TDR Targets

Basic information

Technical information

TDR Targets ID: 629620
Name: 2,4-dimethyl-N-[4-[(4-methylpyrimidin-2-yl)su lfamoyl]phenyl]benzamide
MW: 396.463 | Formula: C20H20N4O3S
H donors: 2 H acceptors: 5 LogP: 3.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)C)C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccc(n1)C
InChi: 1S/C20H20N4O3S/c1-13-4-9-18(14(2)12-13)19(25)23-16-5-7-17(8-6-16)28(26,27)24-20-21-11-10-15(3)22-20/h4-12H,1-3H3,(H,23,25)(H,21,22,24)
InChiKey: GHKBJMDVNDESPL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,4-dimethyl-N-[4-[(4-methyl-2-pyrimidinyl)sulfamoyl]phenyl]benzamide
ZINC02709552

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0639	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0639	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0639	0.0049
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0639	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0593	0.0593
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0597	0.0005
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0593	0.0708
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0983	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0983	0.0983
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0639	0.0763
Loa Loa (eye worm)	glutaminase	0.0273	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0639	0.0639
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0038	0.0684	0.0684
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.6037	0.5787
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Toxoplasma gondii	exonuclease III APE	0.0037	0.0639	1
Loa Loa (eye worm)	CYP4Cod1	0.0038	0.0684	0.0684
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0639	0.5
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0639	1
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0597	0.0597
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0983	1
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0597	0.0721
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0597	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.39	0.39
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0593	0.0593
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1146	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0593	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0639	0.0639
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0597	0.0597
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0232	0.8378	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0597	0.0721
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0597	0.0005
Brugia malayi	beta-lactamase	0.0036	0.0597	0.0597
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0597	0.0597
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0639	0.0049
Mycobacterium ulcerans	glutaminase	0.0273	1	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.9101	0.9101
Loa Loa (eye worm)	glutaminase 2	0.0273	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0983	0.0983
Trichomonas vaginalis	glutaminase, putative	0.0273	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1146	0.1146
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0597	0.0721
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.1489	0.1489
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0597	0.0721
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0639	0.0639
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0597	0.0721
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0639	0.0772
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0597	0.0721
Schistosoma mansoni	glutaminase	0.0273	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1146	0.1146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0983	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.6037	0.5787
Brugia malayi	MH2 domain containing protein	0.0119	0.39	0.39
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Schistosoma mansoni	hypothetical protein	0.0034	0.0521	0.0521
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.0684	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0593	0.0593
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0597	0.6077
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0597	0.0597
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0593	0.0708
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0593	0.6032
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.5686	1
Brugia malayi	Cytochrome P450 family protein	0.0038	0.0684	0.0684
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0983	0.0983
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0597	0.0597
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.9101	0.9101
Toxoplasma gondii	ABC1 family protein	0.0036	0.0597	0.9346
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0597	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0597	0.0713
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0597	0.0721
Leishmania major	cytochrome p450-like protein	0.0038	0.0684	0.0816
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0597	0.0597
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0983	0.0983
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0597	0.0597
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0597	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0597	0.0713
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Brugia malayi	beta-lactamase family protein	0.0036	0.0597	0.0597
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0593	0.6032
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0639	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0639	0.6502
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0593	0.6032
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0639	0.5
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0597	0.0721
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0593	0.6032
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0593	0.0708
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0597	0.0713
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0597	0.0597
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0597	0.0721
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0232	0.8378	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.5686	0.5414
Brugia malayi	beta-lactamase family protein	0.0036	0.0597	0.0597
Brugia malayi	Cytochrome P450 family protein	0.0059	0.1489	0.1489
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.39	0.39
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0597	0.6077
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0593	0.6032
Brugia malayi	Cytochrome P450 family protein	0.0038	0.0684	0.0684
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0521	0.0521
Leishmania major	hypothetical protein, conserved	0.0232	0.8378	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0639	0.0763
Trypanosoma cruzi	cytochrome P450, putative	0.0038	0.0684	0.0816
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0639	0.0763
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0597	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0521	0.0521
Trichomonas vaginalis	esterase, putative	0.0036	0.0597	0.0005
Schistosoma mansoni	ap endonuclease	0.0037	0.0639	0.0639
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0983	0.0983
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0597	0.0721
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0593	0.6032
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0597	0.0713
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0593	0.0593
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0983	1
Schistosoma mansoni	ap endonuclease	0.0037	0.0639	0.0639
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0639	0.6502
Trypanosoma cruzi	cytochrome P450, putative	0.0038	0.0684	0.0816
Loa Loa (eye worm)	cytochrome P450 family protein	0.0038	0.0684	0.0684
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0597	0.0005
Loa Loa (eye worm)	hypothetical protein	0.005	0.1146	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0597	0.0597
Trypanosoma brucei	cytochrome P450, putative	0.0038	0.0684	0.0816
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0597	0.0597
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.9101	0.9044
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.8283	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0597	0.0597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 629620