TDR Targets

Basic information

Technical information

TDR Targets ID: 710763
Name: 5-(2,4-dichlorophenyl)-N-(4-methoxy-3-nitroph enyl)furan-2-carboxamide
MW: 407.204 | Formula: C18H12Cl2N2O5
H donors: 1 H acceptors: 3 LogP: 4.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1[N+](=O)[O-])NC(=O)c1ccc(o1)c1ccc(cc1Cl)Cl
InChi: 1S/C18H12Cl2N2O5/c1-26-16-5-3-11(9-14(16)22(24)25)21-18(23)17-7-6-15(27-17)12-4-2-10(19)8-13(12)20/h2-9H,1H3,(H,21,23)
InChiKey: GOZDFTXEBHPBKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(2,4-dichlorophenyl)-N-(4-methoxy-3-nitro-phenyl)furan-2-carboxamide
5-(2,4-dichlorophenyl)-N-(4-methoxy-3-nitrophenyl)-2-furancarboxamide
5-(2,4-dichlorophenyl)-N-(4-methoxy-3-nitro-phenyl)-2-furamide
ZINC04869849

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	thioredoxin reductase	0.0098	0.254	0.2591
Trypanosoma cruzi	polo-like protein kinase, putative	0.0196	0.594	0.8553
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0291	0.9226	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0225	0.6939	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0196	0.594	1
Schistosoma mansoni	hypothetical protein	0.0082	0.1993	0.1827
Echinococcus granulosus	chromobox protein 1	0.0074	0.1689	0.2806
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0566	0.0904
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0566	0.0904
Trypanosoma brucei	unspecified product	0.004	0.0523	0.063
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0082	0.1993	0.1827
Leishmania major	DNA polymerase eta, putative	0.004	0.0523	0.0712
Trypanosoma brucei	polo-like protein kinase	0.0196	0.594	0.8541
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.0523	0.0129
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.3698	0.6092
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0313	0.0528
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.0313	0.0123
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0453	0.0713
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0621	0.0998
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0523	0.063
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0313	0.5
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0324
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.0313	0.0123
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0313	0.0408
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0523	0.063
Schistosoma mansoni	hypothetical protein	0.0082	0.1993	0.1827
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0523	0.0712
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0082	0.1993	0.3355
Trypanosoma cruzi	polo-like protein kinase, putative	0.0196	0.594	0.8553
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0523	0.0712
Echinococcus multilocularis	dna polymerase eta	0.004	0.0523	0.0832
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2502	0.4182
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0313	0.5
Schistosoma mansoni	chromobox protein	0.0074	0.1689	0.1518
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0249	0.7773	0.842
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0249	0.7773	0.3739
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.3698	0.6225
Echinococcus granulosus	dna polymerase kappa	0.004	0.0523	0.0832
Loa Loa (eye worm)	thioredoxin reductase	0.0098	0.254	0.4075
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.0313	0.0475
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0523	0.0535
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.0523	0.0832
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0523	0.0712
Brugia malayi	jmjC domain containing protein	0.0101	0.2637	0.4439
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0313	0.0307
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.0313	0.0324
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0675	0.1088
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0523	0.0712
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0196	0.594	0.8553
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0523	0.0881
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0675	0.0823
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Schistosoma mansoni	hypothetical protein	0.0179	0.5351	0.5255
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0202	0.0289
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1689	0.2806
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.1689	0.2591
Loa Loa (eye worm)	hypothetical protein	0.004	0.0523	0.0559
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0147	0.0196
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0101	0.2637	0.4409
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.0523	0.0832
Schistosoma mansoni	DNA polymerase eta	0.004	0.0523	0.0328
Echinococcus granulosus	thioredoxin glutathione reductase	0.0098	0.254	0.4246
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3698	0.3567
Schistosoma mansoni	apoptosis regulator bax	0.0082	0.1993	0.1827
Echinococcus multilocularis	chromobox protein 1	0.0074	0.1689	0.2806
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.2502	0.4182
Loa Loa (eye worm)	apoptosis regulator protein	0.0082	0.1993	0.312
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0313	0.5
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0307
Trypanosoma cruzi	trypanothione reductase, putative	0.0098	0.254	0.3632
Trypanosoma cruzi	hypothetical protein, conserved	0.0225	0.6939	1
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0082	0.1993	0.3319
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0566	0.0633
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.3698	0.6205
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0967	0.1332
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0313	0.0477
Loa Loa (eye worm)	glutathione reductase	0.0098	0.254	0.4075
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0428	0.0392
Echinococcus multilocularis	peregrin	0.0031	0.0202	0.0289
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.0523	0.0328
Echinococcus granulosus	geminin	0.0179	0.5351	0.9003
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0523	0.0328
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.0523	0.063
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0313	0.0408
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0523	0.0535
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0196	0.594	1
Echinococcus granulosus	dna polymerase eta	0.004	0.0523	0.0832
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Onchocerca volvulus		0.0032	0.0256	0.0094
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0291	0.9226	1
Schistosoma mansoni	kinase	0.01	0.2592	0.2439
Brugia malayi	serine/threonine-protein kinase plk-2	0.0196	0.594	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1993	0.312
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0523	0.0535
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0428	0.023
Brugia malayi	TAR-binding protein	0.0131	0.3698	0.6225
Brugia malayi	PHD-finger family protein	0.0031	0.0202	0.0341
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.3698	0.6092
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0224	0.6906	0.7477
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3698	0.3567
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.1342	0.1985
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0477
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.0313	0.0324
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0098	0.254	0.4246
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0196	0.594	1
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0313	0.0123
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0291	0.9226	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0196	0.594	1
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0082	0.1993	0.3319
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0675	0.1088
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0202	0.0289
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0523	0.0832
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.0313	0.0123
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0477
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.0313	0.0307
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0313	0.0408
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0224	0.6906	0.7477
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0101	0.2637	0.4409
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0621	0.0998
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0249	0.7773	0.842
Brugia malayi	jmjC domain containing protein	0.0037	0.0428	0.072
Echinococcus multilocularis	geminin	0.0179	0.5351	0.9003
Toxoplasma gondii	thioredoxin reductase	0.0098	0.254	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0313	0.0324
Leishmania major	DNA polymerase kappa, putative	0.004	0.0523	0.0712
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0453	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0256	0.0094
Plasmodium falciparum	glutathione reductase	0.0098	0.254	0.2591
Echinococcus granulosus	peregrin	0.0031	0.0202	0.0289
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1689	0.2806
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.0313	0.0475
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0313	0.0408
Plasmodium vivax	glutathione reductase, putative	0.0098	0.254	0.2591
Schistosoma mansoni	serine/threonine protein kinase	0.0196	0.594	0.5856
Treponema pallidum	hypothetical protein	0.0291	0.9226	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0428	0.067
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0224	0.6906	0.7477
Trypanosoma brucei	hypothetical protein, conserved	0.0225	0.6939	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0523	0.0832
Echinococcus granulosus	tar DNA binding protein	0.0131	0.3698	0.6205
Brugia malayi	Thioredoxin reductase	0.0098	0.254	0.4276
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0523	0.0832
Giardia lamblia	DINP protein human, muc B family	0.004	0.0523	0.0559
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3698	0.3567
Mycobacterium tuberculosis	Probable reductase	0.0224	0.6906	0.7477
Brugia malayi	RNA binding protein	0.0131	0.3698	0.6225
Schistosoma mansoni	jumonji domain containing protein	0.008	0.1916	0.1749
Schistosoma mansoni	hypothetical protein	0.0179	0.5351	0.5255
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.1689	0.2806
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0313	0.0477
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.0523	0.0559
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0523	0.0881
Brugia malayi	Heterochromatin protein 1	0.0074	0.1689	0.2844
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0082	0.1993	0.3319
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0224	0.6906	0.7477
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Brugia malayi	chromobox protein homolog 3	0.0041	0.0566	0.0952
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0098	0.254	0.2729
Schistosoma mansoni	hypothetical protein	0.0082	0.1993	0.1827
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0523	0.063
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0249	0.7773	0.842
Trypanosoma brucei	trypanothione reductase	0.0098	0.254	0.3576
Leishmania major	trypanothione reductase	0.0098	0.254	0.3632
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0453	0.0256
Brugia malayi	hypothetical protein	0.0038	0.0453	0.0762
Mycobacterium tuberculosis	Probable dehydrogenase	0.0224	0.6906	0.7477
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.0313	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0523	0.0535
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0313	0.0307
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0291	0.9226	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0147	0.0196
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3698	0.3567
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0291	0.9226	1
Schistosoma mansoni	chromobox protein	0.0074	0.1689	0.1518
Schistosoma mansoni	hypothetical protein	0.0038	0.0453	0.0256
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0196	0.594	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0523	0.0712
Trichomonas vaginalis	CAMK family protein kinase	0.0196	0.594	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.3698	0.3567
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.0313	0.0123
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0523	0.063
Brugia malayi	glutathione reductase	0.0098	0.254	0.4276
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0082	0.1993	0.3319
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0428	0.067
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0313	0.0408
Leishmania major	hypothetical protein, conserved	0.0225	0.6939	1
Plasmodium falciparum	glutathione reductase	0.0034	0.0313	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0566	0.0633
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0313	0.0408
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0523	0.0712
Plasmodium vivax	thioredoxin reductase, putative	0.0098	0.254	0.2591
Echinococcus granulosus	chromobox protein 1	0.0074	0.1689	0.2806
Loa Loa (eye worm)	RNA binding protein	0.0131	0.3698	0.6092
Giardia lamblia	Kinase, PLK	0.0196	0.594	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0428	0.023
Brugia malayi	Bromodomain containing protein	0.0031	0.0202	0.0341

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 710763