Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0034 | 0.051 | 0.051 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0048 | 0.0048 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0154 | 0.4072 | 0.6407 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0048 | 0.0048 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0452 | 0.0406 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0034 | 0.051 | 0.0464 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0114 | 0.2899 | 0.2899 |
Brugia malayi | beta-lactamase | 0.0034 | 0.051 | 0.051 |
Brugia malayi | MH2 domain containing protein | 0.0114 | 0.2899 | 0.2899 |
Schistosoma mansoni | lamin | 0.0033 | 0.0452 | 0.0406 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.022 | 0.607 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0452 | 0.0452 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0034 | 0.051 | 0.051 |
Mycobacterium leprae | Probable lipase LipE | 0.0034 | 0.051 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0709 | 0.0664 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0452 | 0.0406 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0452 | 0.0452 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0352 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0709 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0709 | 0.0709 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0352 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0452 | 0.0406 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0452 | 0.0452 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.051 | 0.051 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0352 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0452 | 0.0406 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0452 | 0.0406 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.051 | 0.051 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0452 | 0.0406 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.4072 | 1 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1279 | 0.1279 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0352 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0452 | 0.0406 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0034 | 0.051 | 0.0464 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0352 | 1 | 0.5 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0352 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.051 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0435 | 0.0435 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0352 | 1 | 1 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0352 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0034 | 0.051 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.051 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Echinococcus multilocularis | 0.0352 | 1 | 1 | |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0352 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.051 | 0.051 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0452 | 0.0452 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0114 | 0.2899 | 0.2899 |
Onchocerca volvulus | 0.0034 | 0.051 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0452 | 0.0406 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0452 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1279 | 0.1279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3548 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.