Detailed information for compound 667704

Basic information

Technical information
  • TDR Targets ID: 667704
  • Name: N,4-bis(2,4-dimethoxyphenyl)-6-methyl-2-sulfa nylidene-3,4-dihydro-1H-pyrimidine-5-carboxam ide
  • MW: 443.516 | Formula: C22H25N3O5S
  • H donors: 2 H acceptors: 1 LogP: 2.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)NC(=O)C1=C(C)N=C(NC1c1ccc(cc1OC)OC)S
  • InChi: 1S/C22H25N3O5S/c1-12-19(21(26)24-16-9-7-14(28-3)11-18(16)30-5)20(25-22(31)23-12)15-8-6-13(27-2)10-17(15)29-4/h6-11,20H,1-5H3,(H,24,26)(H2,23,25,31)
  • InChiKey: DJKYNKBJHUHCCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,4-bis(2,4-dimethoxyphenyl)-6-methyl-2-thioxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • STOCK3S-28704

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Endonuclease G 0.0145 0.1372 0.1072
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0203 0.2277 0.2009
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0111 0.0847 0.0529
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0078 0.0336 0.149
Onchocerca volvulus 0.0241 0.2865 0.3177
Trypanosoma cruzi hypothetical protein 0.0078 0.0336 0.2265
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0241 0.2865 0.2865
Trypanosoma brucei polo-like protein kinase 0.0111 0.0847 0.6084
Schistosoma mansoni neuropeptide receptor 0.0125 0.1061 0.1061
Echinococcus multilocularis ectonucleotide 0.0203 0.2277 0.2009
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Echinococcus multilocularis Endonuclease G 0.0145 0.1372 0.1072
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0189 0.2069 0.1793
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0847 0.6084
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0203 0.2277 0.2009
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0111 0.0847 0.0529
Brugia malayi endonuclease G, mitochondrial precursor 0.0145 0.1372 0.1072
Echinococcus multilocularis G protein coupled receptor 139 0.0125 0.1061 0.0751
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0111 0.0847 0.6084
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0189 0.2069 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0241 0.2865 0.2618
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.2069 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Trypanosoma cruzi endonuclease G, putative 0.0145 0.1372 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0699 1 1
Schistosoma mansoni hypothetical protein 0.0199 0.2215 0.2215
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Echinococcus multilocularis neuropeptide receptor 0.0125 0.1061 0.0751
Loa Loa (eye worm) hypothetical protein 0.0241 0.2865 0.2618
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.2069 1
Onchocerca volvulus 0.0241 0.2865 0.3177
Onchocerca volvulus 0.0189 0.2069 0.1923
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0145 0.1372 1
Leishmania major endonuclease G, putative 0.0145 0.1372 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0145 0.1372 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.2069 1
Trypanosoma cruzi endonuclease G, putative 0.0145 0.1372 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0131 0.1161 0.5
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Brugia malayi Thrombospondin type 1 domain containing protein 0.0519 0.72 0.7102
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0189 0.2069 1
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0145 0.1372 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0847 0.0847
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0847 0.6084
Loa Loa (eye worm) hypothetical protein 0.0203 0.2277 0.2009
Schistosoma mansoni endonuclease related 0.0145 0.1372 0.1372
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0241 0.2865 0.2865
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.2069 1
Onchocerca volvulus 0.0519 0.72 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2865 0.2618
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0241 0.2865 0.2865
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0078 0.0336 0.0336
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0241 0.2865 0.2865
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0189 0.2069 0.1793
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0078 0.0336 0.149
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0189 0.2069 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0078 0.0336 0.149
Echinococcus multilocularis geminin 0.0199 0.2215 0.1944
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0699 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0111 0.0847 0.2952
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.2069 1
Echinococcus granulosus neuropeptide receptor 0.0125 0.1061 0.0751
Trypanosoma brucei endonuclease G, putative 0.0145 0.1372 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0111 0.0847 0.0529
Echinococcus granulosus ectonucleotide 0.0203 0.2277 0.2009
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0145 0.1372 1
Echinococcus granulosus geminin 0.0199 0.2215 0.1944
Trichomonas vaginalis Sentrin-specific protease, putative 0.0078 0.0336 0.149
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0519 0.72 0.7102
Schistosoma mansoni hypothetical protein 0.0199 0.2215 0.2215
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0189 0.2069 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0111 0.0847 0.0529
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0241 0.2865 0.2618
Loa Loa (eye worm) hypothetical protein 0.0241 0.2865 0.2618
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0189 0.2069 1
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0847 0.4002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0699 1 1
Trypanosoma brucei endonuclease G, putative 0.0145 0.1372 1
Schistosoma mansoni hypothetical protein 0.0519 0.72 0.72
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0699 1 1
Trypanosoma brucei endonuclease G, putative 0.0145 0.1372 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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