TDR Targets

Basic information

Technical information

TDR Targets ID: 646100
Name: ethyl 2-bis(4-methylphenyl)phosphorylacetate
MW: 316.331 | Formula: C18H21O3P
H donors: 0 H acceptors: 2 LogP: 3.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CP(=O)(c1ccc(cc1)C)c1ccc(cc1)C
InChi: 1S/C18H21O3P/c1-4-21-18(19)13-22(20,16-9-5-14(2)6-10-16)17-11-7-15(3)8-12-17/h5-12H,4,13H2,1-3H3
InChiKey: NNSZRHPAZZBFQO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-bis(4-methylphenyl)phosphorylacetic acid ethyl ester
ethyl 2-bis(4-methylphenyl)phosphorylethanoate
BIM-0008782.P001
CBMicro_008932

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Schistosoma mansoni	hypothetical protein	0.0865	1	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0073	0.0753	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.1085	0.2853
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1625	0.2661
Echinococcus multilocularis	muscleblind protein	0.0148	0.1625	0.1624
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0074	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1085	0.1765
Schistosoma mansoni	cpg binding protein	0.0064	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0069	0.071	0.1142
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0753	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0021	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0158	0.1743	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0073	0.0753	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1625	0.2661
Schistosoma mansoni	cpg binding protein	0.0064	0.0648	0.0648
Echinococcus granulosus	cpg binding protein	0.0064	0.0648	0.0647
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0115	0.0251
Schistosoma mansoni	alpha glucosidase	0.0073	0.0753	0.0753
Schistosoma mansoni	hypothetical protein	0.0069	0.071	0.071
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0073	0.0753	0.1214
Loa Loa (eye worm)	hypothetical protein	0.0526	0.6048	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0102	0.0578
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0114	0.5
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0074	0.0073
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0021	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0118	0.016
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0187	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1334	0.7649
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0118	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Echinococcus multilocularis	cpg binding protein	0.0064	0.0648	0.0647
Schistosoma mansoni	hypothetical protein	0.0032	0.0274	0.0274
Schistosoma mansoni	ferritin	0.0009	0.0002	0.0002
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0114	0.0646
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0753	1
Echinococcus granulosus	GPCR family 2	0.0032	0.0274	0.0272
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0021	0.0021
Treponema pallidum	bacterioferrin (TpF1)	0.0009	0.0002	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0027	0.0217	0.2862
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0187	0.1065
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0274	0.0419
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0123	0.1334	0.7649
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0187	0.0444
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0021	0.002
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.1334	0.1332
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0021	0.002
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0274	0.0272
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0753	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0753	1
Schistosoma mansoni	microtubule-associated protein tau	0.0729	0.8418	0.8418
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1334	0.7649
Echinococcus granulosus	muscleblind protein	0.0148	0.1625	0.1624
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0027	0.0217	0.0928
Schistosoma mansoni	hypothetical protein	0.0032	0.0274	0.0274
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0753	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.1334	0.7649
Echinococcus multilocularis	microtubule associated protein 2	0.0729	0.8418	0.8418
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0187	0.1065
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.071	0.1846
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0021	0.0021
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0187	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0526	0.6048	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0114	0.0646
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0187	0.0444
Schistosoma mansoni	alpha-glucosidase	0.0284	0.3214	0.3214
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0021	0.0021
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0021	0.002
Trypanosoma brucei	glucosidase, putative	0.0073	0.0753	1
Echinococcus granulosus	microtubule associated protein 2	0.0729	0.8418	0.8418
Loa Loa (eye worm)	hypothetical protein	0.0526	0.6048	1
Echinococcus multilocularis	dnaJ subfamily B	0.0865	1	1
Trichomonas vaginalis	helicase, putative	0.0014	0.0059	0.0765
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0187	0.1065
Schistosoma mansoni	ferritin light chain	0.0009	0.0002	0.0002
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0021	0.0021
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0021	0.0021
Onchocerca volvulus		0.0025	0.0187	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0114	0.0154
Brugia malayi	Muscleblind-like protein	0.0148	0.1625	0.4301
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0021	0.002
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0073	0.0753	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0021	0.002
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0021	0.002
Schistosoma mansoni	ferritin	0.0009	0.0002	0.0002
Schistosoma mansoni	apoferritin-2	0.0009	0.0002	0.0002
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0217	0.2862
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.1334	1
Toxoplasma gondii	hypothetical protein	0.0526	0.6048	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0102	0.0578
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0021	0.0021
Onchocerca volvulus		0.0191	0.2126	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0027	0.0217	0.2862
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0158	0.1743	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0274	0.0272
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0753	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0114	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0114	0.0154
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0115	0.1242	0.0924
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0187	0.1065
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0129	0.1403	0.1403
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0021	0.002
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0274	0.0677
Schistosoma mansoni	hypothetical protein	0.0032	0.0274	0.0274
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0753	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0021	0.0021
Schistosoma mansoni	ferritin light chain	0.0009	0.0002	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0187	0.1065
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.0765
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0118	0.0116
Echinococcus multilocularis	lysosomal alpha glucosidase	0.033	0.375	0.3749
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0114	0.0154
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0187	0.1065
Brugia malayi	Glycosyl hydrolases family 31 protein	0.033	0.375	1
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0114	0.5
Schistosoma mansoni	coup transcription factor	0.0011	0.0021	0.0021
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0021	0.0021
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0217	0.2862
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.1085	0.2853
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0021	0.002
Schistosoma mansoni	hypothetical protein	0.0032	0.0274	0.0274
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0187	0.1065
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0027	0.0217	0.2862
Echinococcus multilocularis	lysosomal alpha glucosidase	0.033	0.375	0.3749
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0217	0.2862
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0021	0.002
Schistosoma mansoni	apoferritin-2	0.0009	0.0002	0.0002
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0274	0.0677
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0753	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0187	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0114	0.0154
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0027	0.0217	0.0524
Echinococcus granulosus	lysosomal alpha glucosidase	0.033	0.375	0.3749
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0217	0.0324
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.1625	0.1624
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0274	0.0272
Leishmania major	alpha glucosidase II subunit, putative	0.0073	0.0753	0.4935
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0021	0.002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0021	0.0021
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0021	0.002
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0187	0.0275
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0059	0.0765
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0021	0.0021
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0102	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0114	0.0154
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0061	0.0608	0.0973
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0274	0.0272
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0021	0.002
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0187	0.1065
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0074	0.0073
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0027	0.0217	0.0524
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.1334	0.1332
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0021	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Trichomonas vaginalis	alpha-glucosidase, putative	0.0073	0.0753	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0187	0.1065
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.033	0.375	0.6186
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0102	0.0578
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0021	0.002
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.1334	0.1334
Schistosoma mansoni	ferritin	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0187	0.0275
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0073	0.0753	0.1962
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Schistosoma mansoni	cpg binding protein	0.0061	0.0608	0.0608
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0021	0.002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0074	0.0073
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0187	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.1334	0.1097
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0274	0.0419
Onchocerca volvulus		0.0061	0.0608	0.2785
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0073	0.0753	0.0752
Echinococcus granulosus	neutral alpha glucosidase AB	0.0073	0.0753	0.0752
Schistosoma mansoni	ferritin	0.0009	0.0002	0.0002
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0217	0.2862
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0526	0.6048	1
Schistosoma mansoni	alpha-glucosidase	0.0284	0.3214	0.3214
Leishmania major	glycosyl hydrolase-like protein	0.0027	0.0217	0.0258
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0002	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0073	0.0753	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0021	0.002
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0059	0.0765
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0021	0.002
Trichomonas vaginalis	alpha-glucosidase, putative	0.0027	0.0217	0.2862
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0059	0.0765
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0187	0.0444
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0274	0.0272
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.1085	0.1765
Brugia malayi	CXXC zinc finger family protein	0.0061	0.0608	0.1572
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0021	0.002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0074	0.0074

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 646100