Detailed information for compound 667629

Basic information

Technical information
  • TDR Targets ID: 667629
  • Name: 2-(2,4-difluorophenoxy)-N-pyridin-3-ylacetami de
  • MW: 264.228 | Formula: C13H10F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 1.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccnc1)COc1ccc(cc1F)F
  • InChi: 1S/C13H10F2N2O2/c14-9-3-4-12(11(15)6-9)19-8-13(18)17-10-2-1-5-16-7-10/h1-7H,8H2,(H,17,18)
  • InChiKey: NRRLTEOBGABBAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-difluorophenoxy)-N-(3-pyridyl)acetamide
  • 2-(2,4-difluorophenoxy)-N-pyridin-3-yl-ethanamide
  • ZINC00315034
  • Acetamide, 2-(2,4-difluorophenoxy)-N-(3-pyridyl)-
  • 2-(2,4-Difluorophenoxy)-N-(3-pyridinyl)acetamide
  • STK008459

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0312 0.1986 0.1573
Schistosoma mansoni hypothetical protein 0.0673 0.5767 0.5549
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0263 0.1473 0.1034
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0187 0.0683 0.5
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0312 0.1986 0.1986
Echinococcus granulosus Endonuclease G 0.0187 0.0683 0.0203
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1077 1 1
Onchocerca volvulus 0.0312 0.1986 0.3443
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0263 0.1473 0.1034
Onchocerca volvulus 0.0673 0.5767 1
Leishmania major endonuclease G, putative 0.0187 0.0683 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1077 1 1
Brugia malayi endonuclease G, mitochondrial precursor 0.0187 0.0683 0.0683
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1077 1 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.0943 0.0943
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0557 0.4549 0.5
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0557 0.4549 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0557 0.4549 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0557 0.4549 1
Trypanosoma cruzi endonuclease G, putative 0.0187 0.0683 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Brugia malayi Thrombospondin type 1 domain containing protein 0.0673 0.5767 0.5767
Trypanosoma cruzi endonuclease G, putative 0.0187 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1986 0.1986
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0187 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.1473 0.1473
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0557 0.4549 0.5
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0312 0.1986 0.1573
Brugia malayi Protein-tyrosine phosphatase 0.0222 0.1043 0.1043
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0557 0.4549 0.5
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0557 0.4549 1
Onchocerca volvulus 0.0157 0.0368 0.0639
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0557 0.4549 0.5
Loa Loa (eye worm) hypothetical protein 0.0312 0.1986 0.1986
Echinococcus granulosus ectonucleotide 0.0263 0.1473 0.1034
Loa Loa (eye worm) hypothetical protein 0.0148 0.0269 0.0269
Echinococcus multilocularis ectonucleotide 0.0263 0.1473 0.1034
Onchocerca volvulus 0.0557 0.4549 0.7888
Echinococcus multilocularis Endonuclease G 0.0187 0.0683 0.0203
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0312 0.1986 0.1573
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1077 1 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0312 0.1986 0.1573
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0187 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0269 0.0269
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0557 0.4549 0.4549
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0385 0.2753 0.5
Onchocerca volvulus 0.0312 0.1986 0.3443
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0673 0.5767 0.5767
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0557 0.4549 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0269 0.0269
Schistosoma mansoni endonuclease related 0.0187 0.0683 0.0203
Trypanosoma brucei endonuclease G, putative 0.0187 0.0683 1
Trypanosoma brucei endonuclease G, putative 0.0187 0.0683 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0557 0.4549 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0557 0.4549 0.4549
Loa Loa (eye worm) hypothetical protein 0.0312 0.1986 0.1986
Trypanosoma brucei endonuclease G, putative 0.0187 0.0683 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0312 0.1986 0.1573
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0187 0.0683 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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