Detailed information for compound 708694

Basic information

Technical information
  • TDR Targets ID: 708694
  • Name: N-[2-(4-acetylpiperazin-1-yl)phenyl]-3-methox ybenzamide
  • MW: 353.415 | Formula: C20H23N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)Nc1ccccc1N1CCN(CC1)C(=O)C
  • InChi: 1S/C20H23N3O3/c1-15(24)22-10-12-23(13-11-22)19-9-4-3-8-18(19)21-20(25)16-6-5-7-17(14-16)26-2/h3-9,14H,10-13H2,1-2H3,(H,21,25)
  • InChiKey: LCIFKIQLDCSUTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(4-acetylpiperazin-1-yl)phenyl]-3-methoxy-benzamide
  • N-[2-(4-acetyl-1-piperazinyl)phenyl]-3-methoxybenzamide
  • N-[2-(4-ethanoylpiperazin-1-yl)phenyl]-3-methoxy-benzamide
  • STK295186
  • ZINC04840992

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1849 0.1849
Brugia malayi Thioredoxin reductase 0.0046 0.1849 0.4809
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.8837 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.1091 0.1091
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.6694 0.7537
Schistosoma mansoni hypothetical protein 0.0165 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.6694 0.7537
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.5891 0.6614
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.2677 0.2677
Loa Loa (eye worm) hypothetical protein 0.0069 0.3413 0.8085
Schistosoma mansoni hypothetical protein 0.0165 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.4204 1
Trypanosoma brucei trypanothione reductase 0.0046 0.1849 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.1254 0.2863
Loa Loa (eye worm) hypothetical protein 0.004 0.1412 0.3245
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.8837 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.1849 1
Brugia malayi PHD-finger family protein 0.0024 0.0356 0.0618
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.5891 0.6614
Brugia malayi Bromodomain containing protein 0.0037 0.1249 0.3126
Plasmodium falciparum glutathione reductase 0.0046 0.1849 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.4204 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0198 0.0198
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.1091 0.1091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.5891 0.6614
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.5891 0.6614
Brugia malayi Bromodomain containing protein 0.0073 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1539 0.3553
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1849 0.5
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.5891 0.6614
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0136 0.0136
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.8837 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1849 1
Schistosoma mansoni bromodomain containing protein 0.0061 0.2916 0.2916
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.8837 0.5
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.4204 0.5
Brugia malayi glutathione reductase 0.0046 0.1849 0.4809
Echinococcus granulosus Aminotransferase class III 0.0021 0.0136 0.0136
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1849 0.4302
Mycobacterium ulcerans hypothetical protein 0.0148 0.8837 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0136 0.5
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Echinococcus multilocularis geminin 0.0165 1 1
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.6694 0.7537
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1849 0.1849
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable reductase 0.0105 0.5891 0.6614
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.5891 0.6614
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0198 0.0198
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1849 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.8837 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.2677 0.2677
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0136 0.5
Plasmodium falciparum thioredoxin reductase 0.0046 0.1849 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.6694 0.7537
Loa Loa (eye worm) glutathione reductase 0.0046 0.1849 0.4302
Leishmania major trypanothione reductase 0.0046 0.1849 0.5
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1849 0.1969
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0198 0.0198

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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