Detailed information for compound 697300

Basic information

Technical information
  • TDR Targets ID: 697300
  • Name: 1-[(4-chlorophenyl)methyl]-N-(2-methyl-4-nitr ophenyl)-6-oxopyridine-3-carboxamide
  • MW: 397.812 | Formula: C20H16ClN3O4
  • H donors: 1 H acceptors: 4 LogP: 3.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cn1cc(ccc1=O)C(=O)Nc1ccc(cc1C)[N+](=O)[O-]
  • InChi: 1S/C20H16ClN3O4/c1-13-10-17(24(27)28)7-8-18(13)22-20(26)15-4-9-19(25)23(12-15)11-14-2-5-16(21)6-3-14/h2-10,12H,11H2,1H3,(H,22,26)
  • InChiKey: TWUARPAMZDCQLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(4-chlorophenyl)methyl]-N-(2-methyl-4-nitro-phenyl)-6-oxo-pyridine-3-carboxamide
  • 1-[(4-chlorophenyl)methyl]-N-(2-methyl-4-nitrophenyl)-6-oxo-3-pyridinecarboxamide
  • 1-(4-chlorobenzyl)-6-keto-N-(2-methyl-4-nitro-phenyl)nicotinamide
  • ZINC07574046

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.3832 0.5669
Mycobacterium ulcerans hypothetical protein 0.0074 0.1336 0.344
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0212 0.3147
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0261 0.1787
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1336 0.1313
Loa Loa (eye worm) hypothetical protein 0.0054 0.0904 0.1341
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0614 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1336 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1336 0.1313
Echinococcus multilocularis GPCR, family 2 0.0017 0.01 0.0133
Toxoplasma gondii thioredoxin reductase 0.004 0.059 0.148
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1336 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0614 0.4485
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0196
Mycobacterium tuberculosis Conserved protein 0.0074 0.1336 0.1313
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1336 0.1983
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1336 0.1313
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1336 1
Plasmodium vivax glutathione reductase, putative 0.004 0.059 0.4301
Schistosoma mansoni importin beta-1 0.003 0.0385 0.0534
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.01 0.0133
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0614 0.0897
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1771 0.2616
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0261 0.1787
Loa Loa (eye worm) hypothetical protein 0.0025 0.0268 0.0398
Echinococcus granulosus tar DNA binding protein 0.0128 0.2516 0.3724
Trypanosoma brucei trypanothione reductase 0.004 0.059 0.4301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1771 0.2598
Echinococcus multilocularis musashi 0.0027 0.0313 0.045
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0212 0.1411
Trichomonas vaginalis esterase, putative 0.0074 0.1336 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.01 0.0295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0188 0.3832 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0083
Loa Loa (eye worm) hypothetical protein 0.0027 0.0313 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0268 0.097
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0024
Leishmania major trypanothione reductase 0.004 0.059 0.148
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0385 0.2736
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0268 0.097
Brugia malayi Importin beta-1 subunit 0.003 0.0385 0.1439
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1336 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.1694 0.1671
Brugia malayi beta-lactamase family protein 0.0074 0.1336 0.5259
Schistosoma mansoni ran 0.0022 0.0212 0.0275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1771 0.2616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1336 0.195
Schistosoma mansoni ap endonuclease 0.0041 0.0614 0.0875
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0132 0.0105
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0212 0.3147
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0268 0.0634
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1336 0.195
Schistosoma mansoni hypothetical protein 0.0037 0.0532 0.0752
Loa Loa (eye worm) hypothetical protein 0.0037 0.0532 0.0789
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0904 0.3522
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.1913 0.1891
Brugia malayi TAR-binding protein 0.0128 0.2516 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0904 0.1341
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.059 0.0565
Plasmodium falciparum thioredoxin reductase 0.004 0.059 0.959
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1336 0.1313
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0614 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0385 0.0557
Brugia malayi RNA binding protein 0.0128 0.2516 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1336 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0083
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0268 0.0242
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0268 0.1408
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0385 0.2736
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0268 0.0634
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.01 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0268 0.0634
Leishmania major GTP-binding protein, putative 0.0022 0.0212 0.0486
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0042 0.0062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.01 0.0133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0268 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0268 0.097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1336 0.1313
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0132 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0042 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2516 1
Schistosoma mansoni hypothetical protein 0.0195 0.3973 0.5879
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Loa Loa (eye worm) beta-lactamase 0.0074 0.1336 0.1983
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0132 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.1913 0.1891
Plasmodium vivax thioredoxin reductase, putative 0.004 0.059 0.4301
Loa Loa (eye worm) hypothetical protein 0.003 0.0385 0.0572
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0614 0.2359
Schistosoma mansoni ap endonuclease 0.0041 0.0614 0.0875
Toxoplasma gondii exonuclease III APE 0.0041 0.0614 0.1543
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.01 0.0133
Echinococcus granulosus snurportin 1 0.0322 0.6739 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.3832 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2516 0.3734
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1336 0.1313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1771 0.2616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0196
Onchocerca volvulus 0.0027 0.0313 0.0419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0303 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.011 0.0083
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0614 0.4485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.01 0.0149
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0614 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.059 0.0876
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0268 0.0398
Echinococcus granulosus GPCR family 2 0.0017 0.01 0.0133
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.1694 0.1671
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0385 0.0941
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0268 0.0242
Mycobacterium tuberculosis Probable reductase 0.009 0.1694 0.1671
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.059 0.4301
Echinococcus granulosus lamin dm0 0.0027 0.0313 0.045
Mycobacterium tuberculosis Conserved protein 0.0074 0.1336 0.1313
Leishmania major hypothetical protein, conserved 0.0074 0.1336 0.344
Schistosoma mansoni hypothetical protein 0.0195 0.3973 0.5879
Brugia malayi beta-lactamase family protein 0.0074 0.1336 0.5259
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1336 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0132 0.1787
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0268 0.0634
Echinococcus multilocularis snurportin 1 0.0322 0.6739 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0614 0.4485
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0268 0.1408
Plasmodium vivax importin-beta 2, putative 0.003 0.0385 0.2736
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2516 0.3724
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0532 0.2028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1771 0.2598
Schistosoma mansoni lamin 0.0027 0.0313 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.01 0.0133
Brugia malayi RNA, U transporter 1 0.0086 0.1596 0.6303
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1336 0.344
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0027 0.0024
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1336 0.197
Brugia malayi Thioredoxin reductase 0.004 0.059 0.2262
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0109
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.1913 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0132 0.0801
Echinococcus granulosus intermediate filament protein 0.0027 0.0313 0.045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0614 0.0589
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.3832 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0268 0.0634
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0261 0.1787
Leishmania major importin beta-1 subunit, putative 0.0024 0.0261 0.0615
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1771 0.7006
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.1694 0.1671
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0188 0.3832 0.3816
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.1694 0.1671
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0614 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0313 0.0426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0614 0.0897
Mycobacterium ulcerans lipase LipD 0.0074 0.1336 0.344
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0614 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2516 0.3708
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0188 0.3832 0.568
Echinococcus granulosus lamin 0.0027 0.0313 0.045
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2516 0.3708
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2516 0.3734
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0261 0.1787
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.6739 1
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0109
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0614 0.1543
Toxoplasma gondii ABC1 family protein 0.0074 0.1336 0.344
Loa Loa (eye worm) glutathione reductase 0.004 0.059 0.0876
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.1694 0.1671
Onchocerca volvulus 0.0074 0.1336 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1336 0.197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0313 0.0465
Echinococcus granulosus geminin 0.0195 0.3973 0.5889
Toxoplasma gondii aldehyde dehydrogenase 0.0188 0.3832 1
Trichomonas vaginalis ran, putative 0.0022 0.0212 0.1411
Schistosoma mansoni lamin 0.0027 0.0313 0.0426
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0109
Brugia malayi intermediate filament protein 0.0027 0.0313 0.115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0196
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0212 0.0486
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1336 0.344
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2516 0.3708
Brugia malayi glutathione reductase 0.004 0.059 0.2262
Brugia malayi beta-lactamase 0.0074 0.1336 0.5259
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0602 0.0878
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2516 0.3708
Onchocerca volvulus 0.0074 0.1336 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.1336 0.1313
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0614 0.4485
Entamoeba histolytica hypothetical protein 0.0024 0.0261 0.1223
Mycobacterium ulcerans aldehyde dehydrogenase 0.0188 0.3832 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0268 0.0634
Loa Loa (eye worm) hypothetical protein 0.0025 0.0268 0.0398
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0268 0.0634
Echinococcus multilocularis lamin dm0 0.0027 0.0313 0.045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0188 0.3832 0.568
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1336 0.6492
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0614 0.4485
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0614 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0212 0.0299
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0149
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1336 0.1313
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0268 0.0634
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0614 0.4485
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0313 0.0465
Loa Loa (eye worm) RNA binding protein 0.0128 0.2516 0.3734
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0212 0.1411
Onchocerca volvulus 0.0027 0.0313 0.0419
Plasmodium falciparum glutathione reductase 0.004 0.059 0.959
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0212 0.0742
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1336 1
Schistosoma mansoni ran 0.0022 0.0212 0.0275
Onchocerca volvulus 0.0074 0.1336 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1336 0.5259
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0212 0.0299
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1336 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1771 0.2616
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0268 0.1408
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0614 0.1543
Loa Loa (eye worm) hypothetical protein 0.0074 0.1336 0.1983
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0212 0.0314
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.1694 0.8667
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0212 0.1411
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0602 0.0878
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0313 0.115
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0212 0.1411
Plasmodium falciparum importin beta, putative 0.003 0.0385 0.6101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0196
Echinococcus granulosus importin subunit beta 1 0.003 0.0385 0.0557
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.1913 0.1891
Mycobacterium leprae Probable lipase LipE 0.0074 0.1336 0.6492
Echinococcus multilocularis geminin 0.0195 0.3973 0.5889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0196
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0268 0.0634
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2516 0.3708
Mycobacterium ulcerans beta-lactamase 0.0074 0.1336 0.344
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1771 0.2628
Schistosoma mansoni hypothetical protein 0.0322 0.6739 1
Schistosoma mansoni aldehyde dehydrogenase 0.0188 0.3832 0.5669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1771 0.2598
Echinococcus multilocularis lamin 0.0027 0.0313 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0904 0.3522
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0268 0.0634
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1336 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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