Detailed information for compound 631789

Basic information

Technical information
  • TDR Targets ID: 631789
  • Name: STK269982
  • MW: 299.752 | Formula: C17H14ClNO2
  • H donors: 0 H acceptors: 2 LogP: 2.74 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2C3C=CC(C2C(=O)N1c1ccccc1Cl)C1C3C1
  • InChi: 1S/C17H14ClNO2/c18-12-3-1-2-4-13(12)19-16(20)14-8-5-6-9(11-7-10(8)11)15(14)17(19)21/h1-6,8-11,14-15H,7H2
  • InChiKey: PEZUNMPHVSMCGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBMicro_007015
  • BIM-0006764.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0107 0.1576 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0188 0.0653
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1295 0.8204
Schistosoma mansoni hypothetical protein 0.0295 0.5766 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0412 0.0715
Schistosoma mansoni alpha-glucosidase 0.0143 0.2364 0.4101
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0262 0.0262
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0412 0.0412
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0 0.5
Loa Loa (eye worm) glutathione reductase 0.0037 0.0014 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0014 0.0031
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1295 0.8204
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0412 0.0412
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0107 0.1576 1
Brugia malayi Thioredoxin reductase 0.0037 0.0014 0.0047
Echinococcus granulosus neuropeptide receptor A26 0.0485 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.288 0.6548
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.1083 0.6844
Brugia malayi mbt repeat family protein 0.0049 0.0262 0.0911
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0234 0.4398 0.7627
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0107 0.1576 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0188 0.0188
Brugia malayi glutathione reductase 0.0037 0.0014 0.0047
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0262 0.0455
Mycobacterium tuberculosis Probable reductase 0.0085 0.1083 0.6844
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0 0.5
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0234 0.4398 0.4398
Plasmodium falciparum M17 leucyl aminopeptidase 0.0107 0.1576 1
Leishmania major trypanothione reductase 0.0037 0.0014 0.0086
Brugia malayi hypothetical protein 0.0108 0.1578 0.548
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0107 0.1576 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0262 0.0455
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3449 0.3449
Trypanosoma brucei trypanothione reductase 0.0037 0.0014 0.0086
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0107 0.1576 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.1083 0.6844
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0025 0.0025
Echinococcus granulosus leukotriene A 4 hydrolase 0.0234 0.4398 0.4398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0326
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.288 0.288
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0262 0.0262
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0262 0.0455
Toxoplasma gondii leucyl aminopeptidase LAP 0.0107 0.1576 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0107 0.1576 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0014 0.0086
Mycobacterium ulcerans leucyl aminopeptidase 0.0107 0.1576 0.5
Onchocerca volvulus 0.0096 0.1319 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0 0.5
Schistosoma mansoni alpha-glucosidase 0.0143 0.2364 0.4101
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0412 0.1432
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.1083 0.6844
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0 0.5
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3449 0.3449
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0412 0.0412
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0055 0.0412 0.0938
Echinococcus multilocularis leucine aminopeptidase protein 0.0107 0.1576 0.1576
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0107 0.1576 1
Echinococcus multilocularis neuropeptide s receptor 0.0485 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.288 1
Echinococcus granulosus leucine aminopeptidase protein 0.0107 0.1576 0.1576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0188 0.0326
Loa Loa (eye worm) MBCTL1 0.0055 0.0412 0.0938
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0188 0.0188
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0262 0.0596
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1295 0.4309
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1295 0.8204
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.288 0.288
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0107 0.1576 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0188 0.0428
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.1083 0.6844
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0 0.5
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0412 0.0412
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.288 0.288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0188 0.0188
Toxoplasma gondii thioredoxin reductase 0.0037 0.0014 0.0086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0188 0.0188
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0262 0.0262
Echinococcus multilocularis neuropeptide receptor A26 0.0485 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0596
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0234 0.4398 1
Brugia malayi mbt repeat family protein 0.0049 0.0262 0.0911
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.1083 0.6844
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0 0.5
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0262 0.0262
Chlamydia trachomatis cytosol aminopeptidase 0.0107 0.1576 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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