Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1293 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.067 | 0.4985 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1293 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1293 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.067 | 0.4985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0262 | 0.1305 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0233 | 0.147 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0161 | 0.0895 | 0.5863 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0578 | 0.3576 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.2235 | 0.4392 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0062 | 0.0096 | 0.049 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.0262 | 0.034 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0168 | 0.0947 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1293 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0712 | 0.3316 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0161 | 0.0895 | 0.1661 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0233 | 0.147 | 0.2833 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0161 | 0.0895 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0062 | 0.0096 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.023 | 0.1446 | 0.9824 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0233 | 0.147 | 0.2833 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0233 | 0.147 | 0.2811 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0062 | 0.0096 | 0.049 |
Brugia malayi | Protein kinase domain containing protein | 0.0169 | 0.096 | 0.6286 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.1443 | 0.2777 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0161 | 0.0895 | 0.5863 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.0262 | 0.121 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1293 | 1 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.0262 | 0.037 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0062 | 0.0096 | 0.049 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0712 | 0.3316 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1293 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0062 | 0.0096 | 0.0107 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.0262 | 0.037 |
Brugia malayi | Protein kinase domain containing protein | 0.0161 | 0.0895 | 0.5818 |
Echinococcus granulosus | microtubule associated protein 2 | 0.067 | 0.4985 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0169 | 0.096 | 0.1767 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1293 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0161 | 0.0895 | 0.1635 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0712 | 0.3643 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0062 | 0.0096 | 0.003 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0168 | 0.0947 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.1955 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.2235 | 0.4392 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.1955 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.1443 | 0.2777 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.1955 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0062 | 0.0096 | 0.049 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1443 | 0.9803 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0161 | 0.0895 | 0.1661 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0169 | 0.096 | 0.6326 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0062 | 0.0096 | 0.003 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0168 | 0.0947 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.0062 | 0.0096 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0233 | 0.147 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0578 | 0.4983 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0578 | 0.4983 |
Brugia malayi | hypothetical protein | 0.0229 | 0.1443 | 0.98 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0578 | 0.3576 |
Brugia malayi | follicle stimulating hormone receptor | 0.023 | 0.1446 | 0.9823 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0578 | 0.3506 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0161 | 0.0895 | 0.5818 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0168 | 0.0947 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.1955 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0168 | 0.0947 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.