TDR Targets

Basic information

Technical information

TDR Targets ID: 630676
Name: N-(6-chloro-1,3-benzothiazol-2-yl)-2-(phenoxy )acetamide
MW: 318.778 | Formula: C15H11ClN2O2S
H donors: 1 H acceptors: 2 LogP: 4.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1nc2c(s1)cc(cc2)Cl)COc1ccccc1
InChi: 1S/C15H11ClN2O2S/c16-10-6-7-12-13(8-10)21-15(17-12)18-14(19)9-20-11-4-2-1-3-5-11/h1-8H,9H2,(H,17,18,19)
InChiKey: QQQRNJFNQJMNSZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(6-chloro-1,3-benzothiazol-2-yl)-2-(phenoxy)ethanamide
Oprea1_633112
AK-968/11369498
N-(6-Chloro-benzothiazol-2-yl)-2-phenoxy-acetamide
BAS 00543328
ZINC00048801
IFLab1_001255
Oprea1_736089
ST006838
IDI1_009122

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0228	0.0837
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0228	0.1727
Echinococcus granulosus	geminin	0.0167	0.4808	0.4795
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.3553	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0023	0.0025
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.2723	1
Brugia malayi	beta-lactamase	0.0035	0.0228	0.0571
Toxoplasma gondii	microneme protein MIC17B	0.0032	0.0113	0.012
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.2723	1
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.3553	0.3538
Trichomonas vaginalis	esterase, putative	0.0035	0.0228	0.0837
Onchocerca volvulus	Huntingtin homolog	0.0132	0.3608	1
Echinococcus multilocularis	snurportin 1	0.0315	1	1
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2723	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0228	0.0837
Toxoplasma gondii	microneme protein, putative	0.0032	0.0113	0.012
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0228	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Toxoplasma gondii	ABC1 family protein	0.0035	0.0228	0.0242
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2723	1
Toxoplasma gondii	hypothetical protein	0.0032	0.0113	0.012
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2723	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0067	0.1319	0.1299
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2723	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0113	0.0089
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0113	0.0089
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.2723	0.2706
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Echinococcus granulosus	tissue type plasminogen activator	0.0067	0.1319	0.1299
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0113	0.012
Onchocerca volvulus		0.0035	0.0228	0.033
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Brugia malayi	beta-lactamase family protein	0.0035	0.0228	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2632	0.2615
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0228	0.0205
Brugia malayi	hypothetical protein	0.0132	0.3608	1
Schistosoma mansoni	hypothetical protein	0.0067	0.1319	0.1299
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0228	0.0837
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0113	0.0089
Onchocerca volvulus		0.0104	0.2632	0.7208
Onchocerca volvulus		0.0085	0.1962	0.5292
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.3553	0.9846
Plasmodium vivax	importin-beta 2, putative	0.003	0.0023	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.2723	0.2706
Brugia malayi	phosphofructokinase	0.0107	0.2723	0.753
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0228	0.0205
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0228	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2632	0.2615
Toxoplasma gondii	microneme protein MIC17A	0.0032	0.0113	0.012
Schistosoma mansoni	hypothetical protein	0.0167	0.4808	0.4795
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2723	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1319	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Toxoplasma gondii	kringle domain-containing protein	0.0067	0.1319	0.14
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.2723	1
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0228	0.0205
Loa Loa (eye worm)	TK/ROR protein kinase	0.0067	0.1319	0.1299
Plasmodium falciparum	cysteine repeat modular protein 1	0.0067	0.1319	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Toxoplasma gondii	subtilisin SUB12	0.0032	0.0113	0.012
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.2723	0.2706
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0032	0.0113	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3553	0.3538
Brugia malayi	Trypsin family protein	0.0104	0.2632	0.7278
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0113	0.0089
Echinococcus multilocularis	geminin	0.0167	0.4808	0.4795
Echinococcus granulosus	tar DNA binding protein	0.0131	0.3553	0.3538
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.2723	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.2632	0.2615
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0228	0.0758
Brugia malayi	RNA binding protein	0.0131	0.3553	0.9846
Brugia malayi	Protein kinase domain containing protein	0.0067	0.1319	0.3614
Toxoplasma gondii	PAN domain-containing protein	0.0299	0.942	1
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.2723	0.2706
Brugia malayi	RNA, U transporter 1	0.0084	0.1924	0.5303
Toxoplasma gondii	PAN domain-containing protein	0.0299	0.942	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.2723	0.2706
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0228	0.0205
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0032	0.0113	0.012
Brugia malayi	6-phosphofructokinase	0.0107	0.2723	0.753
Loa Loa (eye worm)	PAN domain-containing protein	0.0032	0.0113	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3608	0.3593
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Onchocerca volvulus		0.0067	0.1319	0.3451
Onchocerca volvulus		0.0035	0.0228	0.033
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Brugia malayi	6-phosphofructokinase	0.0107	0.2723	0.753
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.2723	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0315	1	1
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0113	0.012
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0228	0.0205
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.6887	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0104	0.2632	0.2615
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.2723	0.2706
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3553	0.3538
Toxoplasma gondii	microneme protein MIC4	0.0032	0.0113	0.012
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.2723	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0067	0.1319	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0228	0.0571
Plasmodium falciparum	importin beta, putative	0.003	0.0023	0.0177
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.3553	0.3538
Brugia malayi	TAR-binding protein	0.0131	0.3553	0.9846
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0228	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0228	0.0205
Leishmania major	hypothetical protein, conserved	0.0067	0.1319	0.4374
Schistosoma mansoni	hypothetical protein	0.0167	0.4808	0.4795
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.1319	0.4374
Onchocerca volvulus	Huntingtin homolog	0.0132	0.3608	1
Loa Loa (eye worm)	RNA binding protein	0.0131	0.3553	0.3538
Schistosoma mansoni	hypothetical protein	0.0315	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3553	0.3538
Toxoplasma gondii	microneme protein MIC17C	0.0032	0.0113	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3553	0.3538
Loa Loa (eye worm)	hypothetical protein	0.0132	0.3608	0.3593
Brugia malayi	Kringle domain containing protein	0.0067	0.1319	0.3614
Brugia malayi	PAN domain containing protein	0.0032	0.0113	0.0249
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.2723	0.3747
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0113	0.012
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3553	0.3538
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.2723	1
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.2723	0.2706
Onchocerca volvulus		0.0035	0.0228	0.033
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.2723	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0228	0.0837
Toxoplasma gondii	PAN domain-containing protein	0.0032	0.0113	0.012
Toxoplasma gondii	hypothetical protein	0.0032	0.0113	0.012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 630676