Detailed information for compound 646384

Basic information

Technical information
  • TDR Targets ID: 646384
  • Name: 2-chloro-N-(3,5-dichlorophenyl)-5-iodobenzami de
  • MW: 426.464 | Formula: C13H7Cl3INO
  • H donors: 1 H acceptors: 1 LogP: 5.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(c(c1)C(=O)Nc1cc(Cl)cc(c1)Cl)Cl
  • InChi: 1S/C13H7Cl3INO/c14-7-3-8(15)5-10(4-7)18-13(19)11-6-9(17)1-2-12(11)16/h1-6H,(H,18,19)
  • InChiKey: HBIMNIQUSDPXKF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-N-(3,5-dichlorophenyl)-5-iodo-benzamide
  • 6203-56-1
  • CDS1_003625
  • DivK1c_004665
  • CBMicro_011049
  • BIM-0010932.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0022
Echinococcus granulosus neutral amino acid transporter 0.0618 0.8932 0.8929
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.1302 0.1282
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.022 0.0222
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.03 0.0278
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0796 0.0796
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0619 0.1106
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0618 0.8932 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0213 0.0192
Loa Loa (eye worm) hypothetical protein 0.0068 0.0796 0.0869
Echinococcus granulosus excitatory amino acid transporter 2 0.0618 0.8932 0.8929
Treponema pallidum glutamate/aspartate transporter 0.0274 0.3839 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0717 0.0717
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0618 0.8932 0.8929
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.03
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0442 0.0676
Echinococcus multilocularis cpg binding protein 0.0031 0.0241 0.0219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0439 0.0468
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.0345
Echinococcus granulosus Excitatory amino acid transporter 0.0618 0.8932 0.8929
Treponema pallidum glutamate transporter 0.0274 0.3839 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.5
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0274 0.3839 0.3826
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0796 0.0796
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0239 0.0239
Toxoplasma gondii hypothetical protein 0.0051 0.0539 0.0963
Echinococcus granulosus neutral amino acid transporter A 0.0618 0.8932 0.8929
Echinococcus multilocularis excitatory amino acid transporter 2 0.0618 0.8932 0.8929
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0439 0.0418
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1996 0.4285
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.017 0.2294 0.2294
Brugia malayi CXXC zinc finger family protein 0.0029 0.0217 0.0219
Echinococcus granulosus microsomal glutathione S transferase 3 0.0393 0.5593 0.5583
Onchocerca volvulus 0.0239 0.3321 0.3562
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.03 0.0312
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.03 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0239 0.0239
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0151 0.027
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1302 0.1302
Echinococcus granulosus excitatory amino acid transporter 3 0.0618 0.8932 0.8929
Schistosoma mansoni cpg binding protein 0.0031 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Mycobacterium leprae conserved hypothetical protein 0.0035 0.03 0.5
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.4456 1
Echinococcus granulosus neutral amino acid transporter A 0.0618 0.8932 0.8929
Loa Loa (eye worm) excitatory amino acid transporter 0.0618 0.8932 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2893 0.3222
Echinococcus multilocularis Excitatory amino acid transporter 0.0618 0.8932 0.8929
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0239 0.0428
Schistosoma mansoni cpg binding protein 0.0031 0.0241 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0239 0.0217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0534 0.0574
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0239 0.0217
Schistosoma mansoni microtubule-associated protein tau 0.069 1 1
Brugia malayi Pre-SET motif family protein 0.021 0.2893 0.3223
Echinococcus granulosus sodium:dicarboxylate symporter 0.0618 0.8932 0.8929
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0274 0.3839 0.3839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0239 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0439 0.0439
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0618 0.8932 0.8929
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0274 0.3839 0.3839
Schistosoma mansoni cpg binding protein 0.0029 0.0217 0.0217
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0618 0.8932 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.03 0.0312
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0618 0.8932 1
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0312
Brugia malayi beta-lactamase 0.0035 0.03 0.0312
Brugia malayi Melibiase family protein 0.0068 0.0796 0.087
Onchocerca volvulus 0.0035 0.03 0.0096
Echinococcus multilocularis neutral amino acid transporter A 0.0618 0.8932 0.8929
Echinococcus granulosus cpg binding protein 0.0031 0.0241 0.0219
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1302 0.1302
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0393 0.5593 0.5593
Brugia malayi Excitatory amino acid transporter 0.0618 0.8932 1
Chlamydia trachomatis glutamate symporter 0.0618 0.8932 1
Brugia malayi Cytochrome P450 family protein 0.0029 0.022 0.0222
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1302 0.1302
Echinococcus multilocularis geminin 0.017 0.2294 0.2276
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.4456 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.03 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0439 0.0439
Echinococcus multilocularis excitatory amino acid transporter 3 0.0618 0.8932 0.8929
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0439 0.0469
Onchocerca volvulus 0.0035 0.03 0.0096
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0393 0.5593 0.5583
Toxoplasma gondii MAPEG family protein 0.0393 0.5593 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0022 0.0001
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.1302 0.1282
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0239 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.1302 0.1282
Toxoplasma gondii melibiase subfamily protein 0.0102 0.1302 0.2327
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1996 0.4285
Brugia malayi hypothetical protein 0.0025 0.0151 0.0146
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3321 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0393 0.5593 0.5593
Echinococcus granulosus excitatory amino acid transporter 2 0.0618 0.8932 0.8929
Toxoplasma gondii ABC1 family protein 0.0035 0.03 0.0536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0439 0.0418
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0022 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0439 0.0418
Plasmodium vivax SET domain protein, putative 0.0031 0.0239 0.5915
Echinococcus granulosus geminin 0.017 0.2294 0.2276
Mycobacterium leprae Probable lipase LipE 0.0035 0.03 0.5
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0618 0.8932 0.8932
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0442 0.0676
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0145
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0442 0.0676
Echinococcus multilocularis Excitatory amino acid transporter 0.0618 0.8932 0.8929
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0274 0.3839 0.3826
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0439 0.0418
Onchocerca volvulus 0.0035 0.03 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0035 0.03 1
Brugia malayi beta-lactamase family protein 0.0035 0.03 0.0312
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.4456 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0586 0.1009
Loa Loa (eye worm) hypothetical protein 0.0051 0.0534 0.0574
Loa Loa (eye worm) hypothetical protein 0.0035 0.0297 0.0309
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0442 0.0676
Echinococcus multilocularis microtubule associated protein 2 0.069 1 1
Echinococcus granulosus Excitatory amino acid transporter 0.0618 0.8932 0.8929
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.017 0.2294 0.2294
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.4456 1
Echinococcus multilocularis neutral amino acid transporter A 0.0618 0.8932 0.8929
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.2246 0.2254
Brugia malayi Pre-SET motif family protein 0.0031 0.0239 0.0244
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0534 0.0575
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0796 0.1643
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0534 0.0575
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1302 0.1302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0439 0.0439
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0297 0.0309
Schistosoma mansoni hypothetical protein 0.0035 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0031 0.0239 0.0244
Onchocerca volvulus 0.0031 0.0239 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.0312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.03 0.03
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0217 0.0218
Echinococcus multilocularis excitatory amino acid transporter 2 0.0618 0.8932 0.8929
Loa Loa (eye worm) beta-lactamase 0.0035 0.03 0.0312
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.3073 0.3212
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.03 0.0345
Echinococcus multilocularis neutral amino acid transporter A 0.0618 0.8932 0.8929
Leishmania major hypothetical protein, conserved 0.0035 0.03 0.0345
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1996 0.4285
Mycobacterium ulcerans hypothetical protein 0.0166 0.2246 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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