Detailed information for compound 650823

Basic information

Technical information
  • TDR Targets ID: 650823
  • Name: 5-(5-bromothiophen-2-yl)-N-[(2-ethoxyphenyl)m ethylideneamino]-1H-pyrazole-3-carboxamide
  • MW: 419.296 | Formula: C17H15BrN4O2S
  • H donors: 2 H acceptors: 2 LogP: 3.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C=NNC(=O)c1n[nH]c(c1)c1ccc(s1)Br
  • InChi: 1S/C17H15BrN4O2S/c1-2-24-14-6-4-3-5-11(14)10-19-22-17(23)13-9-12(20-21-13)15-7-8-16(18)25-15/h3-10H,2H2,1H3,(H,20,21)(H,22,23)/b19-10+
  • InChiKey: BXPGWFVRQZLHTQ-VXLYETTFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(5-bromo-2-thienyl)-N-[(2-ethoxyphenyl)methyleneamino]-1H-pyrazole-3-carboxamide
  • 5-(5-bromo-2-thienyl)-N-[(2-ethoxybenzylidene)amino]-1H-pyrazole-3-carboxamide
  • BAS 01859590
  • ST021432

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cam kinase protein 1 0.0036 0.0484 0.0776
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0541 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0084 0.0017
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0512 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0493 0.0774
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0512 0.8508
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0493 0.8303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Schistosoma mansoni inositol monophosphatase 0.0038 0.0512 0.0652
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0283 0.0212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0493 0.8303
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0493 0.8303
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0283 0.0398
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0405 0.0682
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0512 0.0676
Trypanosoma brucei unspecified product 0.002 0.0152 0.2244
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1007 0.1873
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0084 0.0218
Schistosoma mansoni protein kinase 0.0036 0.0484 0.061
Echinococcus multilocularis dna polymerase eta 0.002 0.0152 0.0118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1834 0.3322
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0484 0.0415
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0152 0.0848
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0484 0.0829
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0191 0.3649 0.3602
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 0.553
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0541 0.5014
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0084 0.0011
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0512 0.0652
Plasmodium vivax sugar transporter, putative 0.0017 0.0084 0.0011
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0469 0.0728
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0283 0.4367
Echinococcus multilocularis GPCR, family 2 0.0032 0.0405 0.0494
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0512 0.0652
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1007 0.1437
Loa Loa (eye worm) hypothetical protein 0.005 0.0772 0.137
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0494
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Echinococcus multilocularis dna polymerase kappa 0.002 0.0152 0.0118
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Loa Loa (eye worm) hypothetical protein 0.0035 0.0469 0.0801
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0405 0.0494
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0152 0.0207
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0152 0.0118
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0152 0.0118
Loa Loa (eye worm) sugar transporter 0.0118 0.216 0.3973
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0283 0.0324
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0084 0.1039
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2244
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0017
Brugia malayi Sugar transporter family protein 0.0017 0.0084 0.0021
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0152 0.0282
Leishmania major glucose transporter, lmgt2 0.0037 0.0493 0.4506
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0152 0.0149
Schistosoma mansoni protein kinase 0.0036 0.0484 0.061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1677 0.3067
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2244
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0152 0.2244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1677 0.238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0152 0.0848
Leishmania major protein kinase, putative 0.0036 0.0484 0.4405
Schistosoma mansoni DNA polymerase eta 0.002 0.0152 0.0118
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0017
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0494
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0084 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1834 0.3322
Echinococcus multilocularis muscleblind protein 1 0.0152 0.285 0.412
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0469 0.0588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1677 0.238
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0084 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0512 0.8508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1677 0.238
Echinococcus granulosus GPCR family 2 0.0032 0.0405 0.0494
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0484 0.0634
Brugia malayi hypothetical protein 0.0017 0.0084 0.0021
Schistosoma mansoni protein kinase 0.0036 0.0484 0.061
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0152 0.0129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Leishmania major glucose transporter, lmgt1 0.0037 0.0493 0.4506
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0541 0.0883
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0313
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0512 0.9369
Leishmania major glucose transporter, lmgt3 0.0037 0.0493 0.4506
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0484 0.0776
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0084 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0152 0.0848
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Loa Loa (eye worm) hypothetical protein 0.0152 0.285 0.5266
Mycobacterium ulcerans sugar transporter 0.0017 0.0084 0.0156
Brugia malayi hypothetical protein 0.0017 0.0084 0.0021
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0017
Echinococcus granulosus muscleblind protein 0.0152 0.285 0.412
Leishmania major hypothetical protein, conserved 0.0017 0.0084 0.012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0484 0.061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1677 0.238
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0512 0.9258
Echinococcus multilocularis tumor protein p63 0.0343 0.677 0.9934
Loa Loa (eye worm) hypothetical protein 0.0102 0.1834 0.3361
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0541 0.0472
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.1534
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0484 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0017
Brugia malayi Inositol-1 0.0038 0.0512 0.0829
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0541 0.0864
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0589 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1007 1
Schistosoma mansoni glucose transport protein 0.0118 0.216 0.3097
Trypanosoma brucei sugar transporter, putative 0.0017 0.0084 0.1039
Loa Loa (eye worm) inositol-1 0.0038 0.0512 0.0882
Schistosoma mansoni ap endonuclease 0.0039 0.0541 0.0695
Schistosoma mansoni ap endonuclease 0.0039 0.0541 0.0695
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1007 0.1385
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Loa Loa (eye worm) hypothetical protein 0.0152 0.285 0.5266
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0541 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0541 0.0695
Brugia malayi major facilitator superfamily protein 0.0017 0.0084 0.0021
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0084 0.0021
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0283 0.4082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0493 0.0774
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0469 0.8427
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.1534
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0469 0.0748
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0493 0.0774
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0283 0.0313
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0152 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1007 1
Schistosoma mansoni glutaminase 0.0275 0.5374 0.7864
Schistosoma mansoni inositol monophosphatase 0.0038 0.0512 0.0652
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0405 0.0628
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0084 0.012
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0494
Toxoplasma gondii protein kinase, putative 0.0334 0.6571 1
Echinococcus multilocularis geminin 0.0345 0.6814 1
Echinococcus multilocularis General substrate transporter 0.0101 0.1821 0.2593
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1677 0.238
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0084 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1834 0.3361
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Echinococcus granulosus dna polymerase kappa 0.002 0.0152 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1007 0.1385
Toxoplasma gondii sugar transporter ST1 0.0017 0.0084 0.0017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Plasmodium falciparum protein kinase 7 0.0334 0.6571 0.6546
Echinococcus multilocularis muscleblind protein 0.0152 0.285 0.412
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0469 0.0588
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.1534
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0084 0.0017
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 0.553
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0283 0.0377
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0484 0.0415
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0283 0.0212
Leishmania major DNA polymerase kappa, putative 0.002 0.0152 0.0848
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0512 0.0953
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1007 0.1385
Onchocerca volvulus 0.005 0.0772 1
Loa Loa (eye worm) glutaminase 2 0.0275 0.5374 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1007 0.1873
Toxoplasma gondii exonuclease III APE 0.0039 0.0541 0.0721
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0484 0.0829
Trichomonas vaginalis glutaminase, putative 0.0275 0.5374 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0493 0.0774
Trypanosoma brucei glucose transporter 1E 0.0037 0.0493 0.8303
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1007 0.1385
Loa Loa (eye worm) hypothetical protein 0.0035 0.0469 0.0801
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0217 0.0252
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0541 0.0936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0283 0.0453
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0484 0.0634
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0512 0.0809
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0541 0.1006
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0541 0.0864
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0283 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0084 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0541 0.9067
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0431 0.3844
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0469 0.0748
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0541 0.0472
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0484 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0207
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0152 0.0149
Plasmodium falciparum hexose transporter 0.0118 0.216 0.2103
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0493 0.0774
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1173 0.2075
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0493 0.8148
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0469 0.0588
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0438 0.0542
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0017
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0484 0.0415
Echinococcus granulosus General substrate transporter 0.0101 0.1821 0.2593
Schistosoma mansoni glucose transporter 0.0017 0.0084 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1677 0.3026
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0493 0.0774
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0512 0.8633
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0431 0.8598
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0202 0.1387
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0084 0.0218
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0541 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0512 0.4705
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0084 0.0017
Entamoeba histolytica hypothetical protein 0.0026 0.0283 0.3382
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0484 0.0415
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0438 0.0542
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1007 0.1873
Loa Loa (eye worm) hypothetical protein 0.0032 0.0405 0.0682
Brugia malayi Sugar transporter family protein 0.0118 0.216 0.3938
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0283 0.4578
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0484 0.0415
Plasmodium vivax CDK-related protein kinase 6, putative 0.0501 1 1
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0017
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0202 0.1387
Loa Loa (eye worm) glutaminase 0.0275 0.5374 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0152 0.1534
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0405 0.0494
Schistosoma mansoni glucose transport protein 0.0118 0.216 0.3097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1677 0.238
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0152 0.1534
Giardia lamblia DINP protein human, muc B family 0.002 0.0152 0.1487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0405 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.0839
Mycobacterium ulcerans glutaminase 0.0275 0.5374 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0512 0.0809
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0493 0.0774
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0084 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0484 0.0756
Entamoeba histolytica protein kinase, putative 0.0036 0.0484 0.8537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0405 0.0628
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0283 0.0313
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.0527
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0084 0.0156
Trypanosoma cruzi hexose transporter 0.0037 0.0493 0.8148
Echinococcus granulosus tumor protein p63 0.0343 0.677 0.9934
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0283 0.3046
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0084 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0541 0.5014
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0589 0.052
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0152 0.0118
Schistosoma mansoni hypothetical protein 0.007 0.1173 0.1632
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0484 0.0634
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0589 0.0795
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0084 0.012
Echinococcus granulosus solute carrier family 22 0.0017 0.0084 0.0017
Leishmania major DNA polymerase eta, putative 0.002 0.0152 0.0848
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0484 0.061
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0191 0.3649 0.5503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0152 0.2244
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0589 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0484 0.0415
Brugia malayi major facilitator superfamily protein 0.0017 0.0084 0.0021
Schistosoma mansoni hypothetical protein 0.0345 0.6814 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.216 0.3097
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0541 0.9145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1677 0.238
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0546
Toxoplasma gondii sugar transporter ST2 0.0017 0.0084 0.0017
Plasmodium falciparum mitogen-activated protein kinase 2 0.0191 0.3649 0.3602
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0072 0.0058
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0017
Brugia malayi Sugar transporter family protein 0.0017 0.0084 0.0021
Trypanosoma cruzi hexose transporter, putative 0.002 0.0154 0.1571
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0283 0.0313
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0589 0.052
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Loa Loa (eye worm) sugar transporter 0.0017 0.0084 0.0079
Schistosoma mansoni glucose transport protein 0.0118 0.216 0.3097
Loa Loa (eye worm) hypothetical protein 0.007 0.1173 0.2121
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0084 0.0218
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0493 0.4506
Toxoplasma gondii facilitative glucose transporter GT1 0.0118 0.216 0.3213
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0283 0.0527
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0484 0.8135
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0484 0.0829
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0541 0.0695
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0152 0.0129
Plasmodium vivax hexose transporter 0.0118 0.216 0.2103
Toxoplasma gondii sugar transporter ST3 0.0017 0.0084 0.0017
Trypanosoma brucei glucose transporter, putative 0.0037 0.0493 0.8303
Entamoeba histolytica protein kinase, putative 0.0036 0.0484 0.8537
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0084 0.012
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0494
Trypanosoma brucei glucose transporter 2A 0.0037 0.0493 0.8303
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0493 0.8148
Brugia malayi Muscleblind-like protein 0.0152 0.285 0.5239
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0405 0.0494
Schistosoma mansoni sugar transporter 0.0017 0.0084 0.0017
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0283 0.2257
Echinococcus multilocularis solute carrier family 22 0.0017 0.0084 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.216 0.3925
Echinococcus granulosus geminin 0.0345 0.6814 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0772 0.1038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0541 0.9067
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0469 1
Echinococcus granulosus dna polymerase eta 0.002 0.0152 0.0118
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0484 0.061
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0084 0.0079
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0118 0.216 0.3097
Brugia malayi glutaminase DH11.1 0.0275 0.5374 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0469 0.8152
Schistosoma mansoni hypothetical protein 0.0118 0.216 0.3097
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0152 0.2244
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0493 0.8148
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0469 0.0588
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0072 0.0839
Schistosoma mansoni hypothetical protein 0.0345 0.6814 1
Brugia malayi hypothetical protein 0.0017 0.0084 0.0021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0541 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0079
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0484 0.0415
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0152 0.0118
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0589 1
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0084 0.0156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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