
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0577 0.2442
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Onchocerca volvulus 0.0029 0.0196 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Echinococcus granulosus solute carrier family 22 0.0029 0.0196 0.0515
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0592 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1294 0.3203
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1294 0.3203
Entamoeba histolytica protein kinase, putative 0.0063 0.0591 0.1618
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2242 0.9771
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0393 0.105
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0265 0.0329
Echinococcus granulosus solute carrier family 22 0.0029 0.0196 0.0515
Brugia malayi major facilitator superfamily protein 0.0029 0.0196 0.0766
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0196 0.0379
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0196 0.0766
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0211 0.2294 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0196 0.0515
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0591 0.2507
Echinococcus multilocularis lamin dm0 0.0026 0.0162 0.0423
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Echinococcus granulosus tar DNA binding protein 0.0124 0.1294 0.349
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0211 0.2294 1
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0591 0.1666
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0695 0.238
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0601 0.193
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0601 0.193
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Echinococcus multilocularis tar DNA binding protein 0.0124 0.1294 0.349
Leishmania major ATP-dependent phosphofructokinase 0.0211 0.2294 1
Trypanosoma brucei glucose transporter 2A 0.0064 0.0601 0.193
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Echinococcus granulosus intermediate filament protein 0.0026 0.0162 0.0423
Entamoeba histolytica phosphofructokinase, putative 0.0211 0.2294 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0112
Onchocerca volvulus 0.0029 0.0196 0.0141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0393 0.0831
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0577 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Onchocerca volvulus Putative transporter 0.0029 0.0196 0.0141
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0393 0.0654
Brugia malayi 6-phosphofructokinase 0.0211 0.2294 1
Brugia malayi intermediate filament protein 0.0026 0.0162 0.0617
Echinococcus multilocularis musashi 0.0026 0.0162 0.0423
Trichomonas vaginalis phosphofructokinase, putative 0.0211 0.2294 0.8835
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0057 0.0518 0.1355
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0592 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0601 0.193
Echinococcus multilocularis geminin 0.0333 0.3698 1
Schistosoma mansoni hypothetical protein 0.0207 0.2249 0.5903
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Onchocerca volvulus 0.0029 0.0196 0.0141
Loa Loa (eye worm) hypothetical protein 0.0051 0.0442 0.1927
Schistosoma mansoni sugar transporter 0.0029 0.0196 0.0096
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0878
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0577 0.1331
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0695 0.238
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.0705
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0592 0.0404
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0057 0.0518 0.0328
Onchocerca volvulus 0.0029 0.0196 0.0141
Onchocerca volvulus 0.0029 0.0196 0.0141
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0695 0.238
Brugia malayi phosphofructokinase 0.0211 0.2294 1
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.1294 0.5599
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0601 0.193
Loa Loa (eye worm) RNA binding protein 0.0124 0.1294 0.564
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0057 0.0518 0.1255
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0577 0.2442
Echinococcus granulosus 6 phosphofructokinase 0.0211 0.2294 0.62
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0591 0.2577
Brugia malayi TAR-binding protein 0.0124 0.1294 0.5599
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0393 0.0201
Onchocerca volvulus 0.0029 0.0196 0.0141
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0189 0.0497
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0393 0.0201
Brugia malayi hypothetical protein 0.0029 0.0196 0.0766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0592 0.0404
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0211 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Loa Loa (eye worm) 6-phosphofructokinase 0.0211 0.2294 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0591 0.1587
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.1294 0.564
Brugia malayi Pre-SET motif family protein 0.003 0.0201 0.0791
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0263 0.0696
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Schistosoma mansoni glucose transport protein 0.0207 0.2249 0.5903
Toxoplasma gondii protein kinase, putative 0.0586 0.661 1
Schistosoma mansoni hypothetical protein 0.0333 0.3698 1
Loa Loa (eye worm) sugar transporter 0.0207 0.2249 0.9801
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0196 0.0515
Entamoeba histolytica hypothetical protein 0.0046 0.0393 0.0642
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0196 0.0853
Schistosoma mansoni glucose transport protein 0.0207 0.2249 0.5903
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1294 0.3203
Brugia malayi Sugar transporter family protein 0.0207 0.2249 0.9799
Schistosoma mansoni hypothetical protein 0.0333 0.3698 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0211 0.2294 1
Echinococcus granulosus lamin dm0 0.0026 0.0162 0.0423
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0327 0.0554
Loa Loa (eye worm) hypothetical protein 0.0062 0.0577 0.2513
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0393 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1294 0.3203
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Toxoplasma gondii phosphofructokinase PFKII 0.0057 0.0518 0.0502
Brugia malayi Pre-SET motif family protein 0.0207 0.2242 0.9769
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0162 0.0617
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0592 0.0404
Leishmania major protein kinase, putative 0.0063 0.0591 0.1885
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0313 0.0557
Onchocerca volvulus 0.0029 0.0196 0.0141
Trypanosoma brucei glucose transporter 1E 0.0064 0.0601 0.193
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0592 0.0404
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0154 0.0671
Echinococcus multilocularis solute carrier family 22 0.0029 0.0196 0.0515
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0057 0.0518 0.0502
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0313 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0124 0.1294 0.3203
Brugia malayi Cam kinase protein 1 0.0063 0.0591 0.2507
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0601 0.1705
Brugia malayi major facilitator superfamily protein 0.0029 0.0196 0.0766
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0393 0.105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0162 0.0705
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0601 0.1705
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0601 0.193
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0393 0.5182
Schistosoma mansoni 6-phosphofructokinase 0.0211 0.2294 0.6032
Brugia malayi hypothetical protein 0.0029 0.0196 0.0766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0196 0.0379
Echinococcus multilocularis solute carrier family 22 0.0029 0.0196 0.0515
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0601 0.1705
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0393 0.094
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0057 0.0518 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0592 0.0404
Echinococcus multilocularis 6 phosphofructokinase 0.0211 0.2294 0.62
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0263 0.0285
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Plasmodium vivax 6-phosphofructokinase, putative 0.0057 0.0518 0.0328
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0196 0.0515
Onchocerca volvulus 0.0029 0.0196 0.0141
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0577 0.1603
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0335 0.372 0.5495
Brugia malayi Sugar transporter family protein 0.0029 0.0196 0.0766
Echinococcus multilocularis General substrate transporter 0.0178 0.1913 0.5166
Onchocerca volvulus 0.0029 0.0196 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0601 0.1705
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0601 0.1705
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0695 0.051
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0057 0.0518 0.1855
Onchocerca volvulus 0.0029 0.0196 0.0141
Schistosoma mansoni 6-phosphofructokinase 0.0211 0.2294 0.6032
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0393 0.6923
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0057 0.0518 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.088 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0201 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0211 0.2294 0.8835
Onchocerca volvulus 0.0029 0.0196 0.0141
Onchocerca volvulus 0.0029 0.0196 0.0141
Onchocerca volvulus 0.0235 0.2571 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0196 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0156 0.0681
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0211 0.2294 0.8835
Echinococcus granulosus General substrate transporter 0.0178 0.1913 0.5166
Schistosoma mansoni sugar transporter 0.0029 0.0196 0.0096
Onchocerca volvulus 0.0029 0.0196 0.0141
Plasmodium vivax SET domain protein, putative 0.003 0.0201 0.0006
Echinococcus multilocularis solute carrier family 22 0.0029 0.0196 0.0515
Echinococcus granulosus solute carrier family 22 0.0029 0.0196 0.0515
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2571 1
Schistosoma mansoni protein kinase 0.0063 0.0591 0.1215
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0601 0.193
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0592 0.0617
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0591 0.1885
Entamoeba histolytica phosphofructokinase, putative 0.0211 0.2294 1
Loa Loa (eye worm) TAR-binding protein 0.0124 0.1294 0.564
Schistosoma mansoni protein kinase 0.0063 0.0591 0.1215
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Echinococcus multilocularis lamin 0.0026 0.0162 0.0423
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0201 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0601 0.1705
Entamoeba histolytica phosphofructokinase, putative 0.0211 0.2294 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0196 0.0379
Schistosoma mansoni sugar transporter 0.0029 0.0196 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0591 0.2577
Trichomonas vaginalis phosphofructokinase, putative 0.0057 0.0518 0.1355
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0695 0.238
Plasmodium falciparum mitogen-activated protein kinase 2 0.0335 0.372 0.3595
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.2249 0.6076
Plasmodium falciparum hexose transporter 0.0207 0.2249 0.2094
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Onchocerca volvulus 0.003 0.0201 0.0164
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0211 0.2294 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0577 0.1173
Schistosoma mansoni sugar transporter 0.0029 0.0196 0.0096
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0196 0.0766
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0695 0.238
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0196 0.0515
Schistosoma mansoni glucose transport protein 0.0207 0.2249 0.5903
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0393 0.094
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0577 0.1173
Onchocerca volvulus 0.0029 0.0196 0.0141
Trypanosoma brucei glucose transporter, putative 0.0064 0.0601 0.193
Plasmodium falciparum protein kinase 7 0.0586 0.661 0.6542
Toxoplasma gondii 6-phosphofructokinase 0.0057 0.0518 0.0502
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0853
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0695 0.0779
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0546 0.1464
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0592 0.0617
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0201 0.0531
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0591 0.1587
Brugia malayi 6-phosphofructokinase 0.0211 0.2294 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0201 0.0112
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0577 0.1545
Brugia malayi Sugar transporter family protein 0.0029 0.0196 0.0766
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0024
Leishmania major glucose transporter, lmgt3 0.0064 0.0601 0.193
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0335 0.372 0.3595
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0022 0.0094
Loa Loa (eye worm) 6-phosphofructokinase 0.0211 0.2294 1
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0695 0.051
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0393 0.0308
Loa Loa (eye worm) sugar transporter 0.0029 0.0196 0.0853
Trichomonas vaginalis phosphofructokinase, putative 0.0211 0.2294 0.8835
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0057 0.0518 0.8451
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0546 0.1464
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0393 0.1634
Echinococcus granulosus geminin 0.0333 0.3698 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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