Detailed information for compound 657809

Basic information

Technical information
  • TDR Targets ID: 657809
  • Name: 2-fluoro-N-[2-(3-fluorophenyl)-1,3-benzoxazol -5-yl]benzamide
  • MW: 350.318 | Formula: C20H12F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)c1nc2c(o1)ccc(c2)NC(=O)c1ccccc1F
  • InChi: 1S/C20H12F2N2O2/c21-13-5-3-4-12(10-13)20-24-17-11-14(8-9-18(17)26-20)23-19(25)15-6-1-2-7-16(15)22/h1-11H,(H,23,25)
  • InChiKey: KVEYCPZWHQMLKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0074828
  • SMR000116482
  • ZINC00826361
  • Oprea1_124937
  • MLS000526008
  • Oprea1_026186
  • 2-Fluoro-N-[2-(3-fluoro-phenyl)-benzooxazol-5-yl]-benzamide
  • BAS 00413041
  • ST053793

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis protein dispatched 1 0.0058 0.0553 0.0547
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0043 0.0393 0.0386
Brugia malayi Dopamine receptor protein 2 0.0012 0.0074 0.0576
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0074 0.0067
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0087
Onchocerca volvulus 0.0012 0.0074 0.1872
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0077 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni cpg binding protein 0.0032 0.0284 0.0334
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0074 0.0576
Echinococcus granulosus hypothetical protein 0.0012 0.0074 0.0079
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0087
Onchocerca volvulus 0.0012 0.0077 0.2027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Brugia malayi RE15519p 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Mycobacterium tuberculosis Probable nucleoside hydrolase IunH (purine nucleosidase) 0.0084 0.0813 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0074 0.0576
Echinococcus multilocularis serotonin receptor 0.0012 0.0074 0.0067
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0087
Trichomonas vaginalis hypothetical protein 0.0084 0.0813 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0087
Schistosoma mansoni myosin xvIII 0.0012 0.0074 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0266 0.2223
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0033 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Echinococcus multilocularis serotonin receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0074 0.0576
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0079
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0087
Leishmania major inosine-adenosine-guanosine-nucleoside hydrolase, putative 0.0728 0.7423 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0005 0.0006 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0074 0.0067
Brugia malayi protein C24B5.3 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0074 0.0576
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0522 0.0607
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Echinococcus granulosus allatostatin A receptor 0.0012 0.0074 0.0079
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0079
Onchocerca volvulus 0.003 0.0266 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0033 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0074 0.0079
Schistosoma mansoni DNA ligase IV 0.0012 0.0077 0.0091
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1175 0.1375
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0079
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0268 0.4628
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0077 0.2015
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus cpg binding protein 0.0032 0.0284 0.0327
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0005 0.0011 0.004
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0087
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0074 0.0576
Brugia malayi hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0074 0.0576
Brugia malayi hypothetical protein 0.0007 0.0029 0.0196
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0074 0.0576
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0268 0.0259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0074 0.0576
Brugia malayi hypothetical protein 0.002 0.0157 0.1288
Schistosoma mansoni patched 1 0.0051 0.0479 0.0563
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0077 0.0655
Brugia malayi hypothetical protein 0.0012 0.0077 0.0607
Brugia malayi Serotonin receptor 0.0012 0.0074 0.0576
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0077 0.0655
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0067
Echinococcus granulosus fibroblast growth factor receptor 4 0.0043 0.0393 0.0454
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0074 0.0576
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.4381 0.4378
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0479 0.0473
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0074 0.0576
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0074 0.0067
Trypanosoma brucei inosine-adenosine-guanosine-nucleosidehydrolase 0.0728 0.7423 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1175 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0522 0.4412
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Brugia malayi putative neuropeptide receptor 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus multilocularis nibrin 0.0012 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0074 0.0079
Brugia malayi G-protein coupled receptor 0.0012 0.0074 0.0576
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0074 0.0087
Schistosoma mansoni hypothetical protein 0.0049 0.046 0.0541
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0728 0.7423 1
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Leishmania major inosine-guanine nucleoside hydrolase, putative 0.0084 0.0813 0.0762
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0077 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0074 0.0087
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi Dopamine receptor 0.0012 0.0074 0.0576
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0077 0.0655
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Patched related family protein 10 0.0007 0.0029 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0077 0.0655
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0074 0.0576
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0077 0.0932
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0051 0.0479 0.4042
Schistosoma mansoni hypothetical protein 0.0014 0.0095 0.0112
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0074 0.0067
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0077 0.0655
Brugia malayi hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0062 0.0597 0.505
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Treponema pallidum DNA ligase (lig) 0.0012 0.0077 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0112
Brugia malayi G protein-coupled receptor 0.0012 0.0074 0.0576
Echinococcus granulosus sex peptide receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0074 0.0576
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0074 0.0067
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0084 0.0813 1
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0087
Brugia malayi CXXC zinc finger family protein 0.003 0.0266 0.2223
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) TK protein kinase 0.0044 0.0406 0.3416
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0067
Brugia malayi GnHR receptor homolog 0.0012 0.0074 0.0576
Echinococcus granulosus serotonin receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0079
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0077 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0074 0.0079
Leishmania major hypothetical protein, conserved 0.0084 0.0813 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Onchocerca volvulus 0.0012 0.0074 0.1872
Trypanosoma cruzi inosine-guanine nucleoside hydrolase, putative 0.0084 0.0813 0.1002
Brugia malayi sulfakinin receptor protein 0.0012 0.0074 0.0576
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus twitchin 0.0006 0.0019 0.0015
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1698 0.1991
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0074 0.0067
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0095 0.0089
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0043 0.0393 0.0454
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0268 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0284 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0077 0.0655
Brugia malayi Patched related family protein 12 0.0007 0.0029 0.0196
Echinococcus multilocularis somatostatin receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Schistosoma mansoni nephrin 0.0006 0.0019 0.0023
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0067
Leishmania major nonspecific nucleoside hydrolase 0.0084 0.0813 0.0762
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0074 0.0067
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0074 0.0087
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8503 1
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Echinococcus granulosus expressed conserved protein 0.0112 0.1101 0.1288
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni neuropeptide receptor 0.0012 0.0074 0.0087
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0077 0.2015
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1175 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0074 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus somatostatin receptor 0.0012 0.0074 0.0079
Schistosoma mansoni histamine h1 receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0522 0.0516
Echinococcus granulosus neuroglian 0.0006 0.0019 0.0015
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0077 0.0083
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0074 0.0067
Echinococcus granulosus neuropeptide receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0074 0.0576
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0479 0.0556
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.0376
Brugia malayi Melatonin receptor type 1A 0.0012 0.0074 0.0576
Echinococcus multilocularis sex peptide receptor 0.0012 0.0074 0.0067
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi hypothetical protein 0.003 0.0268 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0077 0.0655
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0043 0.0393 0.0386
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis protein patched 0.0051 0.0479 0.0473
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0074 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0074 0.0079
Brugia malayi Patched related family protein 4 0.0007 0.0029 0.0196
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0074 0.0079
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0084 0.0813 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0074 0.0079
Onchocerca volvulus 0.0012 0.0074 0.1872
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0074 0.0079
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0074 0.0079
Schistosoma mansoni cell adhesion molecule 0.0005 0.0006 0.0008
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0074 0.0576
Giardia lamblia Hypothetical protein 0.0084 0.0813 1
Brugia malayi AKH receptor 0.0012 0.0074 0.0576
Brugia malayi Patched protein homolog 1 0.0007 0.0029 0.0196
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0087
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0074 0.0576
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0074 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0074 0.0079
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0074 0.0067
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0077 0.0071
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0074 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0077 0.0655
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni hypothetical protein 0.0049 0.046 0.0541
Echinococcus granulosus nibrin 0.0012 0.0077 0.0083
Schistosoma mansoni hypothetical protein 0.0049 0.046 0.0541
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Brugia malayi ORL1-like opioid receptor 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0615 0.0723
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0074 0.0087
Echinococcus granulosus roundabout 2 0.0006 0.0019 0.0015
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Onchocerca volvulus 0.0012 0.0074 0.1872
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0074 0.0576
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0074 0.0067
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi hypothetical protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) patched family protein 0.0007 0.0029 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0522 0.0614
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1175 0.1169
Chlamydia trachomatis DNA ligase 0.0012 0.0077 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0522 0.0607
Brugia malayi Myosin head containing protein 0.0007 0.0029 0.0196
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0053
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0005 0.0006 0.0008
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0074 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni hypothetical protein 0.0431 0.4381 0.5153
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0479 0.0556
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus g protein coupled receptor 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0479 0.4042
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0074 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0074 0.0067
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0074 0.1872
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0074 0.0576
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Brugia malayi Serotonin receptor 0.0012 0.0074 0.0576
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1698 0.1693
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Onchocerca volvulus 0.0012 0.0074 0.1872
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0522 0.0614
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0074 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0045
Brugia malayi G-protein coupled receptor 0.0012 0.0074 0.0576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0074 0.0067
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0074 0.0067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0074 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni hypothetical protein 0.0049 0.046 0.0541
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0813 0.1002
Brugia malayi topoisomerase 0.0012 0.0077 0.0607
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8503 0.8502
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0074 0.0067
Schistosoma mansoni topbp1 0.0012 0.0077 0.0091
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus dnaJ subfamily B 0.0431 0.4381 0.5149
Loa Loa (eye worm) patched family protein 0.0007 0.0029 0.0196
Brugia malayi protein C24B5.3 0.0007 0.0029 0.0196
Schistosoma mansoni biogenic amine receptor 0.0012 0.0074 0.0087
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0074 0.1872
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0077 0.0655
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis roundabout 2 0.0006 0.0019 0.0013
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus orexin receptor type 2 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0112
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0813 0.1002
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0074 0.0067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0406 0.3416
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0522 0.0516
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0074 0.0067
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0074 0.0079
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0077 0.0000031374
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni cpg binding protein 0.003 0.0266 0.0313
Trypanosoma cruzi inosine-adenosine-guanosine-nucleosidehydrolase, putative 0.0728 0.7423 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi DKFZp564C0469 protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi neuropeptide F receptor 0.0012 0.0074 0.0576
Schistosoma mansoni adenoreceptor 0.0012 0.0074 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0074 0.0087
Schistosoma mansoni tyrosine kinase 0.0043 0.0393 0.0462
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8503 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0522 0.0614
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0268 0.0259
Loa Loa (eye worm) patched family protein 0.0007 0.0029 0.0196
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0077 0.5
Schistosoma mansoni topbp1 0.0012 0.0077 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0479 0.5753
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0074 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1194 0.1404
Schistosoma mansoni vesicular amine transporter 0.0005 0.0006 0.0008
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0077 0.0655
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Onchocerca volvulus 0.0012 0.0074 0.1872
Echinococcus granulosus fmrfamide receptor 0.0012 0.0074 0.0079
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0084 0.0813 1
Schistosoma mansoni cpg binding protein 0.0032 0.0284 0.0334
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Trypanosoma brucei inosine-guanine nucleoside hydrolase 0.0084 0.0813 0.1002
Echinococcus granulosus neuropeptide receptor 0.0012 0.0074 0.0079
Trichomonas vaginalis inosine-uridine preferring nucleoside hydrolase, putative 0.0084 0.0813 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0074 0.0079
Schistosoma mansoni amine GPCR 0.0012 0.0074 0.0087
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Schistosoma mansoni opsin-like receptor 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0119 0.1175 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0052 0.0386
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0077 0.0932
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0074 0.0576
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi CHE-14 protein 0.0051 0.0479 0.4042
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.2235
Echinococcus multilocularis neuroglian 0.0006 0.0019 0.0013
Brugia malayi neuropeptide F receptor 0.0012 0.0074 0.0576
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0074 0.0576
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0074 0.0079
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0074 0.0087
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0077 0.0607
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0196
Brugia malayi larval opioid receptor 0.0012 0.0074 0.0576
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0095 0.0105
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0268 1
Onchocerca volvulus 0.0012 0.0074 0.1872
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0074 0.0079
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0074 0.0067
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0074 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0074 0.0087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0074 0.0087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0522 0.4412
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0544 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi hypothetical protein 0.0007 0.0029 0.0196
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Entamoeba histolytica Inosine-uridine preferring nucleoside hydrolase, putative 0.0084 0.0813 0.6703
Brugia malayi Dopamine receptor protein 1 0.0012 0.0074 0.0576
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0074 0.0079
Echinococcus multilocularis expressed conserved protein 0.0112 0.1101 0.1095
Brugia malayi hypothetical protein 0.0012 0.0074 0.0576
Loa Loa (eye worm) patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Brugia malayi Patched family protein 0.0007 0.0029 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.0576
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0268 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0074 0.0079
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0074 0.0087

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 1.2589 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.