TDR Targets

Basic information

Technical information

TDR Targets ID: 672568
Name: N-(2,4-difluorophenyl)-2-[(4-ethoxyphenyl)-me thylsulfonylamino]acetamide
MW: 384.398 | Formula: C17H18F2N2O4S
H donors: 1 H acceptors: 3 LogP: 2.51 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)N(S(=O)(=O)C)CC(=O)Nc1ccc(cc1F)F
InChi: 1S/C17H18F2N2O4S/c1-3-25-14-7-5-13(6-8-14)21(26(2,23)24)11-17(22)20-16-9-4-12(18)10-15(16)19/h4-10H,3,11H2,1-2H3,(H,20,22)
InChiKey: AVYVNSIWXGPACH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-difluorophenyl)-2-[(4-ethoxyphenyl)-methylsulfonyl-amino]acetamide
N-(2,4-difluorophenyl)-2-[(4-ethoxyphenyl)-mesyl-amino]acetamide
N-(2,4-difluorophenyl)-2-[(4-ethoxyphenyl)-methylsulfonyl-amino]ethanamide
ZINC01122227
T0515-6959

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0001	0.0001
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0011	0.0001	0.0001
Echinococcus multilocularis	inositol monophosphatase 1	0.0074	0.0224	0.0224
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0049	0.0027
Onchocerca volvulus		0.0025	0.0049	0.3839
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0066	0.0196	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0048	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0119	0.0119
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0224	0.0224
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0049	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0049	0.0049
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0018	0.0018
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Echinococcus multilocularis	muscleblind protein	0.0298	0.1012	0.1012
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0027	0.5561
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0049	0.0027
Brugia malayi	hypothetical protein	0.0016	0.0018	0.0018
Echinococcus multilocularis	muscleblind protein 1	0.0298	0.1012	0.1012
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0027	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0049	0.0027
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0119	0.0119
Echinococcus granulosus	inositol monophosphatase 1	0.0074	0.0224	0.0224
Schistosoma mansoni	hypothetical protein	0.0016	0.0018	0.0018
Brugia malayi	hypothetical protein	0.0025	0.0048	0.0048
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0862	0.3	1
Loa Loa (eye worm)	hypothetical protein	0.0298	0.1012	0.1014
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0049	0.0049
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0049	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0084	0.0084
Brugia malayi	Inositol-1	0.0074	0.0224	0.0224
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0027	0.0205
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0119	0.0119
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0016	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0176	0.0583	0.0583
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0298	0.1012	0.1014
Echinococcus granulosus	survival motor neuron protein 1	0.023	0.0772	0.0772
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.014	0.014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0119	0.0119
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0018	0.0018
Schistosoma mansoni	protein kinase	0.2848	1	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0224	0.0595
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0119	0.0119
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0049	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0049	0.1115
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0074	0.0224	1
Schistosoma mansoni	hypothetical protein	0.0176	0.0583	0.0583
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0066	0.0196	1
Loa Loa (eye worm)	inositol-1	0.0074	0.0224	0.0224
Echinococcus multilocularis	geminin	0.0176	0.0583	0.0583
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0049	0.0049
Brugia malayi	hypothetical protein	0.023	0.0772	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0224	1
Onchocerca volvulus		0.0047	0.0127	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0048	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0796	0.2769	0.2769
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.023	0.0772	0.0773
Schistosoma mansoni	hypothetical protein	0.0016	0.0018	0.0018
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0048	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0027	0.5561
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0018	0.0018
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0127	0.0127
Echinococcus multilocularis	survival motor neuron protein 1	0.023	0.0772	0.0772
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0862	0.3	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0018	0.0018
Trichomonas vaginalis	inositol monophosphatase, putative	0.0074	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0119	0.0119
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0049	0.1115
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0224	0.0224
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0047	0.0127	0.0127
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0049	0.1473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0119	0.0119
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.2848	1	1
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0862	0.3	0.3004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0119	0.0119
Schistosoma mansoni	hypothetical protein	0.0035	0.0084	0.0084
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.2848	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0048	0.2162
Loa Loa (eye worm)	hypothetical protein	0.0858	0.2985	0.2989
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0018	0.0018
Echinococcus granulosus	muscleblind protein	0.0298	0.1012	0.1012
Schistosoma mansoni	hypothetical protein	0.0016	0.0018	0.0018
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0127	0.0127
Echinococcus granulosus	GPCR family 2	0.0016	0.0018	0.0018
Brugia malayi	Muscleblind-like protein	0.0298	0.1012	0.1012
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0074	0.0224	1
Loa Loa (eye worm)	hypothetical protein	0.2844	0.9985	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.014	0.014
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0224	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0027	0.0027
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0049	0.1115
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0084	0.0084
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0224	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0018	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0049	0.1473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0119	0.0119
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0049	0.1115
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0074	0.0224	0.5
Echinococcus granulosus	geminin	0.0176	0.0583	0.0583
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0049	0.1115
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0074	0.0224	1
Schistosoma mansoni	protein kinase	0.2848	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.005	0.014	0.014
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0049	0.1115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 672568