Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3266 | 0.4334 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 0.9766 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4323 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.0578 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0106 | 0.0114 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.1257 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9262 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1188 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.9446 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 0.9766 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3679 | 0.3972 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3266 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0774 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3266 | 0.4094 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3667 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4323 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.0578 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.7536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4417 | 0.4769 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3266 | 0.4334 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.9446 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.1257 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3266 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3266 | 0.4094 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3266 | 0.2209 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.7536 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7978 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.7536 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.7536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3266 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4087 | 0.4413 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.7536 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.