TDR Targets

Basic information

Technical information

TDR Targets ID: 676389
Name: 2-[(4-bromophenyl)methyl-(4-chlorophenyl)sulf onylamino]-N-cyclopropylacetamide
MW: 457.769 | Formula: C18H18BrClN2O3S
H donors: 1 H acceptors: 3 LogP: 3.78 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)Cl)Cc1ccc(cc1)Br)NC1CC1
InChi: 1S/C18H18BrClN2O3S/c19-14-3-1-13(2-4-14)11-22(12-18(23)21-16-7-8-16)26(24,25)17-9-5-15(20)6-10-17/h1-6,9-10,16H,7-8,11-12H2,(H,21,23)
InChiKey: LXEJNEFJWJCDFR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[(4-bromophenyl)methyl-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-acetamide
2-[(4-bromobenzyl)-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-acetamide
2-[(4-bromophenyl)methyl-(4-chlorophenyl)sulfonyl-amino]-N-cyclopropyl-ethanamide
ZINC01163120
STK152191

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0258	0.0258
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0085	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0253	0.1053
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0227	0.1644	0.1644
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.009	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Brugia malayi	hypothetical protein	0.001	0.0019	0.0008
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.009	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0011	0.0011
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.0085	0.0085
Schistosoma mansoni	zinc finger protein	0.0009	0.0011	0.0011
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0085	0.0085
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.0085	0.0085
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0011	0.0011
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.0085	0.0085
Entamoeba histolytica	hypothetical protein	0.0042	0.0258	0.2926
Brugia malayi	hypothetical protein	0.001	0.0019	0.0008
Schistosoma mansoni	patched 1	0.0041	0.0253	0.0253
Schistosoma mansoni	acetylcholinesterase	0.0227	0.1644	0.1644
Echinococcus multilocularis	acetylcholinesterase	0.1346	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0013	0.0002
Brugia malayi	CHE-14 protein	0.0041	0.0253	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Schistosoma mansoni	hypothetical protein	0.004	0.0242	0.0242
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0253	0.0253
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.0085	0.0074
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.009	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0009	0.0011	0.0011
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0227	0.1644	0.1644
Schistosoma mansoni	hypothetical protein	0.0042	0.0258	0.0258
Loa Loa (eye worm)	carboxylesterase	0.0227	0.1644	0.1635
Loa Loa (eye worm)	hypothetical protein	0.1346	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1346	1	1
Onchocerca volvulus		0.0227	0.1644	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0009	0.0011	0.0011
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.009	0.0079
Brugia malayi	ecdysteroid receptor	0.0019	0.0085	0.0074
Onchocerca volvulus	Protein ultraspiracle homolog	0.0019	0.0085	0.0451
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.0085	0.0074
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0013	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.0085	0.0074
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0227	0.1644	1
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0085	0.0085
Echinococcus multilocularis	nuclear receptor nhr 48	0.0009	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0042	0.0258	0.2926
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0008
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0019	0.0008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0412	0.0412
Schistosoma mansoni	hypothetical protein	0.0419	0.3079	0.3079
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0258	0.0258
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0165	0.0154
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0227	0.1644	0.1644
Onchocerca volvulus	Bile acid receptor homolog	0.0019	0.0085	0.0451
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.009	0.009
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0674	0.0674
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0227	0.1644	0.1635
Schistosoma mansoni	cpg binding protein	0.0031	0.0178	0.0178
Echinococcus multilocularis	protein patched	0.0041	0.0253	0.0253
Entamoeba histolytica	hypothetical protein	0.0042	0.0258	0.2926
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0011	0.0011
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0085	0.0085
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0019	0.0008
Brugia malayi	Carboxylesterase family protein	0.0227	0.1644	0.1635
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0019	0.0085	0.0451
Mycobacterium ulcerans	carboxylesterase, LipT	0.0227	0.1644	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.009	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0362	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0011	0.0011
Brugia malayi	nuclear hormone receptor	0.0019	0.0085	0.0074
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.0085	0.0085
Brugia malayi	Carboxylesterase family protein	0.0227	0.1644	0.1635
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0011	0.0011
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.009	0.5
Echinococcus granulosus	acetylcholinesterase	0.1346	1	1
Onchocerca volvulus		0.0227	0.1644	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.0085	0.0085
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0297	0.0297
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.0085	0.0085
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.0085	0.0085
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.0085	0.0074
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.001	0.0019	0.0008
Loa Loa (eye worm)	carboxylesterase	0.0227	0.1644	0.1635
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0011	0.0011
Schistosoma mansoni	hypothetical protein	0.004	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.004	0.0242	0.0242
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0009	0.0011	0.0011
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.009	0.5
Echinococcus granulosus	neuroligin	0.0227	0.1644	0.1644
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.0085	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0008
Schistosoma mansoni	ap endonuclease	0.0019	0.009	0.009
Onchocerca volvulus		0.0029	0.0165	0.0944
Brugia malayi	steroid hormone receptor	0.0019	0.0085	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.0085	0.0074
Onchocerca volvulus		0.0019	0.0085	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Schistosoma mansoni	coup transcription factor	0.0019	0.0085	0.0085
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.0085	0.0085
Echinococcus granulosus	geminin	0.0341	0.249	0.249
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.0085	0.0085
Brugia malayi	Carboxylesterase family protein	0.0227	0.1644	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Echinococcus multilocularis	acetylcholinesterase	0.1346	1	1
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0085	0.0074
Brugia malayi	hypothetical protein	0.0042	0.0258	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Echinococcus granulosus	thyroid hormone receptor alpha	0.0009	0.0011	0.0011
Schistosoma mansoni	gliotactin	0.0227	0.1644	0.1644
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.009	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.0085	0.0085
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.0085	0.0074
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.009	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0663	0.0653
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0009	0.0011	0.0011
Echinococcus multilocularis	cpg binding protein	0.0031	0.0178	0.0178
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0019	0.0019
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.001	0.0019	0.0019
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0663	0.0663
Echinococcus granulosus	para nitrobenzyl esterase	0.0227	0.1644	0.1644
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.0971	0.0971
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0253	0.0243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.0085	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.0085	0.0074
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.0085	0.0085
Trichomonas vaginalis	spcc417.12 protein, putative	0.0227	0.1644	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0013	0.0013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0085	0.0085
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0011	0.0011
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.0085	0.0085
Schistosoma mansoni	nuclear receptor	0.0009	0.0011	0.0011
Echinococcus granulosus	acetylcholinesterase	0.1346	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.0971	0.0971
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0227	0.1644	0.1644
Echinococcus multilocularis	expressed conserved protein	0.009	0.062	0.062
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.0085	0.0085
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Echinococcus granulosus	carboxylesterase 5A	0.1346	1	1
Schistosoma mansoni	hypothetical protein	0.0341	0.249	0.249
Onchocerca volvulus		0.0227	0.1644	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0227	0.1644	0.1644
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0165	0.0154
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.0085	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Brugia malayi	Carboxylesterase family protein	0.0227	0.1644	0.1635
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.0085	0.0085
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0085	0.0085
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0663	0.0653
Entamoeba histolytica	hypothetical protein	0.0042	0.0258	0.2926
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.0085	0.0074
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.0085	0.0085
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.0085	0.0074
Schistosoma mansoni	ap endonuclease	0.0019	0.009	0.009
Loa Loa (eye worm)	carboxylesterase	0.1346	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.0085	0.0085
Schistosoma mansoni	nuclear receptor	0.0009	0.0011	0.0011
Echinococcus multilocularis	neuroligin	0.0227	0.1644	0.1644
Echinococcus multilocularis	carboxylesterase 5A	0.1346	1	1
Echinococcus granulosus	cpg binding protein	0.0031	0.0178	0.0178
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.009	0.5
Echinococcus granulosus	BC026374 protein S09 family	0.0227	0.1644	0.1644
Schistosoma mansoni	BC026374 protein (S09 family)	0.0227	0.1644	0.1644
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.0085	0.0074
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.0085	0.0085
Schistosoma mansoni	cpg binding protein	0.0031	0.0178	0.0178
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0663	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0227	0.1644	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0009	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0085	0.0074
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0227	0.1644	0.1644
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.001	0.0019	0.0019
Echinococcus multilocularis	dnaJ subfamily B	0.0419	0.3079	0.3079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0085	0.0085
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.0085	0.0074
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0008
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0227	0.1644	1
Echinococcus multilocularis	geminin	0.0341	0.249	0.249
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0253	0.0243
Onchocerca volvulus		0.0227	0.1644	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0085	0.0074
Loa Loa (eye worm)	hypothetical protein	0.1346	1	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1644	0.1635
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0008
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0227	0.1644	0.1644
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.0085	0.0074
Schistosoma mansoni	hypothetical protein	0.0341	0.249	0.249
Loa Loa (eye worm)	acetylcholinesterase 1	0.1346	1	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.009	0.0079
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0227	0.1644	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.0085	0.0085
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0663	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0085	0.0074
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0085	0.0074
Brugia malayi	Carboxylesterase family protein	0.1346	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0323	0.0312
Echinococcus granulosus	expressed conserved protein	0.009	0.062	0.062
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0009	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0085	0.0074
Schistosoma mansoni	nuclear receptor nhr-48	0.0009	0.0011	0.0011
Echinococcus granulosus	dnaJ subfamily B	0.0419	0.3079	0.3079
Brugia malayi	nuclear receptor RXR	0.001	0.0019	0.0008
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0085	0.0074
Onchocerca volvulus		0.0227	0.1644	1
Schistosoma mansoni	hypothetical protein	0.004	0.0242	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0085	0.0074
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.0085	0.0074
Echinococcus multilocularis	para nitrobenzyl esterase	0.0227	0.1644	0.1644
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0253	0.0253
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.001	0.0019	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.0085	0.0074
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0258	0.0258
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0253	0.0253

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 676389