Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0452 | 0.0406 |
Loa Loa (eye worm) | beta-lactamase | 0.0034 | 0.051 | 0.051 |
Echinococcus granulosus | lamin | 0.0033 | 0.0452 | 0.0406 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.051 | 0.0464 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0154 | 0.4072 | 0.6407 |
Mycobacterium leprae | Probable lipase LipE | 0.0034 | 0.051 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0034 | 0.051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0709 | 0.0709 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0452 | 0.0452 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0709 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0452 | 0.0452 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0452 | 0.0452 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0114 | 0.2899 | 0.2899 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0352 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0452 | 0.0406 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 0.5 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0352 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0352 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0352 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.4072 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0034 | 0.051 | 0.0464 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1279 | 0.1279 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0452 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0034 | 0.051 | 0.051 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.022 | 0.607 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0452 | 0.0406 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0352 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1279 | 0.1279 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0114 | 0.2899 | 0.2899 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0452 | 0.0452 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0352 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0034 | 0.051 | 0.0464 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0048 | 0.0048 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0048 | 0.0048 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.051 | 0.051 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0452 | 0.0406 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0352 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0435 | 0.0435 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0034 | 0.051 | 0.051 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0452 | 0.0452 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.051 | 0.0464 |
Schistosoma mansoni | lamin | 0.0033 | 0.0452 | 0.0406 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1279 | 0.1279 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0048 | 0.0048 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0709 | 0.0709 |
Brugia malayi | beta-lactamase | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0114 | 0.2899 | 0.2899 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0352 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0048 | 0.0048 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0452 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Echinococcus multilocularis | 0.0352 | 1 | 1 | |
Echinococcus multilocularis | musashi | 0.0033 | 0.0452 | 0.0406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3548 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.