Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.032 | 0.1672 | 0.1835 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.019 | 0.019 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1828 | 1 | 1 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0182 | 0.0909 | 0.0884 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0182 | 0.0909 | 0.0884 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0187 | 0.0933 | 0.1011 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1828 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0137 | 0.0124 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1645 | 0.8993 | 0.899 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0137 | 0.0111 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1645 | 0.8993 | 0.8993 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0179 | 0.6334 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.045 | 0.045 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0187 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0264 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.044 | 0.044 |
Trichomonas vaginalis | set domain proteins, putative | 0.0249 | 0.1277 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.0459 | 0.0434 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.0027 | 0.0001 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0027 | 0.0001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0179 | 0.5537 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0081 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0744 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0075 | 0.4158 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0252 | 0.0227 |
Onchocerca volvulus | 0.0249 | 0.1277 | 1 | |
Brugia malayi | PXA domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0264 | 0.0265 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0821 | 0.0797 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0182 | 0.0909 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0027 | 0.0001 |
Echinococcus granulosus | expressed protein | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0187 | 0.0933 | 0.1011 |
Loa Loa (eye worm) | RGS-3 protein | 0.0182 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0179 | 0.0179 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.044 | 0.0462 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0252 | 0.0253 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.044 | 0.0414 |
Brugia malayi | PXA domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0068 | 0.0047 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.045 | 0.0473 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.044 | 0.0462 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0.0027 | 0.1483 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0686 | 0.0736 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0252 | 0.0253 |
Echinococcus multilocularis | alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Onchocerca volvulus | 0.0024 | 0.0033 | 0.0055 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.045 | 0.0425 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | RUN | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0182 | 0.0909 | 0.0909 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0744 | 0.072 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.032 | 0.1672 | 0.1835 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Echinococcus multilocularis | expressed protein | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0182 | 0.0909 | 0.0984 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0909 | 0.0884 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0033 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0264 | 0.0238 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.0027 | 0.1483 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0264 | 0.0238 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.111 | 0.1086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.017 | 0.0161 |
Onchocerca volvulus | 0.0031 | 0.0075 | 0.0384 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1645 | 0.8993 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1645 | 0.8993 | 0.8993 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0137 | 0.0124 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0819 | 0.4425 | 0.4906 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.044 | 0.0462 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0033 | 0.1268 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0075 | 0.0048 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.0027 | 0.0001 |
Echinococcus granulosus | alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.044 | 0.0462 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0027 | 0.0027 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0137 | 0.0124 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0909 | 0.0884 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0417 | 0.0436 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0137 | 0.0137 |
Echinococcus granulosus | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0182 | 0.0909 | 0.0885 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0885 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0027 | 0.0027 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.045 | 0.4765 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1645 | 0.8993 | 1 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0182 | 0.0909 | 0.0885 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0075 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0033 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0686 | 0.0736 |
Schistosoma mansoni | alkaline phosphatase | 0.032 | 0.1672 | 0.165 |
Echinococcus multilocularis | RUN | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.111 | 0.111 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.0027 | 0.0001 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0033 | 0.1268 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0417 | 0.0436 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0137 | 0.0111 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.032 | 0.1672 | 0.1835 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0137 | 0.0124 |
Schistosoma mansoni | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0885 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Onchocerca volvulus | 0.0153 | 0.0744 | 0.5739 | |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.032 | 0.1672 | 0.1835 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.0933 | 0.0909 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0264 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0179 | 0.0153 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0075 | 0.0054 |
Schistosoma mansoni | alkaline phosphatase | 0.032 | 0.1672 | 0.165 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.0933 | 0.0909 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0075 | 0.0054 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0075 | 0.0049 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0137 | 0.0137 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0182 | 0.0909 | 0.0885 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0182 | 0.0909 | 0.0884 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.045 | 0.0473 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Echinococcus granulosus | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.