TDR Targets

Basic information

Technical information

TDR Targets ID: 654130
Name: N-[(4-propan-2-ylphenyl)methylideneamino]thio phene-2-carboxamide
MW: 272.365 | Formula: C15H16N2OS
H donors: 1 H acceptors: 1 LogP: 3.97 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)C=NNC(=O)c1cccs1)C
InChi: 1S/C15H16N2OS/c1-11(2)13-7-5-12(6-8-13)10-16-17-15(18)14-4-3-9-19-14/h3-11H,1-2H3,(H,17,18)/b16-10+
InChiKey: TUDJYZHNMQJILC-MHWRWJLKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-isopropylphenyl)methyleneamino]thiophene-2-carboxamide
N-[(4-isopropylphenyl)methyleneamino]-2-thiophenecarboxamide
N-[(4-isopropylbenzylidene)amino]thiophene-2-carboxamide
STK011933

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PXA domain containing protein	0.0182	0.0909	0.0884
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0182	0.0909	0.0885
Brugia malayi	hypothetical protein	0.0182	0.0909	0.0884
Loa Loa (eye worm)	hypothetical protein	0.005	0.0179	0.0179
Echinococcus granulosus	regulator of G protein signaling 7	0.0182	0.0909	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Schistosoma mansoni	alkaline phosphatase	0.032	0.1672	0.165
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0179	0.5537
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.0933	0.0909
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0182	0.0909	0.0884
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1828	1	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0182	0.0909	0.6769
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0027	0.1483
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0264	0.0238
Schistosoma mansoni	regulator of G protein signaling	0.0182	0.0909	0.0885
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.044	0.0462
Echinococcus granulosus	regulator of G protein signaling 3	0.0182	0.0909	0.0984
Schistosoma mansoni	axis inhibition protein axin	0.0182	0.0909	0.0885
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0027	0.0027
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.0459	0.0434
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0064	0.0252	0.0253
Brugia malayi	regulator of G-protein signaling rgs-7	0.0182	0.0909	0.0884
Echinococcus granulosus	axis inhibition protein axin	0.0182	0.0909	0.0984
Brugia malayi	regulator of G-protein signaling egl-10	0.0182	0.0909	0.0884
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1645	0.8993	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0033	0.1268
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.032	0.1672	0.1835
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0027	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0075	0.0049
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0182	0.0909	0.0885
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0033	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0064	0.0252	0.0253
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0182	0.0909	0.0909
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Echinococcus granulosus	RUN	0.0023	0.0027	0.0001
Echinococcus multilocularis	alkaline phosphatase	0.032	0.1672	0.1835
Echinococcus multilocularis	RUN	0.0023	0.0027	0.0001
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0264	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0264	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0068	0.0047
Schistosoma mansoni	polycystin 1-related	0.0023	0.0027	0.0001
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0182	0.0909	0.0984
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.044	0.0414
Brugia malayi	CHE-14 protein	0.0043	0.0137	0.0111
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.032	0.1672	0.1835
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.044	0.0415
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0179	0.5
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0264	1
Schistosoma mansoni	lipoxygenase	0.0064	0.0252	0.0227
Echinococcus multilocularis	protein dispatched 1	0.0049	0.017	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0033	0.0033
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.044	0.044
Echinococcus multilocularis	regulator of G protein signaling 3	0.0182	0.0909	0.0984
Brugia malayi	PXA domain containing protein	0.0182	0.0909	0.0884
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0033	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0033	0.0033
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0182	0.0909	0.0984
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0099	0.045	0.045
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.0686	0.0736
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0027	0.0001
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0033	0.1268
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0264	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1645	0.8993	0.8993
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0182	0.0909	0.0885
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0182	0.0909	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.032	0.1672	0.1835
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0137	0.0124
Echinococcus granulosus	axis inhibition protein axin	0.0182	0.0909	0.0984
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1645	0.8993	0.899
Echinococcus multilocularis	regulator of G protein signaling	0.0182	0.0909	0.0984
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0179	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0033	0.1268
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.0686	0.0736
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0264	1
Onchocerca volvulus		0.0031	0.0075	0.0384
Brugia malayi	hypothetical protein	0.0153	0.0744	0.072
Echinococcus granulosus	Regulator of G protein signaling 20	0.0182	0.0909	0.0984
Schistosoma mansoni	hypothetical protein	0.0041	0.0128	0.0103
Loa Loa (eye worm)	PXA domain-containing protein	0.0182	0.0909	0.0909
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.032	0.1672	0.1835
Echinococcus multilocularis	regulator of G protein signaling 7	0.0182	0.0909	0.0984
Entamoeba histolytica	hypothetical protein	0.0182	0.0909	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.044	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.045	0.0473
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0027	0.0001
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.045	0.4765
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0075	0.0075
Brugia malayi	hypothetical protein	0.005	0.0179	0.0153
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0033	0.1268
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0033	0.1268
Plasmodium vivax	SET domain protein, putative	0.0031	0.0075	0.4158
Entamoeba histolytica	hypothetical protein	0.0182	0.0909	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0182	0.0909	0.0984
Schistosoma mansoni	serine/threonine protein kinase	0.1828	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0033	0.1268
Echinococcus multilocularis	axis inhibition protein axin	0.0182	0.0909	0.0984
Echinococcus multilocularis	protein patched	0.0043	0.0137	0.0124
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0179	1
Echinococcus granulosus	alkaline phosphatase	0.032	0.1672	0.1835
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0179	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0027	0.0001
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0027	0.0001
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0179	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0182	0.0909	0.0884
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1645	0.8993	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0182	0.0909	0.0984
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1645	0.8993	0.8993
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0264	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0182	0.0909	0.0984
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0179	0.5
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0187	0.0933	0.1011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.044	0.0415
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0137	0.0137
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0264	0.0265
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Brugia malayi	hypothetical protein	0.0032	0.0081	0.0054
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0075	0.0054
Leishmania major	hypothetical protein, conserved	0.005	0.0179	0.6334
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.044	0.0462
Onchocerca volvulus		0.0249	0.1277	1
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0417	0.0436
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0264	0.0265
Brugia malayi	Pre-SET motif family protein	0.0219	0.111	0.1086
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0027	0.0001
Echinococcus multilocularis	expressed protein	0.0182	0.0909	0.0984
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.0933	0.0909
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.044	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0137	0.0137
Schistosoma mansoni	loxhd1	0.0023	0.0027	0.0001
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0744	0.0744
Schistosoma mansoni	rab6-interacting	0.0023	0.0027	0.0001
Schistosoma mansoni	regulator of G protein signaling	0.0182	0.0909	0.0885
Brugia malayi	Pre-SET motif family protein	0.0031	0.0075	0.0048
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0819	0.4425	0.4906
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0137	0.0124
Schistosoma mansoni	z-protein (S1r protein)	0.0182	0.0909	0.0885
Schistosoma mansoni	regulator of G protein signaling	0.0182	0.0909	0.0885
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0033	0.0007
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0033	0.1268
Schistosoma mansoni	axis inhibition protein axin	0.0182	0.0909	0.0885
Schistosoma mansoni	lipoxygenase	0.0023	0.0027	0.0001
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0264	0.0238
Schistosoma mansoni	alkaline phosphatase	0.032	0.1672	0.165
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0075	0.0054
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0187	0.0933	0.1011
Echinococcus multilocularis	axis inhibition protein axin	0.0182	0.0909	0.0984
Schistosoma mansoni	hypothetical protein	0.0041	0.0128	0.0103
Schistosoma mansoni	regulator of G protein signaling	0.0182	0.0909	0.0885
Brugia malayi	hypothetical protein	0.0182	0.0909	0.0884
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0182	0.0909	0.0884
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0187	0.0933	0.0933
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0075	0.0054
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.045	0.0473
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0027	0.0001
Schistosoma mansoni	patched 1	0.0043	0.0137	0.0111
Entamoeba histolytica	hypothetical protein	0.0182	0.0909	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0033	0.1268
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.111	0.111
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0075	0.0049
Schistosoma mansoni	hypothetical protein	0.0041	0.0128	0.0103
Echinococcus granulosus	expressed protein	0.0182	0.0909	0.0984
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.044	0.0462
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0033	0.1268
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0909	0.6769
Schistosoma mansoni	hypothetical protein	0.0166	0.0821	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.032	0.1672	0.1835
Echinococcus granulosus	intestinal type alkaline phosphatase	0.032	0.1672	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0075	0.0049
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.045	0.0425
Schistosoma mansoni	regulator of G protein signaling	0.0182	0.0909	0.0885
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0033	0.1268
Schistosoma mansoni	rab6-interacting	0.0023	0.0027	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0052	0.019	0.019
Loa Loa (eye worm)	RGS-3 protein	0.0182	0.0909	0.0909
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0	0.5
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0027	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0909	0.0909
Schistosoma mansoni	hypothetical protein	0.0041	0.0128	0.0103
Onchocerca volvulus		0.0153	0.0744	0.5739
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0137	0.0124
Echinococcus granulosus	regulator of G protein signaling 7	0.0182	0.0909	0.0984
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0075	0.0049
Echinococcus granulosus	expressed conserved protein	0.0093	0.0417	0.0436
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.1277	1
Onchocerca volvulus		0.0024	0.0033	0.0055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 654130