TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.371 | Formula: C19H18N4O4
H donors: 0 H acceptors: 5 LogP: 2.36 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cnc(nc1N(N1C(=O)C=C(C1=O)C)C)c1ccccc1
InChi: 1S/C19H18N4O4/c1-4-27-19(26)14-11-20-16(13-8-6-5-7-9-13)21-17(14)22(3)23-15(24)10-12(2)18(23)25/h5-11H,4H2,1-3H3
InChiKey: UAPVOVDIEFMQMQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Starlite/ChEMBL	References
Homo sapiens	FBJ murine osteosarcoma viral oncogene homolog	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR011616,bZIP transcription factor, bZIP_1;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic tran	Get druggable targets OG5_142533	All targets in OG5_142533

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0021	0.0021
Echinococcus granulosus	nmda type glutamate receptor	0.0025	0.0016	0.0033
Schistosoma mansoni	DNA polymerase eta	0.0029	0.0028	0.0043
Schistosoma mansoni	cathepsin D (A01 family)	0.0149	0.038	0.0587
Schistosoma mansoni	hypothetical protein	0.0056	0.0108	0.0167
Schistosoma mansoni	integrin alpha-ps	0.0999	0.2868	0.4435
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0066	0.2496
Trichomonas vaginalis	cyclin A, putative	0.0042	0.0066	0.2496
Toxoplasma gondii	aspartyl protease ASP1	0.0051	0.0091	0.8347
Trypanosoma cruzi	glutathionylspermidine synthase, putative	0.0354	0.0981	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0087	0.0198	0.04
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0093	0.0093
Echinococcus multilocularis	cpg binding protein	0.0031	0.0035	0.0071
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0128	0.0197
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0056	0.0108	0.0219
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0051	0.0091	0.0185
Schistosoma mansoni	hypothetical protein	0.0064	0.0131	0.0203
Echinococcus granulosus	dna polymerase kappa	0.0082	0.0183	0.0369
Giardia lamblia	Tenascin-like	0.0051	0.0093	1
Echinococcus granulosus	tyrosine kinase	0.0022	0.0006	0.0013
Echinococcus multilocularis	glutamate receptor 2	0.0068	0.0141	0.0285
Echinococcus granulosus	adam	0.0051	0.0093	0.0189
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0025	0.0016	0.0033
Giardia lamblia	Tenascin-X	0.0051	0.0093	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0082	0.0183	0.1862
Loa Loa (eye worm)	hypothetical protein	0.0139	0.035	0.035
Trypanosoma cruzi	cyclin 6, putative	0.0042	0.0066	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0093	0.0093
Plasmodium falciparum	plasmepsin IV	0.0051	0.0091	0.5
Echinococcus multilocularis	dna polymerase kappa	0.0082	0.0183	0.0369
Echinococcus granulosus	integrin alpha 3	0.1707	0.4944	1
Giardia lamblia	High cysteine protein	0.0051	0.0093	1
Trypanosoma cruzi	trypanothione synthetase-like protein, putative	0.0022	0.0007	0.0072
Leishmania major	hypothetical protein, conserved	0.0022	0.0007	0.0497
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0034	0.0041	0.0064
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0025	0.0016	0.0033
Leishmania major	DNA polymerase kappa, putative	0.0042	0.0066	0.4632
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Echinococcus granulosus	fibrillin 1	0.0051	0.0093	0.0189
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Brugia malayi	Guanylyl cyclase protein 23	0.0027	0.0021	0.0033
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0034	0.0041	0.0041
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0072
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0029	0.0028	0.0028
Trypanosoma brucei	trypanothione synthetase	0.0068	0.0143	0.5311
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0082	0.0183	0.1862
Echinococcus granulosus	integrin alpha ps	0.0999	0.2868	0.58
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0082	0.0183	0.1862
Echinococcus granulosus	integrin alpha ps	0.0479	0.1345	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0015	0.0015
Loa Loa (eye worm)	glutamate receptor 1	0.0068	0.0141	0.0141
Trypanosoma brucei	amidase, putative	0.0022	0.0007	0.0214
Brugia malayi	Kelch motif family protein	0.0242	0.0651	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0041	0.0041
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0203	0.0538	0.0832
Giardia lamblia	Tenascin-37	0.0051	0.0093	1
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0242	0.0651	0.0651
Giardia lamblia	Neurogenic locus Notch protein precursor	0.0051	0.0093	1
Schistosoma mansoni	integrin alpha	0.2227	0.6467	1
Brugia malayi	EGF-like domain containing protein	0.0051	0.0093	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0214
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.004	0.1447
Schistosoma mansoni	hypothetical protein	0.0056	0.0108	0.0167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0214
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1286	0.3709	0.5735
Loa Loa (eye worm)	hypothetical protein	0.1749	0.5065	0.5065
Brugia malayi	EGF-like domain containing protein	0.0051	0.0093	0.0144
Echinococcus granulosus	glutamate receptor 2	0.0087	0.0198	0.04
Echinococcus multilocularis	adam	0.0051	0.0093	0.0189
Trypanosoma cruzi	trypanothione synthetase	0.0068	0.0143	0.1454
Schistosoma mansoni	hypothetical protein	0.0111	0.0267	0.0413
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0029	0.0028	0.4186
Giardia lamblia	hypothetical protein	0.0051	0.0093	1
Loa Loa (eye worm)	hypothetical protein	0.0828	0.2368	0.2368
Entamoeba histolytica	cyclin, putative	0.0042	0.0066	1
Schistosoma mansoni	integrin alpha-ps	0.052	0.1466	0.2267
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0087	0.0198	0.04
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0082	0.0183	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0082	0.0183	0.6816
Schistosoma mansoni	glutamate receptor kainate	0.0068	0.0141	0.0218
Schistosoma mansoni	glutamate receptor AMPA	0.0068	0.0141	0.0218
Trypanosoma brucei	DNA polymerase kappa, putative	0.0062	0.0124	0.4627
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0051	0.0091	0.0091
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0029	0.0028	0.0056
Leishmania major	cyclin	0.0042	0.0066	0.4622
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1345	0.1345
Onchocerca volvulus		0.0051	0.0093	0.7376
Echinococcus multilocularis	cyclin B	0.0042	0.0066	0.0133
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0087	0.0198	0.04
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0025	0.0016	0.0033
Echinococcus granulosus	receptor type guanylyl cyclase	0.0063	0.0126	0.0256
Echinococcus granulosus	cpg binding protein	0.0031	0.0035	0.0071
Trichomonas vaginalis	teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative	0.0051	0.0093	0.4254
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0126	0.0126
Schistosoma mansoni	apoptosis regulator bax	0.0056	0.0108	0.0167
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0051	0.0091	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0108	0.0108
Schistosoma mansoni	glutamate receptor AMPA	0.0068	0.0141	0.0218
Echinococcus multilocularis	fibrillin 1	0.0051	0.0093	0.0189
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0689	0.1961	0.3967
Brugia malayi	Integrin alpha pat-2 precursor	0.2227	0.6467	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0087	0.0198	0.04
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0055	0.0105	0.0213
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0072
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.004	0.1447
Brugia malayi	latrophilin 2 splice variant baaae	0.0139	0.035	0.0541
Echinococcus multilocularis	integrin alpha 3	0.1707	0.4944	1
Brugia malayi	Glutamate receptor 2 precursor	0.0068	0.0141	0.0218
Trichomonas vaginalis	cyclins, putative	0.0042	0.0066	0.2496
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0087	0.0198	0.04
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0066	0.0066
Schistosoma mansoni	cpg binding protein	0.0031	0.0035	0.0054
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0066	0.2496
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0087	0.0198	0.04
Plasmodium falciparum	plasmepsin VI	0.0051	0.0091	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0072
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0234	0.0628	0.0971
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0066	0.2496
Schistosoma mansoni	cpg binding protein	0.003	0.003	0.0047
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Echinococcus multilocularis	nmda type glutamate receptor	0.0025	0.0016	0.0033
Schistosoma mansoni	cathepsin D (A01 family)	0.0149	0.038	0.0587
Schistosoma mansoni	hypothetical protein	0.0064	0.0131	0.0203
Schistosoma mansoni	tyrosine kinase	0.0022	0.0006	0.001
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0056	0.0108	0.0167
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0063	0.0126	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0016	0.0025
Echinococcus granulosus	GPCR family 2	0.0064	0.0131	0.0266
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0087	0.0198	0.04
Onchocerca volvulus		0.003	0.003	0.2381
Echinococcus multilocularis	glutamate receptor 2	0.0087	0.0198	0.04
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0042	0.0066	0.4632
Echinococcus multilocularis	tyrosine kinase	0.0022	0.0006	0.0013
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0705	0.2008	0.4062
Loa Loa (eye worm)	glutamate receptor 2	0.0068	0.0141	0.0141
Trypanosoma cruzi	DNA polymerase eta, putative	0.0029	0.0028	0.0281
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0066	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0651	0.0651
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0025	0.0016	0.0033
Trypanosoma cruzi	trypanothione synthetase, putative	0.0022	0.0007	0.0072
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0042	0.0066	0.0672
Echinococcus multilocularis	integrin beta 2	0.1178	0.3392	0.6861
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0139	0.035	0.0541
Echinococcus granulosus	fibrillin 2	0.0051	0.0093	0.0189
Plasmodium falciparum	plasmepsin II	0.0051	0.0091	0.5
Echinococcus granulosus	cyclin B	0.0042	0.0066	0.0133
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0025	0.0016	0.0033
Brugia malayi	polk-prov protein	0.0062	0.0124	0.0192
Schistosoma mansoni	glutamate receptor NMDA	0.0068	0.0141	0.0218
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0051	0.0091	0.4129
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0131	0.0266
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0029	0.0028	0.0043
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0051	0.0091	0.8347
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0006	0.0006
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0497
Brugia malayi	ImpB/MucB/SamB family protein	0.0029	0.0028	0.0043
Plasmodium vivax	aspartyl proteinase, putative	0.0051	0.0091	0.5
Giardia lamblia	Tenascin precursor	0.0051	0.0093	1
Echinococcus multilocularis	integrin alpha ps	0.0999	0.2868	0.58
Trichomonas vaginalis	cyclins, putative	0.0042	0.0066	0.2496
Onchocerca volvulus		0.0027	0.0021	0.1672
Loa Loa (eye worm)	apoptosis regulator protein	0.0056	0.0108	0.0108
Trypanosoma cruzi	trypanothione synthetase, putative	0.0022	0.0007	0.0072
Trypanosoma brucei	trypanothione synthetase, putative	0.0068	0.0143	0.5311
Trypanosoma cruzi	cyclin, putative	0.0042	0.0066	0.0672
Leishmania major	trypanothione synthetase-like protein	0.0022	0.0007	0.0497
Trichomonas vaginalis	cyclins, putative	0.0042	0.0066	0.2496
Schistosoma mansoni	glutamate receptor NMDA	0.0087	0.0198	0.0306
Schistosoma mansoni	tyrosine kinase	0.0022	0.0006	0.001
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0066	0.0102
Loa Loa (eye worm)	hypothetical protein	0.1685	0.4878	0.4878
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0091	0.0141
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0068	0.0141	0.0285
Schistosoma mansoni	hypothetical protein	0.0479	0.1345	0.208
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0082	0.0183	0.1862
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.003	0.003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0828	0.2368	0.3662
Echinococcus granulosus	integrin beta 2	0.1178	0.3392	0.6861
Echinococcus multilocularis	glutamate receptor 2	0.0062	0.0125	0.0252
Schistosoma mansoni	cyclin B	0.0042	0.0066	0.0102
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0072
Mycobacterium ulcerans	DNA polymerase IV	0.0082	0.0183	1
Brugia malayi	Glutamate receptor 1 precursor	0.0068	0.0141	0.0218
Echinococcus granulosus	glutamate receptor 2	0.0062	0.0125	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0131	0.0131
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0089	0.0204	0.0412
Trichomonas vaginalis	cyclins, putative	0.0042	0.0066	0.2496
Brugia malayi	hypothetical protein	0.0242	0.0651	0.1006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Trypanosoma brucei	DNA polymerase eta, putative	0.0029	0.0028	0.0985
Giardia lamblia	DINP protein human, muc B family	0.0042	0.0066	0.005
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0055	0.0105	0.0213
Trypanosoma cruzi	trypanothione synthetase	0.0068	0.0143	0.1454
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0042	0.0066	0.4622
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0028	0.0028
Brugia malayi	ImpB/MucB/SamB family protein	0.0029	0.0028	0.0043
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0007	0.0072
Loa Loa (eye worm)	hypothetical protein	0.052	0.1466	0.1466
Echinococcus multilocularis	integrin alpha ps	0.0479	0.1345	0.2721
Schistosoma mansoni	ATP-binding cassette transporter	0.0068	0.0141	0.0218
Trypanosoma brucei	DNA polymerase IV, putative	0.0069	0.0144	0.537
Schistosoma mansoni	integrin beta subunit	0.0936	0.2685	0.4152
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0063	0.0126	0.0256
Giardia lamblia	High cysteine protein	0.0051	0.0093	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0203	0.0538	0.0538
Plasmodium vivax	plasmepsin IV, putative	0.0051	0.0091	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0131	0.0203
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0042	0.0066	0.0102
Onchocerca volvulus		0.0042	0.0066	0.5213
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0066	0.2432
Plasmodium falciparum	plasmepsin I	0.0051	0.0091	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0108	1
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0497
Trypanosoma brucei	mitotic cyclin 6	0.0042	0.0066	0.2427
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0022	0.0007	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0064	0.0131	0.0203
Brugia malayi	CXXC zinc finger family protein	0.003	0.003	0.0047
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0056	0.0108	0.0219
Leishmania major	DNA polymerase eta, putative	0.0029	0.0028	0.1935
Schistosoma mansoni	protein kinase	0.0063	0.0126	0.0196
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Trypanosoma cruzi	cyclin, putative	0.0042	0.0066	0.0672
Brugia malayi	EGF-like domain containing protein	0.0051	0.0093	0.0144
Leishmania major	trypanothione synthetase, putative	0.0022	0.0007	0.0497
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0025	0.0016	0.0033
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0025	0.0016	0.0033
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0025	0.0016	0.0033
Brugia malayi	Receptor family ligand binding region containing protein	0.0063	0.0126	0.0196
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.1685	0.4878	0.7543
Schistosoma mansoni	glutamate receptor kainate	0.0068	0.0141	0.0218
Schistosoma mansoni	glutamate receptor kainate	0.0068	0.0141	0.0218
Leishmania major	trypanothione synthetase, putative	0.0068	0.0143	1
Trypanosoma brucei	unspecified product	0.0069	0.0144	0.537
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0705	0.2008	0.4062
Echinococcus multilocularis	NMDA receptor	0.0025	0.0016	0.0033
Echinococcus multilocularis	integrin alpha ps	0.0999	0.2868	0.58
Giardia lamblia	Neurogenic locus notch-like protein	0.0051	0.0093	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0042	0.0066	1
Trypanosoma brucei	RNA helicase, putative	0.0111	0.0267	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0082	0.0183	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0131	0.0203
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0627	0.178	0.178
Brugia malayi	Angiotensin-converting enzyme family protein	0.0627	0.178	0.2752
Echinococcus multilocularis	fibrillin 2	0.0051	0.0093	0.0189
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0056	0.0108	0.0167
Trypanosoma brucei	DNA polymerase kappa, putative	0.0033	0.004	0.1447
Echinococcus granulosus	dna polymerase eta	0.0029	0.0028	0.0056
Echinococcus multilocularis	dna polymerase eta	0.0029	0.0028	0.0056
Echinococcus multilocularis	protein jagged 2	0.0051	0.0093	0.0189
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0063	0.0126	0.0126
Loa Loa (eye worm)	integrin beta-2	0.159	0.4599	0.4599
Toxoplasma gondii	hypothetical protein	0.0051	0.0093	0.8543
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0029	0.0028	0.0056
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Schistosoma mansoni	hypothetical protein	0.0064	0.0131	0.0203
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0087	0.0198	0.04
Trypanosoma brucei	DNA polymerase IV, putative	0.0082	0.0183	0.6816
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0131	0.0266
Loa Loa (eye worm)	hypothetical protein	0.1229	0.3542	0.3542
Brugia malayi	Integrin beta pat-3 precursor	0.159	0.4599	0.7112
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0124	0.0124
Brugia malayi	EGF-like domain containing protein	0.0051	0.0093	0.0144
Trichomonas vaginalis	hypothetical protein	0.0051	0.0093	0.4254
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0131	0.0266
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0068	0.0141	0.0285
Mycobacterium ulcerans	DNA polymerase IV	0.0082	0.0183	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0131	0.0131
Schistosoma mansoni	hypothetical protein	0.0056	0.0108	0.0167
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0029	0.0028	0.0043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0062	0.0124	0.4627
Trypanosoma brucei	DNA polymerase kappa, putative	0.0082	0.0183	0.6816
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0689	0.1961	0.3967
Schistosoma mansoni	cpg binding protein	0.0031	0.0035	0.0054
Trypanosoma brucei	CHAP domain containing protein, putative	0.0022	0.0007	0.0214
Trypanosoma brucei	glutathionylspermidine synthetase, putative	0.0022	0.0007	0.0214
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0089	0.0204	0.0412

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2 uM	Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 2 uM	Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 2 uM	Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 2 uM	Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 64372