Detailed information for compound 660407

Basic information

Technical information
  • TDR Targets ID: 660407
  • Name: 2-methyl-8-[2-(4-methyl-2-nitrophenoxy)ethoxy ]quinoline
  • MW: 338.357 | Formula: C19H18N2O4
  • H donors: 0 H acceptors: 3 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)c(OCCOc1ccc(cc1[N+](=O)[O-])C)ccc2
  • InChi: 1S/C19H18N2O4/c1-13-6-9-17(16(12-13)21(22)23)24-10-11-25-18-5-3-4-15-8-7-14(2)20-19(15)18/h3-9,12H,10-11H2,1-2H3
  • InChiKey: QKDCKRCBCGUUPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-8-[2-(4-methyl-2-nitro-phenoxy)ethoxy]quinoline
  • ZINC02825245

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.1812 0.8745
Echinococcus multilocularis fmrfamide receptor 0.0133 0.2844 0.3155
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0881 0.3199
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0141 0.3022 0.3363
Loa Loa (eye worm) glutathione reductase 0.0039 0.0609 0.0467
Loa Loa (eye worm) melatonin receptor type 1A 0.0133 0.2844 0.2736
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0133 0.2844 0.3155
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1177 0.1272
Schistosoma mansoni neuropeptide receptor 0.0133 0.2844 0.3208
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.2844 0.3208
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0122 0.2581 0.2902
Schistosoma mansoni amine GPCR 0.0133 0.2844 0.3208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0083
Echinococcus granulosus 7tm_1 domain containing protein 0.0133 0.2844 0.3155
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.2051 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0149 0.0078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1177 0.1204
Leishmania major trypanothione reductase 0.0039 0.0609 0.0467
Echinococcus multilocularis g-protein coupled receptor 0.0133 0.2844 0.3155
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0881 1
Schistosoma mansoni loxhd1 0.0024 0.023 0.0172
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0805 0.0768
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0133 0.2844 0.3155
Schistosoma mansoni hypothetical protein 0.0133 0.2844 0.3208
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0149 0.0149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0609 0.2431
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0025
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis somatostatin receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus neuropeptide receptor 0.0133 0.2844 0.3155
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0133 0.2844 0.3208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Brugia malayi G protein-coupled receptor F59B2.13 0.0133 0.2844 0.2736
Echinococcus multilocularis fmrfamide receptor 0.0133 0.2844 0.3155
Echinococcus granulosus tumor protein p63 0.0341 0.7798 0.8951
Onchocerca volvulus 0.0133 0.2844 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Echinococcus granulosus fmrfamide receptor 0.0133 0.2844 0.3155
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1177 0.4383
Leishmania major C-8 sterol isomerase-like protein 0.0433 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Echinococcus multilocularis geminin 0.0378 0.8694 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.1812 0.86
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0204 0.5
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.2844 0.3155
Schistosoma mansoni biogenic amine receptor 0.0133 0.2844 0.3208
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.023 0.0095
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0133 0.2844 0.3155
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.023 0.0804
Brugia malayi Dopamine receptor 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni polycystin 1-related 0.0024 0.023 0.0172
Trypanosoma brucei unspecified product 0.002 0.0149 0.0149
Echinococcus granulosus g protein coupled receptor 0.0133 0.2844 0.3155
Schistosoma mansoni ap endonuclease 0.0022 0.0204 0.0142
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0149 0.0078
Brugia malayi GnHR receptor homolog 0.0133 0.2844 0.2736
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0344 0.1894
Loa Loa (eye worm) hypothetical protein 0.0276 0.6261 0.6204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0805 0.0768
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0204 0.0379
Onchocerca volvulus 0.005 0.0859 0.2407
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0204 0.0379
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.2844 0.3155
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.2844 0.3208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0805 0.0768
Onchocerca volvulus 0.0133 0.2844 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0173 0.379 0.4261
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0609 0.0467
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0133 0.2844 0.3155
Onchocerca volvulus 0.0028 0.0344 0.0434
Echinococcus granulosus neuropeptide FF receptor 2 0.0133 0.2844 0.3155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Echinococcus granulosus 7TM GPCR rhodopsin 0.0133 0.2844 0.3155
Schistosoma mansoni neuropeptide receptor 0.0133 0.2844 0.3208
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.1812 0.8745
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0609 0.6152
Echinococcus multilocularis neuropeptide FF receptor 2 0.0133 0.2844 0.3155
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0149 0.0016
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis neuropeptide receptor A26 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Onchocerca volvulus Neuropeptide F receptor homolog 0.0133 0.2844 1
Echinococcus multilocularis orexin receptor type 2 0.0133 0.2844 0.3155
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.2844 0.3155
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0133 0.2844 0.3155
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0433 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0133 0.2844 0.3208
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.2051 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni hypothetical protein 0.0133 0.2844 0.3208
Onchocerca volvulus 0.0133 0.2844 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0344 0.1894
Schistosoma mansoni amine GPCR 0.0133 0.2844 0.3208
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0149 0.0149
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.023 0.0095
Echinococcus granulosus neuropeptide receptor 0.0133 0.2844 0.3155
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0881 0.5009
Echinococcus multilocularis tumor protein p63 0.0341 0.7798 0.8951
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0141 0.3022 0.3363
Mycobacterium tuberculosis Probable reductase 0.009 0.1812 0.8745
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.023 0.0095
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.2844 0.3208
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0344 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0344 0.0198
Schistosoma mansoni biogenic amine receptor 0.0133 0.2844 0.3208
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1177 0.1044
Schistosoma mansoni DNA polymerase eta 0.002 0.0149 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.2844 0.3155
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.2844 0.2736
Echinococcus granulosus peptide allatostatin:somatostatin 0.0133 0.2844 0.3155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.0378 0.8694 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0805 0.084
Echinococcus granulosus somatostatin receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0276 0.6261 0.6204
Brugia malayi AKH receptor 0.0133 0.2844 0.2736
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.2844 0.3155
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0204 0.0878
Trypanosoma brucei C-8 sterol isomerase, putative 0.0433 1 1
Brugia malayi Serotonin receptor 0.0133 0.2844 0.2736
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0122 0.2581 0.2902
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi putative neuropeptide receptor 0.0133 0.2844 0.2736
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.2844 0.3155
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1177 0.5414
Echinococcus granulosus biogenic amine 5HT receptor 0.0276 0.6261 0.7152
Brugia malayi Serotonin receptor 0.0133 0.2844 0.2736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Loa Loa (eye worm) acetyltransferase 0.0173 0.379 0.3696
Brugia malayi hypothetical protein 0.0024 0.023 0.0083
Echinococcus granulosus RUN 0.0024 0.023 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Schistosoma mansoni lipoxygenase 0.0098 0.2014 0.2243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.023 0.0937
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0133 0.2844 0.2736
Echinococcus multilocularis RUN 0.0024 0.023 0.0095
Echinococcus multilocularis allatostatin A receptor 0.0133 0.2844 0.3155
Onchocerca volvulus 0.0133 0.2844 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0204 0.0056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.1611 0.1776
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0122 0.2581 0.2902
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi neuropeptide F receptor 0.0133 0.2844 0.2736
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.2844 0.3208
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0133 0.2844 0.3208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0133 0.2844 0.3155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0344 0.0198
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0173 0.0237
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0133 0.2844 0.2736
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.1812 0.8745
Brugia malayi Dopamine receptor protein 1 0.0133 0.2844 0.2736
Onchocerca volvulus 0.0133 0.2844 1
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0621 0.0553
Echinococcus multilocularis g protein coupled receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.2844 0.3155
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0344 0.0198
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0204 0.0307
Schistosoma mansoni biogenic amine (5HT) receptor 0.0276 0.6261 0.7175
Echinococcus multilocularis dro:myosuppressin receptor 0.0133 0.2844 0.3155
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0344 0.1894
Echinococcus multilocularis neuropeptide receptor 0.0133 0.2844 0.3155
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0133 0.2844 0.3208
Schistosoma mansoni biogenic amine receptor 0.0133 0.2844 0.3208
Brugia malayi hypothetical protein 0.0024 0.023 0.0083
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Loa Loa (eye worm) doublecortin family protein 0.0024 0.023 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.2844 0.3155
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.2844 0.3155
Echinococcus granulosus tachykinin peptides receptor 99D 0.0133 0.2844 0.3155
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.2844 0.3208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0025
Schistosoma mansoni opsin-like receptor 0.0133 0.2844 0.3208
Onchocerca volvulus 0.0133 0.2844 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Schistosoma mansoni hypothetical protein 0.0133 0.2844 0.3208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0805 0.0666
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.1812 0.8745
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0133 0.2844 0.2736
Echinococcus granulosus serotonin receptor 0.0133 0.2844 0.3155
Brugia malayi putative neuropeptide receptor NPR1 0.0133 0.2844 0.2736
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.023 0.0095
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0204 0.0438
Brugia malayi Dopamine receptor protein 2 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis serotonin receptor 0.0276 0.6261 0.7152
Loa Loa (eye worm) hypothetical protein 0.0433 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.2844 0.3155
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0859 0.0903
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.023 0.0095
Brugia malayi neuropeptide F receptor 0.0133 0.2844 0.2736
Onchocerca volvulus 0.0133 0.2844 1
Brugia malayi sulfakinin receptor protein 0.0133 0.2844 0.2736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Toxoplasma gondii thioredoxin reductase 0.0039 0.0609 0.2109
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.2844 0.3155
Echinococcus granulosus g protein coupled receptor 0.0133 0.2844 0.3155
Schistosoma mansoni histamine h1 receptor 0.0133 0.2844 0.3208
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0204 0.0056
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0133 0.2844 0.3155
Brugia malayi G-protein coupled receptor 0.0133 0.2844 0.2736
Schistosoma mansoni lipoxygenase 0.0141 0.3022 0.3414
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni hypothetical protein 0.0024 0.023 0.0172
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0881 0.3199
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0344 0.1894
Brugia malayi G-protein coupled receptor 0.0133 0.2844 0.2736
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0204 0.0065
Echinococcus granulosus G protein coupled receptor 139 0.0133 0.2844 0.3155
Brugia malayi Tachykinin-like peptides receptor 99D 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0344 0.1039
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0204 0.0204
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0881 0.0857
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0133 0.2844 0.3208
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0149 0.0149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0204 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.023 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0344 0.0198
Echinococcus multilocularis serotonin receptor 0.0276 0.6261 0.7152
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0407 0.9384 0.9374
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0149 0.0149
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.2844 0.3155
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.023 0.0083
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0133 0.2844 0.3208
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0133 0.2844 0.3155
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0133 0.2844 0.2736
Loa Loa (eye worm) TYRA-2 protein 0.0133 0.2844 0.2736
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0133 0.2844 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.2844 0.3155
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Schistosoma mansoni amine GPCR 0.0133 0.2844 0.3208
Echinococcus granulosus dro:myosuppressin receptor 0.0133 0.2844 0.3155
Echinococcus granulosus allatostatin A receptor 0.0133 0.2844 0.3155
Schistosoma mansoni rab6-interacting 0.0024 0.023 0.0172
Brugia malayi ORL1-like opioid receptor 0.0133 0.2844 0.2736
Schistosoma mansoni ap endonuclease 0.0022 0.0204 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0025
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0081 0.1611 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.2844 0.2736
Echinococcus multilocularis sex peptide receptor 0.0133 0.2844 0.3155
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Schistosoma mansoni myosin xvIII 0.0133 0.2844 0.3208
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni neuropeptide receptor 0.0133 0.2844 0.3208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0344 0.1894
Brugia malayi follicle stimulating hormone receptor 0.0407 0.9384 0.9374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0805 0.084
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0133 0.2844 0.3208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0344 0.0198
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0204 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0133 0.2844 0.3208
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0122 0.2581 0.2902
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1177 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.2844 0.3208
Echinococcus multilocularis neuropeptide s receptor 0.0133 0.2844 0.3155
Schistosoma mansoni opsin-like receptor 0.0133 0.2844 0.3208
Echinococcus multilocularis G-protein coupled receptor, putative 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni hypothetical protein 0.0133 0.2844 0.3208
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0081 0.1611 0.1776
Echinococcus granulosus neuropeptide receptor A26 0.0133 0.2844 0.3155
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.2844 0.3155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1177 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0344 0.0198
Onchocerca volvulus 0.0133 0.2844 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.495 0.4873
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0133 0.2844 0.3208
Onchocerca volvulus 0.0133 0.2844 1
Echinococcus multilocularis neuropeptide receptor 0.0133 0.2844 0.3155
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0609 0.0467
Schistosoma mansoni hypothetical protein 0.0378 0.8694 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0204 0.0511
Echinococcus granulosus geminin 0.0378 0.8694 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus g-protein coupled receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.2844 0.2736
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0173 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.2844 0.3208
Brugia malayi hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus neuropeptide s receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Loa Loa (eye worm) hypothetical protein 0.005 0.0859 0.0721
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0204 0.0065
Schistosoma mansoni amine GPCR 0.0133 0.2844 0.3208
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0122 0.2581 0.2847
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0344 0.0198
Brugia malayi Melibiase family protein 0.0081 0.1611 0.1485
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.1812 0.8745
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0133 0.2844 0.2736
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0204 0.0539
Onchocerca volvulus 0.0133 0.2844 1
Toxoplasma gondii melibiase subfamily protein 0.0122 0.2581 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi larval opioid receptor 0.0133 0.2844 0.2736
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0344 0.3085
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0621 0.0553
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.2051 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1177 0.1272
Schistosoma mansoni alpha-1 adrenergic receptor 0.0133 0.2844 0.3208
Plasmodium falciparum thioredoxin reductase 0.0039 0.0609 0.7175
Brugia malayi Melatonin receptor type 1A 0.0133 0.2844 0.2736
Onchocerca volvulus 0.0133 0.2844 1
Schistosoma mansoni amine GPCR 0.0133 0.2844 0.3208
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.2844 0.3155
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0133 0.2844 0.3155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.2844 0.3155
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Echinococcus multilocularis G protein coupled receptor 139 0.0133 0.2844 0.3155
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0204 0.0878
Schistosoma mansoni neuropeptide f receptor 76f 0.0133 0.2844 0.3208
Echinococcus granulosus sex peptide receptor 0.0133 0.2844 0.3155
Brugia malayi RE15519p 0.0133 0.2844 0.2736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Brugia malayi Doublecortin family protein 0.0024 0.023 0.0083
Echinococcus granulosus orexin receptor type 2 0.0133 0.2844 0.3155
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.2844 0.3155
Schistosoma mansoni opsin-like receptor 0.0133 0.2844 0.3208
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0122 0.2581 0.2847
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0344 0.1894
Loa Loa (eye worm) hypothetical protein 0.0028 0.0344 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0133 0.2844 0.3155
Trypanosoma brucei trypanothione reductase 0.0039 0.0609 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0805 0.0768
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Brugia malayi G protein-coupled receptor 0.0133 0.2844 0.2736
Onchocerca volvulus 0.0133 0.2844 1
Echinococcus multilocularis g protein coupled receptor 0.0133 0.2844 0.3155
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0133 0.2844 0.2736
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1177 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1177 0.1204
Onchocerca volvulus 0.0133 0.2844 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus hypothetical protein 0.0133 0.2844 0.3155
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0149 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Echinococcus granulosus alpha 1A adrenergic receptor 0.0133 0.2844 0.3155
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0133 0.2844 0.2736
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0204 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0344 0.1039
Onchocerca volvulus 0.0133 0.2844 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.078 1
Echinococcus granulosus g protein coupled receptor 0.0133 0.2844 0.3155
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0881 0.5009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.2844 0.3208
Brugia malayi Thioredoxin reductase 0.0039 0.0609 0.0467
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0344 0.3085
Schistosoma mansoni adenoreceptor 0.0133 0.2844 0.3208
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.2844 0.3155
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0133 0.2844 0.3155
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.2051 1
Brugia malayi glutathione reductase 0.0039 0.0609 0.0467
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0204 0.0056
Schistosoma mansoni rab6-interacting 0.0024 0.023 0.0172
Loa Loa (eye worm) hypothetical protein 0.0133 0.2844 0.2736
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0149 0.0149
Onchocerca volvulus 0.0133 0.2844 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0609 0.6152
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0173 0.379 0.4306
Echinococcus multilocularis g protein coupled receptor 0.0133 0.2844 0.3155
Schistosoma mansoni neuropeptide receptor 0.0133 0.2844 0.3208
Mycobacterium ulcerans hypothetical protein 0.0028 0.0344 0.1894
Echinococcus granulosus histone acetyltransferase KAT2B 0.0168 0.3674 0.4126
Plasmodium falciparum glutathione reductase 0.0039 0.0609 0.7175
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.2844 0.3155
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0122 0.2581 0.2847
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0344 0.3085
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.2844 0.3208
Onchocerca volvulus 0.0133 0.2844 1
Brugia malayi acetyltransferase, GNAT family protein 0.0173 0.379 0.3696
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0344 0.1894
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0133 0.2844 0.2736
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.078 1
Onchocerca volvulus 0.0133 0.2844 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0805 0.084
Loa Loa (eye worm) hypothetical protein 0.0081 0.1611 0.1485
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0805 0.0666
Toxoplasma gondii exonuclease III APE 0.0022 0.0204 0.049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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