TDR Targets

Basic information

Technical information

TDR Targets ID: 693026
Name: 2-(5-ethoxy-1,6-dimethyl-2,4-dioxopyrido[2,3- d]pyrimidin-3-yl)-N,N-di(propan-2-yl)acetamid e
MW: 376.45 | Formula: C19H28N4O4
H donors: 0 H acceptors: 4 LogP: 1.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1c(C)cnc2c1c(=O)n(CC(=O)N(C(C)C)C(C)C)c(=O)n2C
InChi: 1S/C19H28N4O4/c1-8-27-16-13(6)9-20-17-15(16)18(25)22(19(26)21(17)7)10-14(24)23(11(2)3)12(4)5/h9,11-12H,8,10H2,1-7H3
InChiKey: YQDGOTISPIWHKH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(5-ethoxy-1,6-dimethyl-2,4-dioxo-pyrido[2,3-d]pyrimidin-3-yl)-N,N-diisopropyl-acetamide
2-(5-ethoxy-1,6-dimethyl-2,4-dioxo-3-pyrido[2,3-d]pyrimidinyl)-N,N-diisopropylacetamide
2-(5-ethoxy-2,4-diketo-1,6-dimethyl-pyrido[2,3-d]pyrimidin-3-yl)-N,N-diisopropyl-acetamide
2-(5-ethoxy-1,6-dimethyl-2,4-dioxo-pyrido[2,3-d]pyrimidin-3-yl)-N,N-di(propan-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0478	1	1
Echinococcus multilocularis	peregrin	0.0034	0.0303	0.0691
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.2119	1
Echinococcus granulosus	muscleblind protein	0.0161	0.3079	0.7015
Echinococcus multilocularis	muscleblind protein 1	0.0161	0.3079	0.7015
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0222	0.0222
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0117	0.2119	0.5
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0452	0.2641
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.01	0.1736	0.3955
Giardia lamblia	Kinesin-5	0.0029	0.0184	0.1076
Loa Loa (eye worm)	6-phosphofructokinase	0.0117	0.2119	0.2119
Brugia malayi	jmjC domain containing protein	0.01	0.1736	0.1736
Echinococcus multilocularis	lamin	0.0029	0.0192	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0163	0.3119	0.3119
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0222	0.234
Brugia malayi	jmjC domain containing protein	0.0037	0.0362	0.0362
Brugia malayi	Bromodomain containing protein	0.0034	0.0303	0.0303
Brugia malayi	6-phosphofructokinase	0.0117	0.2119	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3079	0.3079
Leishmania major	ATP-dependent phosphofructokinase	0.0117	0.2119	0.3174
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0099	0.1712	0.1712
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.01	0.1736	0.3955
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0605	0.0605
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0117	0.2119	1
Brugia malayi	PHD-finger family protein	0.003	0.0222	0.0222
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1869	0.1869
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1869	0.1869
Leishmania major	mitochondrial DNA polymerase beta	0.0326	0.6677	1
Schistosoma mansoni	lamin	0.0029	0.0192	0.0512
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0605	0.1609
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0534	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0534	0.5626
Schistosoma mansoni	hypothetical protein	0.0033	0.0288	0.0767
Entamoeba histolytica	kinesin, putative	0.0029	0.0184	0.087
Echinococcus multilocularis	isocitrate dehydrogenase	0.0034	0.029	0.066
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0605	0.0605
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0948	0.2161
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.2293	0.2293
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.029	0.066
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0605	0.1379
Plasmodium vivax	kinesin-5	0.0029	0.0184	0.3454
Giardia lamblia	Kinase, PLK	0.0099	0.1712	1
Echinococcus granulosus	lamin dm0	0.0029	0.0192	0.0438
Brugia malayi	serine/threonine-protein kinase plk-2	0.0099	0.1712	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0181	0.0181
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0558	0.0835
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Plasmodium falciparum	kinesin-5	0.0029	0.0184	0.4076
Loa Loa (eye worm)	6-phosphofructokinase	0.0117	0.2119	0.2119
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0032	0.0249	0.1175
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0288	0.0657
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1113	0.1667
Schistosoma mansoni	lamin	0.0029	0.0192	0.0512
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0192	0.0192
Toxoplasma gondii	hypothetical protein	0.0053	0.0705	0.7434
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0099	0.1712	0.3902
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0152	0.2879	0.656
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0034	0.029	0.0875
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0777	0.1163
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0152	0.2879	0.7655
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.029	0.0434
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.2119	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0034	0.029	0.6402
Mycobacterium ulcerans	6-phosphofructokinase	0.0117	0.2119	0.6408
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.2293	0.2293
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1138	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3079	0.3079
Loa Loa (eye worm)	hypothetical protein	0.0478	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.1288	0.3425
Brugia malayi	MH2 domain containing protein	0.0125	0.2293	0.2293
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0326	0.6677	1
Echinococcus granulosus	6 phosphofructokinase	0.0117	0.2119	0.4829
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1869	0.1869
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0948	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0192	0.0192
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0288	0.0657
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0948	0.2868
Echinococcus granulosus	kinesin family 1	0.0221	0.4389	1
Brugia malayi	Kinesin motor domain containing protein	0.0029	0.0184	0.0184
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0558	0.0835
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0624	0.2943
Loa Loa (eye worm)	hypothetical protein	0.003	0.0222	0.0222
Mycobacterium ulcerans	hypothetical protein	0.0172	0.3307	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.029	0.066
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0326	0.6677	1
Schistosoma mansoni	hypothetical protein	0.003	0.0222	0.059
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1869	0.1869
Echinococcus granulosus	peregrin	0.0034	0.0303	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0478	1	1
Echinococcus multilocularis	kinesin family 1	0.0221	0.4389	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0697	0.0697
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.029	0.066
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0222	0.234
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0222	0.416
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0288	0.0288
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0605	0.1609
Schistosoma mansoni	kinase	0.005	0.0652	0.1734
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.029	0.0434
Echinococcus multilocularis	muscleblind protein	0.0161	0.3079	0.7015
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0034	0.029	0.066
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0034	0.029	0.077
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0117	0.2119	0.3174
Giardia lamblia	PHD finger protein 15	0.003	0.0222	0.1296
Echinococcus granulosus	intermediate filament protein	0.0029	0.0192	0.0438
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0032	0.0249	0.1175
Toxoplasma gondii	6-phosphofructokinase	0.0032	0.0249	0.2625
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.1113	0.1667
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Schistosoma mansoni	hypothetical protein	0.0192	0.3761	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0154	0.2927	0.4383
Toxoplasma gondii	kinesin motor domain-containing protein	0.0029	0.0184	0.1943
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0534	0.2518
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0192	0.0192
Brugia malayi	hypothetical protein	0.0163	0.3119	0.3119
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.029	0.3053
Brugia malayi	Muscleblind-like protein	0.0161	0.3079	0.3079
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1138	0.1138
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0034	0.029	0.029
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0558	0.0835
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0117	0.2119	0.6408
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0948	0.2868
Brugia malayi	6-phosphofructokinase	0.0117	0.2119	0.2119
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0452	0.2134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0605	0.1379
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0362	0.0825
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0099	0.1712	0.3902
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0362	0.0825
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0034	0.029	0.5426
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.2927	0.4383
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0222	0.0506
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0117	0.2119	0.3174
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Toxoplasma gondii	phosphofructokinase PFKII	0.0032	0.0249	0.2625
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0288	0.0657
Echinococcus multilocularis	Protein lozenge	0.006	0.0867	0.1975
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0034	0.029	0.066
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0624	0.2943
Echinococcus multilocularis	lamin dm0	0.0029	0.0192	0.0438
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0948	0.2868
Echinococcus multilocularis	geminin	0.0177	0.3423	0.7798
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0558	0.0835
Schistosoma mansoni	hypothetical protein	0.0033	0.0288	0.0767
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0605	0.1379
Echinococcus granulosus	geminin	0.0177	0.3423	0.7798
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0288	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0192	0.0192
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1113	0.1667
Schistosoma mansoni	6-phosphofructokinase	0.0117	0.2119	0.5635
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.029	0.0434
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.1712	0.2565
Loa Loa (eye worm)	runx1	0.006	0.0867	0.0867
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.1113	0.1113
Schistosoma mansoni	hypothetical protein	0.0177	0.3423	0.91
Schistosoma mansoni	hypothetical protein	0.0072	0.1138	0.3025
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0249	0.5
Trypanosoma cruzi	polo-like protein kinase, putative	0.0099	0.1712	0.2565
Schistosoma mansoni	hypothetical protein	0.0033	0.0288	0.0767
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.2119	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0249	0.4665
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.093	0.093
Brugia malayi	acetyltransferase, GNAT family protein	0.0152	0.2879	0.2879
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.1113	0.2959
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0605	0.1379
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.2927	0.4383
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.1113	0.1113
Schistosoma mansoni	hypothetical protein	0.0177	0.3423	0.91
Trypanosoma brucei	polo-like protein kinase	0.0099	0.1712	0.2565
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.2119	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0362	0.0962
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0249	0.5505
Schistosoma mansoni	hypothetical protein	0.0033	0.0288	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0288	0.0288
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.0249	0.1175
Echinococcus granulosus	GPCR family 2	0.0033	0.0288	0.0657
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0452	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0948	0.142
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0288	0.0657
Echinococcus granulosus	lamin	0.0029	0.0192	0.0438
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0605	0.1609
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0534	0.1216
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0948	0.2868
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0483	0.11
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0288	0.0288
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0099	0.1712	0.2565
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0222	0.059
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.1113	0.2536
Loa Loa (eye worm)	phosphofructokinase	0.0117	0.2119	0.2119
Brugia malayi	Isocitrate dehydrogenase	0.0034	0.029	0.029
Brugia malayi	isocitrate dehydrogenase	0.0034	0.029	0.029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0172	0.3307	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0534	0.5626
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.2119	1
Schistosoma mansoni	lozenge	0.006	0.0867	0.2304
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0249	0.5505
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0034	0.029	0.0434
Loa Loa (eye worm)	acetyltransferase	0.0152	0.2879	0.2879
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0948	0.2522
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0249	0.4665
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0457	0.1042
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.2119	1
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0034	0.029	0.0434
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0948	0.2522
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0534	0.2518
Onchocerca volvulus	Alhambra homolog	0.003	0.0222	0.003
Plasmodium falciparum	phd finger protein, putative	0.003	0.0222	0.4908
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.1712	0.808
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0148	0.2786	0.6348
Brugia malayi	intermediate filament protein	0.0029	0.0192	0.0192
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0362	0.0362
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0192	0.0512
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0249	0.5
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0032	0.0249	0.2625
Brugia malayi	phosphofructokinase	0.0117	0.2119	0.2119
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.2119	1
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.1712	0.4553
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0326	0.6677	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1113	0.1667
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0222	0.0506
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.0249	0.1454
Echinococcus multilocularis	musashi	0.0029	0.0192	0.0438
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.1113	0.2536
Onchocerca volvulus		0.0163	0.3119	0.2984
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0029	0.0184	0.0184
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0457	0.1042
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0288	0.0288
Echinococcus multilocularis	6 phosphofructokinase	0.0117	0.2119	0.4829
Schistosoma mansoni	kinesin eg-5	0.0029	0.0184	0.049
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0362	0.0962
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.1113	0.5251
Toxoplasma gondii	isocitrate dehydrogenase	0.0034	0.029	0.3053
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0948	0.2161
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0099	0.1712	0.808
Schistosoma mansoni	6-phosphofructokinase	0.0117	0.2119	0.5635
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0249	0.1175
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0099	0.1712	0.155
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0483	0.11

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 693026