Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0264 | 0.0238 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.111 | 0.1086 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.017 | 0.0161 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Onchocerca volvulus | 0.0031 | 0.0075 | 0.0384 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1645 | 0.8993 | 1 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1645 | 0.8993 | 0.8993 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.044 | 0.0462 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0819 | 0.4425 | 0.4906 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0137 | 0.0124 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0033 | 0.1268 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0075 | 0.0048 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Echinococcus granulosus | alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0027 | 0.0027 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.044 | 0.0462 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0137 | 0.0124 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0909 | 0.0884 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0417 | 0.0436 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Echinococcus granulosus | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0137 | 0.0137 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0182 | 0.0909 | 0.0885 |
Schistosoma mansoni | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0885 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0182 | 0.0909 | 0.6769 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0027 | 0.0027 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.045 | 0.4765 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1645 | 0.8993 | 1 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0182 | 0.0909 | 0.0885 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0075 | 0.0054 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0033 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0033 | 0.1268 |
Echinococcus multilocularis | RUN | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | alkaline phosphatase | 0.032 | 0.1672 | 0.165 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.0686 | 0.0736 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.111 | 0.111 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.0027 | 0.0001 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0033 | 0.1268 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0137 | 0.0111 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0417 | 0.0436 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0137 | 0.0124 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.032 | 0.1672 | 0.1835 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Schistosoma mansoni | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0885 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.032 | 0.1672 | 0.1835 |
Onchocerca volvulus | 0.0153 | 0.0744 | 0.5739 | |
Brugia malayi | hypothetical protein | 0.005 | 0.0179 | 0.0153 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0264 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.0933 | 0.0909 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0075 | 0.0054 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.0933 | 0.0909 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0075 | 0.0054 |
Schistosoma mansoni | alkaline phosphatase | 0.032 | 0.1672 | 0.165 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0075 | 0.0049 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0137 | 0.0137 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0182 | 0.0909 | 0.0885 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0182 | 0.0909 | 0.0884 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.045 | 0.0473 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.032 | 0.1672 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.019 | 0.019 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0033 | 0.0007 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0182 | 0.0909 | 0.0884 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0182 | 0.0909 | 0.0884 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1828 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0187 | 0.0933 | 0.1011 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1828 | 1 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1645 | 0.8993 | 0.899 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0137 | 0.0124 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0137 | 0.0111 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1645 | 0.8993 | 0.8993 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0187 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.045 | 0.045 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0179 | 0.6334 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0264 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0027 | 0.0027 |
Trichomonas vaginalis | set domain proteins, putative | 0.0249 | 0.1277 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.044 | 0.044 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0075 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.0459 | 0.0434 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0027 | 0.0001 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.0027 | 0.0001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0179 | 0.5537 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0128 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0744 | 0.0744 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0081 | 0.0054 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.0027 | 0.0001 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0075 | 0.4158 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0252 | 0.0227 |
Onchocerca volvulus | 0.0249 | 0.1277 | 1 | |
Brugia malayi | PXA domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0264 | 0.0265 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0821 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0075 | 0.0075 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0182 | 0.0909 | 0.0885 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0033 | 0.1268 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0182 | 0.0909 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Echinococcus granulosus | expressed protein | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | RGS-3 protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0187 | 0.0933 | 0.1011 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.044 | 0.0462 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0252 | 0.0253 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0182 | 0.0909 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0179 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.044 | 0.0414 |
Brugia malayi | PXA domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0068 | 0.0047 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0182 | 0.0909 | 0.0984 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.044 | 0.0462 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0182 | 0.0909 | 0.0884 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.045 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0.0027 | 0.1483 |
Schistosoma mansoni | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0885 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.0686 | 0.0736 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0252 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | alkaline phosphatase | 0.032 | 0.1672 | 0.1835 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0027 | 0.0001 |
Onchocerca volvulus | 0.0024 | 0.0033 | 0.0055 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.045 | 0.0425 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.0027 | 0.0001 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0033 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0033 | 0.0033 |
Echinococcus granulosus | RUN | 0.0023 | 0.0027 | 0.0001 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0182 | 0.0909 | 0.0909 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0182 | 0.0909 | 0.0984 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0744 | 0.072 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.032 | 0.1672 | 0.1835 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0182 | 0.0909 | 0.0984 |
Echinococcus multilocularis | expressed protein | 0.0182 | 0.0909 | 0.0984 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.044 | 0.0415 |
Brugia malayi | hypothetical protein | 0.0182 | 0.0909 | 0.0884 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0033 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.0909 | 0.6769 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0264 | 0.0238 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0182 | 0.0909 | 0.0984 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.0027 | 0.1483 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0179 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.