TDR Targets

Basic information

Technical information

TDR Targets ID: 658226
Name: 4-methoxy-N-[(2,4,5-trimethoxyphenyl)methylid eneamino]benzamide
MW: 344.362 | Formula: C18H20N2O5
H donors: 1 H acceptors: 1 LogP: 2.72 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)N/N=C/c1cc(OC)c(cc1OC)OC
InChi: 1S/C18H20N2O5/c1-22-14-7-5-12(6-8-14)18(21)20-19-11-13-9-16(24-3)17(25-4)10-15(13)23-2/h5-11H,1-4H3,(H,20,21)/b19-11+
InChiKey: KPGHRYTUTQTZGE-YBFXNURJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-methoxy-N-[(2,4,5-trimethoxyphenyl)methyleneamino]benzamide
4-methoxy-N-[(2,4,5-trimethoxybenzylidene)amino]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0731	0.1805
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0038	0.0049
Loa Loa (eye worm)	hypothetical protein	0.003	0.0038	0.0036
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Schistosoma mansoni	P2X receptor subunit	0.0114	0.1506	0.5404
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0186	0.2764	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0038	0.0012
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0041	0.0239	0.0777
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0102	0.1302	0.3022
Echinococcus granulosus	chromobox protein 1	0.0069	0.0731	0.1819
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0198	0.0545
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Onchocerca volvulus		0.0236	0.3642	0.9694
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0028	0.001	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.015	0.0413
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0038	0.0031
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0046	0.0323	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1302	0.3767
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0029	0.0023	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1989	0.5797
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0133	0.0273
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0102	0.1302	0.345
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0046	0.0323	0.0876
Toxoplasma gondii	hypothetical protein	0.0036	0.015	0.0434
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0029	0.0023	0.0009
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus multilocularis	p2X purinoceptor 4	0.0114	0.1506	0.3786
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0133	0.039
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0225	0.0525
Schistosoma mansoni	chromobox protein	0.0069	0.0731	0.2575
Schistosoma mansoni	sodium/chloride dependent transporter	0.0046	0.0323	0.1083
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0731	0.2082
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	0.3413	0.9085
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0323	0.0876
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.025	0.0687
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0041	0.0239	0.0613
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0731	0.2008
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0239	0.0656
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0043	0.0263	0.0607
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.015	0.0413
Brugia malayi	jmjC domain containing protein	0.0095	0.1181	0.1158
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0253	0.3934	1
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0223	0.3413	1
Echinococcus multilocularis	geminin	0.0169	0.2468	0.6249
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0046	0.0323	0.0759
Echinococcus multilocularis	p2X purinoceptor 4	0.0114	0.1506	0.3786
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0041	0.0239	0.0613
Schistosoma mansoni	P2X receptor subunit	0.0114	0.1506	0.5404
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0052	0.0075
Giardia lamblia	PHD finger protein 15	0.0029	0.0026	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0237	0.0769
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus granulosus	sodium and chloride dependent glycine	0.0046	0.0323	0.0775
Trypanosoma brucei	fatty acid desaturase, putative	0.0243	0.3756	1
Schistosoma mansoni	hypothetical protein	0.0169	0.2468	0.8918
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0029	0.0023	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0038	0.0031
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.025	0.0687
Brugia malayi	chromobox protein homolog 3	0.0039	0.0198	0.0173
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0038	0.0044
Schistosoma mansoni	P2X receptor subunit	0.0114	0.1506	0.5404
Onchocerca volvulus		0.0041	0.0237	0.0565
Brugia malayi	WGR domain containing protein	0.0186	0.2764	0.2745
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0133	0.0315
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0038	0.0042
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0186	0.2764	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Schistosoma mansoni	sodium/chloride dependent transporter	0.0046	0.0323	0.1083
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0046	0.0323	0.0297
Echinococcus granulosus	sodium and chloride dependent glycine	0.0046	0.0323	0.0775
Leishmania major	stearic acid desaturase, putative	0.0243	0.3756	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0028	0.001	0.0026
Loa Loa (eye worm)	acyl-CoA desaturase	0.0223	0.3413	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0198	0.0509
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0193	0.2891	1
Brugia malayi	acyl-CoA desaturase	0.0223	0.3413	0.3395
Echinococcus granulosus	geminin	0.0169	0.2468	0.6256
Onchocerca volvulus		0.0243	0.3756	1
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0186	0.2764	0.7013
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0198	0.0545
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0731	0.1805
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.015	0.0413
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.1181	0.2967
Echinococcus granulosus	poly adp ribose polymerase 2	0.0102	0.1302	0.3277
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.1181	0.2955
Plasmodium falciparum	stearoyl-CoA desaturase	0.0223	0.3413	1
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0102	0.1302	0.4659
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0041	0.0239	0.0613
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	0.3413	0.9085
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0839	0.2969
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0041	0.0239	0.0562
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0566	0.1595
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0133	0.0291
Echinococcus granulosus	p2X purinoceptor 4	0.0114	0.1506	0.3798
Leishmania major	fatty-acid desaturase, putative	0.0243	0.3756	1
Echinococcus granulosus	chromobox protein 1	0.0069	0.0731	0.1819
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0253	0.3934	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0038	0.0044
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0225	0.0509
Plasmodium vivax	SET domain protein, putative	0.003	0.0038	0.0036
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0186	0.2764	0.7007
Schistosoma mansoni	P2X receptor subunit	0.0114	0.1506	0.5404
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0038	0.0044
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0088	0.1061	0.378
Brugia malayi	jmjC domain containing protein	0.0035	0.0133	0.0107
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0041	0.0239	0.0656
Echinococcus granulosus	WGR domain containing protein	0.0058	0.0527	0.1297
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0102	0.1302	0.345
Brugia malayi	Pre-SET motif family protein	0.0207	0.3141	0.3123
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0073	0.0798	0.2279
Schistosoma mansoni	hypothetical protein	0.0169	0.2468	0.8918
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0323	0.0876
Trypanosoma cruzi	fatty acid desaturase, putative	0.0243	0.3756	1
Echinococcus granulosus	p2X purinoceptor 4	0.0114	0.1506	0.3798
Echinococcus granulosus	peregrin	0.0029	0.0026	0.0018
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0026	0.0018
Echinococcus multilocularis	p2X purinoceptor 4	0.0114	0.1506	0.3786
Schistosoma mansoni	chromobox protein	0.0069	0.0731	0.2575
Onchocerca volvulus		0.0243	0.3756	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0041	0.0239	0.0656
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0133	0.039
Brugia malayi	WGR domain containing protein	0.0102	0.1302	0.1279
Brugia malayi	Heterochromatin protein 1	0.0069	0.0731	0.0707
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0102	0.1302	0.3265
Onchocerca volvulus		0.0031	0.0052	0.0068
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0058	0.0527	0.1297
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0041	0.0239	0.0545
Loa Loa (eye worm)	hypothetical protein	0.005	0.0389	0.107
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.025	0.06
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0198	0.0462
Echinococcus granulosus	p2X purinoceptor 4	0.0114	0.1506	0.3798
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.3141	0.9198
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.3642	1
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0731	0.2008
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0041	0.0239	0.0656

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 658226