TDR Targets

Basic information

Technical information

TDR Targets ID: 689586
Name: N-[4-(6-methoxypyridazin-3-yl)phenyl]-3,4-dim ethylbenzenesulfonamide
MW: 369.437 | Formula: C19H19N3O3S
H donors: 1 H acceptors: 4 LogP: 3.06 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(nn1)c1ccc(cc1)NS(=O)(=O)c1ccc(c(c1)C)C
InChi: 1S/C19H19N3O3S/c1-13-4-9-17(12-14(13)2)26(23,24)22-16-7-5-15(6-8-16)18-10-11-19(25-3)21-20-18/h4-12,22H,1-3H3
InChiKey: CCQWCUUZIOGUCV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-(6-methoxypyridazin-3-yl)phenyl]-3,4-dimethyl-benzenesulfonamide
N-[4-(6-methoxy-3-pyridazinyl)phenyl]-3,4-dimethylbenzenesulfonamide
ZINC05204215

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	6-phosphofructokinase	0.0116	0.2119	0.2119
Schistosoma mansoni	hypothetical protein	0.0033	0.0277	0.0738
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.1851	0.4217
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0265	0.4965
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.007	0.1113	0.1667
Echinococcus granulosus	geminin	0.017	0.3306	0.7532
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.007	0.1113	0.1113
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.007	0.1113	0.2536
Echinococcus multilocularis	geminin	0.017	0.3306	0.7532
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2927	0.4383
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.1113	0.1667
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0604	0.1607
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.2877	0.6555
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0948	0.252
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0249	0.2627
Schistosoma mansoni	hypothetical protein	0.0033	0.0277	0.0738
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0249	0.2627
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0033	0.0279	0.6169
Brugia malayi	jmjC domain containing protein	0.0039	0.0414	0.0414
Loa Loa (eye worm)	phosphofructokinase	0.0116	0.2119	0.2119
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Brugia malayi	Kinesin motor domain containing protein	0.0028	0.0184	0.0184
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0033	0.0279	0.0842
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.0948	0.2865
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0452	0.2441
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0249	0.5512
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0279	0.0417
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.1835	0.1835
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.2119	0.5635
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0249	0.1175
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.1851	0.2772
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0277	0.0632
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0152	0.2927	0.4383
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.0414	0.0414
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0414	0.0942
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0604	0.1607
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0457	0.1042
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.2119	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.0948	0.2159
Mycobacterium tuberculosis	Conserved hypothetical protein	0.017	0.3307	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0558	0.0835
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0948	0.2865
Schistosoma mansoni	kinesin eg-5	0.0028	0.0184	0.049
Echinococcus multilocularis	peregrin	0.0036	0.0346	0.0788
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0692	0.3266
Loa Loa (eye worm)	runx1	0.0059	0.0867	0.0867
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0033	0.0279	0.0417
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0265	0.0265
Brugia malayi	Isocitrate dehydrogenase	0.0033	0.0279	0.0279
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.007	0.1113	0.1113
Brugia malayi	6-phosphofructokinase	0.0116	0.2119	0.2119
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0279	0.0417
Echinococcus granulosus	intermediate filament protein	0.0029	0.0192	0.0438
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0604	0.1377
Mycobacterium ulcerans	hypothetical protein	0.017	0.3307	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0277	0.0738
Schistosoma mansoni	lozenge	0.0059	0.0867	0.2304
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.1835	0.1835
Mycobacterium ulcerans	6-phosphofructokinase	0.0116	0.2119	0.6408
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0116	0.2119	0.5
Giardia lamblia	PHD finger protein 15	0.0032	0.0265	0.143
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0249	0.5512
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0028	0.0184	0.0184
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.0414	0.0942
Toxoplasma gondii	kinesin motor domain-containing protein	0.0028	0.0184	0.1945
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.2784	0.6343
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0249	0.1175
Trypanosoma brucei	polo-like protein kinase	0.0104	0.1851	0.2772
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0249	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0533	0.5625
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0948	0.2865
Schistosoma mansoni	lamin	0.0029	0.0192	0.0512
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.2119	1
Brugia malayi	isocitrate dehydrogenase	0.0033	0.0279	0.0279
Echinococcus multilocularis	musashi	0.0029	0.0192	0.0438
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0452	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3119	0.3119
Echinococcus multilocularis	lamin dm0	0.0029	0.0192	0.0438
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0265	0.0603
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.1113	0.1667
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0249	0.4671
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.007	0.1113	0.2959
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0322	0.6677	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.1851	0.8732
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.0948	0.1419
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0277	0.0277
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.1113	0.1667
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0414	0.11
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0533	0.1215
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.1851	0.2772
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0265	0.5859
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.2119	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0279	0.0417
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0533	0.2515
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0948	0.2865
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0533	0.2515
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0604	0.1377
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0279	0.294
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0033	0.0279	0.0279
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.2119	0.3174
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.1114	0.1114
Onchocerca volvulus	Alhambra homolog	0.0032	0.0265	0.0074
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.0948	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0277	0.0632
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.2877	0.765
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0249	0.4671
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0116	0.2119	1
Echinococcus multilocularis	Protein lozenge	0.0059	0.0867	0.1975
Schistosoma mansoni	hypothetical protein	0.017	0.3306	0.8789
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0542	0.1235
Schistosoma mansoni	hypothetical protein	0.0033	0.0277	0.0738
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.1851	0.2772
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0452	1
Echinococcus granulosus	6 phosphofructokinase	0.0116	0.2119	0.4829
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.2292	0.2292
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0948	0.252
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0604	0.0604
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0265	0.0265
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0558	0.0835
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Echinococcus granulosus	lamin	0.0029	0.0192	0.0438
Schistosoma mansoni	lamin	0.0029	0.0192	0.0512
Giardia lamblia	Kinase, PLK	0.0104	0.1851	1
Plasmodium falciparum	kinesin-5	0.0028	0.0184	0.4081
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0604	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0277	0.0277
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.007	0.1113	0.5251
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0265	0.2793
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0033	0.0279	0.0635
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.2119	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.077	0.077
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.2877	0.2877
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0033	0.0279	0.5227
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.1835	0.1835
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0777	0.1163
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0192	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0192	0.0192
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.2119	1
Echinococcus multilocularis	lamin	0.0029	0.0192	0.0438
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.1851	0.8732
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3079	0.3079
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0457	0.1042
Brugia malayi	Muscleblind-like protein	0.0159	0.3079	0.3079
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.2119	0.2119
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0249	0.1345
Brugia malayi	phosphofructokinase	0.0116	0.2119	0.2119
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0279	0.0635
Onchocerca volvulus		0.0472	1	1
Echinococcus multilocularis	6 phosphofructokinase	0.0116	0.2119	0.4829
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.1851	0.1851
Echinococcus multilocularis	muscleblind protein 1	0.0159	0.3079	0.7015
Schistosoma mansoni	6-phosphofructokinase	0.0116	0.2119	0.5635
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0279	0.0635
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0414	0.11
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Brugia malayi	hypothetical protein	0.0161	0.3119	0.3119
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0192	0.0192
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.1851	0.1851
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.1851	0.4217
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0105	0.1876	0.4274
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0249	0.1175
Leishmania major	ATP-dependent phosphofructokinase	0.0116	0.2119	0.3174
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0604	0.1607
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.1851	0.4921
Brugia malayi	Bromodomain containing protein	0.0036	0.0346	0.0346
Entamoeba histolytica	kinesin, putative	0.0028	0.0184	0.087
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0277	0.0277
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0533	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0558	0.0835
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0604	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0181	0.0181
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.6677	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0033	0.0279	0.0741
Toxoplasma gondii	hypothetical protein	0.0052	0.0705	0.7441
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0604	0.1377
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0033	0.0279	0.0417
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0249	0.5
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0265	0.0603
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.007	0.1113	0.2536
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0265	0.2793
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0265	0.0704
Echinococcus granulosus	lamin dm0	0.0029	0.0192	0.0438
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Loa Loa (eye worm)	6-phosphofructokinase	0.0116	0.2119	0.2119
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0277	0.0632
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0277	0.0632
Schistosoma mansoni	hypothetical protein	0.0032	0.0265	0.0704
Echinococcus multilocularis	muscleblind protein	0.0159	0.3079	0.7015
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0279	0.294
Onchocerca volvulus		0.0161	0.3119	0.2984
Plasmodium vivax	kinesin-5	0.0028	0.0184	0.3458
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0533	0.5625
Brugia malayi	PHD-finger family protein	0.0032	0.0265	0.0265
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0152	0.2927	0.4383
Brugia malayi	intermediate filament protein	0.0029	0.0192	0.0192
Schistosoma mansoni	hypothetical protein	0.019	0.3761	1
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0116	0.2119	0.3174
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.1851	0.1691
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.0558	0.0835
Echinococcus multilocularis	isocitrate dehydrogenase	0.0033	0.0279	0.0635
Loa Loa (eye worm)	hypothetical protein	0.007	0.1114	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3079	0.3079
Loa Loa (eye worm)	hypothetical protein	0.0472	1	1
Schistosoma mansoni	hypothetical protein	0.007	0.1114	0.2962
Echinococcus granulosus	muscleblind protein	0.0159	0.3079	0.7015
Brugia malayi	MH2 domain containing protein	0.0124	0.2292	0.2292
Trichomonas vaginalis	phosphofructokinase, putative	0.0116	0.2119	1
Entamoeba histolytica	phosphofructokinase, putative	0.0116	0.2119	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0279	0.0635
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0277	0.0632
Loa Loa (eye worm)	acetyltransferase	0.015	0.2877	0.2877
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1835	0.1835
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0277	0.0277
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0192	0.0192
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.1019	0.1019
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0105	0.1876	0.4274
Leishmania major	mitochondrial DNA polymerase beta	0.0322	0.6677	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0116	0.2119	0.6408
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.2292	0.2292
Schistosoma mansoni	jumonji domain containing protein	0.0083	0.1399	0.372
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Schistosoma mansoni	hypothetical protein	0.017	0.3306	0.8789
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0033	0.0279	0.0635
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0692	0.3266
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0542	0.1235
Giardia lamblia	Kinesin-5	0.0028	0.0184	0.0996
Echinococcus granulosus	kinesin family 1	0.0219	0.4389	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.0948	0.2159
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0249	0.2627
Echinococcus granulosus	peregrin	0.0036	0.0346	0.0788
Schistosoma mansoni	kinase	0.0053	0.0723	0.1921
Echinococcus multilocularis	kinesin family 1	0.0219	0.4389	1
Loa Loa (eye worm)	hypothetical protein	0.0472	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0249	0.1175
Echinococcus granulosus	GPCR family 2	0.0033	0.0277	0.0632
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0322	0.6677	1
Brugia malayi	jmjC domain containing protein	0.0105	0.1876	0.1876

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 689586