TDR Targets

Basic information

Technical information

TDR Targets ID: 647164
Name: (Z)-3-[5-(2-chloro-4-nitrophenyl)furan-2-yl]- 2-cyano-N-(3-methylphenyl)prop-2-enamide
MW: 407.807 | Formula: C21H14ClN3O4
H donors: 1 H acceptors: 4 LogP: 5.25 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#C/C(=C/c1ccc(o1)c1ccc(cc1Cl)[N+](=O)[O-])/C(=O)Nc1cccc(c1)C
InChi: 1S/C21H14ClN3O4/c1-13-3-2-4-15(9-13)24-21(26)14(12-23)10-17-6-8-20(29-17)18-7-5-16(25(27)28)11-19(18)22/h2-11H,1H3,(H,24,26)/b14-10-
InChiKey: GCOABVHWBIGVRX-UVTDQMKNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(Z)-3-[5-(2-chloro-4-nitro-phenyl)-2-furyl]-2-cyano-N-(3-methylphenyl)prop-2-enamide
(Z)-3-[5-(2-chloro-4-nitrophenyl)-2-furyl]-2-cyano-N-(3-methylphenyl)prop-2-enamide
(Z)-3-[5-(2-chloro-4-nitro-phenyl)-2-furyl]-2-cyano-N-(3-methylphenyl)acrylamide
(Z)-3-[5-(2-chloro-4-nitro-phenyl)furan-2-yl]-2-cyano-N-(3-methylphenyl)prop-2-enamide
5907-74-4
STK183116
ZINC04723194

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.043	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0123	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0276	0.0267
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0614	0.0605
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0614	0.0605
Entamoeba histolytica	hypothetical protein	0.0149	0.3386	0.338
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0078	0.0069
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.043	1	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0614	1
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.043	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0276	0.0267
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.1469	0.1469
Schistosoma mansoni	hypothetical protein	0.0338	0.7828	0.7828
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0611	0.0602
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0576	0.0576
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0473	1
Entamoeba histolytica	hypothetical protein	0.0281	0.6482	0.6479
Trichomonas vaginalis	ran, putative	0.0023	0.0417	0.0408
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Echinococcus multilocularis	snurportin 1	0.0338	0.7828	0.7826
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0417	0.6744
Brugia malayi	Pre-SET motif family protein	0.003	0.0576	0.0567
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0276	0.0267
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0417	0.0408
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.043	1	1
Plasmodium vivax	SET domain protein, putative	0.003	0.0576	0.0567
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0576	0.0567
Echinococcus granulosus	dUTP pyrophosphatase	0.043	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0338	0.7828	0.7826
Entamoeba histolytica	hypothetical protein	0.043	1	1
Entamoeba histolytica	hypothetical protein	0.0281	0.6482	0.6479
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.043	1	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.043	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Schistosoma mansoni	cpg binding protein	0.0033	0.0653	0.0653
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Schistosoma mansoni	cpg binding protein	0.0032	0.0611	0.0611
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Echinococcus granulosus	cpg binding protein	0.0033	0.0653	0.0645
Echinococcus multilocularis	dUTP pyrophosphatase	0.043	1	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0653	0.0653
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.1157	0.1149
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0417	0.0408
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0276	0.0267
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0078	0.0078
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0078	0.0069
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.1157	0.1149
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0611	0.0602
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0576	0.0576
Leishmania major	GTP-binding protein, putative	0.0023	0.0417	0.8795
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0576	0.0576
Entamoeba histolytica	hypothetical protein	0.0026	0.0473	0.0464
Echinococcus granulosus	GPCR family 2	0.0017	0.0276	0.0267
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0149	0.3386	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.043	1	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0614	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0276	0.0267
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.043	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0749	0.0741
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.043	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0614	0.0605
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0276	0.0267
Loa Loa (eye worm)	hypothetical protein	0.003	0.0576	0.0567
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.5372	0.5368
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.043	1	1
Brugia malayi	RNA, U transporter 1	0.009	0.1988	0.1981
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.043	1	1
Plasmodium falciparum	importin beta, putative	0.0032	0.0614	0.0605
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0149	0.3386	0.5
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0417	0.0408
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0078	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Schistosoma mansoni	hypothetical protein	0.0037	0.0749	0.0749
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.4706	0.4701
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0576	0.0567
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.1157	0.1149
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0036	0.0027
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.012	0.0111
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0149	0.3386	0.338
Schistosoma mansoni	importin beta-1	0.0032	0.0614	0.0614
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Onchocerca volvulus		0.0032	0.0611	0.0073
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0534	0.0526
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0417	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0276	0.0267
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0473	0.0464
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0576	0.0567
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.043	1	1
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0473	0.0464
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0276	0.0267
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0614	0.0605
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0123	0.0114
Brugia malayi	Importin beta-1 subunit	0.0032	0.0614	0.0605
Schistosoma mansoni	hypothetical protein	0.0017	0.0276	0.0276
Schistosoma mansoni	importin-beta 2	0.0006	0.0009	0.0009
Echinococcus granulosus	snurportin 1	0.0338	0.7828	0.7826
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0149	0.3386	0.338
Schistosoma mansoni	hypothetical protein	0.0017	0.0276	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1157	0.1149
Schistosoma mansoni	ran	0.0023	0.0417	0.0417
Schistosoma mansoni	ran	0.0023	0.0417	0.0417
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0036	0.0027
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0614	0.0605
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.043	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0576	0.0567
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0749	0.0741
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0473	0.0464
Onchocerca volvulus		0.0234	0.5372	1
Loa Loa (eye worm)	dUTP diphosphatase	0.043	1	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0417	0.0408
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0473	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0417	0.0408
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0149	0.3386	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0036	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0036	0.0027
Echinococcus multilocularis	cpg binding protein	0.0033	0.0653	0.0645
Schistosoma mansoni	hypothetical protein	0.0017	0.0276	0.0276
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0123	0.0114
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0576	0.0576
Brugia malayi	Pre-SET motif family protein	0.0205	0.4706	0.4701
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.043	1	1
Entamoeba histolytica	hypothetical protein	0.043	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.13	0.1293
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0417	0.0408
Schistosoma mansoni	hypothetical protein	0.0017	0.0276	0.0276
Entamoeba histolytica	Ran family GTPase	0.0023	0.0417	0.0408
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0417	0.0408
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0276	0.0267
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0078	0.0069
Trichomonas vaginalis	helicase, putative	0.0007	0.0036	0.0027
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0149	0.3386	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 647164