Detailed information for compound 705427

Basic information

Technical information
  • TDR Targets ID: 705427
  • Name: 2-[1-[(2-chlorophenyl)methyl]imidazol-2-yl]su lfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
  • MW: 425.855 | Formula: C19H15ClF3N3OS
  • H donors: 1 H acceptors: 2 LogP: 4.87 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(F)(F)F)CSc1nccn1Cc1ccccc1Cl
  • InChi: 1S/C19H15ClF3N3OS/c20-16-7-2-1-4-13(16)11-26-9-8-24-18(26)28-12-17(27)25-15-6-3-5-14(10-15)19(21,22)23/h1-10H,11-12H2,(H,25,27)
  • InChiKey: KGZSYIYQGFTGKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[1-[(2-chlorophenyl)methyl]-2-imidazolyl]thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[[1-(2-chlorobenzyl)imidazol-2-yl]thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[1-[(2-chlorophenyl)methyl]imidazol-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.0008
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0197 0.1516
Brugia malayi hypothetical protein 0.004 0.008 0.0145
Brugia malayi Sugar transporter family protein 0.0046 0.012 0.0333
Trichomonas vaginalis sugar transport protein, putative 0.0046 0.012 0.055
Trichomonas vaginalis sugar transporter, putative 0.0101 0.0528 0.2414
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0197 0.0898
Echinococcus multilocularis solute carrier family 22 0.0046 0.012 0.0333
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0589 1
Leishmania major glucose transporter, lmgt3 0.0101 0.0528 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Schistosoma mansoni protein kinase 0.01 0.0522 0.2211
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0524 0.3674 0.558
Onchocerca volvulus 0.0046 0.012 0.3147
Plasmodium falciparum lysine--tRNA ligase 0.0072 0.0319 0.0319
Onchocerca volvulus 0.0046 0.012 0.3147
Onchocerca volvulus 0.0046 0.012 0.3147
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Brugia malayi Cell death protein 3 precursor 0.0057 0.0208 0.0743
Echinococcus granulosus caspase 2 0.0057 0.0208 0.0743
Schistosoma mansoni hypothetical protein 0.004 0.008 0.0145
Plasmodium falciparum calcium-dependent protein kinase 4 0.01 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0097 0.0504 0.2017
Loa Loa (eye worm) sugar transporter 0.0324 0.2189 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus multilocularis solute carrier family 22 0.0046 0.012 0.0333
Toxoplasma gondii transporter, major facilitator family protein 0.0046 0.012 0.0183
Echinococcus granulosus synaptic vesicle 2 protein 0.0046 0.012 0.0333
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0046 0.012 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0589 0.2692
Echinococcus multilocularis General substrate transporter 0.0279 0.185 0.8418
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Toxoplasma gondii facilitative glucose transporter GT1 0.0324 0.2189 0.3324
Echinococcus multilocularis synaptic vesicle 2 protein 0.0046 0.012 0.0333
Brugia malayi hypothetical protein 0.0046 0.012 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Plasmodium vivax CDK-related protein kinase 6, putative 0.1377 1 1
Brugia malayi MAP kinase sur-1 0.0056 0.0197 0.069
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0046 0.012 0.012
Toxoplasma gondii sugar transporter ST2 0.0046 0.012 0.0183
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0113 0.0624 0.0947
Trypanosoma brucei THT1 - hexose transporter, putative 0.0101 0.0528 0.8107
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0097 0.0504 0.2126
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0046 0.012 0.151
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0197 0.1516
Onchocerca volvulus 0.0046 0.012 0.3147
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0046 0.012 0.0333
Plasmodium falciparum calcium-dependent protein kinase 1 0.01 0.0523 0.0523
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0522 0.2386
Onchocerca volvulus 0.0046 0.012 0.3147
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.01 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.0833
Chlamydia trachomatis lysine--tRNA ligase 0.0072 0.0319 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0589 0.9315
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0589 0.2692
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0197 0.069
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0046 0.012 0.151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0126 0.0357
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.012 0.0333
Entamoeba histolytica hypothetical protein 0.0072 0.0319 0.5417
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0072 0.0319 0.395
Plasmodium falciparum proline--tRNA ligase 0.0113 0.0624 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Brugia malayi major facilitator superfamily protein 0.0046 0.012 0.0333
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0055 0.019 0.1383
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0197 0.0898
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.01 0.0522 0.2211
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.012 0.0333
Echinococcus granulosus solute carrier family 22 0.0046 0.012 0.0333
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.0624 1
Onchocerca volvulus Putative transporter 0.0046 0.012 0.3147
Entamoeba histolytica protein kinase, putative 0.01 0.0522 0.8864
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0522 0.2211
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0197 0.1516
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0046 0.012 0.0333
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Trypanosoma cruzi hexose transporter, putative 0.0101 0.0528 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0197 0.1516
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.008 0.0145
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Plasmodium falciparum protein kinase 7 0.0917 0.6585 0.6585
Brugia malayi hypothetical protein 0.0046 0.012 0.0333
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0072 0.0319 0.2307
Onchocerca volvulus 0.0046 0.012 0.3147
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0589 0.2524
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0197 0.069
Echinococcus granulosus General substrate transporter 0.0279 0.185 0.8418
Echinococcus granulosus lysyl tRNA synthetase 0.0072 0.0319 0.1262
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.0833
Loa Loa (eye worm) hypothetical protein 0.0057 0.0208 0.0615
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Mycobacterium ulcerans integral membrane transport protein 0.0046 0.012 0.151
Schistosoma mansoni protein kinase 0.01 0.0522 0.2211
Plasmodium falciparum mitogen-activated protein kinase 2 0.0524 0.3674 0.3674
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0126 0.0357
Leishmania major glucose transporter, lmgt1 0.0101 0.0528 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.0624 1
Onchocerca volvulus 0.0046 0.012 0.3147
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Plasmodium vivax hexose transporter 0.0324 0.2189 0.2189
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0319 0.511
Toxoplasma gondii sugar transporter ST1 0.0046 0.012 0.0183
Loa Loa (eye worm) hypothetical protein 0.0097 0.0504 0.2017
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0253 0.1156
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0504 0.2126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0126 0.0357
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0624 1
Giardia lamblia Hexose transporter 0.0046 0.012 0.2388
Plasmodium falciparum calcium-dependent protein kinase 2 0.01 0.0523 0.0523
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0208 0.0743
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0197 0.069
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0589 1
Echinococcus multilocularis calcium dependent protein kinase 0.0093 0.0473 0.1983
Schistosoma mansoni glucose transporter 0.0046 0.012 0.0333
Trichomonas vaginalis glucose transporter, putative 0.0101 0.0528 0.2414
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0589 0.2524
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0097 0.0504 0.8554
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0097 0.0504 0.2126
Trypanosoma cruzi hexose transporter 0.0101 0.0528 0.8107
Onchocerca volvulus 0.0046 0.012 0.3147
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus granulosus solute carrier family 22 0.0046 0.012 0.0333
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0072 0.0319 0.1458
Schistosoma mansoni glucose transport protein 0.0324 0.2189 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0589 0.2692
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0589 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0524 0.3674 0.3674
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0197 0.3902
Trypanosoma cruzi hexose transporter, putative 0.0101 0.0528 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0046 0.012 0.055
Plasmodium vivax lysine--tRNA ligase, putative 0.0072 0.0319 0.0319
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Onchocerca volvulus 0.0046 0.012 0.3147
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0319 0.511
Loa Loa (eye worm) hypothetical protein 0.0079 0.0369 0.1375
Echinococcus granulosus solute carrier family 22 0.0046 0.012 0.0333
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0197 0.0561
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0197 0.0898
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0589 0.2421
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.01 0.0523 0.0523
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0589 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0126 0.0357
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0589 0.2421
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Toxoplasma gondii sugar transporter ST3 0.0046 0.012 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0589 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0197 0.069
Echinococcus multilocularis solute carrier family 22 0.0046 0.012 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0589 0.9315
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.012 0.055
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0197 0.1516
Giardia lamblia Prolyl-tRNA synthetase 0.0097 0.0504 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0097 0.0504 0.2126
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.012 0.055
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0097 0.0504 0.2303
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0589 0.2524
Onchocerca volvulus 0.0046 0.012 0.3147
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus granulosus solute carrier family 22 0.0046 0.012 0.0333
Brugia malayi major facilitator superfamily protein 0.0046 0.012 0.0333
Schistosoma mansoni sugar transporter 0.0046 0.012 0.0333
Brugia malayi Sugar transporter family protein 0.0046 0.012 0.0333
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0589 0.2692
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Giardia lamblia Sugar-proton symporter 0.0046 0.012 0.2388
Leishmania major glucose transporter, lmgt2 0.0101 0.0528 0.8107
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Trypanosoma brucei THT1 - hexose transporter, putative 0.0101 0.0528 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.01 0.0523 0.0523
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.012 0.0199
Echinococcus multilocularis lysyl tRNA synthetase 0.0072 0.0319 0.1262
Onchocerca volvulus 0.0046 0.012 0.3147
Brugia malayi lysyl-tRNA synthetase 0.0072 0.0319 0.1262
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.012 0.0333
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.01 0.0522 0.7985
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0126 0.0357
Trypanosoma brucei glucose transporter 2A 0.0101 0.0528 0.8107
Plasmodium falciparum hexose transporter 0.0324 0.2189 0.2189
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0528 0.2414
Echinococcus multilocularis caspase 2 0.0057 0.0208 0.0743
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0197 0.0898
Brugia malayi 6-phosphofructokinase 0.0109 0.0589 0.2524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0126 0.0357
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0319 0.1262
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.0833
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.01 0.0522 0.2104
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Onchocerca volvulus 0.0046 0.012 0.3147
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0097 0.0504 0.2126
Echinococcus granulosus calcium dependent protein kinase 0.0093 0.0473 0.1983
Onchocerca volvulus 0.0046 0.012 0.3147
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Leishmania major lysyl-tRNA synthetase, putative 0.0072 0.0319 0.395
Leishmania major protein kinase, putative 0.01 0.0522 0.7985
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0319 0.1262
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0197 0.1516
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Onchocerca volvulus 0.0046 0.012 0.3147
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0126 0.0224
Trichomonas vaginalis glucose transporter, putative 0.0101 0.0528 0.2414
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0097 0.0504 0.7573
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0072 0.0319 0.395
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.0238 0.2513
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Schistosoma mansoni protein kinase 0.01 0.0522 0.2211
Leishmania major glucose transporter/membrane transporter D2, putative 0.0101 0.0528 0.8107
Schistosoma mansoni glucose transport protein 0.0324 0.2189 1
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0528 0.2414
Trichomonas vaginalis sugar transporter, putative 0.0101 0.0528 0.2414
Brugia malayi Cam kinase protein 1 0.01 0.0522 0.2211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0126 0.0357
Onchocerca volvulus 0.0046 0.012 0.3147
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0238 0.2513
Toxoplasma gondii lysine-tRNA ligase 0.0072 0.0319 0.0485
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0199
Schistosoma mansoni sugar transporter 0.0046 0.012 0.0333
Trypanosoma cruzi hexose transporter, putative 0.0101 0.0528 0.8107
Mycobacterium ulcerans sugar transporter 0.0046 0.012 0.151
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0589 0.2421
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Schistosoma mansoni glucose transport protein 0.0324 0.2189 1
Trichomonas vaginalis sugar transporter, putative 0.0101 0.0528 0.2414
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0589 0.2524
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.012 0.055
Brugia malayi 6-phosphofructokinase 0.0109 0.0589 0.2524
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0589 0.9315
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0589 1
Toxoplasma gondii protein kinase, putative 0.0917 0.6585 1
Schistosoma mansoni hypothetical protein 0.0324 0.2189 1
Plasmodium vivax sugar transporter, putative 0.0046 0.012 0.012
Schistosoma mansoni sugar transporter 0.0046 0.012 0.0333
Brugia malayi Sugar transporter family protein 0.0324 0.2189 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.01 0.0523 0.0794
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Echinococcus granulosus Sugar transporter ERD6 protein 0.0046 0.012 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.012 0.055
Onchocerca volvulus 0.0046 0.012 0.3147
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0624 1
Giardia lamblia Lysyl-tRNA synthetase 0.0072 0.0319 0.6332
Trypanosoma brucei protein kinase, putative 0.0056 0.0197 0.1516
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.0833
Trichomonas vaginalis myo-inositol transporter, putative 0.0046 0.012 0.055
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0197 0.069
Echinococcus multilocularis solute carrier family 22 0.0046 0.012 0.0333
Loa Loa (eye worm) hypothetical protein 0.0072 0.0319 0.1141
Plasmodium vivax proline--tRNA ligase, putative 0.0113 0.0624 0.0624
Loa Loa (eye worm) sugar transporter 0.0046 0.012 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Entamoeba histolytica protein kinase, putative 0.01 0.0522 0.8864
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.01 0.0522 0.2104
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0037 0.1158
Trypanosoma brucei glucose transporter, putative 0.0101 0.0528 0.8107
Loa Loa (eye worm) hypothetical protein 0.01 0.0522 0.2104
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0522 0.2211
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.01 0.0523 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.012 0.055
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0624 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0101 0.0528 0.8107
Plasmodium vivax calcium-dependent protein kinase, putative 0.01 0.0523 0.0523
Trypanosoma brucei glucose transporter 1E 0.0101 0.0528 0.8107
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.01 0.0522 0.2211
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0197 0.0299
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0126 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.01 0.0523 0.0794
Brugia malayi phosphofructokinase 0.0109 0.0589 0.2524
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.2189 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.01 0.0523 0.0523
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0208 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0589 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.008 0.0145
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.012 0.0199
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0324 0.2189 1
Schistosoma mansoni sugar transporter 0.0046 0.012 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2189 1
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0037 0.0627
Brugia malayi hypothetical protein 0.0046 0.012 0.0333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0197 0.1516
Trichomonas vaginalis sugar transporter, putative 0.0046 0.012 0.055
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0504 0.2126
Plasmodium falciparum calcium-dependent protein kinase 5 0.01 0.0523 0.0523

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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