Detailed information for compound 675279

Basic information

Technical information
  • TDR Targets ID: 675279
  • Name: 8-methoxy-2-(trichloromethyl)-1H-quinazolin-4 -one
  • MW: 293.534 | Formula: C10H7Cl3N2O2
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1nc(nc2O)C(Cl)(Cl)Cl
  • InChi: 1S/C10H7Cl3N2O2/c1-17-6-4-2-3-5-7(6)14-9(10(11,12)13)15-8(5)16/h2-4H,1H3,(H,14,15,16)
  • InChiKey: FZQKJIKWJCYNSE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • T0500-2822
  • ZINC00308992

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.0127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.024 0.0639
Schistosoma mansoni protein kinase 0.2643 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0052 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0127
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.024 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0211 1
Echinococcus multilocularis geminin 0.0175 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0175 0.0625 0.0625
Loa Loa (eye worm) inositol-1 0.0074 0.024 0.024
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0052 0.0028
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0052 0.1115
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0296 0.1085 0.1087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0175 0.0625 0.0625
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0828 0.0828
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.015 0.015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0052 0.1115
Loa Loa (eye worm) hypothetical protein 0.0296 0.1085 0.1087
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0052 0.1115
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.009
Brugia malayi Inositol-1 0.0074 0.024 0.024
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0029 0.0205
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0127 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0052 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.08 0.2998 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0052 0.1115
Brugia malayi hypothetical protein 0.0016 0.0019 0.0019
Echinococcus multilocularis muscleblind protein 1 0.0296 0.1085 0.1085
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0029 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0127 0.0127
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.002
Schistosoma mansoni inositol monophosphatase 0.0074 0.024 0.024
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0052 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Echinococcus multilocularis muscleblind protein 0.0296 0.1085 0.1085
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0029 0.5565
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0052 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0211 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0052 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0127
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.024 0.024
Mycobacterium ulcerans hypothetical protein 0.0025 0.0052 0.1115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0052 0.1474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0052 0.2162
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.024 0.5
Brugia malayi hypothetical protein 0.0024 0.0052 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.024 1
Echinococcus granulosus geminin 0.0175 0.0625 0.0625
Schistosoma mansoni protein kinase 0.2643 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.005 0.015 0.015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0052 0.1115
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.2639 0.9985 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.024 0.0639
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0052 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.024 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.009 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.002 0.002
Echinococcus granulosus muscleblind protein 0.0296 0.1085 0.1085
Loa Loa (eye worm) hypothetical protein 0.0796 0.2983 0.2987
Brugia malayi Latrophilin receptor protein 2 0.0016 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Schistosoma mansoni survival motor neuron protein 0.0047 0.0137 0.0137
Echinococcus granulosus GPCR family 2 0.0016 0.002 0.002
Brugia malayi Muscleblind-like protein 0.0296 0.1085 0.1085
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.024 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2643 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.0127
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.08 0.2998 0.3002
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2643 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0052 0.1115
Schistosoma mansoni inositol monophosphatase 0.0074 0.024 0.024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0047 0.0137 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0052 0.1474
Echinococcus multilocularis GPCR, family 2 0.0016 0.002 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0137 0.0137
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0828 0.0828
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.08 0.2998 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0127
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.2969 0.2969
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.0828 0.0829
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0052 0.0028
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0029 0.5565
Brugia malayi hypothetical protein 0.0229 0.0828 0.0828
Onchocerca volvulus 0.0025 0.0052 0.3841
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0029
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.024 1
Onchocerca volvulus 0.0047 0.0137 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0052 0.1115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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